{"id":"https://openalex.org/W1980569438","doi":"https://doi.org/10.1016/1074-7613(95)90005-5","title":"Development of B cells in scid mice with immunoglobulin transgenes: Implications for the Control of V(D)J recombination","display_name":"Development of B cells in scid mice with immunoglobulin transgenes: Implications for the Control of V(D)J recombination","publication_year":1995,"publication_date":"1995-06-01","ids":{"openalex":"https://openalex.org/W1980569438","doi":"https://doi.org/10.1016/1074-7613(95)90005-5","mag":"1980569438","pmid":"https://pubmed.ncbi.nlm.nih.gov/7796294"},"language":"en","primary_location":{"id":"doi:10.1016/1074-7613(95)90005-5","doi":"https://doi.org/10.1016/1074-7613(95)90005-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/1074-7613(95)90005-5","pdf_url":"https://doi.org/10.1016/1074-7613(95)90005-5","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/1074-7613(95)90005-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078495808","display_name":"Yung Chang","orcid":"https://orcid.org/0000-0002-3480-4563","observed_orcids":["https://orcid.org/0000-0002-3480-4563"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yung Chang","raw_affiliation_strings":["Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065957832","display_name":"Gayle C. Bosma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gayle C. Bosma","raw_affiliation_strings":["Fox Chase Cancer Center Institute for Cancer Research 7701 Burholme Avenue Philadelphia, Pennsylvania 19111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center Institute for Cancer Research 7701 Burholme Avenue Philadelphia, Pennsylvania 19111, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038396889","display_name":"Melvin J. Bosma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melvin J. Bosma","raw_affiliation_strings":["Fox Chase Cancer Center Institute for Cancer Research 7701 Burholme Avenue Philadelphia, Pennsylvania 19111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center Institute for Cancer Research 7701 Burholme Avenue Philadelphia, Pennsylvania 19111, USA","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":1.0595,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.76006161,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2","issue":"6","first_page":"607","last_page":"616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.7749999761581421},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.8709999918937683},{"id":"https://openalex.org/keywords/v-d-j-recombination","display_name":"V(D)J recombination","score":0.996999979019165},{"id":"https://openalex.org/keywords/pro-b-cells","display_name":"pro-B cells","score":0.7149999737739563},{"id":"https://openalex.org/keywords/pre-b-cells","display_name":"pre-B cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/rag1","display_name":"RAG1","score":0.7839999794960022},{"id":"https://openalex.org/keywords/rag2","display_name":"RAG2","score":1.0}],"concepts":[{"id":"https://openalex.org/C113646796","wikidata":"https://www.wikidata.org/wiki/Q50263283","display_name":"Recombination-activating gene","level":4,"score":0.9270492196083069},{"id":"https://openalex.org/C2781376893","wikidata":"https://www.wikidata.org/wiki/Q18031023","display_name":"RAG2","level":4,"score":0.8378081321716309},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8317850828170776},{"id":"https://openalex.org/C102414288","wikidata":"https://www.wikidata.org/wiki/Q1172461","display_name":"Recombinase","level":4,"score":0.7648346424102783},{"id":"https://openalex.org/C2780254951","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"V(D)J recombination","level":4,"score":0.7201540470123291},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.7093448638916016},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.5945974588394165},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.5765878558158875},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4978179931640625},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49528756737709045},{"id":"https://openalex.org/C2992511266","wikidata":"https://www.wikidata.org/wiki/Q1093098","display_name":"Gene rearrangement","level":3,"score":0.4468666613101959},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43420732021331787},{"id":"https://openalex.org/C2778724333","wikidata":"https://www.wikidata.org/wiki/Q14401","display_name":"Kappa","level":2,"score":0.4148358702659607},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3469327390193939},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007133","descriptor_name":"Immunoglobulin Joining Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007138","descriptor_name":"Immunoglobulin delta-Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015322","descriptor_name":"Gene Rearrangement, B-Lymphocyte","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/1074-7613(95)90005-5","doi":"https://doi.org/10.1016/1074-7613(95)90005-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/1074-7613(95)90005-5","pdf_url":"https://doi.org/10.1016/1074-7613(95)90005-5","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},{"id":"pmid:7796294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7796294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/1074-7613(95)90005-5","doi":"https://doi.org/10.1016/1074-7613(95)90005-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/1074-7613(95)90005-5","pdf_url":"https://doi.org/10.1016/1074-7613(95)90005-5","source":{"id":"https://openalex.org/S199671312","display_name":"Immunity","issn_l":"1074-7613","issn":["1074-7613","1097-4180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2478364638","display_name":null,"funder_award_id":"CA-04946","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7884667142","display_name":"SCID MICE AND THE CONTROL OF LYMPHOCYTE DIFFERENTIATION","funder_award_id":"R01AI013323","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1980569438.pdf"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W85405230","https://openalex.org/W136540884","https://openalex.org/W1534269392","https://openalex.org/W1543086249","https://openalex.org/W1590260451","https://openalex.org/W1596219107","https://openalex.org/W1865215802","https://openalex.org/W1913174861","https://openalex.org/W1964459498","https://openalex.org/W1966254031","https://openalex.org/W1966481793","https://openalex.org/W1970232857","https://openalex.org/W1972263794","https://openalex.org/W1975868741","https://openalex.org/W1981267088","https://openalex.org/W1985928819","https://openalex.org/W2000110243","https://openalex.org/W2006111721","https://openalex.org/W2007679715","https://openalex.org/W2010901031","https://openalex.org/W2017105911","https://openalex.org/W2023318533","https://openalex.org/W2032144081","https://openalex.org/W2032192541","https://openalex.org/W2034271713","https://openalex.org/W2034884571","https://openalex.org/W2039140653","https://openalex.org/W2041217108","https://openalex.org/W2043420091","https://openalex.org/W2048240423","https://openalex.org/W2050291003","https://openalex.org/W2061234561","https://openalex.org/W2064631075","https://openalex.org/W2069501059","https://openalex.org/W2070818143","https://openalex.org/W2072957347","https://openalex.org/W2075174748","https://openalex.org/W2087377243","https://openalex.org/W2088091759","https://openalex.org/W2097833129","https://openalex.org/W2098497060","https://openalex.org/W2104059056","https://openalex.org/W2112161923","https://openalex.org/W2119947571","https://openalex.org/W2126464081","https://openalex.org/W2132007838","https://openalex.org/W2132875885","https://openalex.org/W2134544592","https://openalex.org/W2139175329","https://openalex.org/W2139968053","https://openalex.org/W2140489687","https://openalex.org/W2142778960","https://openalex.org/W2150066505","https://openalex.org/W2154213298","https://openalex.org/W2165579893","https://openalex.org/W2168142439","https://openalex.org/W2173547083","https://openalex.org/W2300651393"],"related_works":["https://openalex.org/W76558812","https://openalex.org/W1913174861","https://openalex.org/W6999909656","https://openalex.org/W2095372875","https://openalex.org/W2087377243","https://openalex.org/W7097457793","https://openalex.org/W2083118297","https://openalex.org/W1969733242","https://openalex.org/W2122688151","https://openalex.org/W7100807124"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}