{"id":"https://openalex.org/W1980280682","doi":"https://doi.org/10.1213/01.ane.0000049820.88505.85","title":"Changes in Cerebral Microcirculation During and After Abdominal Aortic Cross-Clamping in Rabbits: The Role of Thromboxane A2 Receptor","display_name":"Changes in Cerebral Microcirculation During and After Abdominal Aortic Cross-Clamping in Rabbits: The Role of Thromboxane A2 Receptor","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W1980280682","doi":"https://doi.org/10.1213/01.ane.0000049820.88505.85","mag":"1980280682","pmid":"https://pubmed.ncbi.nlm.nih.gov/12598238"},"language":"en","primary_location":{"id":"doi:10.1213/01.ane.0000049820.88505.85","doi":"https://doi.org/10.1213/01.ane.0000049820.88505.85","is_oa":false,"landing_page_url":"https://doi.org/10.1213/01.ane.0000049820.88505.85","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016734389","display_name":"Masayoshi Uchida","orcid":"https://orcid.org/0000-0002-8269-555X","observed_orcids":["https://orcid.org/0000-0002-8269-555X"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masayoshi Uchida","raw_affiliation_strings":["Departments of *Anesthesiology and Critical Care Medicine and \u2020Internal Medicine, Gifu University School of Medicine, Gifu City, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Anesthesiology and Critical Care Medicine and \u2020Internal Medicine, Gifu University School of Medicine, Gifu City, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049794253","display_name":"Hiroki Iida","orcid":"https://orcid.org/0000-0003-0924-598X","observed_orcids":["https://orcid.org/0000-0003-0924-598X"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroki Iida","raw_affiliation_strings":["and reprint requests to Hiroki Iida, MD, Department of Anesthesiology and Critical Care Medicine, Gifu University School of Medicine, 40 Tsukasamachi, Gifu City, Gifu 5008705, Japan. Address e-mail to [email\u00a0protected]","reprint requests to Hiroki Iida, MD, Department of Anesthesiology and Critical Care Medicine, Gifu University School of Medicine, 40 Tsukasamachi, Gifu City, Gifu 5008705, Japan. Address e-mail to [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and reprint requests to Hiroki Iida, MD, Department of Anesthesiology and Critical Care Medicine, Gifu University School of Medicine, 40 Tsukasamachi, Gifu City, Gifu 5008705, Japan. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"reprint requests to Hiroki Iida, MD, Department of Anesthesiology and Critical Care Medicine, Gifu University School of Medicine, 40 Tsukasamachi, Gifu City, Gifu 5008705, Japan. Address e-mail to [email\u00a0protected]","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035516669","display_name":"Mami Iida","orcid":"https://orcid.org/0000-0001-6803-4483","observed_orcids":["https://orcid.org/0000-0001-6803-4483"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mami Iida","raw_affiliation_strings":["Internal Medicine, Gifu University School of Medicine, Gifu City, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Gifu University School of Medicine, Gifu City, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5097690688","display_name":"and Shuji Dohi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"and Shuji Dohi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016734389","https://openalex.org/A5049794253"],"corresponding_institution_ids":["https://openalex.org/I42405503"],"apc_list":null,"apc_paid":null,"fwci":0.2153,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.57461783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"96","issue":"3","first_page":"651","last_page":"656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.2671000063419342,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.05909999832510948,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-microcirculation","display_name":"cerebral microcirculation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/thromboxane-a2-receptor","display_name":"thromboxane A2 receptor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/seratrodast","display_name":"seratrodast","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cerebral-hemodynamics","display_name":"cerebral hemodynamics","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.6779999732971191},{"id":"https://openalex.org/keywords/aortic-unclamping","display_name":"aortic unclamping","score":0.7080000042915344},{"id":"https://openalex.org/keywords/topical-vasodilator","display_name":"topical vasodilator","score":0.4819999933242798},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C84111939","wikidata":"https://www.wikidata.org/wiki/Q5125465","display_name":"Clamping","level":2,"score":0.6757117509841919},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.6710559725761414},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5765776038169861},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.5704808831214905},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.5035004019737244},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4580354690551758},{"id":"https://openalex.org/C51603380","wikidata":"https://www.wikidata.org/wiki/Q411978","display_name":"Thromboxane