{"id":"https://openalex.org/W1980201642","doi":"https://doi.org/10.1371/journal.ppat.1003486","title":"IL-22 and IDO1 Affect Immunity and Tolerance to Murine and Human Vaginal Candidiasis","display_name":"IL-22 and IDO1 Affect Immunity and Tolerance to Murine and Human Vaginal Candidiasis","publication_year":2013,"publication_date":"2013-07-11","ids":{"openalex":"https://openalex.org/W1980201642","doi":"https://doi.org/10.1371/journal.ppat.1003486","mag":"1980201642","pmid":"https://pubmed.ncbi.nlm.nih.gov/23853597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3708875"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1003486","doi":"https://doi.org/10.1371/journal.ppat.1003486","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003486","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003486&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003486&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074898230","display_name":"Antonella DE LUCA","orcid":"https://orcid.org/0000-0002-6866-5530","observed_orcids":["https://orcid.org/0000-0002-6866-5530"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]},{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella De Luca","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","Istituto Superiore di Sanit\u00e0, Roma, Italy, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Istituto Superiore di Sanit\u00e0, Roma, Italy, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083146403","display_name":"Agostinho Carvalho","orcid":"https://orcid.org/0000-0001-8935-8030","observed_orcids":["https://orcid.org/0000-0001-8935-8030"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Agostinho Carvalho","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052656152","display_name":"Cristina Cunha","orcid":"https://orcid.org/0000-0002-6002-5782","observed_orcids":["https://orcid.org/0000-0002-6002-5782"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Cunha","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073273997","display_name":"Rossana Giulietta Iannitti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossana G. Iannitti","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079900713","display_name":"Lucia Pitzurra","orcid":"https://orcid.org/0000-0002-6866-7982","observed_orcids":["https://orcid.org/0000-0002-6866-7982"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Pitzurra","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","Microbiology, S. Maria della Misericordia Medical Center, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Microbiology, S. Maria della Misericordia Medical Center, Perugia, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005918750","display_name":"Gloria Giovannini","orcid":"https://orcid.org/0009-0004-1205-0125","observed_orcids":["https://orcid.org/0009-0004-1205-0125"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gloria Giovannini","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019209093","display_name":"Antonella Mencacci","orcid":"https://orcid.org/0000-0001-9221-6172","observed_orcids":["https://orcid.org/0000-0001-9221-6172"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonella Mencacci","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","Microbiology, S. Maria della Misericordia Medical Center, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Microbiology, S. Maria della Misericordia Medical Center, Perugia, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030996048","display_name":"Lorenzo Bartolommei","orcid":"https://orcid.org/0009-0005-2424-9235","observed_orcids":["https://orcid.org/0009-0005-2424-9235"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Bartolommei","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009727581","display_name":"Silvia Moretti","orcid":"https://orcid.org/0000-0002-8177-7254","observed_orcids":["https://orcid.org/0000-0002-8177-7254"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Moretti","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027442852","display_name":"Cristina Massi-Benedetti","orcid":"https://orcid.org/0000-0003-0120-9992","observed_orcids":["https://orcid.org/0000-0003-0120-9992"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Massi-Benedetti","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081156604","display_name":"Dietmar Fuchs","orcid":"https://orcid.org/0000-0003-1627-9563","observed_orcids":["https://orcid.org/0000-0003-1627-9563"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Dietmar Fuchs","raw_affiliation_strings":["Innsbruck Medical University, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innsbruck Medical University, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029380574","display_name":"Flavia De Bernardis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavia De Bernardis","raw_affiliation_strings":["Istituto Superiore di Sanit\u00e0, Roma, Italy, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Superiore di Sanit\u00e0, Roma, Italy, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079557352","display_name":"Paolo Puccetti","orcid":"https://orcid.org/0000-0001-6674-2128","observed_orcids":["https://orcid.org/0000-0001-6674-2128"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Puccetti","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087834518","display_name":"Luigina