{"id":"https://openalex.org/W1980219201","doi":"https://doi.org/10.1111/j.1365-313x.2008.03684.x","title":"The E2 ubiquitin\u2010conjugating enzymes, AtUBC1 and AtUBC2, play redundant roles and are involved in activation of FLC expression and repression of flowering in Arabidopsis thaliana","display_name":"The E2 ubiquitin\u2010conjugating enzymes, AtUBC1 and AtUBC2, play redundant roles and are involved in activation of FLC expression and repression of flowering in Arabidopsis thaliana","publication_year":2008,"publication_date":"2008-09-16","ids":{"openalex":"https://openalex.org/W1980219201","doi":"https://doi.org/10.1111/j.1365-313x.2008.03684.x","mag":"1980219201","pmid":"https://pubmed.ncbi.nlm.nih.gov/18798874"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-313x.2008.03684.x","doi":"https://doi.org/10.1111/j.1365-313x.2008.03684.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-313x.2008.03684.x","pdf_url":null,"source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100727208","display_name":"Lin Xu","orcid":"https://orcid.org/0000-0003-4718-1286","observed_orcids":["https://orcid.org/0000-0003-4718-1286"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210107907","display_name":"Institut de Biologie Mol\u00e9culaire des Plantes","ror":"https://ror.org/01jm8fn98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210107907","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lin Xu","raw_affiliation_strings":["Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015249699","display_name":"Rozenn M\u00e9nard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210107907","display_name":"Institut de Biologie Mol\u00e9culaire des Plantes","ror":"https://ror.org/01jm8fn98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210107907","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rozenn M\u00e9nard","raw_affiliation_strings":["Institut de Biologie Mole\u0301culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionne\u0301 avec l\u2019Universite\u0301 Louis Pasteur Strasbourg 1, 12 rue du Ge\u0301ne\u0301ral Zimmer, 67084 Strasbourg Cedex, France","These authors contributed equally to this work","Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Mole\u0301culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionne\u0301 avec l\u2019Universite\u0301 Louis Pasteur Strasbourg 1, 12 rue du Ge\u0301ne\u0301ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]},{"raw_affiliation_string":"Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067770356","display_name":"Alexandre Berr","orcid":"https://orcid.org/0000-0002-1381-9053","observed_orcids":["https://orcid.org/0000-0002-1381-9053"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210107907","display_name":"Institut de Biologie Mol\u00e9culaire des Plantes","ror":"https://ror.org/01jm8fn98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210107907","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre Berr","raw_affiliation_strings":["Institut de Biologie Mole\u0301culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionne\u0301 avec l\u2019Universite\u0301 Louis Pasteur Strasbourg 1, 12 rue du Ge\u0301ne\u0301ral Zimmer, 67084 Strasbourg Cedex, France","Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Mole\u0301culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionne\u0301 avec l\u2019Universite\u0301 Louis Pasteur Strasbourg 1, 12 rue du Ge\u0301ne\u0301ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]},{"raw_affiliation_string":"Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033815104","display_name":"J\u00f6rg Fuchs","orcid":"https://orcid.org/0000-0003-4171-5371","observed_orcids":["https://orcid.org/0000-0003-4171-5371"]},"institutions":[{"id":"https://openalex.org/I4210127902","display_name":"Leibniz-Institut f\u00fcr Pflanzengenetik und Kulturpflanzenforschung (IPK)","ror":"https://ror.org/02skbsp27","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127902"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Fuchs","raw_affiliation_strings":["Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstrasse 3, D-06466 Gatersleben, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz-Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstrasse 3, D-06466 Gatersleben, Germany","institution_ids":["https://openalex.org/I4210127902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081232934","display_name":"Val\u00e9rie Cognat","orcid":"https://orcid.org/0000-0001-9337-2767","observed_orcids":["https://orcid.org/0000-0001-9337-2767"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210107907","display_name":"Institut de Biologie Mol\u00e9culaire des Plantes","ror":"https://ror.org/01jm8fn98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210107907","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Cognat","raw_affiliation_strings":["Institut de Biologie Mole\u0301culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionne\u0301 avec l\u2019Universite\u0301 Louis Pasteur Strasbourg 1, 12 rue du Ge\u0301ne\u0301ral Zimmer, 67084 Strasbourg Cedex, France","Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Mole\u0301culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionne\u0301 avec l\u2019Universite\u0301 Louis Pasteur Strasbourg 1, 12 rue du