{"id":"https://openalex.org/W1980134669","doi":"https://doi.org/10.1158/1538-7445.am10-597","title":"Abstract 597: Bacteria targeting and tumor vascular destruction by S. typhimurium A1-R depend on the vascularity of the tumor site","display_name":"Abstract 597: Bacteria targeting and tumor vascular destruction by S. typhimurium A1-R depend on the vascularity of the tumor site","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1980134669","doi":"https://doi.org/10.1158/1538-7445.am10-597","mag":"1980134669"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-597","doi":"https://doi.org/10.1158/1538-7445.am10-597","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-597","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100453135","display_name":"Fang Liu","orcid":"https://orcid.org/0009-0002-3148-3378","observed_orcids":["https://orcid.org/0009-0002-3148-3378"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang Liu","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ming Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zhao","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101572148","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0002-7917-1149","observed_orcids":["https://orcid.org/0000-0002-7917-1149"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA","institution_ids":["https://openalex.org/I4210121314"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210121314"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"597","last_page":"597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella-typhimurium-a1-r","display_name":"Salmonella typhimurium A1-R","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tumor-targeting-bacteria","display_name":"tumor-targeting bacteria","score":0.6790000200271606},{"id":"https://openalex.org/keywords/tumor-vascularity","display_name":"tumor vascularity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/lewis-lung-carcinoma","display_name":"Lewis lung carcinoma","score":0.75},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.6399999856948853},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.6119999885559082},{"id":"https://openalex.org/keywords/bacterial-virulence","display_name":"bacterial virulence","score":0.4830000102519989},{"id":"https://openalex.org/keywords/auxotrophic-mutants","display_name":"auxotrophic mutants","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tumor-targeted-therapy","display_name":"tumor-targeted therapy","score":0.4830000102519989},{"id":"https://openalex.org/keywords/tumor-targeted-imaging","display_name":"tumor-targeted imaging","score":0.39500001072883606},{"id":"https://openalex.org/keywords/fluorescence-imaging","display_name":"fluorescence imaging","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C178596483","wikidata":"https://www.wikidata.org/wiki/Q7916472","display_name":"Vascularity","level":2,"score":0.7734876871109009},{"id":"https://openalex.org/C2777847059","wikidata":"https://www.wikidata.org/wiki/Q6537255","display_name":"Lewis lung carcinoma","level":4,"score":0.738223671913147},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.47936517000198364},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47679948806762695},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47193190455436707},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4644456207752228},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3801601231098175},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3577640652656555},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.3214048743247986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3079133629798889},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16222161054611206},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.1477724313735962},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-597","doi":"https://doi.org/10.1158/1538-7445.am10-597","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-597","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965134167","https://openalex