{"id":"https://openalex.org/W1980289166","doi":"https://doi.org/10.1016/s0090-1229(95)90252-x","title":"CD40\u2014CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)","display_name":"CD40\u2014CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W1980289166","doi":"https://doi.org/10.1016/s0090-1229(95)90252-x","mag":"1980289166","pmid":"https://pubmed.ncbi.nlm.nih.gov/7554470"},"language":"en","primary_location":{"id":"doi:10.1016/s0090-1229(95)90252-x","doi":"https://doi.org/10.1016/s0090-1229(95)90252-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0090-1229(95)90252-x","pdf_url":null,"source":{"id":"https://openalex.org/S174675264","display_name":"Clinical Immunology and Immunopathology","issn_l":"0090-1229","issn":["0090-1229","1090-2341"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology and Immunopathology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108519697","display_name":"Narayanaswamy Ramesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Narayanaswamy Ramesh","raw_affiliation_strings":["Division of Immunology, Children's Hospital, Boston, Massachusetts 02115, USA","Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Children's Hospital, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040707258","display_name":"Tomohiro Morio","orcid":"https://orcid.org/0000-0002-9259-1025","observed_orcids":["https://orcid.org/0000-0002-9259-1025"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomohiro Morio","raw_affiliation_strings":["Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081954803","display_name":"Ramsay Fuleihan","orcid":"https://orcid.org/0000-0002-8477-9239","observed_orcids":["https://orcid.org/0000-0002-8477-9239"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramsay Fuleihan","raw_affiliation_strings":["Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048797041","display_name":"Margitta Worm","orcid":"https://orcid.org/0000-0002-3449-1245","observed_orcids":["https://orcid.org/0000-0002-3449-1245"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margitta Worm","raw_affiliation_strings":["Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087340704","display_name":"Anthony Adam Horner","orcid":"https://orcid.org/0000-0002-7991-7561","observed_orcids":["https://orcid.org/0000-0002-7991-7561"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Horner","raw_affiliation_strings":["Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051442111","display_name":"Erdyni N. Tsitsikov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erdyni Tsitsikov","raw_affiliation_strings":["Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113564533","display_name":"Emanuela Castigli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emanuela Castigli","raw_affiliation_strings":["Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111902092","display_name":"Raif S. Geha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raif S. Geha","raw_affiliation_strings":["Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.33,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.39612188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"76","issue":"3","first_page":"S208","last_page":"S213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.06040000170469284,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd40","display_name":"CD40","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.9779999852180481},{"id":"https://openalex.org/keywords/class-switch-recombination","display_name":"class switch recombination","score":0.8479999899864197},{"id":"https://openalex.org/keywords/b-cell-activation","display_name":"B cell activation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/t-cell-dependent-antigens","display_name":"T-dependent antigens","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cd40-signaling","display_name":"CD40 signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.8633317947387695},{"id":"https://openalex.org/C137756551","wikidata":"https://www.wikidata.org/wiki/Q2386881","display_name":"Immunoglobulin class switching","level":4,"score":0.8337098360061646},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.7138665914535522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5092424154281616},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4561131000518799},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4375765919685364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43373903632164},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4285960793495178},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4127552807331085},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2790352702140808},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.19083887338638306},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10022339224815369},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006942","descriptor_name":"Hypergammaglobulinemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006942","descriptor_name":"Hypergammaglobulinemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014960","descriptor_name":"X Chromosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0090-1229(95)90252-x","doi":"https://doi.org/10.1016/s0090-1229(95)90252-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0090-1229(95)90252-x","pdf_url":null,"source":{"id":"https://openalex.org/S174675264","display_name":"Clinical Immunology and Immunopathology","issn_l":"0090-1229","issn":["0090-1229","1090-2341"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310319955","host_organization_name":"Academic Press","host_organization_lineage":["https://openalex.org/P4310319955","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Academic Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Immunology and Immunopathology","raw_type":"journal-article"},{"id":"pmid:7554470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7554470","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical immunology and immunopathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1484262719","https://openalex.org/W1517873264","https://openalex.org/W1518672253","https://openalex.org/W1528551608","https://openalex.org/W1593623110","https://openalex.org/W1838025165","https://openalex.org/W1963750108","https://openalex.org/W1971487921","https://openalex.org/W1977687771","https://openalex.org/W1983795855","https://openalex.org/W1984754431","https://openalex.org/W1996846295","https://openalex.org/W1999079316","https://openalex.org/W2003129497","https://openalex.org/W2014025012","https://openalex.org/W2017302593","https://openalex.org/W2019111271","https://openalex.org/W2042043269","https://openalex.org/W2046044724","https://openalex.org/W2050432242","https://openalex.org/W2058050336","https://openalex.org/W2060382742","https://openalex.org/W2064155027","https://openalex.org/W2069080743","https://openalex.org/W2076820280","https://openalex.org/W2081381862","https://openalex.org/W2090030418","https://openalex.org/W2091085026","https://openalex.org/W2093385116","https://openalex.org/W2102572112","https://openalex.org/W2103134290","https://openalex.org/W2105802396","https://openalex.org/W2118884277","https://openalex.org/W2120649319","https://openalex.org/W2172658766","https://openalex.org/W6654596185","https://openalex.org/W6655155825","https://openalex.org/W6662948833"],"related_works":["https://openalex.org/W2003347074","https://openalex.org/W1983795855","https://openalex.org/W2068355730","https://openalex.org/W2040019425","https://openalex.org/W2003129497","https://openalex.org/W2042043269","https://openalex.org/W2019111271","https://openalex.org/W2038258674","https://openalex.org/W2074113024","https://openalex.org/W2107475627"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