R. Romani","orcid":"https://orcid.org/0000-0002-1356-525X","observed_orcids":["https://orcid.org/0000-0002-1356-525X"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luigina Romani","raw_affiliation_strings":["Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy","institution_ids":["https://openalex.org/I27483092"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087834518"],"corresponding_institution_ids":["https://openalex.org/I27483092"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":7.7852,"has_fulltext":true,"cited_by_count":126,"citation_normalized_percentile":{"value":0.98057896,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"7","first_page":"e1003486","last_page":"e1003486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.4634000062942505,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.4634000062942505,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.11050000041723251,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.08240000158548355,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-22","display_name":"IL-22","score":0.9319999814033508},{"id":"https://openalex.org/keywords/ido1","display_name":"IDO1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/indoleamine-2-3-dioxygenase","display_name":"indoleamine 2,3-dioxygenase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/kynurenine","display_name":"kynurenine","score":0.781000018119812},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.7149999737739563},{"id":"https://openalex.org/keywords/vaginal-candidiasis","display_name":"vaginal candidiasis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/recurrent-vulvovaginal-candidiasis","display_name":"recurrent vulvovaginal candidiasis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.6959999799728394},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9900000095367432},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.6309999823570251},{"id":"https://openalex.org/keywords/fungal-resistance","display_name":"fungal resistance","score":0.5920000076293945},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.6587294936180115},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5641388297080994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5502030849456787},{"id":"https://openalex.org/C2777744392","wikidata":"https://www.wikidata.org/wiki/Q5880","display_name":"Vagina","level":2,"score":0.5301863551139832},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5073608756065369},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.4471101760864258},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.30694645643234253},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2794874906539917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0972541868686676}],"mesh":[{"descriptor_ui":"D000097043","descriptor_name":"Interleukin-22","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002181","descriptor_name":"Candidiasis, Vulvovaginal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002181","descriptor_name":"Candidiasis, Vulvovaginal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002181","descriptor_name":"Candidiasis, Vulvovaginal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002181","descriptor_name":"Candidiasis, Vulvovaginal","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013047","descriptor_name":"Specific Pathogen-Free Organisms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016511","descriptor_name":"Severe Combined Immunodeficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016511","descriptor_name":"Severe Combined Immunodeficiency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016511","descriptor_name":"Severe Combined Immunodeficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018928","descriptor_name":"Immunity, Mucosal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050503","descriptor_name":"Indoleamine-Pyrrole 2,3,-Dioxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050503","descriptor_name":"Indoleamine-Pyrrole 2,3,-Dioxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.ppat.1003486","doi":"https://doi.org/10.1371/journal.ppat.1003486","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003486","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003486&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2704879","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3708875","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23853597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23853597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3708875","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3708875/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d22729873d10418789d2965973ef57e2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d22729873d10418789d2965973ef57e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 9, Iss 7, p e1003486 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1003486","doi":"https://doi.org/10.1371/journal.ppat.1003486","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1003486","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003486&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7592094640","display_name":"Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices","funder_award_id":"260338","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338377","display_name":"FP7 Health","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1980201642.pdf","grobid_xml":"https://content.openalex.org/works/W1980201642.