.org/W2316070506","https://openalex.org/W2043161504","https://openalex.org/W2313593714","https://openalex.org/W2012741386","https://openalex.org/W2418506558","https://openalex.org/W1996304408","https://openalex.org/W1984415151","https://openalex.org/W1898510439","https://openalex.org/W2084873561"],"abstract_inverted_index":{"Abstract":[0],"Our":[1,49],"laboratory":[2],"has":[3,31],"previously":[4],"developed":[5],"a":[6],"tumor-targeting":[7],"double-auxotrophic":[8],"mutant":[9,30],"of":[10,57,69,78,116,118,149,290,297,329,334],"S.":[11],"typhimurium":[12],"termed":[13],"A1-1":[14],"(Cancer":[15],"Research":[16],"66,":[17],"7647-7652,":[18],"2006;":[19],"Proc.":[20],"Natl.":[21],"Acad.":[22],"Sci.":[23],"USA":[24],"104,":[25],"10170-10174,":[26],"2007).":[27],"The":[28,67,162,280],"A1-R":[29,79,95,119,169,222,243,262],"high":[32],"tumor":[33,63,102,111,176,286,292,299],"virulence":[34],"but":[35],"requires":[36],"leucine":[37],"and":[38,144,178,190,208,216,237,272,288],"argentine":[39],"which":[40,154],"disables":[41],"the":[42,54,70,76,81,114,121,136,187,201,204,210,219,227,230,248,252,265,268,273,276,291,295,298,308,315,330,335],"bacteria":[43,170,214,235,285],"from":[44],"growing":[45,83,103,225,246],"in":[46,135,158,200,226,247],"normal":[47],"tissue.":[48],"previous":[50],"studies":[51],"suggested":[52],"that":[53,110,284],"rich":[55],"vascularity":[56,258,296],"tumors":[58,82],"may":[59],"contribute":[60],"to":[61,74,96,120,213,234,255,319],"bacterial":[62],"targeting":[64,117,177,215,236,263,287],"by":[65,183],"A1-R.":[66,256],"goal":[68],"present":[71,281],"study":[72,282],"was":[73,304,317],"determine":[75],"effect":[77],"on":[80,294],"at":[84,104,307],"different":[85,88,106],"sites":[86],"with":[87,101,168,186,261,264],"vascularity.":[89],"In":[90],"this":[91],"study,":[92],"we":[93],"administered":[94],"Lewis":[97,122,126],"lung":[98,123,127],"carcinoma-bearing":[99],"mice":[100,164],"three":[105],"sites.":[107],"We":[108],"observed":[109],"location":[112],"influences":[113],"efficacy":[115],"tumor.":[124],"RFP-expressing":[125],"cancer":[128],"cells":[129],"(1\u00d7107":[130],"cells/ml)":[131],"were":[132,165,181,209,229,251],"transplanted":[133],"subcutaneously":[134],"ear":[137,202,266],"(50":[138],"\u00b5l),":[139,143],"back":[140,228],"skin":[141],"(100":[142],"foot":[145,274],"pad":[146,250,275],"(25":[147],"\u00b5l)":[148],"nestin-GFP":[150],"transgenic":[151],"nude":[152],"mice,":[153],"selectively":[155],"express":[156],"GFP":[157],"nascent":[159],"blood":[160],"vessels.":[161],"tumor-bearing":[163],"then":[166],"treated":[167],"(5\u00d7107)":[171],"via":[172],"tail-vein":[173],"injection.":[174,223,244],"Bacteria":[175],"vascular":[179,270,278],"damage":[180],"evaluated":[182],"fluorescence":[184,197],"imaging":[185,193],"Olympus":[188],"IV100":[189],"OV100":[191],"small-animal":[192],"systems":[194],"designed":[195],"for":[196,338],"imaging.":[198],"Tumors":[199,224,245],"had":[203],"fastest":[205],"growth":[206],"rate":[207],"most":[211,232,269],"sensitive":[212,233,254],"hemorrhaged":[217],"severely":[218],"day":[220],"after":[221,242],"second":[231],"appeared":[238],"necrotic":[239],"3":[240],"days":[241],"food":[249],"least":[253,277],"Tumor":[257],"correlated":[259],"positively":[260],"being":[267],"site":[271],"site.":[279,300],"suggests":[283],"hemorrhage":[289],"depend":[293],"Note:":[301],"This":[302],"abstract":[303],"not":[305],"presented":[306],"AACR":[309],"101st":[310,331],"Annual":[311,332],"Meeting":[312,333],"2010":[313,341],"because":[314],"presenter":[316],"unable":[318],"attend.":[320],"Citation":[321],"Format:":[322],"{Authors}.":[323],"{Abstract":[324],"title}":[325],"[abstract].":[326],"In:":[327],"Proceedings":[328],"American":[336],"Association":[337],"Cancer":[339,349],"Research;":[340],"Apr":[342],"17-21;":[343],"Washington,":[344],"DC.":[345],"Philadelphia":[346],"(PA):":[347],"AACR;":[348],"Res":[350],"2010;70(8":[351],"Suppl):Abstract":[352],"nr":[353],"597.":[354]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
