{"id":"https://openalex.org/W1980012901","doi":"https://doi.org/10.1073/pnas.90.10.4660","title":"Intracellular calcium increases with hyperactivation in intact, moving hamster sperm and oscillates with the flagellar beat cycle.","display_name":"Intracellular calcium increases with hyperactivation in intact, moving hamster sperm and oscillates with the flagellar beat cycle.","publication_year":1993,"publication_date":"1993-05-15","ids":{"openalex":"https://openalex.org/W1980012901","doi":"https://doi.org/10.1073/pnas.90.10.4660","mag":"1980012901","pmid":"https://pubmed.ncbi.nlm.nih.gov/8506314","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/46572"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.90.10.4660","doi":"https://doi.org/10.1073/pnas.90.10.4660","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.90.10.4660","pdf_url":"https://pnas.org/doi/full/10.1073/pnas.90.10.4660","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pnas.org/doi/full/10.1073/pnas.90.10.4660","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086139831","display_name":"Susan S. Su\u00e1rez","orcid":"https://orcid.org/0000-0003-2989-8320","observed_orcids":["https://orcid.org/0000-0003-2989-8320"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S S Suarez","raw_affiliation_strings":["Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0144"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0144","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047855386","display_name":"S. M. Varosi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S M Varosi","raw_affiliation_strings":["Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0144"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0144","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":null,"display_name":"X Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X Dai","raw_affiliation_strings":["Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0144"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0144","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":10.8052,"has_fulltext":true,"cited_by_count":221,"citation_normalized_percentile":{"value":0.99088524,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"90","issue":"10","first_page":"4660","last_page":"4664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sperm-hyperactivation","display_name":"sperm hyperactivation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9919999837875366},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hamster-sperm","display_name":"hamster sperm","score":0.824999988079071},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.6809999942779541},{"id":"https://openalex.org/keywords/acrosome","display_name":"acrosome","score":0.8519999980926514},{"id":"https://openalex.org/keywords/indo-1","display_name":"indo-1","score":0.6790000200271606},{"id":"https://openalex.org/keywords/calcium-sensitive-fluorescent-dyes","display_name":"calcium-sensitive fluorescent dyes","score":0.7059999704360962},{"id":"https://openalex.org/keywords/fertilisation-biology","display_name":"fertilisation (biology)","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2778366672","wikidata":"https://www.wikidata.org/wiki/Q5957687","display_name":"Hyperactivation","level":2,"score":0.9797755479812622},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.8569666743278503},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6427031755447388},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.5392808318138123},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5252739191055298},{"id":"https://openalex.org/C189809214","wikidata":"https://www.wikidata.org/wiki/Q829522","display_name":"Beat (acoustics)","level":2,"score":0.5241803526878357},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.47718608379364014},{"id":"https://openalex.org/C2779995066","wikidata":"https://www.wikidata.org/wiki/Q163261","display_name":"Acrosome reaction","level":3,"score":0.47275620698928833},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.47176340222358704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46472790837287903},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.46185338497161865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4416283369064331},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.42301642894744873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4199678301811218},{"id":"https://openalex.org/C2777129507","wikidata":"https://www.wikidata.org/wiki/Q36857","display_name":"Oviduct","level":2,"score":0.41698792576789856},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2619473934173584},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10393530130386353},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09216371178627014},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08793002367019653},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005407","descriptor_name":"Flagella","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013081","descriptor_name":"Sperm Motility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013082","descriptor_name":"Sperm Tail","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.90.10.4660","doi":"https://doi.org/10.1073/pnas.90.10.4660","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.90.10.4660","pdf_url":"https://pnas.org/doi/full/10.1073/pnas.90.10.4660","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:46572","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/46572","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:8506314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8506314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.90.10.4660","doi":"https://doi.org/10.1073/pnas.90.10.4660","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.90.10.4660","pdf_url":"https://pnas.org/doi/full/10.1073/pnas.90.10.4660","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G64950296","display_name":null,"funder_award_id":"HD19584","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333346","display_name":"College of Veterinary Medicine, University of Florida","ror":null},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1980012901.pdf","grobid_xml":"https://content.openalex.org/works/W1980012901.