{"id":"https://openalex.org/W1980449150","doi":"https://doi.org/10.1038/nbt1353","title":"Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery","display_name":"Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery","publication_year":2007,"publication_date":"2007-10-28","ids":{"openalex":"https://openalex.org/W1980449150","doi":"https://doi.org/10.1038/nbt1353","mag":"1980449150","pmid":"https://pubmed.ncbi.nlm.nih.gov/17965707"},"language":"en","primary_location":{"id":"doi:10.1038/nbt1353","doi":"https://doi.org/10.1038/nbt1353","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nbt1353","pdf_url":null,"source":{"id":"https://openalex.org/S106963461","display_name":"Nature Biotechnology","issn_l":"0733-222X","issn":["0733-222X","1087-0156","1546-1696","2331-3684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037250591","display_name":"Angelo Lombardo","orcid":"https://orcid.org/0000-0001-8262-042X","observed_orcids":["https://orcid.org/0000-0001-8262-042X"]},"institutions":[{"id":"https://openalex.org/I4210142418","display_name":"The San Raffaele Telethon Institute for Gene Therapy","ror":"https://ror.org/036jn4298","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210142418","https://openalex.org/I4210153126","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Lombardo","raw_affiliation_strings":["San Raffaele Telethon Institute for Gene Therapy, via Olgettina, 58, 20132 Milan, Italy","San Raffaele Telethon Institute for Gene Therapy, via Olgettina, 58, Milan, 20132, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Raffaele Telethon Institute for Gene Therapy, via Olgettina, 58, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210142418"]},{"raw_affiliation_string":"San Raffaele Telethon Institute for Gene Therapy, via Olgettina, 58, Milan, 20132, Italy","institution_ids":["https://openalex.org/I4210142418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036091838","display_name":"Pietro Genovese","orcid":"https://orcid.org/0000-0001-9507-9003","observed_orcids":["https://orcid.org/0000-0001-9507-9003"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4210142418","display_name":"The San Raffaele Telethon Institute for Gene Therapy","ror":"https://ror.org/036jn4298","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210142418","https://openalex.org/I4210153126","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Genovese","raw_affiliation_strings":["San Raffaele Telethon Institute for Gene Therapy, via Olgettina, 58, Milan, 20132, Italy","\u201cVita Salute San Raffaele\u201d University, via Olgettina, 58, Milan, 20132, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Raffaele Telethon Institute for Gene Therapy, via Olgettina, 58, Milan, 20132, Italy","institution_ids":["https://openalex.org/I4210142418"]},{"raw_affiliation_string":"\u201cVita Salute San Raffaele\u201d University, via Olgettina, 58, Milan, 20132, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038390437","display_name":"Christian M. Beausejour","orcid":"https://orcid.org/0000-0002-1693-5172","observed_orcids":["https://orcid.org/0000-0002-1693-5172"]},"institutions":[{"id":"https://openalex.org/I4210140998","display_name":"Sangamo BioSciences (United States)","ror":"https://ror.org/046dwx283","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140998"]},{"id":"https://openalex.org/I4210154734","display_name":"Point Richmond Tech Center","ror":"https://ror.org/04mymaj38","country_code":"US","type":"other","lineage":["https://openalex.org/I4210154734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian M Beausejour","raw_affiliation_strings":["Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA","institution_ids":["https://openalex.org/I4210140998","https://openalex.org/I4210154734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110056208","display_name":"Silvia Colleoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134766","display_name":"Istituto Sperimentale Italiano Lazzaro Spallanzani","ror":"https://ror.org/04ebbpp93","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210134766"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Colleoni","raw_affiliation_strings":["Reproductive Technologies Laboratory, CIZ, Istituto Sperimentale Italiano Lazzaro Spallanzani, via Porcellasco 7/F, Cremona, 26100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Technologies Laboratory, CIZ, Istituto Sperimentale Italiano Lazzaro Spallanzani, via Porcellasco 7/F, Cremona, 26100, Italy","institution_ids":["https://openalex.org/I4210134766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023761899","display_name":"Ya-Li Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140998","display_name":"Sangamo BioSciences (United States)","ror":"https://ror.org/046dwx283","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140998"]},{"id":"https://openalex.org/I4210154734","display_name":"Point Richmond Tech Center","ror":"https://ror.org/04mymaj38","country_code":"US","type":"other","lineage":["https://openalex.org/I4210154734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ya-Li Lee","raw_affiliation_strings":["Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA","institution_ids":["https://openalex.org/I4210140998","https://openalex.org/I4210154734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103722649","display_name":"Kenneth A Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140998","display_name":"Sangamo BioSciences (United States)","ror":"https://ror.org/046dwx283","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140998"]},{"id":"https://openalex.org/I4210154734","display_name":"Point Richmond Tech Center","ror":"https://ror.org/04mymaj38","country_code":"US","type":"other","lineage":["https://openalex.org/I4210154734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth A Kim","raw_affiliation_strings":["Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA","institution_ids":["https://openalex.org/I4210140998","https://openalex.org/I4210154734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108458933","display_name":"Dale Genji Ando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140998","display_name":"Sangamo BioSciences (United States)","ror":"https://ror.org/046dwx283","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140998"]},{"id":"https://openalex.org/I4210154734","display_name":"Point Richmond Tech Center","ror":"https://ror.org/04mymaj38","country_code":"US","type":"other","lineage":["https://openalex.org/I4210154734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale Ando","raw_affiliation_strings":["Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA","institution_ids":["https://openalex.org/I4210140998","https://openalex.org/I4210154734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030339120","display_name":"Fyodor D. Urnov","orcid":"https://orcid.org/0000-0001-7542-4084","observed_orcids":["https://orcid.org/0000-0001-7542-4084"]},"institutions":[{"id":"https://openalex.org/I4210140998","display_name":"Sangamo BioSciences (United States)","ror":"https://ror.org/046dwx283","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140998"]},{"id":"https://openalex.org/I4210154734","display_name":"Point Richmond Tech Center","ror":"https://ror.org/04mymaj38","country_code":"US","type":"other","lineage":["https://openalex.org/I4210154734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fyodor D Urnov","raw_affiliation_strings":["Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA","institution_ids":["https://openalex.org/I4210140998","https://openalex.org/I4210154734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007011035","display_name":"Cesare Galli","orcid":"https://orcid.org/0000-0002-9529-6136","observed_orcids":["https://orcid.org/0000-0002-9529-6136"]},"institutions":[{"id":"https://openalex.org/I4210134766","display_name":"Istituto Sperimentale Italiano Lazzaro Spallanzani","ror":"https://ror.org/04ebbpp93","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210134766"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cesare Galli","raw_affiliation_strings":["Dipartimento Clinico Veterinario, University of Bologna, Via Tolara di Sopra 50, Ozzano Emilia, 40064, Italy","Reproductive Technologies Laboratory, CIZ, Istituto Sperimentale Italiano Lazzaro Spallanzani, via Porcellasco 7/F, Cremona, 26100, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento Clinico Veterinario, University of Bologna, Via Tolara di Sopra 50, Ozzano Emilia, 40064, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Reproductive Technologies Laboratory, CIZ, Istituto Sperimentale Italiano Lazzaro Spallanzani, via Porcellasco 7/F, Cremona, 26100, Italy","institution_ids":["https://openalex.org/I4210134766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101665695","display_name":"Philip D. Gregory","orcid":"https://orcid.org/0000-0001-9249-2468","observed_orcids":["https://orcid.org/0000-0001-9249-2468"]},"institutions":[{"id":"https://openalex.org/I4210140998","display_name":"Sangamo BioSciences (United States)","ror":"https://ror.org/046dwx283","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140998"]},{"id":"https://openalex.org/I4210154734","display_name":"Point Richmond Tech Center","ror":"https://ror.org/04mymaj38","country_code":"US","type":"other","lineage":["https://openalex.org/I4210154734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip D Gregory","raw_affiliation_strings":["Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA","institution_ids":["https://openalex.org/I4210140998","https://openalex.org/I4210154734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103171977","display_name":"Michael C. Holmes","orcid":"https://orcid.org/0000-0002-6697-4225","observed_orcids":["https://orcid.org/0000-0002-6697-4225"]},"institutions":[{"id":"https://openalex.org/I4210140998","display_name":"Sangamo BioSciences (United States)","ror":"https://ror.org/046dwx283","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140998"]},{"id":"https://openalex.org/I4210154734","display_name":"Point Richmond Tech Center","ror":"https://ror.org/04mymaj38","country_code":"US","type":"other","lineage":["https://openalex.org/I4210154734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C Holmes","raw_affiliation_strings":["Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sangamo BioSciences, Inc., Pt. Richmond Tech Center, 501 Canal Blvd., Suite A100 Richmond, California, 94804, USA","institution_ids":["https://openalex.org/I4210140998","https://openalex.org/I4210154734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078278744","display_name":"Luigi Naldini","orcid":"https://orcid.org/0000-0002-7835-527X","observed_orcids":["https://orcid.org/0000-0002-7835-527X"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4210142418","display_name":"The San Raffaele Telethon Institute for Gene Therapy","ror":"https://ror.org/036jn4298","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210142418","https://openalex.org/I4210153126","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luigi Naldini","raw_affiliation_strings":["San Raffaele Telethon Institute for Gene Therapy, via Olgettina, 58, Milan, 20132, Italy","\u201cVita Salute San Raffaele\u201d University, via Olgettina, 58, Milan, 20132, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Raffaele Telethon Institute for Gene Therapy, via Olgettina, 58, Milan, 20132, Italy","institution_ids":["https://openalex.org/I4210142418"]},{"raw_affiliation_string":"\u201cVita Salute San Raffaele\u201d University, via Olgettina, 58, Milan, 20132, Italy","institution_ids":["https://openalex.org/I154387261"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078278744"],"corresponding_institution_ids":["https://openalex.org/I154387261","https://openalex.org/I4210142418"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":18.3879,"has_fulltext":false,"cited_by_count":861,"citation_normalized_percentile":{"value":0.99769634,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"25","issue":"11","first_page":"1298","last_page":"1306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.14589999616146088,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-finger-nucleases","display_name":"zinc finger nucleases","score":0.9779999852180481},{"id":"https://openalex.org/keywords/integrase-defective-lentiviral-vectors","display_name":"integrase-defective