{"id":"https://openalex.org/W1980255131","doi":"https://doi.org/10.1161/01.cir.56.1.114","title":"Effect of clofibrate on intravascular coagulation in hyperlipoproteinemia.","display_name":"Effect of clofibrate on intravascular coagulation in hyperlipoproteinemia.","publication_year":1977,"publication_date":"1977-07-01","ids":{"openalex":"https://openalex.org/W1980255131","doi":"https://doi.org/10.1161/01.cir.56.1.114","mag":"1980255131","pmid":"https://pubmed.ncbi.nlm.nih.gov/301067"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.56.1.114","doi":"https://doi.org/10.1161/01.cir.56.1.114","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.56.1.114","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.56.1.114","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.56.1.114","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110397470","display_name":"Angelina C. A. Carvalho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C Carvalho","raw_affiliation_strings":["A C Carvalho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A C Carvalho","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103484864","display_name":"Robert S. Lees","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R S Lees","raw_affiliation_strings":["R S Lees"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R S Lees","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"R A Vaillancourt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Vaillancourt","raw_affiliation_strings":["R A Vaillancourt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R A Vaillancourt","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R W Colman","raw_affiliation_strings":["R W Colman"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R W Colman","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8965,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.90306029,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"56","issue":"1","first_page":"114","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.11069999635219574,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clofibrate","display_name":"clofibrate","score":1.0},{"id":"https://openalex.org/keywords/intravascular-coagulation","display_name":"intravascular coagulation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/type-ii-hyperlipoproteinemia","display_name":"type II hyperlipoproteinemia","score":0.9580000042915344},{"id":"https://openalex.org/keywords/type-iv-hyperlipoproteinemia","display_name":"type IV hyperlipoproteinemia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/fibrin-degradation-products","display_name":"fibrin degradation products","score":0.8349999785423279},{"id":"https://openalex.org/keywords/factor-xii-activation","display_name":"factor XII activation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/prekallikrein","display_name":"prekallikrein","score":0.8840000033378601},{"id":"https://openalex.org/keywords/kallikrein-inhibitor","display_name":"kallikrein inhibitor","score":0.9490000009536743},{"id":"https://openalex.org/keywords/plasma-triglycerides","display_name":"plasma triglycerides","score":0.8029999732971191},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C2779496979","wikidata":"https://www.wikidata.org/wiki/Q2701912","display_name":"Clofibrate","level":2,"score":0.8907938003540039},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.7766938805580139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.764184832572937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.738378643989563},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.7314092516899109},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.6080243587493896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5898277759552002},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.5047594308853149},{"id":"https://openalex.org/C152328610","wikidata":"https://www.wikidata.org/wiki/Q7240014","display_name":"Prekallikrein","level":4,"score":0.49336639046669006},{"id":"https://openalex.org/C2777167447","wikidata":"https://www.wikidata.org/wiki/Q339499","display_name":"Factor XII","level":3,"score":0.4162665903568268},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22658202052116394},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.18653979897499084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15382900834083557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11289063096046448},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000991","descriptor_name":"Antithrombins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002994","descriptor_name":"Clofibrate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004211","descriptor_name":"Disseminated Intravascular Coagulation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004211","descriptor_name":"Disseminated Intravascular Coagulation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005174","descriptor_name":"Factor XII","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005338","descriptor_name":"Fibrin Fibrinogen Degradation Products","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011288","descriptor_name":"Prekallikrein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.56.1.114","doi":"https://doi.org/10.1161/01.cir.56.1.114","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.56.1.114","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.56.1.114","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:301067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/301067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/01.cir.56.1.114","doi":"https://doi.org/10.1161/01.cir.56.1.114","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.56.1.114","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.56.1.114","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1980255131.pdf","grobid_xml":"https://content.openalex.org/works/W1980255131.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W15696836","https://openalex.org/W189503925","https://openalex.org/W1512559452","https://openalex.org/W1788802884","https://openalex.org/W1971827979","https://openalex.org/W1997363755","https://openalex.org/W2002983094","https://openalex.org/W2003116560","https://openalex.org/W2003880335","https://openalex.org/W2046621776","https://openalex.org/W2054129189","https://openalex.org/W2056206185","https://openalex.org/W2066531789","https://openalex.org/W2072827166","https://openalex.org/W2080476072","https://openalex.org/W2093734354","https://openalex.org/W2102953443","https://openalex.org/W2111974086","https://openalex.org/W2117343102","https://openalex.org/W2118095647","https://openalex.org/W2170873480","https://openalex.org/W2258997296","https://openalex.org/W2298231056","https://openalex.org/W2319045997","https://openalex.org/W2333330110","https://openalex.org/W2399000063","https://openalex.org/W2413186286","https://openalex.org/W2418896683","https://openalex.org/W2624371110","https://openalex.org/W2725187802","https://openalex.org/W4246491488"],"related_works":["https://openalex.org/W2029619065","https://openalex.org/W4232062704","https://openalex.org/W2093734354","https://openalex.org/W2884580578","https://openalex.org/W2443763978","https://openalex.org/W1980605573","https://openalex.org/W2463340387","https://openalex.org/W7096924806","https://openalex.org/W3144192102","https://openalex.org/W2044506538"],"abstract_inverted_index":{"Intravascular":[0],"coagulation":[1,65,141,150],"(IVC)":[2],"was":[3,32],"evaluated":[4],"in":[5,29,41,139,151],"19":[6],"patients":[7,49,97,122,154],"with":[8,13],"type":[9,14,44,47,95,120,152],"II":[10,45,96,153],"and":[11,18,46,83,113,126,155],"11":[12],"IV":[15,48,121],"hyperlipoproteinemia":[16],"before":[17],"after":[19],"clofibrate":[20,91],"therapy":[21,147],"by":[22,34,69],"measurements":[23],"of":[24,36,62,93,115,144],"soluble":[25],"fibrin":[26,37],"complexes":[27],"(SFC)":[28],"plasma;":[30],"fibrinolysis":[31],"estimated":[33],"quantitation":[35],"(ogen)":[38],"degradation":[39],"products":[40],"serum.":[42],"Untreated":[43],"had":[50,60,123],"increased":[51],"SFC":[52,125],"(P":[53,73,79,86,133],"less":[54,74,80,87,134],"than":[55,75,81,88,135],"0.01).":[56,136],"The":[57],"former":[58],"also":[59],"activation":[61,112],"the":[63,94],"intrinsic":[64],"pathway":[66],"as":[67],"evidenced":[68],"decreased":[70,104,109,130],"plasma":[71,101,131],"prekallikrein":[72],"0.001),":[76,82],"kallikrein":[77],"inhibitors":[78],"factor":[84,110],"XII":[85,111],"0.02).":[89],"Although":[90],"treatment":[92],"did":[98],"not":[99],"change":[100],"lipids,":[102],"it":[103],"intravascular":[105,149],"coagulation,":[106],"apparently":[107],"via":[108],"stimulation":[114],"fibrinolysis.":[116],"In":[117],"contrast,":[118],"treated":[119],"unchanged":[124],"FDP":[127],"levels,":[128],"despite":[129],"triglycerides":[132],"Clofibrate-induced":[137],"changes":[138],"blood":[140],"are":[142],"independent":[143],"lipid-lowering.":[145],"Clofibrate":[146],"decreases":[148],"may":[156],"help":[157],"to":[158],"prevent":[159],"thromboembolic":[160],"sequelae.":[161]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
