{"id":"https://openalex.org/W1980336239","doi":"https://doi.org/10.1002/glia.20476","title":"Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo","display_name":"Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo","publication_year":2007,"publication_date":"2007-01-22","ids":{"openalex":"https://openalex.org/W1980336239","doi":"https://doi.org/10.1002/glia.20476","mag":"1980336239","pmid":"https://pubmed.ncbi.nlm.nih.gov/17243097"},"language":"en","primary_location":{"id":"doi:10.1002/glia.20476","doi":"https://doi.org/10.1002/glia.20476","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.20476","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077097017","display_name":"Zhou Zhu","orcid":"https://orcid.org/0000-0002-0642-8919","observed_orcids":["https://orcid.org/0000-0002-0642-8919","https://orcid.org/0009-0006-6003-9996"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhou Zhu","raw_affiliation_strings":["Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","ZZ and QZ contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]},{"raw_affiliation_string":"ZZ and QZ contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381909","display_name":"Qiang Zhang","orcid":"https://orcid.org/0000-0002-3680-6394","observed_orcids":["https://orcid.org/0000-0002-3680-6394"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Zhang","raw_affiliation_strings":["Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","ZZ and QZ contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]},{"raw_affiliation_string":"ZZ and QZ contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762512","display_name":"Zhiyuan Yu","orcid":"https://orcid.org/0000-0001-6157-3986","observed_orcids":["https://orcid.org/0000-0001-6157-3986"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyuan Yu","raw_affiliation_strings":["Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069397472","display_name":"Liang Zhang","orcid":"https://orcid.org/0000-0002-1567-6666","observed_orcids":["https://orcid.org/0000-0002-1567-6666"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Zhang","raw_affiliation_strings":["Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069692734","display_name":"Dai\u2010Shi Tian","orcid":"https://orcid.org/0000-0002-7627-0811","observed_orcids":["https://orcid.org/0000-0002-7627-0811"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daishi Tian","raw_affiliation_strings":["Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063609423","display_name":"Suiqiang Zhu","orcid":"https://orcid.org/0000-0002-0421-3391","observed_orcids":["https://orcid.org/0000-0002-0421-3391","https://orcid.org/0000-0001-6252-9450"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suiqiang Zhu","raw_affiliation_strings":["Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082736053","display_name":"Bitao Bu","orcid":"https://orcid.org/0000-0002-9106-0361","observed_orcids":["https://orcid.org/0000-0002-9106-0361","https://orcid.org/0000-0001-5369-7751","https://orcid.org/0009-0008-7458-8835","https://orcid.org/0000-0002-4539-9938"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bitao Bu","raw_affiliation_strings":["Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100656337","display_name":"Minjie Xie","orcid":"https://orcid.org/0000-0001-7317-3066","observed_orcids":["https://orcid.org/0000-0001-7317-3066"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minjie Xie","raw_affiliation_strings":["Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100392124","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-9176-5150","observed_orcids":["https://orcid.org/0000-0002-9176-5150"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100392124"],"corresponding_institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":5.1027,"has_fulltext":false,"cited_by_count":116,"citation_normalized_percentile":{"value":0.94854787,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"55","issue":"5","first_page":"546","last_page":"558"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-astrogliosis","display_name":"reactive astrogliosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cell-cycle-inhibition","display_name":"cell cycle inhibition","score":0.8610000014305115},{"id":"https://openalex.org/keywords/olomoucine","display_name":"olomoucine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.8379999995231628},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8339999914169312},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.781000018119812},{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9039999842643738},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.9819825291633606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6714471578598022},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5478926301002502},{"id":"https://openalex.org/C2777594495","wikidata":"https://www.wikidata.org/wiki/Q5569540","display_name":"Glial scar","level":4,"score":0.5384125709533691},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.5192675590515137},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.4650600552558899},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.46321043372154236},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.4239968955516815},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.4172937572002411},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37686097621917725},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34931421279907227},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23378971219062805},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.22361311316490173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2070780098438263},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1974485218524933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1674935221672058},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.09439027309417725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08765196800231934},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007701","descriptor_name":"Kinetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019938","descriptor_name":"Cyclin D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020768","descriptor_name":"Middle Cerebral