Ge\u0301ne\u0301ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]},{"raw_affiliation_string":"Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033340586","display_name":"Denise Meyer","orcid":"https://orcid.org/0000-0001-6945-1641","observed_orcids":["https://orcid.org/0000-0001-6945-1641"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210107907","display_name":"Institut de Biologie Mol\u00e9culaire des Plantes","ror":"https://ror.org/01jm8fn98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210107907","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Denise Meyer","raw_affiliation_strings":["Institut de Biologie Mole\u0301culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionne\u0301 avec l\u2019Universite\u0301 Louis Pasteur Strasbourg 1, 12 rue du Ge\u0301ne\u0301ral Zimmer, 67084 Strasbourg Cedex, France","Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Mole\u0301culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionne\u0301 avec l\u2019Universite\u0301 Louis Pasteur Strasbourg 1, 12 rue du Ge\u0301ne\u0301ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]},{"raw_affiliation_string":"Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050043536","display_name":"Wen\u2010Hui Shen","orcid":"https://orcid.org/0000-0001-7988-6382","observed_orcids":["https://orcid.org/0000-0001-7988-6382"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210107907","display_name":"Institut de Biologie Mol\u00e9culaire des Plantes","ror":"https://ror.org/01jm8fn98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210107907","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Wen\u2010Hui Shen","raw_affiliation_strings":["Institut de Biologie Mole\u0301culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionne\u0301 avec l\u2019Universite\u0301 Louis Pasteur Strasbourg 1, 12 rue du Ge\u0301ne\u0301ral Zimmer, 67084 Strasbourg Cedex, France","Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Mole\u0301culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionne\u0301 avec l\u2019Universite\u0301 Louis Pasteur Strasbourg 1, 12 rue du Ge\u0301ne\u0301ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]},{"raw_affiliation_string":"Institut de Biologie Mol\u00e9culaire des Plantes (IBMP), Laboratoire Propre du CNRS (UPR2357) conventionn\u00e9 avec l'Universit\u00e9 Louis Pasteur Strasbourg 1, 12 rue du G\u00e9n\u00e9ral Zimmer, 67084 Strasbourg Cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050043536"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210107907"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":8.6147,"has_fulltext":false,"cited_by_count":169,"citation_normalized_percentile":{"value":0.97463306,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"57","issue":"2","first_page":"279","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ubiquitin-conjugating-enzyme","display_name":"E2 ubiquitin-conjugating enzyme","score":0.9890000224113464},{"id":"https://openalex.org/keywords/flowering-locus-c","display_name":"FLOWERING LOCUS C","score":0.9120000004768372},{"id":"https://openalex.org/keywords/flowering-repressor","display_name":"floral repressor","score":0.718999981880188},{"id":"https://openalex.org/keywords/flowering-time","display_name":"flowering time","score":0.8849999904632568},{"id":"https://openalex.org/keywords/early-flowering","display_name":"early flowering","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.7860000133514404},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8709999918937683}],"concepts":[{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.798414945602417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7838300466537476},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7494444251060486},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7102645635604858},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.6277611255645752},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.622482180595398},{"id":"https://openalex.org/C2780336964","wikidata":"https://www.wikidata.org/wiki/Q3746807","display_name":"Flowering Locus C","level":5,"score":0.6086803674697876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5764592885971069},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.5364426374435425},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5082806944847107},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4490910768508911},{"id":"https://openalex.org/C182561583","wikidata":"https://www.wikidata.org/wiki/Q7876535","display_name":"Ubiquitin-conjugating enzyme","level":5,"score":0.41645291447639465},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4102601110935211},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4056050777435303},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28443020582199097}],"mesh":[{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017343","descriptor_name":"Genes, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018749","descriptor_name":"RNA, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026161","descriptor_name":"MADS Domain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035264","descriptor_name":"Flowers","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D035264","descriptor_name":"Flowers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044763","descriptor_name":"Ubiquitin-Conjugating Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044763","descriptor_name":"Ubiquitin-Conjugating Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-313x.2008.03684.x","doi":"https://doi.org/10.1111/j.1365-313x.2008.03684.