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W630057471","https://openalex.org/W1519635099","https://openalex.org/W1544605152","https://openalex.org/W1589732339","https://openalex.org/W1966419912","https://openalex.org/W1970317907","https://openalex.org/W1971674142","https://openalex.org/W1981324396","https://openalex.org/W1986849356","https://openalex.org/W1990602082","https://openalex.org/W1995216096","https://openalex.org/W1996024251","https://openalex.org/W2000271290","https://openalex.org/W2008328165","https://openalex.org/W2021270159","https://openalex.org/W2029623594","https://openalex.org/W2033270364","https://openalex.org/W2042632160","https://openalex.org/W2043615134","https://openalex.org/W2045465480","https://openalex.org/W2052865938","https://openalex.org/W2061225056","https://openalex.org/W2071328400","https://openalex.org/W2071767338","https://openalex.org/W2078532790","https://openalex.org/W2078818404","https://openalex.org/W2085556812","https://openalex.org/W2094722022","https://openalex.org/W2098840797","https://openalex.org/W2102960826","https://openalex.org/W2107866215","https://openalex.org/W2112639590","https://openalex.org/W2121774813","https://openalex.org/W2129491007","https://openalex.org/W2131811477","https://openalex.org/W2141260882","https://openalex.org/W2174190166","https://openalex.org/W2403793803","https://openalex.org/W2408307858","https://openalex.org/W4238781098","https://openalex.org/W4255806385","https://openalex.org/W6602036895","https://openalex.org/W6603931438","https://openalex.org/W6733322018","https://openalex.org/W6742603813","https://openalex.org/W6813643927"],"related_works":["https://openalex.org/W2150205541","https://openalex.org/W2053786989","https://openalex.org/W131911175","https://openalex.org/W2157744295","https://openalex.org/W2099247728","https://openalex.org/W7101137565","https://openalex.org/W2142725840","https://openalex.org/W2127527366","https://openalex.org/W2107348505","https://openalex.org/W2003431136"],"abstract_inverted_index":{"At":[0],"some":[1],"time":[2],"before":[3],"fertilization,":[4],"mammalian":[5],"sperm":[6,24,63,161,190,230],"undergo":[7],"a":[8,108],"change":[9],"in":[10,35,78,135,145,156,159,169,179,185,200,209,229,238],"movement":[11],"pattern,":[12],"termed":[13],"hyperactivation.":[14],"There":[15],"is":[16,45,54],"evidence":[17],"that":[18,176],"hyperactivation":[19],"offers":[20],"an":[21],"advantage":[22],"to":[23,47,72,181],"for":[25,31,39,128],"detaching":[26],"from":[27],"the":[28,36,41,57,89,94,115,136,142,146,170,174,182,201,210,219],"oviductal":[29],"mucosa,":[30],"penetrating":[32,40],"viscoelastic":[33],"substances":[34],"oviduct,":[37],"and":[38,96,112,117,138,144,203],"zona":[42],"pellucida.":[43],"Hyperactivation":[44],"known":[46,55],"require":[48],"extracellular":[49],"calcium,":[50],"but":[51],"little":[52],"else":[53],"about":[56],"mechanisms":[58],"by":[59,106,217],"which":[60],"calcium":[61,75],"affects":[62],"movement.":[64],"The":[65,99,225],"calcium-sensitive":[66],"fluorescent":[67],"dye":[68,95,100],"indo-1":[69],"was":[70,101,132],"used":[71],"follow":[73],"intracellular":[74],"levels":[76],"([Ca2+]i)":[77],"individual":[79],"moving":[80],"sperm.":[81],"Sperm":[82],"were":[83,121,167,177,197,214],"loaded":[84],"with":[85,222],"10":[86],"microM":[87],"of":[88,93,141,173,187],"acetoxymethyl":[90],"ester":[91],"form":[92],"then":[97],"rinsed.":[98],"excited":[102],"at":[103,114,124],"340":[104],"nm":[105],"using":[107],"filtered":[109],"xenon":[110],"stroboscope,":[111],"images":[113],"405-nm":[116],"490-nm":[118],"excitation":[119],"maxima":[120],"simultaneously":[122],"digitized":[123],"30":[125],"per":[126],"sec":[127],"2.1":[129],"sec.":[130],"[Ca2+]i":[131,165,195,226],"significantly":[133,232],"higher":[134],"acrosomal":[137,202],"postacrosomal":[139,204],"regions":[140],"head":[143],"flagellar":[147,220],"midpiece":[148,175],"(the":[149],"principal":[150],"piece":[151],"could":[152],"not":[153,215],"be":[154],"measured)":[155],"hyperactivated":[157,189],"than":[158,235],"nonhyperactivated":[160],"(P":[162],"<":[163],"0.0001).":[164],"oscillations":[166,196,227,236],"detected":[168,199,228,237],"proximal":[171],"half":[172],"identical":[178],"frequency":[180,184],"flagellar-beat-cycle":[183],"12":[186],"17":[188],"(median,":[191],"3.5":[192],"Hz).":[193],"Rapid":[194],"also":[198],"regions,":[205],"as":[206,208],"well":[207],"distal":[211],"midpiece.":[212],"Oscillations":[213],"eliminated":[216],"dampening":[218],"bending":[221],"methyl":[223],"cellulose.":[224],"are":[231],"more":[233],"rapid":[234],"other":[239],"cell":[240],"types.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