Artery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/glia.20476","doi":"https://doi.org/10.1002/glia.20476","is_oa":false,"landing_page_url":"https://doi.org/10.1002/glia.20476","pdf_url":null,"source":{"id":"https://openalex.org/S147407642","display_name":"Glia","issn_l":"0894-1491","issn":["0894-1491","1098-1136"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"journal-article"},{"id":"pmid:17243097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17243097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Glia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1826719783","https://openalex.org/W1965422825","https://openalex.org/W1965924957","https://openalex.org/W1970458627","https://openalex.org/W1975111111","https://openalex.org/W1978342595","https://openalex.org/W1984506820","https://openalex.org/W1985885934","https://openalex.org/W1993616699","https://openalex.org/W1997090583","https://openalex.org/W2003326405","https://openalex.org/W2004391147","https://openalex.org/W2005416260","https://openalex.org/W2006207066","https://openalex.org/W2006289803","https://openalex.org/W2009097826","https://openalex.org/W2015121221","https://openalex.org/W2016237837","https://openalex.org/W2022144987","https://openalex.org/W2027898349","https://openalex.org/W2029080338","https://openalex.org/W2030047809","https://openalex.org/W2040786733","https://openalex.org/W2051947267","https://openalex.org/W2054926970","https://openalex.org/W2057435451","https://openalex.org/W2058705034","https://openalex.org/W2059994807","https://openalex.org/W2062792770","https://openalex.org/W2065691470","https://openalex.org/W2065949360","https://openalex.org/W2066809700","https://openalex.org/W2066900385","https://openalex.org/W2074725734","https://openalex.org/W2076162707","https://openalex.org/W2087038357","https://openalex.org/W2087574737","https://openalex.org/W2089354050","https://openalex.org/W2091463635","https://openalex.org/W2092133052","https://openalex.org/W2106123852","https://openalex.org/W2109003160","https://openalex.org/W2113570143","https://openalex.org/W2115276278","https://openalex.org/W2125683177","https://openalex.org/W2127338217","https://openalex.org/W2135129680","https://openalex.org/W2138589078","https://openalex.org/W2143938651","https://openalex.org/W2145278696","https://openalex.org/W2154021054","https://openalex.org/W2154104720","https://openalex.org/W2155103945","https://openalex.org/W2155520053","https://openalex.org/W2156048460","https://openalex.org/W2160053097","https://openalex.org/W2315829975","https://openalex.org/W2461719807"],"related_works":["https://openalex.org/W3142005653","https://openalex.org/W2357029010","https://openalex.org/W2077697251","https://openalex.org/W2372417105","https://openalex.org/W2363037414","https://openalex.org/W1496776616","https://openalex.org/W1971615051","https://openalex.org/W2370748865","https://openalex.org/W2771862748","https://openalex.org/W1981554128"],"abstract_inverted_index":{"Astrogliosis":[0],"occurs":[1],"in":[2,33,49,59,115,127,142,225,231,244,271,274,304],"a":[3,60,80,116,293],"variety":[4],"of":[5,19,89,124,146,173,222,237],"neuropathological":[6],"disorders":[7],"and":[8,10,41,113,119,139,164,180,216,240,255,263,273],"injuries,":[9],"excessive":[11],"astrogliosis":[12,29,47,280],"can":[13,30,281],"be":[14,31,282],"devastating":[15],"to":[16,70,214,252,296,301],"the":[17,34,75,90,97,109,128,153,170,220,232,241],"recovery":[18],"neuronal":[20,302],"function.":[21],"In":[22,74,152],"this":[23,72],"study,":[24],"we":[25,217],"asked":[26],"whether":[27],"reactive":[28,134,159,298],"suppressed":[32],"lesion":[35,242],"area":[36],"by":[37,53,107,150,285],"cell":[38,81,92,98,104,199,286],"cycle":[39,82,99,105,200,287],"inhibition":[40],"thus":[42],"have":[43],"therapeutic":[44],"benefits.":[45],"Reactive":[46],"induced":[48,79,133],"either":[50],"cultured":[51,76,129],"astrocytes":[52,224],"hypoxia":[54,78],"or":[55,58],"scratch":[56,131],"injury,":[57],"middle":[61],"cerebral":[62,175,267],"artery":[63],"occlusion":[64],"(MCAO)":[65],"ischemia":[66,155,176],"model":[67],"were":[68,148,167,212],"combined":[69],"address":[71],"issue.":[73],"astrocytes,":[77,130,144],"activation":[83,106],"that":[84,186,198,219,279],"was":[85,228],"associated":[86],"with":[87],"upregulation":[88,123],"proliferating":[91],"nuclear":[93],"marker":[94],"(PCNA).":[95],"Significantly,":[96],"inhibitor,":[100],"olomoucine,":[101],"inhibited":[102,191],"hypoxia-induced":[103,122],"arresting":[108],"cells":[110],"at":[111,169,177,259],"G1/S":[112],"G2/M":[114],"dose-dependent":[117],"manner":[118],"also":[120,248],"reversed":[121],"PCNA.":[125],"Also":[126],"injury":[132],"astrogliosis,":[135,204],"such":[136],"as":[137,250,292],"hypertrophy":[138],"an":[140],"increase":[141],"BrdU(+)":[143],"both":[145],"which":[147,289],"ameliorated":[149],"olomoucine.":[151],"MCAO":[154],"mouse":[156],"model,":[157],"dense":[158],"glial":[160],"fibrillary":[161],"acidic":[162],"protein":[163],"PCNA":[165],"immunoreactivity":[166],"evident":[168],"boundary":[171,233],"zone":[172],"focal":[174],"days":[178,260],"7":[179],"30":[181,264],"after":[182,265],"MCAO.":[183],"We":[184],"found":[185,218],"intraperitoneal":[187],"olomoucine":[188],"administration":[189],"significantly":[190,283],"these":[192,226,270],"astrogliosis-associated":[193],"changes.":[194],"To":[195],"demonstrate":[196],"further":[197],"regulation":[201],"impacts":[202],"on":[203],"cyclin":[205,245,253,256],"D1":[206],"gene":[207],"knockout":[208],"mice":[209,227,247,258],"(cyclin":[210],"D1(-/-))":[211],"subjected":[213],"ischemia,":[215],"percentage":[221],"Ki67-positive":[223],"markedly":[229],"reduced":[230],"zone.":[234],"The":[235],"number":[236],"apoptotic":[238],"neurons":[239],"volume":[243],"D1(-/-)":[246],"decreased":[249],"compared":[251],"D1(+/+)":[254],"D1(+/-)":[257],"3,":[261],"7,":[262],"local":[266],"ischemia.":[268],"Together,":[269],"vitro":[272],"vivo":[275],"results":[276],"strongly":[277],"suggest":[278],"affected":[284],"inhibition,":[288],"therefore":[290],"emerges":[291],"promising":[294],"intervention":[295],"attenuate":[297],"glia-related":[299],"damage":[300],"function":[303],"brain":[305],"pathology.":[306]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}