{"id":"https://openalex.org/W1980407273","doi":"https://doi.org/10.1016/j.etap.2011.12.010","title":"In vitro and in vivo study of cucurbitacins-type triterpene glucoside from Citrullus colocynthis growing in Saudi Arabia against hepatocellular carcinoma","display_name":"In vitro and in vivo study of cucurbitacins-type triterpene glucoside from Citrullus colocynthis growing in Saudi Arabia against hepatocellular carcinoma","publication_year":2011,"publication_date":"2011-12-16","ids":{"openalex":"https://openalex.org/W1980407273","doi":"https://doi.org/10.1016/j.etap.2011.12.010","mag":"1980407273","pmid":"https://pubmed.ncbi.nlm.nih.gov/22245841"},"language":"en","primary_location":{"id":"doi:10.1016/j.etap.2011.12.010","doi":"https://doi.org/10.1016/j.etap.2011.12.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.etap.2011.12.010","pdf_url":null,"source":{"id":"https://openalex.org/S108944336","display_name":"Environmental Toxicology and Pharmacology","issn_l":"1382-6689","issn":["1382-6689","1872-7077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology and Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1980407273"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020398380","display_name":"Seif-Eldin Nasr Ayyad","orcid":"https://orcid.org/0000-0001-6364-9139","observed_orcids":["https://orcid.org/0000-0001-6364-9139"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Seif-Eldin N. Ayyad","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, King Abdulaziz University, PO. Box 80203, Jeddah 21589, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, King Abdulaziz University, PO. Box 80203, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047159570","display_name":"Ahmed Abdel\u2010Lateff","orcid":"https://orcid.org/0000-0002-7226-1205","observed_orcids":["https://orcid.org/0000-0002-7226-1205"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Ahmed Abdel-Lateff","raw_affiliation_strings":["Department of Health Information Technology, Jeddah Community College, King AbdulAziz University, P.O. Box 80283, Jeddah 21589, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Information Technology, Jeddah Community College, King AbdulAziz University, P.O. Box 80283, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090235978","display_name":"Walied Mohamed Alarif","orcid":"https://orcid.org/0000-0003-3236-6237","observed_orcids":["https://orcid.org/0000-0003-3236-6237"]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Walied M. Alarif","raw_affiliation_strings":["Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P.O. 80207, Jeddah 21589, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P.O. 80207, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025081335","display_name":"Francesca Romana Patacchioli","orcid":"https://orcid.org/0000-0001-9672-2603","observed_orcids":["https://orcid.org/0000-0001-9672-2603"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca R. Patacchioli","raw_affiliation_strings":["Department of Physiology and Pharmacology \u201cV. Erspamer\u201d, Sapienza University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology \u201cV. Erspamer\u201d, Sapienza University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085849450","display_name":"Farid Abd-Elreheim Badria","orcid":"https://orcid.org/0000-0001-7230-3105","observed_orcids":["https://orcid.org/0000-0001-7230-3105"]},"institutions":[{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Farid A. Badria","raw_affiliation_strings":["Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt","institution_ids":["https://openalex.org/I159247623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082014324","display_name":"Saleh T. Ezmirly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Saleh T. Ezmirly","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047159570"],"corresponding_institution_ids":["https://openalex.org/I185163786"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":1.6649,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.81114812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"33","issue":"2","first_page":"245","last_page":"251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12370","display_name":"Advances in Cucurbitaceae Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/citrullus-colocynthis","display_name":"Citrullus colocynthis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cucurbitacins","display_name":"cucurbitacins","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ehrlich-ascites-carcinoma","display_name":"Ehrlich ascites carcinoma","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7699999809265137},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/prolonged-survival","display_name":"survival prolongation","score":0.5180000066757202},{"id":"https://openalex.org/keywords/biochemical-parameters","display_name":"biochemical parameters","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2908615114","wikidata":"https://www.wikidata.org/wiki/Q913609","display_name":"Citrullus colocynthis","level":2,"score":0.8801946640014648},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7754303216934204},{"id":"https://openalex.org/C2781347565","wikidata":"https://www.wikidata.org/wiki/Q137173","display_name":"Glucoside","level":3,"score":0.6533055305480957},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6233249306678772},{"id":"https://openalex.org/C2780527577","wikidata":"https://www.wikidata.org/wiki/Q2915788","display_name":"Triterpene","level":3,"score":0.6208038926124573},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.6052461862564087},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6016543507575989},{"id":"https://openalex.org/C2776197502","wikidata":"https://www.wikidata.org/wiki/Q25326666","display_name":"Ehrlich ascites carcinoma","level":3,"score":0.5946282744407654},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5628528594970703},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.45702263712882996},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4304355978965759},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3790701627731323},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2994117736816406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2954000234603882},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18025320768356323},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.07933095097541809},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06928125023841858},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002286","descriptor_name":"Carcinoma, Ehrlich Tumor","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002286","descriptor_name":"Carcinoma, Ehrlich Tumor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012529","descriptor_name":"Saudi Arabia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029773","descriptor_name":"Citrullus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054728","descriptor_name":"Cucurbitacins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D054728","descriptor_name":"Cucurbitacins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.etap.2011.12.010","doi":"https://doi.org/10.1016/j.etap.2011.12.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.etap.2011.12.010","pdf_url":null,"source":{"id":"https://openalex.org/S108944336","display_name":"Environmental Toxicology and Pharmacology","issn_l":"1382-6689","issn":["1382-6689","1872-7077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:22245841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22245841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental toxicology and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/432812","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/432812","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324204","display_name":"Saudi Basic Industries Corporation","ror":"https://ror.org/03nqwhd11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W116067267","https://openalex.org/W122258800","https://openalex.org/W156988821","https://openalex.org/W204049245","https://openalex.org/W1657787344","https://openalex.org/W1965124696","https://openalex.org/W1976128207","https://openalex.org/W1986019469","https://openalex.org/W1999926470","https://openalex.org/W2009978665","https://openalex.org/W2038972387","https://openalex.org/W2042149290","https://openalex.org/W2042923157","https://openalex.org/W2049745820","https://openalex.org/W2057589352","https://openalex.org/W2077237452","https://openalex.org/W2079499545","https://openalex.org/W2086640935","https://openalex.org/W2104187605","https://openalex.org/W2158428883","https://openalex.org/W2165710014"],"related_works":["https://openalex.org/W1828161921","https://openalex.org/W4313454110","https://openalex.org/W2803654087","https://openalex.org/W4213226329","https://openalex.org/W2739220534","https://openalex.org/W2299616408","https://openalex.org/W2067746193","https://openalex.org/W2348346680","https://openalex.org/W2891392105","https://openalex.org/W3038107671"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
