{"id":"https://openalex.org/W1980162425","doi":"https://doi.org/10.1016/j.febslet.2007.03.046","title":"The aryl hydrocarbon receptor, more than a xenobiotic\u2010interacting protein","display_name":"The aryl hydrocarbon receptor, more than a xenobiotic\u2010interacting protein","publication_year":2007,"publication_date":"2007-03-30","ids":{"openalex":"https://openalex.org/W1980162425","doi":"https://doi.org/10.1016/j.febslet.2007.03.046","mag":"1980162425","pmid":"https://pubmed.ncbi.nlm.nih.gov/17412325"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2007.03.046","doi":"https://doi.org/10.1016/j.febslet.2007.03.046","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2007.03.046","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1980162425"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.science/hal-02175734","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049343245","display_name":"Robert Barouki","orcid":"https://orcid.org/0000-0001-9471-399X","observed_orcids":["https://orcid.org/0000-0001-9471-399X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210112450","display_name":"Health and Functional Exposomics","ror":"https://ror.org/021ryxk89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210112450"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Robert Barouki","raw_affiliation_strings":["INSERM, UMR-S 747, 75270 Paris Cedex 06, France. robert.barouki@univ-paris5.fr","INSERM, UMR-S 747, 75270 Paris Cedex 06, France","Universite\u0301 Rene\u0301 Descartes Paris 5, 45 Rue des Saints-Pe\u0300res, 75270 Paris Cedex 06, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, UMR-S 747, 75270 Paris Cedex 06, France. robert.barouki@univ-paris5.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210112450"]},{"raw_affiliation_string":"INSERM, UMR-S 747, 75270 Paris Cedex 06, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210112450"]},{"raw_affiliation_string":"Universite\u0301 Rene\u0301 Descartes Paris 5, 45 Rue des Saints-Pe\u0300res, 75270 Paris Cedex 06, France","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058260355","display_name":"Xavier Coumoul","orcid":"https://orcid.org/0000-0003-2928-9648","observed_orcids":["https://orcid.org/0000-0003-2928-9648"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210112450","display_name":"Health and Functional Exposomics","ror":"https://ror.org/021ryxk89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210112450"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Xavier Coumoul","raw_affiliation_strings":["INSERM, UMR-S 747, 75270 Paris Cedex 06, France","Universite\u0301 Rene\u0301 Descartes Paris 5, 45 Rue des Saints-Pe\u0300res, 75270 Paris Cedex 06, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM, UMR-S 747, 75270 Paris Cedex 06, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210112450"]},{"raw_affiliation_string":"Universite\u0301 Rene\u0301 Descartes Paris 5, 45 Rue des Saints-Pe\u0300res, 75270 Paris Cedex 06, France","institution_ids":["https://openalex.org/I4387156284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043370759","display_name":"Pedro M. Fern\u00e1ndez\u2010Salguero","orcid":"https://orcid.org/0000-0003-2839-5027","observed_orcids":["https://orcid.org/0000-0003-2839-5027"]},"institutions":[{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Pedro M. Fernandez-Salguero","raw_affiliation_strings":["Departamento de Bioqui\u0301mica y Biologi\u0301a Molecular, Facultad de Ciencias, Universidad de Extremadura, Avda. de Elvas s/n, 06080 Badajoz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqui\u0301mica y Biologi\u0301a Molecular, Facultad de Ciencias, Universidad de Extremadura, Avda. de Elvas s/n, 06080 Badajoz, Spain","institution_ids":["https://openalex.org/I80606768"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5043370759"],"corresponding_institution_ids":["https://openalex.org/I80606768"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":3.2325,"has_fulltext":false,"cited_by_count":416,"citation_normalized_percentile":{"value":0.95112782,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"581","issue":"19","first_page":"3608","last_page":"3615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":1.0},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.9599834680557251},{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.8577420115470886},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.6811476945877075},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6412464380264282},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.6343070864677429},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.5383006930351257},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.502964437007904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46676820516586304},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4618716537952423},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4611729383468628},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.44097772240638733},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4247239828109741},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.41578954458236694},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2167297899723053},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19481205940246582},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15476584434509277},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.127162903547287}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.febslet.2007.03.046","doi":"https://doi.org/10.1016/j.febslet.2007.03.046","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2007.03.046","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:17412325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17412325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02175734v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02175734","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"FEBS