{"id":"https://openalex.org/W1980471049","doi":"https://doi.org/10.1038/clpt.1984.48","title":"Kinetics of epsilon-aminocaproic acid distribution, elimination, and antifibrinolytic effects in normal subjects","display_name":"Kinetics of epsilon-aminocaproic acid distribution, elimination, and antifibrinolytic effects in normal subjects","publication_year":1984,"publication_date":"1984-03-01","ids":{"openalex":"https://openalex.org/W1980471049","doi":"https://doi.org/10.1038/clpt.1984.48","mag":"1980471049","pmid":"https://pubmed.ncbi.nlm.nih.gov/6697646"},"language":"en","primary_location":{"id":"doi:10.1038/clpt.1984.48","doi":"https://doi.org/10.1038/clpt.1984.48","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.1984.48","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110296907","display_name":"Marilynn C. Frederiksen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1324242722","display_name":"Shirley Ryan AbilityLab","ror":"https://ror.org/02ja0m249","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324242722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marilynn C Frederiksen","raw_affiliation_strings":["Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1324242722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037992799","display_name":"Dennis J. Bowsher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1324242722","display_name":"Shirley Ryan AbilityLab","ror":"https://ror.org/02ja0m249","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324242722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis J Bowsher","raw_affiliation_strings":["Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1324242722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111760917","display_name":"Tsuen Ih Ruo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1324242722","display_name":"Shirley Ryan AbilityLab","ror":"https://ror.org/02ja0m249","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324242722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsuen Ih Ruo","raw_affiliation_strings":["Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1324242722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028506802","display_name":"Thomas K. Henthorn","orcid":"https://orcid.org/0000-0002-8993-3936","observed_orcids":["https://orcid.org/0000-0002-8993-3936"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1324242722","display_name":"Shirley Ryan AbilityLab","ror":"https://ror.org/02ja0m249","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324242722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas K Henthorn","raw_affiliation_strings":["Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1324242722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111620776","display_name":"Chung-hsin Ts'ao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1324242722","display_name":"Shirley Ryan AbilityLab","ror":"https://ror.org/02ja0m249","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324242722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung-Hsin Ts'ao","raw_affiliation_strings":["Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1324242722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108100836","display_name":"David Green","orcid":"https://orcid.org/0009-0004-9572-9853","observed_orcids":["https://orcid.org/0009-0004-9572-9853"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1324242722","display_name":"Shirley Ryan AbilityLab","ror":"https://ror.org/02ja0m249","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324242722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Green","raw_affiliation_strings":["Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1324242722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111884412","display_name":"Arthur J. Atkinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1324242722","display_name":"Shirley Ryan AbilityLab","ror":"https://ror.org/02ja0m249","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324242722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arthur J Atkinson","raw_affiliation_strings":["Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Center and Departments of Medicine, Pharmacology, and Pathology, Northwestern University Medical School, and the Atherosclerosis Program of the Rehabilitation Institute of Chicago","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1324242722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111884412"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1324242722"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":0.2449,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.52401048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"35","issue":"3","first_page":"387","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.08060000091791153,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0722000002861023,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epsilon-aminocaproic-acid","display_name":"epsilon-aminocaproic acid","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8980000019073486},{"id":"https://openalex.org/keywords/antifibrinolytic-effect","display_name":"antifibrinolytic