{"id":"https://openalex.org/W1980300504","doi":"https://doi.org/10.1016/j.bbalip.2004.11.003","title":"Novel pathways of bile acid metabolism involving CYP3A4","display_name":"Novel pathways of bile acid metabolism involving CYP3A4","publication_year":2004,"publication_date":"2004-12-13","ids":{"openalex":"https://openalex.org/W1980300504","doi":"https://doi.org/10.1016/j.bbalip.2004.11.003","mag":"1980300504","pmid":"https://pubmed.ncbi.nlm.nih.gov/15708356"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbalip.2004.11.003","doi":"https://doi.org/10.1016/j.bbalip.2004.11.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbalip.2004.11.003","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111532990","display_name":"Karl Bodin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karl Bodin","raw_affiliation_strings":["Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Huddinge, SE-141 86 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Huddinge, SE-141 86 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039285728","display_name":"Ulla Lindbom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulla Lindbom","raw_affiliation_strings":["Department of Neurology, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036246480","display_name":"Ulf Diczfalusy","orcid":"https://orcid.org/0000-0001-6643-3763","observed_orcids":["https://orcid.org/0000-0001-6643-3763"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Ulf Diczfalusy","raw_affiliation_strings":["Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Huddinge, SE-141 86 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet, Huddinge, SE-141 86 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036246480"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":3670,"currency":"USD","value_usd":3670},"apc_paid":null,"fwci":1.9466,"has_fulltext":false,"cited_by_count":139,"citation_normalized_percentile":{"value":0.83189655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"1687","issue":"1-3","first_page":"84","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.24779999256134033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lithocholic-acid","display_name":"lithocholic acid","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pregnane-x-receptor","display_name":"pregnane X receptor","score":0.968999981880188},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nuclear-receptor-activation","display_name":"nuclear receptor activation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/deoxycholic-acid","display_name":"deoxycholic acid","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cyp3a4-induction","display_name":"CYP3A4 induction","score":0.8240000009536743},{"id":"https://openalex.org/keywords/bile-acid-homeostasis","display_name":"bile acid homeostasis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/secondary-bile-acids","display_name":"secondary bile acids","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.8575515747070312},{"id":"https://openalex.org/C2780420665","wikidata":"https://www.wikidata.org/wiki/Q3323035","display_name":"Lithocholic acid","level":3,"score":0.7828003168106079},{"id":"https://openalex.org/C2780749602","wikidata":"https://www.wikidata.org/wiki/Q425680","display_name":"Deoxycholic acid","level":3,"score":0.7526065111160278},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.7242916822433472},{"id":"https://openalex.org/C132040763","wikidata":"https://www.wikidata.org/wiki/Q409867","display_name":"Pregnane X receptor","level":5,"score":0.7230566740036011},{"id":"https://openalex.org/C2780965833","wikidata":"https://www.wikidata.org/wiki/Q241374","display_name":"Ursodeoxycholic acid","level":2,"score":0.6647989749908447},{"id":"https://openalex.org/C7309524","wikidata":"https://www.wikidata.org/wiki/Q14905630","display_name":"CYP27A1","level":3,"score":0.5814722776412964},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5029367804527283},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49884629249572754},{"id":"https://openalex.org/C2778697171","wikidata":"https://www.wikidata.org/wiki/Q418006","display_name":"Cholestyramine","level":3,"score":0.41423895955085754},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4085221588611603},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.36601972579956055},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.3640674352645874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3290644586086273},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.11214101314544678},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001647","descriptor_name":"Bile Acids and Salts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010103","descriptor_name":"Oxygen Isotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbalip.2004.11.003","doi":"https://doi.org/10.1016/j.bbalip.2004.11.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbalip.2004.11.003","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},{"id":"pmid:15708356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15708356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318496","display_name":"Gunvor och Josef An\u00e9rs Siftelse","ror":"https://ror.org/03mx1q892"},{"id":"https://openalex.org/F4320322169","display_name":"Hj\u00e4rt-Lungfonden","ror":"https://ror.org/052261q33"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320326014","display_name":"Ruth och Richard Julins Stiftelse","ror":"https://ror.org/00n6n0g86"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1524668721","https://openalex.org/W1584638689","https://openalex.org/W1593685937","https://openalex.org/W1750420467","https://openalex.org/W1765706822","https://openalex.org/W1946165458","https://openalex.org/W1964087196","https://openalex.org/W1974196453","https://openalex.org/W1984345984","https://openalex.org/W1990392247","https://openalex.org/W2002428319","https://openalex.org/W2003734532","https://openalex.org/W2003816126","https://openalex.org/W2005822112","https://openalex.org/W2010383638","https://openalex.org/W2013803788","https://openalex.org/W2019349841","https://openalex.org/W2021206718","https://openalex.org/W2021444563","https://openalex.org/W2023591222","https://openalex.org/W2026160870","https://openalex.org/W2036155956","https://openalex.org/W2037187747","https://openalex.org/W2061519730","https://openalex.org/W2067548372","https://openalex.org/W2080483323","https://openalex.org/W2081147169","https://openalex.org/W2082196885","https://openalex.org/W2082464993","https://openalex.org/W2084462922","https://openalex.org/W2096828108","https://openalex.org/W2100360692","https://openalex.org/W2114756989","https://openalex.org/W2126146158","https://openalex.org/W2127059331","https://openalex.org/W2160450046","https://openalex.org/W2167648459","https://openalex.org/W2187761348","https://openalex.org/W2188151150","https://openalex.org/W2329037174","https://openalex.org/W2461798325","https://openalex.org/W2481417390"],"related_works":["https://openalex.org/W2067548372","https://openalex.org/W1860026848","https://openalex.org/W1982237658","https://openalex.org/W2911242186","https://openalex.org/W2908014754","https://openalex.org/W2134065514","https://openalex.org/W2082196885","https://openalex.org/W2467485523","https://openalex.org/W2278949176","https://openalex.org/W4395006501"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}