{"id":"https://openalex.org/W1980366208","doi":"https://doi.org/10.1016/s0016-5085(08)64103-7","title":"M1849 The Pathogenesis of Barrett's Esophagus: the Combination of Acid and Bile Is Synergistic in the Induction of CDX2 and EGFR Activation in Esophageal Cells","display_name":"M1849 The Pathogenesis of Barrett's Esophagus: the Combination of Acid and Bile Is Synergistic in the Induction of CDX2 and EGFR Activation in Esophageal Cells","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W1980366208","doi":"https://doi.org/10.1016/s0016-5085(08)64103-7","mag":"1980366208"},"language":"en","primary_location":{"id":"doi:10.1016/s0016-5085(08)64103-7","doi":"https://doi.org/10.1016/s0016-5085(08)64103-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(08)64103-7","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086330212","display_name":"Nelly E. Avissar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nelly E. Avissar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038121589","display_name":"Liana M Toia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liana Toia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058646714","display_name":"Yingchuan Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yingchuan Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031154642","display_name":"Alexi C. Matousek","orcid":"https://orcid.org/0000-0001-9352-3393","observed_orcids":["https://orcid.org/0000-0001-9352-3393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexi Matousek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020860800","display_name":"Daniel Philip Raymond","orcid":"https://orcid.org/0000-0002-0978-3406","observed_orcids":["https://orcid.org/0000-0002-0978-3406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Raymond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103958341","display_name":"Carolyn E. Jones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn E. Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044209397","display_name":"Thomas J. Watson","orcid":"https://orcid.org/0000-0002-3282-494X","observed_orcids":["https://orcid.org/0000-0002-3282-494X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J. Watson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020843186","display_name":"Jeffrey H. Peters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey H. Peters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"134","issue":"4","first_page":"A","last_page":"875"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11658","display_name":"Esophageal and GI Pathology","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.9369999766349792},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cdx2","display_name":"CDX2","score":0.953000009059906},{"id":"https://openalex.org/keywords/egfr-activation","display_name":"EGFR activation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cpg-dinucleotides","display_name":"CpG","score":0.40400001406669617},{"id":"https://openalex.org/keywords/perioperative-immunomodulation","display_name":"perioperative immunomodulation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/gastrotomy","display_name":"gastrotomy","score":0.6539999842643738},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.6883639097213745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6798403859138489},{"id":"https://openalex.org/C139812875","wikidata":"https://www.wikidata.org/wiki/Q3704821","display_name":"Dehiscence","level":2,"score":0.582598865032196},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.46741676330566406},{"id":"https://openalex.org/C2778754067","wikidata":"https://www.wikidata.org/wiki/Q354111","display_name":"Abdominal wall","level":2,"score":0.4655163288116455},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.45787331461906433},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4515692889690399},{"id":"https://openalex.org/C2780664938","wikidata":"https://www.wikidata.org/wiki/Q1398178","display_name":"Wound dehiscence","level":2,"score":0.43204164505004883},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.42325639724731445},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.4142357110977173},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38063618540763855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3678451478481293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1205938458442688},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.1127828061580658},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0016-5085(08)64103-7","doi":"https://doi.org/10.1016/s0016-5085(08)64103-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(08)64103-7","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2034801899","https://openalex.org/W2051870842","https://openalex.org/W1985218313","https://openalex.org/W2337597730","https://openalex.org/W2384596727","https://openalex.org/W3021797283","https://openalex.org/W2412718938","https://openalex.org/W4246858314","https://openalex.org/W7120585669","https://openalex.org/W1970714911"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2016-06-24T00:00:00"}