receptor","level":4,"score":0.44232290983200073},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4352344870567322},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4033779501914978},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34160590171813965},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.22565683722496033},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07028678059577942},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003250","descriptor_name":"Constriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011448","descriptor_name":"Prostaglandin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017482","descriptor_name":"Receptors, Thromboxane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1213/01.ane.0000049820.88505.85","doi":"https://doi.org/10.1213/01.ane.0000049820.88505.85","is_oa":false,"landing_page_url":"https://doi.org/10.1213/01.ane.0000049820.88505.85","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:12598238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12598238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W123586170","https://openalex.org/W378330417","https://openalex.org/W1963781173","https://openalex.org/W1967929888","https://openalex.org/W1990068152","https://openalex.org/W1990563051","https://openalex.org/W1990731151","https://openalex.org/W1991350233","https://openalex.org/W2004774282","https://openalex.org/W2020385862","https://openalex.org/W2039021391","https://openalex.org/W2039215217","https://openalex.org/W2046939913","https://openalex.org/W2055478337","https://openalex.org/W2056424121","https://openalex.org/W2068476180","https://openalex.org/W2075180364","https://openalex.org/W2078807165","https://openalex.org/W2089593001","https://openalex.org/W2133821432","https://openalex.org/W2323034879","https://openalex.org/W2418046054","https://openalex.org/W2472121179"],"related_works":["https://openalex.org/W2060543080","https://openalex.org/W2410917212","https://openalex.org/W2046835998","https://openalex.org/W3164881177","https://openalex.org/W2461340800","https://openalex.org/W2331144082","https://openalex.org/W1990731151","https://openalex.org/W2046939913","https://openalex.org/W1964846632","https://openalex.org/W2038068150"],"abstract_inverted_index":{"UNLABELLED:":[0],"Little":[1],"is":[2,227],"known":[3],"about":[4],"any":[5],"changes":[6],"in":[7,19,38,54,184],"cerebral":[8,21,34],"hemodynamics,":[9],"during":[10,188],"and":[11,16,31,78,99,121,130,137,143,145,191],"after":[12,192,199],"abdominal":[13,28],"aortic":[14,29,59,71,154,197],"cross-clamping":[15,30,60],"unclamping,":[17],"especially":[18],"the":[20,25,39,44,126,179,185,189,222,238],"microcirculation.":[22],"We":[23],"studied":[24],"effects":[26],"of":[27,43,68,112,128,151,171,181,212],"unclamping":[32,198],"on":[33],"pial":[35,64,74,159,213],"vessel":[36,65],"diameter":[37],"presence":[40],"or":[41,95],"absence":[42],"thromboxane":[45,217,233],"(Tx)A(2)":[46],"receptor":[47,115,219],"antagonist":[48],"using":[49],"a":[50,69,113,152,157,200,209,216],"closed":[51],"cranial":[52],"window":[53],"27":[55],"rabbits.":[56],"Although":[57],"infrarenal":[58],"did":[61],"not":[62],"affect":[63],"diameter,":[66],"release":[67],"20-min":[70,153,201],"cross-clamp":[72,155,193],"caused":[73,203],"arterioles":[75,103,132],"to":[76],"dilate":[77],"then":[79],"constrict.":[80],"A":[81],"significant":[82],"constriction":[83,127,139,211],"persisted":[84],"for":[85,92,101,140,147],"at":[86,118,228],"least":[87,229],"60":[88,134],"min":[89],"(maximum,":[90],"-17%":[91],"large":[93,129],"[>":[94],"=75":[96],"micro":[97,105],"m]":[98,106],"-28%":[100],"small":[102,131],"[<75":[104],"compared":[107],"with":[108],"baseline).":[109],"Topical":[110],"administration":[111,170],"TxA(2)":[114,182],"antagonist,":[116,220],"seratrodast,":[117,172],"10(-7)":[119,141],"M":[120],"10(-6)":[122,148],"M,":[123,142],"significantly":[124],"attenuated":[125,167,221],"(at":[133],"min,":[135],"-9%":[136],"-13%":[138],"-6%":[144],"-7%":[146],"M).":[149],"Release":[150],"induced":[156],"sustained":[158,210],"arteriolar":[160],"constriction.":[161],"Because":[162],"this":[163],"unclamping-induced":[164],"vasoconstriction":[165,223],"was":[166,174],"by":[168,208,232,242],"topical":[169],"it":[173,226],"likely":[175],"partially":[176],"mediated":[177,231],"via":[178],"washout":[180],"produced":[183],"ischemic":[186,241],"region":[187,239],"clamp":[190,202],"release.":[194],"IMPLICATIONS:":[195],"Abdominal":[196],"an":[204],"initial":[205],"dilation":[206],"followed":[207],"arterioles.":[214],"Seratrodast,":[215],"A(2)":[218,234],"suggesting":[224],"that":[225],"partly":[230],"washed":[235],"out":[236],"from":[237],"rendered":[240],"clamping.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
