{"id":"https://openalex.org/W1980559693","doi":"https://doi.org/10.1021/cg500573e","title":"Surface Mediated Structures: Stabilization of Metastable Polymorphs on the Example of Paracetamol","display_name":"Surface Mediated Structures: Stabilization of Metastable Polymorphs on the Example of Paracetamol","publication_year":2014,"publication_date":"2014-07-07","ids":{"openalex":"https://openalex.org/W1980559693","doi":"https://doi.org/10.1021/cg500573e","mag":"1980559693","pmid":"https://pubmed.ncbi.nlm.nih.gov/25126023","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4125415"},"language":"en","primary_location":{"id":"doi:10.1021/cg500573e","doi":"https://doi.org/10.1021/cg500573e","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cg500573e","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/cg500573e?ref=article_openPDF","source":{"id":"https://openalex.org/S16561315","display_name":"Crystal Growth & Design","issn_l":"1528-7483","issn":["1528-7483","1528-7505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crystal Growth & Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/cg500573e?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024152386","display_name":"Heike M. A. Ehmann","orcid":"https://orcid.org/0000-0002-2680-1733","observed_orcids":["https://orcid.org/0000-0002-2680-1733"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Heike M. A. Ehmann","raw_affiliation_strings":["Institute\rof Pharmaceutical\rScience, Department of Pharmaceutical Technology, Karl-Franzens University of Graz, Universit\u00e4tsplatz 1, 8010 Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rof Pharmaceutical\rScience, Department of Pharmaceutical Technology, Karl-Franzens University of Graz, Universit\u00e4tsplatz 1, 8010 Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015337472","display_name":"Oliver Werzer","orcid":"https://orcid.org/0000-0003-0732-4422","observed_orcids":["https://orcid.org/0000-0003-0732-4422"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Oliver Werzer","raw_affiliation_strings":["Institute\rof Pharmaceutical\rScience, Department of Pharmaceutical Technology, Karl-Franzens University of Graz, Universit\u00e4tsplatz 1, 8010 Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute\rof Pharmaceutical\rScience, Department of Pharmaceutical Technology, Karl-Franzens University of Graz, Universit\u00e4tsplatz 1, 8010 Graz, Austria","institution_ids":["https://openalex.org/I15766117"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024152386"],"corresponding_institution_ids":["https://openalex.org/I15766117"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":2916,"currency":"EUR","value_usd":3144},"fwci":1.8858,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.84953621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"8","first_page":"3680","last_page":"3684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10389","display_name":"Polymer crystallization and properties","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paracetamol","display_name":"paracetamol","score":0.9430000185966492},{"id":"https://openalex.org/keywords/polymorphism","display_name":"polymorphism","score":0.9139999747276306},{"id":"https://openalex.org/keywords/metastable-polymorphs","display_name":"metastable polymorphs","score":0.8889999985694885},{"id":"https://openalex.org/keywords/silica-surfaces","display_name":"silica surfaces","score":0.7960000038146973},{"id":"https://openalex.org/keywords/spin-coating","display_name":"spin coating","score":0.6499999761581421},{"id":"https://openalex.org/keywords/heat-treatment","display_name":"heat treatment","score":0.8870000243186951},{"id":"https://openalex.org/keywords/polymorph-stability","display_name":"polymorph stability","score":0.5419999957084656},{"id":"https://openalex.org/keywords/pharmaceutical-polymorphs","display_name":"pharmaceutical polymorphs","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C89464430","wikidata":"https://www.wikidata.org/wiki/Q849516","display_name":"Metastability","level":2,"score":0.7725839614868164},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5692209005355835},{"id":"https://openalex.org/C207114421","wikidata":"https://www.wikidata.org/wiki/Q133900","display_name":"Diffraction","level":2,"score":0.5528073310852051},{"id":"https://openalex.org/C2781448156","wikidata":"https://www.wikidata.org/wiki/Q1570182","display_name":"Coating","level":2,"score":0.47887036204338074},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.47562721371650696},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4581327736377716},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.42776763439178467},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.4226210117340088},{"id":"https://openalex.org/C2994054872","wikidata":"https://www.wikidata.org/wiki/Q3489404","display_name":"Solid surface","level":2,"score":0.4218667149543762},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41882389783859253},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.37561678886413574},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.374361515045166},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1569335162639618},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09124836325645447},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1021/cg500573e","doi":"https://doi.org/10.1021/cg500573e","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cg500573e","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/cg500573e?ref=article_openPDF","source":{"id":"https://openalex.org/S16561315","display_name":"Crystal