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-313x.2008.03684.x","pdf_url":null,"source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},{"id":"pmid:18798874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18798874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant journal : for cell and molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00367327v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00367327","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Plant Journal, 2009, 57, pp.279-288","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G390078721","display_name":"Epigenetic role of histone methylation in environmental adaptation in Arabidopsis","funder_award_id":"ANR-06-BLAN-0054","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1519266993","https://openalex.org/W1521650410","https://openalex.org/W1546615793","https://openalex.org/W1585503692","https://openalex.org/W1665182114","https://openalex.org/W1923325553","https://openalex.org/W1963651550","https://openalex.org/W1963996414","https://openalex.org/W1984786295","https://openalex.org/W2039778682","https://openalex.org/W2048712749","https://openalex.org/W2050004861","https://openalex.org/W2056998476","https://openalex.org/W2059631140","https://openalex.org/W2059698383","https://openalex.org/W2060875411","https://openalex.org/W2063799895","https://openalex.org/W2066158198","https://openalex.org/W2071636376","https://openalex.org/W2075539470","https://openalex.org/W2078770765","https://openalex.org/W2083548220","https://openalex.org/W2098115340","https://openalex.org/W2103546861","https://openalex.org/W2107900085","https://openalex.org/W2108014213","https://openalex.org/W2114800743","https://openalex.org/W2116122104","https://openalex.org/W2119301405","https://openalex.org/W2123243207","https://openalex.org/W2130788976","https://openalex.org/W2131841148","https://openalex.org/W2132650496","https://openalex.org/W2133757548","https://openalex.org/W2137608671","https://openalex.org/W2138157690","https://openalex.org/W2140019714","https://openalex.org/W2140142936","https://openalex.org/W2146548897","https://openalex.org/W2146865704","https://openalex.org/W2163813691","https://openalex.org/W2166987747"],"related_works":["https://openalex.org/W2116075116","https://openalex.org/W2065578311","https://openalex.org/W1986114666","https://openalex.org/W2134698325","https://openalex.org/W1981755495","https://openalex.org/W2021486167","https://openalex.org/W2037979333","https://openalex.org/W2028759807","https://openalex.org/W2056998476","https://openalex.org/W2920893248"],"abstract_inverted_index":{"Post-translational":[0],"modifications":[1],"of":[2,6,53,65,91,105,129,157,196,212],"proteins":[3],"by":[4,28,208],"addition":[5],"ubiquitin":[7,37],"can":[8],"regulate":[9],"protein":[10],"degradation":[11],"and":[12,16,34,67,75,94,119,134,154,160,167,183],"localization,":[13],"protein-protein":[14],"interactions":[15],"transcriptional":[17],"activation.":[18],"In":[19,163],"the":[20,29,35,50,70,81,102,106,124,194,209,213],"ubiquitylation":[21],"system,":[22],"substrate":[23],"specificity":[24],"is":[25,172,191],"primarily":[26],"determined":[27],"E2":[30],"ubiquitin-conjugating":[31],"enzyme":[32],"(UBC)":[33],"E3":[36,143],"ligase.":[38],"The":[39],"Arabidopsis":[40],"thaliana":[41],"genome":[42],"contains":[43],"37":[44],"genes":[45,55,109,199],"encoding":[46],"UBC":[47],"homologs.":[48],"However,":[49],"biological":[51],"functions":[52],"these":[54,100],"remain":[56],"largely":[57],"uncharacterized.":[58],"Here,":[59],"we":[60],"report":[61],"reverse":[62],"genetic":[63],"characterization":[64],"AtUBC1":[66],"AtUBC2.":[68],"While":[69],"loss-of-function":[71],"single":[72],"mutants":[73,128],"Atubc1-1":[74,84,165],"Atubc2-1":[76,85,166],"only":[77],"show":[78,150],"weak":[79],"phenotypes,":[80],"double":[82,125],"mutant":[83],"shows":[86],"a":[87],"dramatically":[88],"reduced":[89,122,155],"number":[90],"rosette":[92],"leaves":[93],"an":[95,142,151],"early-flowering":[96,152],"phenotype.":[97],"Consistent":[98],"with":[99],"results,":[101],"transcript":[103],"levels":[104,156],"floral":[107,197],"repressor":[108,198],"FLOWERING":[110,116],"LOCUS":[111],"C":[112],"(FLC),":[113],"MADS":[114],"ASSOCIATED":[115],"4":[117],"(MAF4)":[118],"MAF5":[120,161],"are":[121],"in":[123,145,193,203],"mutant.":[126],"Loss-of-function":[127],"HISTONE":[130],"MONOUBIQUITINATION":[131],"1":[132],"(HUB1)":[133],"HUB2,":[135],"which":[136,190],"were":[137],"previously":[138],"reported":[139],"to":[140],"encode":[141],"involved":[144,192],"histone":[146],"H2B":[147,170,188],"ubiquitylation,":[148,189],"also":[149],"phenotype":[153],"FLC,":[158],"MAF4":[159],"transcripts.":[162],"both":[164],"hub2-2":[168],"mutants,":[169],"mono-ubiquitylation":[171],"drastically":[173],"reduced.":[174],"Taken":[175],"together,":[176],"our":[177],"results":[178],"indicate":[179],"that":[180],"E2s":[181],"AtUBC1/AtUBC2":[182],"E3s":[184],"HUB1/HUB2":[185],"together":[186],"mediate":[187],"activation":[195],"as":[200,202,206],"well":[201],"other":[204],"processes":[205],"indicated":[207],"pleiotropic":[210],"phenotypes":[211],"mutants.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}