lentiviral vectors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.8019999861717224},{"id":"https://openalex.org/keywords/human-stem-cells","display_name":"human stem cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/il2rg","display_name":"IL2RG","score":0.9509999752044678},{"id":"https://openalex.org/keywords/common-gamma-chain","display_name":"common gamma chain","score":0.6660000085830688},{"id":"https://openalex.org/keywords/transgene-delivery","display_name":"transgene delivery","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C35802184","wikidata":"https://www.wikidata.org/wiki/Q204773","display_name":"Zinc finger nuclease","level":5,"score":0.9008576273918152},{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.6875121593475342},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.6292641162872314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.618988037109375},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5777149796485901},{"id":"https://openalex.org/C111829913","wikidata":"https://www.wikidata.org/wiki/Q211083","display_name":"Gene targeting","level":3,"score":0.5577726364135742},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5223161578178406},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.517646849155426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5014078617095947},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.494236022233963},{"id":"https://openalex.org/C145290725","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome engineering","level":5,"score":0.486642450094223},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4769403040409088},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.4754773676395416},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4742283523082733},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.44038230180740356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39756354689598083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38382309675216675},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3349568843841553},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.23024755716323853},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013698","descriptor_name":"Templates, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015252","descriptor_name":"Deoxyribonucleases, Type II Site-Specific","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015252","descriptor_name":"Deoxyribonucleases, Type II Site-Specific","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019426","descriptor_name":"Integrases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D053631","descriptor_name":"Interleukin Receptor Common gamma Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/nbt1353","doi":"https://doi.org/10.1038/nbt1353","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nbt1353","pdf_url":null,"source":{"id":"https://openalex.org/S106963461","display_name":"Nature Biotechnology","issn_l":"0733-222X","issn":["0733-222X","1087-0156","1546-1696","2331-3684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Biotechnology","raw_type":"journal-article"},{"id":"pmid:17965707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17965707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/55575","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/55575","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/14750","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/14750","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1509927180","display_name":"Stem Cell Gene Therapy for Hemoglobinopathies","funder_award_id":"P01HL053750","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W36733029","https://openalex.org/W186924384","https://openalex.org/W1531234455","https://openalex.org/W1570434164","https://openalex.org/W1585527972","https://openalex.org/W1804821915","https://openalex.org/W1919588791","https://openalex.org/W1980439517","https://openalex.org/W1981481637","https://openalex.org/W1988865085","https://openalex.org/W1993439119","https://openalex.org/W2003655346","https://openalex.org/W2004360848","https://openalex.org/W2009130202","https://openalex.org/W2009626008","https://openalex.org/W2009761723","https://openalex.org/W2011210369","https://openalex.org/W2014416902","https://openalex.org/W2020466762","https://openalex.org/W2024157997","https://openalex.org/W2027296526","https://openalex.org/W2032107357","https://openalex.org/W2041389422","https://openalex.org/W2051395442","https://openalex.org/W2053524220","https://openalex.org/W2053576250","https://openalex.org/W2057479340","https://openalex.org/W2078308455","https://openalex.org/W2086015868","https://openalex.org/W2090849645","https://openalex.org/W2098058601","https://openalex.org/W2102304447","https://openalex.org/W2107012251","https://openalex.org/W2107278930","https://openalex.org/W2111967568","https://openalex.org/W2113446817","https://openalex.org/W2116565356","https://openalex.org/W2119324304","https://openalex.org/W2126237980","https://openalex.org/W2132256310","https://openalex.org/W2137242970","https://openalex.org/W2137440275","https://openalex.org/W2142775272","https://openalex.org/W2146176862","https://openalex.org/W2149848226","https://openalex.org/W2151137440","https://openalex.org/W2156230193","https://openalex.org/W2159530833","https://openalex.org/W2162983277","https://openalex.org/W2167575455","https://openalex.org/W2167845957","https://openalex.org/W2171050607","https://openalex.org/W2171985637"],"related_works":["https://openalex.org/W7047272727","https://openalex.org/W2419295832","https://openalex.org/W1970539667","https://openalex.org/W1985450313","https://openalex.org/W2565344247","https://openalex.org/W4206429855","https://openalex.org/W1974572528","https://openalex.org/W2563601716","https://openalex.org/W1982969769","https://openalex.org/W2564721368"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":41},{"year":2017,"cited_by_count":55},{"year":2016,"cited_by_count":66},{"year":2015,"cited_by_count":61},{"year":2014,"cited_by_count":78},{"year":2013,"cited_by_count":69},{"year":2012,"cited_by_count":86}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