Growth & Design","issn_l":"1528-7483","issn":["1528-7483","1528-7505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crystal Growth & Design","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3096896","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4125415","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25126023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25126023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crystal growth & design","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4125415","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4125415/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cryst Growth Des","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.988.8195","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.988.8195","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC4125415%26blobtype%3Dpdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1021/cg500573e","doi":"https://doi.org/10.1021/cg500573e","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cg500573e","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/cg500573e?ref=article_openPDF","source":{"id":"https://openalex.org/S16561315","display_name":"Crystal Growth & Design","issn_l":"1528-7483","issn":["1528-7483","1528-7505"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crystal Growth & Design","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2637321583","display_name":"Surface mediated polymorphic structures of drug molecules","funder_award_id":"P25541","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320320887","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1980559693.pdf","grobid_xml":"https://content.openalex.org/works/W1980559693.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1969785959","https://openalex.org/W1980564952","https://openalex.org/W1980609588","https://openalex.org/W1983874564","https://openalex.org/W1989117296","https://openalex.org/W1992517249","https://openalex.org/W1992988964","https://openalex.org/W1995008519","https://openalex.org/W1999795038","https://openalex.org/W2000817381","https://openalex.org/W2019519409","https://openalex.org/W2021622353","https://openalex.org/W2026927105","https://openalex.org/W2027806413","https://openalex.org/W2028014152","https://openalex.org/W2034747755","https://openalex.org/W2036505120","https://openalex.org/W2066736241","https://openalex.org/W2073574009","https://openalex.org/W2088192197","https://openalex.org/W2117642666","https://openalex.org/W2149774755","https://openalex.org/W2161308546","https://openalex.org/W2163620459","https://openalex.org/W2165201506","https://openalex.org/W2168419582","https://openalex.org/W2170309222","https://openalex.org/W2325121297","https://openalex.org/W2327034855","https://openalex.org/W2495725524"],"related_works":["https://openalex.org/W2888364840","https://openalex.org/W6992854282","https://openalex.org/W2805840291","https://openalex.org/W1994843916","https://openalex.org/W3161374760","https://openalex.org/W7008759653","https://openalex.org/W2490824079","https://openalex.org/W4401526543","https://openalex.org/W7223425154","https://openalex.org/W6986324541"],"abstract_inverted_index":{"The":[0],"preparation":[1,85],"of":[2,23,38,52,90,108,124],"typically":[3,56],"thermodynamically":[4],"unstable":[5,57],"polymorphic":[6,24],"structures":[7,25],"is":[8,55,118],"a":[9,39,44,68,73,84,121,133],"challenge.":[10],"However,":[11],"solid":[12,45],"surfaces":[13],"are":[14],"well":[15],"established":[16],"aids":[17],"for":[18,27],"the":[19,36,59,88,104,109,112],"formation":[20],"and":[21,94,106],"stabilization":[22,37],"within,":[26],"instance,":[28],"organic":[29],"electronics.":[30],"In":[31],"this":[32,116],"study,":[33],"we":[34],"report":[35],"pharmaceutically":[40],"relevant":[41],"substance":[42],"via":[43],"surface":[46,71,127],"at":[47,61],"ambient":[48],"conditions.":[49],"Form":[50],"III":[51],"paracetamol,":[53],"which":[54],"in":[58],"bulk":[60],"standard":[62,74],"conditions,":[63],"can":[64],"be":[65],"stabilized":[66],"with":[67,145],"model":[69],"silica":[70],"by":[72,79],"spin":[75],"coating":[76],"procedure":[77],"followed":[78],"rapid":[80],"heat":[81],"treatment.":[82],"Such":[83],"technique":[86],"allows":[87],"use":[89],"atomic":[91],"force":[92],"microscopy":[93],"grazing":[95],"incidence":[96],"X-ray":[97],"diffraction":[98],"measurements":[99],"revealing":[100,126],"detailed":[101],"information":[102],"on":[103],"morphology":[105],"structure":[107],"polymorph.":[110],"Furthermore,":[111],"results":[113],"exhibit":[114],"that":[115],"polymorph":[117],"stable":[119],"over":[120],"long":[122],"period":[123],"time":[125],"mediated":[128],"stabilization.":[129],"These":[130],"findings":[131],"demonstrate":[132],"novel":[134],"approach":[135],"to":[136,142],"provide":[137],"thermodynamic":[138],"stability":[139],"when":[140],"applied":[141],"similar":[143],"molecules":[144],"specific":[146],"applications.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}