{"id":"https://openalex.org/W1980596298","doi":"https://doi.org/10.1046/j.1443-1661.2003.00214.x","title":"CHANGES IN MUCOSAL PHOSPHOLIPID\u2010RELATED PROTECTION IN SOME GASTRIC DISEASES","display_name":"CHANGES IN MUCOSAL PHOSPHOLIPID\u2010RELATED PROTECTION IN SOME GASTRIC DISEASES","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1980596298","doi":"https://doi.org/10.1046/j.1443-1661.2003.00214.x","mag":"1980596298"},"language":"en","primary_location":{"id":"doi:10.1046/j.1443-1661.2003.00214.x","doi":"https://doi.org/10.1046/j.1443-1661.2003.00214.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1443-1661.2003.00214.x","pdf_url":null,"source":{"id":"https://openalex.org/S192766619","display_name":"Digestive Endoscopy","issn_l":"0915-5635","issn":["0915-5635","1443-1661"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Endoscopy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032516319","display_name":"M Matsuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"MIMIAN GRACIELA MATSUDA","raw_affiliation_strings":["Department of Laboratory Medicine, Kumamoto University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kumamoto University School of Medicine","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109317341","display_name":"Atsunobu Misumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ATSUNOBU MISUMI","raw_affiliation_strings":["Kyushu Cancer Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu Cancer Institute,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103842636","display_name":"Akitoshi Murakami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AKITOSHI MURAKAMI","raw_affiliation_strings":["National Hansen Institution Kikuchi Keifuen and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hansen Institution Kikuchi Keifuen and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017310162","display_name":"Chizuko Nakamura","orcid":"https://orcid.org/0000-0003-2346-4361","observed_orcids":["https://orcid.org/0000-0003-2346-4361"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"CHIZUKO NAKAMURA","raw_affiliation_strings":["Department of Pharmacy, Kumamoto University School of Medicine, Kumamoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Kumamoto University School of Medicine, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080037741","display_name":"Umeko Semba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"UMEKO SEMBA","raw_affiliation_strings":["Department of Laboratory Medicine, Kumamoto University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kumamoto University School of Medicine","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044788237","display_name":"Yoko Shibuya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YOKO SHIBUYA","raw_affiliation_strings":["Department of Laboratory Medicine, Kumamoto University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kumamoto University School of Medicine","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058609155","display_name":"Sebasti\u00e3o Mitsuji Miyazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SEBASTI\u00c3O MITSUJI MIYAZAKI","raw_affiliation_strings":["Kyushu Cancer Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu Cancer Institute,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011440500","display_name":"Hiroaki Okabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROAKI OKABE","raw_affiliation_strings":["Department of Laboratory Medicine, Kumamoto University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Kumamoto University School of Medicine","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032516319"],"corresponding_institution_ids":["https://openalex.org/I96036126"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.12349465,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"15","issue":"1","first_page":"35","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.8589000105857849,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.8589000105857849,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.04179999977350235,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastroprotective-effect","display_name":"gastroprotection","score":0.9110000133514404},{"id":"https://openalex.org/keywords/superficial-gastritis","display_name":"superficial gastritis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":0.996999979019165},{"id":"https://openalex.org/keywords/gastric-ulcer","display_name":"gastric ulcer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phosphatidylserine","display_name":"phosphatidylserine","score":0.9520000219345093},{"id":"https://openalex.org/keywords/phosphatidylethanolamine","display_name":"phosphatidylethanolamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.8169999718666077},{"id":"https://openalex.org/keywords/lysophosphatidylcholine","display_name":"lysophosphatidylcholine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/phosphatidylinositol","display_name":"phosphatidylinositol","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.749151885509491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7277542352676392},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6644152998924255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6458690762519836},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.533645749092102},{"id":"https://openalex.org/C2778052355","wikidata":"https://www.wikidata.org/wiki/Q5526783","display_name":"Gastric