{"id":"https://openalex.org/W1980508338","doi":"https://doi.org/10.1115/1.429652","title":"Mechanisms of Stiffening and Strengthening in Media-Equivalents Fabricated Using Glycation","display_name":"Mechanisms of Stiffening and Strengthening in Media-Equivalents Fabricated Using Glycation","publication_year":2000,"publication_date":"2000-02-06","ids":{"openalex":"https://openalex.org/W1980508338","doi":"https://doi.org/10.1115/1.429652","mag":"1980508338","pmid":"https://pubmed.ncbi.nlm.nih.gov/10923288"},"language":"en","primary_location":{"id":"doi:10.1115/1.429652","doi":"https://doi.org/10.1115/1.429652","is_oa":false,"landing_page_url":"https://doi.org/10.1115/1.429652","pdf_url":null,"source":{"id":"https://openalex.org/S4210187999","display_name":"Journal of Biomechanical Engineering","issn_l":"0148-0731","issn":["0148-0731","1528-8951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316053","host_organization_name":"ASM International","host_organization_lineage":["https://openalex.org/P4310316053"],"host_organization_lineage_names":["ASM International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanical Engineering","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1980508338"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032553631","display_name":"T. S. Girton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. S. Girton","raw_affiliation_strings":["Departments of Chemical Engineering & Materials Science and Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455-0132"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering & Materials Science and Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455-0132","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111589057","display_name":"Theodore R. Oegema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. R. Oegema","raw_affiliation_strings":["Orthopaedic Surgery, University of Minnesota, Minneapolis, MN 55455-0132"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Surgery, University of Minnesota, Minneapolis, MN 55455-0132","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000029456","display_name":"Erin D. Grassl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. D. Grassl","raw_affiliation_strings":["Departments of Chemical Engineering & Materials Science and Biomedical Engineering, University of Minnesota, Minneapolis, MN\u200955455-0132"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering & Materials Science and Biomedical Engineering, University of Minnesota, Minneapolis, MN\u200955455-0132","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090769022","display_name":"Brett C. Isenberg","orcid":"https://orcid.org/0000-0001-7208-8804","observed_orcids":["https://orcid.org/0000-0001-7208-8804"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. C. Isenberg","raw_affiliation_strings":["Departments of Chemical Engineering & Materials Science and Biomedical Engineering, University of Minnesota, Minneapolis, MN\u200955455-0132"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering & Materials Science and Biomedical Engineering, University of Minnesota, Minneapolis, MN\u200955455-0132","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073925292","display_name":"Robert T. Tranquillo","orcid":"https://orcid.org/0000-0003-4668-6135","observed_orcids":["https://orcid.org/0000-0003-4668-6135"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. T. Tranquillo","raw_affiliation_strings":["Departments of Chemical Engineering & Materials Science and Biomedical Engineering, University of Minnesota, Minneapolis, MN\u200955455-0132"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemical Engineering & Materials Science and Biomedical Engineering, University of Minnesota, Minneapolis, MN\u200955455-0132","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":9.3124,"has_fulltext":false,"cited_by_count":165,"citation_normalized_percentile":{"value":0.98261828,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"122","issue":"3","first_page":"216","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.08229999989271164,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycation","display_name":"glycation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ribose","display_name":"ribose","score":0.7289999723434448},{"id":"https://openalex.org/keywords/smooth-muscle-cells","display_name":"smooth muscle cells","score":0.621999979019165},{"id":"https://openalex.org/keywords/collagen-hydrogel","display_name":"collagen gel","score":0.652999997138977},{"id":"https://openalex.org/keywords/tensile-stiffness","display_name":"tensile stiffness","score":0.6380000114440918},{"id":"https://openalex.org/keywords/tensile-strength","display_name":"tensile strength","score":0.972000002861023},{"id":"https://openalex.org/keywords/collagen-fibril-alignment","display_name":"collagen fibril alignment","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cell-compaction","display_name":"cell compaction","score":0.5389999747276306},{"id":"https://openalex.org/keywords/extracellular-matrix-production","display_name":"extracellular matrix synthesis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.7490000128746033},{"id":"https://openalex.org/keywords/vascular-grafts","display_name":"vascular grafts","score":0.6370000243186951},{"id":"https://openalex.org/keywords/structural-remodeling","display_name":"structural