Letters, 2007, 581 (19), pp.3608-3615. ⟨10.1016/j.febslet.2007.03.046⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:HAL:hal-02175734v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02175734","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"FEBS Letters, 2007, 581 (19), pp.3608-3615. ⟨10.1016/j.febslet.2007.03.046⟩","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W1525281502","https://openalex.org/W1558953603","https://openalex.org/W1914760203","https://openalex.org/W1968906511","https://openalex.org/W1976846448","https://openalex.org/W1979402778","https://openalex.org/W1982343053","https://openalex.org/W1987273882","https://openalex.org/W1988376244","https://openalex.org/W1989060543","https://openalex.org/W1989986502","https://openalex.org/W1996162026","https://openalex.org/W1997013077","https://openalex.org/W2005404705","https://openalex.org/W2005552328","https://openalex.org/W2005585150","https://openalex.org/W2007225446","https://openalex.org/W2011678217","https://openalex.org/W2014021788","https://openalex.org/W2022645849","https://openalex.org/W2024584876","https://openalex.org/W2026476977","https://openalex.org/W2026570561","https://openalex.org/W2029275372","https://openalex.org/W2029753792","https://openalex.org/W2033901847","https://openalex.org/W2036792438","https://openalex.org/W2039904016","https://openalex.org/W2043241905","https://openalex.org/W2045594266","https://openalex.org/W2046396842","https://openalex.org/W2050572437","https://openalex.org/W2051036666","https://openalex.org/W2056903846","https://openalex.org/W2059565720","https://openalex.org/W2060705127","https://openalex.org/W2062509860","https://openalex.org/W2064230641","https://openalex.org/W2072118688","https://openalex.org/W2076401182","https://openalex.org/W2076951474","https://openalex.org/W2083246359","https://openalex.org/W2090922420","https://openalex.org/W2090939833","https://openalex.org/W2091405398","https://openalex.org/W2091726431","https://openalex.org/W2093069537","https://openalex.org/W2095942531","https://openalex.org/W2097348395","https://openalex.org/W2097893055","https://openalex.org/W2104499380","https://openalex.org/W2111325313","https://openalex.org/W2114629114","https://openalex.org/W2124739658","https://openalex.org/W2129154108","https://openalex.org/W2130760783","https://openalex.org/W2136793746","https://openalex.org/W2136937190","https://openalex.org/W2137081650","https://openalex.org/W2137365670","https://openalex.org/W2138913971","https://openalex.org/W2141642677","https://openalex.org/W2142283610","https://openalex.org/W2146693228","https://openalex.org/W2149540498","https://openalex.org/W2152618449","https://openalex.org/W2153495879","https://openalex.org/W2155308712","https://openalex.org/W2156531916","https://openalex.org/W2159219345","https://openalex.org/W2160882057","https://openalex.org/W2160886287","https://openalex.org/W2163212976","https://openalex.org/W2164762978","https://openalex.org/W2164930070","https://openalex.org/W2165627850","https://openalex.org/W2182760487","https://openalex.org/W2183313539","https://openalex.org/W2185090025","https://openalex.org/W2218756884","https://openalex.org/W2401829656","https://openalex.org/W2522837470"],"related_works":["https://openalex.org/W2365176228","https://openalex.org/W2013346975","https://openalex.org/W2016629712","https://openalex.org/W2000441102","https://openalex.org/W2742390761","https://openalex.org/W2086659744","https://openalex.org/W2005585150","https://openalex.org/W2097989455","https://openalex.org/W2156531916"],"abstract_inverted_index":{"The":[0],"aryl":[1],"hydrocarbon":[2],"(dioxin)":[3],"receptor":[4],"(AhR)":[5],"has":[6],"been":[7],"studied":[8],"for":[9],"several":[10],"decades":[11],"largely":[12],"because":[13],"of":[14,37,49,69,95],"its":[15],"critical":[16],"role":[17],"in":[18,29,98],"xenobiotic-induced":[19],"toxicity":[20],"and":[21,31,65,75,78],"carcinogenesis.":[22],"Albeit":[23],"this":[24,83],"is":[25,57],"a":[26],"major":[27],"issue":[28],"basic":[30],"clinical":[32],"research,":[33],"an":[34,58],"increasing":[35],"number":[36],"investigators":[38],"are":[39],"turning":[40],"their":[41],"efforts":[42],"to":[43,45,88],"try":[44],"understand":[46],"the":[47,50,90,93,96],"physiology":[48],"AhR":[51,97],"under":[52],"normal":[53],"cellular":[54,101],"conditions.":[55],"This":[56],"exciting":[59],"area":[60],"that":[61],"covers":[62],"cell":[63,76],"proliferation":[64],"differentiation,":[66],"endogenous":[67,100],"mechanisms":[68],"activation,":[70],"gene":[71],"regulation,":[72],"tumor":[73],"development":[74],"motility":[77],"migration,":[79],"among":[80],"others.":[81],"In":[82],"review,":[84],"we":[85],"will":[86],"attempt":[87],"summarize":[89],"studies":[91],"supporting":[92],"implication":[94],"those":[99],"processes.":[102]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}