glands","level":4,"score":0.48802056908607483},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.45072272419929504},{"id":"https://openalex.org/C2781170229","wikidata":"https://www.wikidata.org/wiki/Q426095","display_name":"Phosphatidylethanolamine","level":5,"score":0.4368301331996918},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.43108734488487244},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.42728424072265625},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.4073566794395447},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4064875841140747},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1744539439678192},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08420491218566895},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1046/j.1443-1661.2003.00214.x","doi":"https://doi.org/10.1046/j.1443-1661.2003.00214.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1443-1661.2003.00214.x","pdf_url":null,"source":{"id":"https://openalex.org/S192766619","display_name":"Digestive Endoscopy","issn_l":"0915-5635","issn":["0915-5635","1443-1661"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Endoscopy","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W149824388","https://openalex.org/W1505354211","https://openalex.org/W1550436805","https://openalex.org/W1964666898","https://openalex.org/W1966623581","https://openalex.org/W1968389238","https://openalex.org/W1968463549","https://openalex.org/W1976946620","https://openalex.org/W1977445989","https://openalex.org/W1990452831","https://openalex.org/W1997162283","https://openalex.org/W2001821681","https://openalex.org/W2056493048","https://openalex.org/W2057550388","https://openalex.org/W2068674700","https://openalex.org/W2088548183","https://openalex.org/W2096916760","https://openalex.org/W2128348159","https://openalex.org/W2128635872","https://openalex.org/W2137539691","https://openalex.org/W2152311269","https://openalex.org/W2163100786","https://openalex.org/W2283576925","https://openalex.org/W2294227766","https://openalex.org/W2398501071","https://openalex.org/W2405990498","https://openalex.org/W2411693644","https://openalex.org/W2412079990","https://openalex.org/W2418891823","https://openalex.org/W2435903835","https://openalex.org/W2442470503","https://openalex.org/W3161704860"],"related_works":["https://openalex.org/W2137539691","https://openalex.org/W2047003384","https://openalex.org/W2281381293","https://openalex.org/W2584271941","https://openalex.org/W2340765907","https://openalex.org/W7048670056","https://openalex.org/W1525434949","https://openalex.org/W2351747704","https://openalex.org/W2416178594","https://openalex.org/W2024237698"],"abstract_inverted_index":{"Background:":[0],"Phospholipids":[1],"play":[2],"an":[3],"important":[4],"role":[5],"in":[6,20,23,86,92,103,110,120,134,176,182,193,199,252,261,266,272,277],"gastric":[7,33,47,50,113,123,141,144,149,229,269,274,280],"mucosal":[8,34,223,230],"protection.":[9],"The":[10,69,116,169,205,225],"purpose":[11],"of":[12,30,222],"the":[13,24,63,87,93,101,104,132,177,183,188,194,200,214,220,237,244,262],"present":[14],"study":[15],"was":[16,83,108,118,191],"to":[17,57],"investigate":[18],"changes":[19],"various":[21],"phospholipids":[22,227],"fundic":[25,64,88,105,178,201,206,238],"and":[26,39,65,100,143,155,164,171,234,241,255,271],"pyloric":[27,66,94,184,195,215,245,263],"gland":[28,67,89,95,106,179,196,202,207,216,239,246,264,275],"mucosae":[29,276],"patients":[31,41,121,267,278],"with":[32,42,122,268,279],"disease.":[35],"Methods:":[36],"One":[37],"hundred":[38],"five":[40],"superficial":[43,135,253],"gastritis,":[44,136],"duodenal":[45,139,256],"ulcer,":[46,140,257],"ulcer":[48,142],"or":[49],"cancer":[51],"were":[52,72,131,159,167,174],"studied.":[53,115],"Patients":[54],"underwent":[55],"endoscopy":[56],"obtain":[58],"biopsy":[59],"specimens":[60],"from":[61],"both":[62,273],"mucosae.":[68],"phospholipid":[70,81,129],"contents":[71],"measured":[73],"by":[74,138],"high":[75,109],"performance":[76],"liquid":[77],"chromatography.":[78],"Results:":[79],"Total":[80,128],"level":[82,102,190],"significantly":[84],"greater":[85],"mucosa":[90,96,107,180,197,208,265],"than":[91,181,198,213],"(P":[97,125],"=":[98,126],"0.037),":[99],"all":[111,147],"four":[112,148],"diseases":[114],"difference":[117],"significant":[119],"ulcers":[124],"0.0156).":[127],"levels":[130,158,166,173,221],"highest":[133],"followed":[137],"cancer.":[145,281],"In":[146],"diseases,":[150],"phosphatidylserine":[151],"(PS),":[152],"phosphatidylethanolamine":[153],"(PE),":[154],"phosphatidylcholine":[156],"(PC)":[157],"high,":[160],"while":[161],"phosphatidylinositol,":[162],"lysophosphatidylcholine,":[163],"sphingomyelin":[165],"low.":[168],"PE":[170,235],"PC":[172,233],"higher":[175,192],"glandular":[185],"mucosa,":[186,217],"whereas":[187],"PS":[189,242],"mucosa.":[203],"Conclusions:":[204],"has":[209],"stronger":[210],"phospholipid\u2010related":[211],"protection":[212,231,249],"based":[218],"on":[219],"phospholipids.":[224],"main":[226],"for":[228],"are":[232],"(in":[236,243],"mucosa)":[240],"mucosa).":[247],"Phospholipid\u2010related":[248],"is":[250,259],"strong":[251],"gastritis":[254],"but":[258],"reduced":[260],"ulcers,":[270]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}