{"id":"https://openalex.org/W1980328171","doi":"https://doi.org/10.1016/j.bbrc.2006.09.093","title":"Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of UBL5","display_name":"Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of UBL5","publication_year":2006,"publication_date":"2006-09-29","ids":{"openalex":"https://openalex.org/W1980328171","doi":"https://doi.org/10.1016/j.bbrc.2006.09.093","mag":"1980328171","pmid":"https://pubmed.ncbi.nlm.nih.gov/17026961"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2006.09.093","doi":"https://doi.org/10.1016/j.bbrc.2006.09.093","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.09.093","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1980328171"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083980259","display_name":"Ken Hatanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Hatanaka","raw_affiliation_strings":["Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511 Japan","Laboratory of Neurobiophysics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Corporation (JST), PRESTO, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511 Japan","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Neurobiophysics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Corporation (JST), PRESTO, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan","institution_ids":["https://openalex.org/I4210086780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063378634","display_name":"Koji Ikegami","orcid":"https://orcid.org/0000-0002-8642-0414","observed_orcids":["https://orcid.org/0000-0002-8642-0414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koji Ikegami","raw_affiliation_strings":["Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511 Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082442587","display_name":"Hiroshi Takagi","orcid":"https://orcid.org/0000-0002-1786-3174","observed_orcids":["https://orcid.org/0000-0002-1786-3174"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Takagi","raw_affiliation_strings":["Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511 Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102755053","display_name":"Mitsutoshi Setou","orcid":"https://orcid.org/0000-0002-4672-187X","observed_orcids":["https://orcid.org/0000-0002-4672-187X"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4210145863","display_name":"National Institute for Physiological Sciences","ror":"https://ror.org/048v13307","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210145863"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mitsutoshi Setou","raw_affiliation_strings":["Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511 Japan","National Institutes of Natural Sciences, National Institute for Physiological Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan","Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Corporation (JST), PRESTO, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511 Japan","institution_ids":[]},{"raw_affiliation_string":"National Institutes of Natural Sciences, National Institute for Physiological Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan","institution_ids":["https://openalex.org/I4210145863"]},{"raw_affiliation_string":"Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Corporation (JST), PRESTO, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan","institution_ids":["https://openalex.org/I4210086780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102755053"],"corresponding_institution_ids":["https://openalex.org/I4210086780","https://openalex.org/I4210145863"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":0.6633,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.59668793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"350","issue":"3","first_page":"610","last_page":"615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypo-osmotic-shock","display_name":"hypo-osmotic shock","score":0.9079999923706055},{"id":"https://openalex.org/keywords/osmoregulation","display_name":"osmoregulation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/nuclear-export","display_name":"nuclear export","score":0.8360000252723694},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/ubiquitin-like-proteins","display_name":"ubiquitin-like proteins","score":0.8169999718666077},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9490000009536743},{"id":"https://openalex.org/keywords/oxytocin-neurons","display_name":"oxytocin neurons","score":0.8460000157356262},{"id":"https://openalex.org/keywords/vasopressin-neurons","display_name":"vasopressin neurons","score":1.0},{"id":"https://openalex.org/keywords/diuretic-hormone","display_name":"diuretic hormone","score":0.8159999847412109},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C129900496","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmotic concentration","level":2,"score":0.7810530066490173},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.7443005442619324},{"id":"https://openalex.org/C2777687476","wikidata":"https://www.wikidata.org/wiki/Q492272","display_name":"Supraoptic nucleus","level":3,"score":0.7160918116569519},{"id":"https://openalex.org/C58415070","wikidata":"https://www.wikidata.org/wiki/Q909456","display_name":"Osmoregulation","level":3,"score":0.6841463446617126},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.6780867576599121},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5183449983596802},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5159485936164856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5147164463996887},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5116691589355469},{"id":"https://openalex.org/C168529131","wikidata":"https://www.wikidata.org/wiki/Q13656562","display_name":"Osmotic shock","level":3,"score":0.5059289336204529},{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.5044156312942505},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.4593068063259125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42171138525009155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.338949054479599},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23781150579452515},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0713047981262207},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C129513315","wikidata":"https://www.wikidata.org/wiki/Q179615","display_name":"Salinity","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009997","descriptor_name":"Osmotic Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2006.09.093","doi":"https://doi.org/10.1016/j.bbrc.2006.09.093","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2006.09.093","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:17026961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17026961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320338111","display_name":"Precursory Research for Embryonic Science and Technology","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1494849181","https://openalex.org/W1586385744","https://openalex.org/W1591828201","https://openalex.org/W1826524642","https://openalex.org/W1975512387","https://openalex.org/W1985259057","https://openalex.org/W1997040781","https://openalex.org/W1998707155","https://openalex.org/W2003026064","https://openalex.org/W2008804935","https://openalex.org/W2024839121","https://openalex.org/W2043219997","https://openalex.org/W2045739851","https://openalex.org/W2056232522","https://openalex.org/W2066284211","https://openalex.org/W2074606993","https://openalex.org/W2125662652","https://openalex.org/W2134573448","https://openalex.org/W2148622688","https://openalex.org/W2157498064","https://openalex.org/W2161828210","https://openalex.org/W2168979257","https://openalex.org/W2417517488","https://openalex.org/W2791163698"],"related_works":["https://openalex.org/W2163496632","https://openalex.org/W2034473133","https://openalex.org/W2127579699","https://openalex.org/W3086540900","https://openalex.org/W2050276247","https://openalex.org/W2032955356","https://openalex.org/W4398165062","https://openalex.org/W2055038354","https://openalex.org/W2997482536","https://openalex.org/W2066277200"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}