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1494478165","https://openalex.org/W1890445996","https://openalex.org/W1925988920","https://openalex.org/W1942899011","https://openalex.org/W1954254123","https://openalex.org/W1965964543","https://openalex.org/W1966261608","https://openalex.org/W1967857971","https://openalex.org/W1968991425","https://openalex.org/W1972529616","https://openalex.org/W1975310253","https://openalex.org/W1975929837","https://openalex.org/W1981177186","https://openalex.org/W1992445022","https://openalex.org/W1992803997","https://openalex.org/W1997511291","https://openalex.org/W2002612766","https://openalex.org/W2002836781","https://openalex.org/W2011981112","https://openalex.org/W2020169376","https://openalex.org/W2021223304","https://openalex.org/W2023555984","https://openalex.org/W2026489312","https://openalex.org/W2028907151","https://openalex.org/W2033289727","https://openalex.org/W2034453891","https://openalex.org/W2037258736","https://openalex.org/W2045134338","https://openalex.org/W2045377817","https://openalex.org/W2049934524","https://openalex.org/W2051875419","https://openalex.org/W2059056463","https://openalex.org/W2060267424","https://openalex.org/W2066715630","https://openalex.org/W2068834630","https://openalex.org/W2070233886","https://openalex.org/W2070427564","https://openalex.org/W2071287957","https://openalex.org/W2079217010","https://openalex.org/W2084509745","https://openalex.org/W2085586833","https://openalex.org/W2095027014","https://openalex.org/W2096257246","https://openalex.org/W2096841751","https://openalex.org/W2097033529","https://openalex.org/W2101233099","https://openalex.org/W2101524137","https://openalex.org/W2104836362","https://openalex.org/W2106464597","https://openalex.org/W2106684817","https://openalex.org/W2112191495","https://openalex.org/W2115055179","https://openalex.org/W2117201337","https://openalex.org/W2117613919","https://openalex.org/W2117683008","https://openalex.org/W2118614585","https://openalex.org/W2122285073","https://openalex.org/W2123621742","https://openalex.org/W2130319366","https://openalex.org/W2133506666","https://openalex.org/W2136242777","https://openalex.org/W2136926115","https://openalex.org/W2139939599","https://openalex.org/W2143218174","https://openalex.org/W2144280353","https://openalex.org/W2164082708","https://openalex.org/W2164500783","https://openalex.org/W2169128237","https://openalex.org/W2171437874"],"related_works":["https://openalex.org/W2321100323","https://openalex.org/W2979758115","https://openalex.org/W2901178041","https://openalex.org/W2117613919","https://openalex.org/W2164216762","https://openalex.org/W1485724953","https://openalex.org/W7160539734","https://openalex.org/W2130319366","https://openalex.org/W4288077486","https://openalex.org/W2993467131"],"abstract_inverted_index":{"The":[0],"ability":[1],"to":[2,25,41,104,119,125,150],"tolerate":[3],"Candida":[4],"albicans,":[5],"a":[6,77],"human":[7,47],"commensal":[8],"of":[9,20,93,134],"the":[10,32,42,81,91],"gastrointestinal":[11],"tract":[12],"and":[13,22,29,39,46,59,70,114,127,137,141,159],"vagina,":[14],"implicates":[15],"that":[16,97],"host":[17],"defense":[18],"mechanisms":[19,61],"resistance":[21,38,124,147],"tolerance":[23,40,60,149,161],"cooperate":[24],"limit":[26],"fungal":[27],"burden":[28],"inflammation":[30],"at":[31],"different":[33],"body":[34],"sites.":[35],"We":[36],"evaluated":[37],"fungus":[43],"in":[44,54,65,112,145],"experimental":[45],"vulvovaginal":[48],"candidiasis":[49],"(VVC)":[50],"as":[51,53],"well":[52],"recurrent":[55],"VVC":[56],"(RVVC).":[57],"Resistance":[58],"were":[62,117],"both":[63],"activated":[64],"murine":[66],"VVC,":[67],"involving":[68],"IL-22":[69,140],"IL-10-producing":[71],"regulatory":[72],"T":[73],"cells,":[74],"respectively,":[75],"with":[76,100,122,130,148,168],"major":[78],"contribution":[79],"by":[80],"enzyme":[82],"indoleamine":[83],"2,3-dioxygenase":[84],"1":[85],"(IDO1).":[86],"IDO1":[87,115,136,142],"was":[88],"responsible":[89],"for":[90,157],"production":[92],"tolerogenic":[94],"kynurenines,":[95],"such":[96],"replacement":[98],"therapy":[99],"kynurenines":[101,164],"restored":[102],"immunoprotection":[103],"VVC.":[105],"In":[106],"humans,":[107],"two":[108],"functional":[109],"genetic":[110],"variants":[111],"IL22":[113],"genes":[116],"found":[118],"be":[120],"associated":[121],"heightened":[123],"RVVC,":[126,158],"they":[128],"correlated":[129],"increased":[131],"local":[132],"expression":[133],"IL-22,":[135],"kynurenines.":[138],"Thus,":[139],"are":[143,154],"crucial":[144],"balancing":[146],"Candida,":[151],"their":[152],"deficiencies":[153],"risk":[155],"factors":[156],"targeting":[160],"via":[162],"therapeutic":[163],"may":[165],"benefit":[166],"patients":[167],"RVVC.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}