remodeling","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.8402142524719238},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.7874524593353271},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6492911577224731},{"id":"https://openalex.org/C108729823","wikidata":"https://www.wikidata.org/wiki/Q3716064","display_name":"Stiffening","level":2,"score":0.6388511061668396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5783758163452148},{"id":"https://openalex.org/C2778636629","wikidata":"https://www.wikidata.org/wiki/Q422649","display_name":"Biopolymer","level":3,"score":0.465902179479599},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43676772713661194},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.374961256980896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29878440499305725},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29060816764831543},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.27113503217697144},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.10309222340583801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08245253562927246},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001705","descriptor_name":"Bioprosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001807","descriptor_name":"Blood Vessel Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013718","descriptor_name":"Tensile Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1115/1.429652","doi":"https://doi.org/10.1115/1.429652","is_oa":false,"landing_page_url":"https://doi.org/10.1115/1.429652","pdf_url":null,"source":{"id":"https://openalex.org/S4210187999","display_name":"Journal of Biomechanical Engineering","issn_l":"0148-0731","issn":["0148-0731","1528-8951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316053","host_organization_name":"ASM International","host_organization_lineage":["https://openalex.org/P4310316053"],"host_organization_lineage_names":["ASM International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanical Engineering","raw_type":"journal-article"},{"id":"pmid:10923288","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10923288","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomechanical engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3140375532","display_name":"DEVELOPMENT OF A BIOARTIFICIAL ARTERY","funder_award_id":"R01HL060495","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W62271194","https://openalex.org/W1528545723","https://openalex.org/W1592033651","https://openalex.org/W1851722589","https://openalex.org/W1976236115","https://openalex.org/W1979233010","https://openalex.org/W1989704675","https://openalex.org/W1991292711","https://openalex.org/W2002201489","https://openalex.org/W2004181539","https://openalex.org/W2007742631","https://openalex.org/W2009163301","https://openalex.org/W2012283902","https://openalex.org/W2018247382","https://openalex.org/W2021265358","https://openalex.org/W2026793130","https://openalex.org/W2027796832","https://openalex.org/W2029968049","https://openalex.org/W2040549911","https://openalex.org/W2053002867","https://openalex.org/W2070679280","https://openalex.org/W2077207024","https://openalex.org/W2079793213","https://openalex.org/W2087833741","https://openalex.org/W2091422753","https://openalex.org/W2092268844","https://openalex.org/W2093717363","https://openalex.org/W2094166574","https://openalex.org/W2097425865","https://openalex.org/W2105178180","https://openalex.org/W2115126149","https://openalex.org/W2156780019","https://openalex.org/W2158979977","https://openalex.org/W2164406278","https://openalex.org/W2474260257","https://openalex.org/W2606164777","https://openalex.org/W4255641715"],"related_works":["https://openalex.org/W2026793130","https://openalex.org/W2079369870","https://openalex.org/W2020539623","https://openalex.org/W1966174614","https://openalex.org/W2128635158","https://openalex.org/W2023098178","https://openalex.org/W2002204510","https://openalex.org/W2033848362","https://openalex.org/W4401060428","https://openalex.org/W4292760916"],"abstract_inverted_index":{"We":[0,76],"have":[1],"recently":[2],"reported":[3],"that":[4,82,108,169],"glycation":[5],"can":[6],"be":[7],"exploited":[8],"to":[9,26,65,86,100,127,137,184,188],"increase":[10,23],"the":[11,90,102,128,189],"circumferential":[12,193],"tensile":[13,17,142,166],"stiffness":[14],"and":[15,22,61,105,144,173],"ultimate":[16],"strength":[18,143,179],"of":[19,32,95,110],"media-equivalents":[20],"(MEs)":[21],"their":[24],"resistance":[25],"collagenolytic":[27],"degradation,":[28],"all":[29],"without":[30],"loss":[31],"cell":[33],"viability":[34],"(Girton":[35],"et":[36],"al.,":[37],"1999).":[38],"The":[39],"glycated":[40,131],"MEs":[41,132,149],"were":[42],"fabricated":[43,150],"by":[44,89,114,180],"entrapping":[45],"high":[46,155],"passage":[47,156],"adult":[48,157],"rat":[49,158],"aorta":[50,159],"SMCs":[51,91,160,171],"in":[52,68,186],"collagen":[53,96],"gel":[54],"made":[55],"from":[56],"pepsin-digested":[57],"bovine":[58],"dermal":[59],"collagen,":[60],"incubated":[62],"for":[63],"up":[64],"10":[66],"weeks":[67],"complete":[69],"medium":[70],"with":[71,92,151],"30":[72],"mM":[73],"ribose":[74],"added.":[75],"report":[77],"here":[78],"on":[79],"experiments":[80],"showing":[81],"ME":[83],"compaction":[84],"due":[85],"traction":[87],"exerted":[88],"consequent":[93],"alignment":[94],"fibrils":[97],"was":[98,125],"necessary":[99],"realize":[101],"glycation-mediated":[103],"stiffening":[104],"strengthening,":[106],"but":[107,139],"synthesis":[109],"extracellular":[111],"matrix":[112],"constituents":[113],"these":[115],"cells":[116],"likely":[117],"contributed":[118],"little,":[119],"even":[120],"when":[121],"50":[122],"micrograms/ml":[123],"ascorbate":[124],"added":[126],"medium.":[129],"These":[130],"exhibited":[133],"a":[134],"compliance":[135],"similar":[136],"arteries,":[138],"possessed":[140,161],"less":[141,146],"much":[145],"burst":[147],"strength.":[148],"low":[152],"rather":[153],"than":[154],"almost":[162],"ten":[163],"times":[164],"greater":[165],"strength,":[167],"suggesting":[168],"alternative":[170],"sources":[172],"biopolymer":[174],"gels":[175],"may":[176],"yield":[177],"sufficient":[178],"compositional":[181],"remodeling":[182,191],"prior":[183],"implantation":[185],"addition":[187],"structural":[190],"(i.e.,":[192],"alignment)":[194],"already":[195],"obtained.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