effect","score":0.8240000009536743},{"id":"https://openalex.org/keywords/fibrinolysis-inhibition","display_name":"fibrinolysis inhibition","score":0.9440000057220459},{"id":"https://openalex.org/keywords/renal-excretion","display_name":"renal excretion","score":0.7139999866485596},{"id":"https://openalex.org/keywords/elimination-clearance","display_name":"elimination clearance","score":0.6119999885559082},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.7559999823570251},{"id":"https://openalex.org/keywords/clot-lysis-time","display_name":"clot lysis time","score":0.8560000061988831},{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.824999988079071},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.7979999780654907},{"id":"https://openalex.org/keywords/emax-model","display_name":"Emax model","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2781436528","wikidata":"https://www.wikidata.org/wiki/Q575222","display_name":"Antifibrinolytic","level":4,"score":0.892005443572998},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6901046633720398},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.6224545836448669},{"id":"https://openalex.org/C139254425","wikidata":"https://www.wikidata.org/wiki/Q1332167","display_name":"Volume of distribution","level":3,"score":0.5742592811584473},{"id":"https://openalex.org/C2777278314","wikidata":"https://www.wikidata.org/wiki/Q255968","display_name":"Aminocaproic acid","level":2,"score":0.42970210313796997},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.4167523682117462},{"id":"https://openalex.org/C192670549","wikidata":"https://www.wikidata.org/wiki/Q5361061","display_name":"Elimination rate constant","level":4,"score":0.4153158664703369},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3389819860458374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.313808798789978},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2337593138217926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21479207277297974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20969432592391968},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16348755359649658},{"id":"https://openalex.org/C2779637338","wikidata":"https://www.wikidata.org/wiki/Q418666","display_name":"Tranexamic acid","level":3,"score":0.0},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000614","descriptor_name":"Aminocaproates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015119","descriptor_name":"Aminocaproic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015119","descriptor_name":"Aminocaproic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/clpt.1984.48","doi":"https://doi.org/10.1038/clpt.1984.48","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.1984.48","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:6697646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6697646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2039430687","https://openalex.org/W2423071440","https://openalex.org/W2037022496","https://openalex.org/W2439478066","https://openalex.org/W7100268386","https://openalex.org/W2469054014","https://openalex.org/W2161125819","https://openalex.org/W2467475486","https://openalex.org/W1978219963","https://openalex.org/W2419519714"],"abstract_inverted_index":{"The":[0],"kinetics":[1,66],"of":[2,45,51,60,72,78,106,119,129,143,155],"epsilon-aminocaproic":[3],"acid":[4],"(EACA)":[5],"distribution":[6,22],"and":[7,36,54,85,147],"elimination":[8,30,38,53],"were":[9,67,91,102],"studied":[10],"in":[11,70,82],"six":[12],"normal":[13],"subjects":[14,74],"after":[15,97],"a":[16,115],"single":[17],"10-gm":[18],"iv":[19],"dose.":[20],"Steady-state":[21],"volume":[23],"averaged":[24,58],"30.01":[25],"or":[26,132],"0.39":[27],"l/kg.":[28],"Mean":[29],"t":[31],"1/2":[32],"was":[33,40,111],"294":[34],"min":[35,96],"the":[37,73,76,127,140,144,151],"clearance":[39,57],"0.19":[41],"l/min.":[42],"Renal":[43],"excretion":[44],"unchanged":[46],"EACA":[47,56,63,99,156],"accounted":[48],"for":[49,139],"68%":[50],"its":[52],"renal":[55],"115%":[59],"creatinine":[61],"clearance.":[62],"antifibrinolytic":[64,89],"effect":[65],"also":[68],"characterized":[69],"five":[71],"by":[75],"monitoring":[77],"clot":[79],"lysis":[80],"times":[81],"whole":[83],"blood":[84],"platelet-rich":[86],"plasma.":[87],"Peak":[88],"effects":[90],"observed":[92],"15":[93],"to":[94,113],"60":[95],"peak":[98],"plasma":[100],"concentrations":[101],"attained.":[103],"A":[104],"model":[105],"maximal":[107],"fibrinolysis":[108],"inhibition":[109,117],"(Emax)":[110],"used":[112],"estimate":[114],"half-maximal":[116],"(IC50)":[118],"63":[120],"+/-":[121],"19.7":[122],"microgram/ml.":[123],"This":[124],"agrees":[125],"with":[126,150],"value":[128],"0.55":[130],"mM":[131],"72":[133],"microgram/ml":[134],"that":[135],"has":[136],"been":[137],"reported":[138],"dissociation":[141],"constant":[142],"EACA-plasminogen":[145],"complex":[146],"is":[148],"consistent":[149],"proposed":[152],"biochemical":[153],"mechanism":[154],"action.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}