{"id":"https://openalex.org/W1979989586","doi":"https://doi.org/10.1242/dev.01885","title":"Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia","display_name":"Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia","publication_year":2005,"publication_date":"2005-06-08","ids":{"openalex":"https://openalex.org/W1979989586","doi":"https://doi.org/10.1242/dev.01885","mag":"1979989586","pmid":"https://pubmed.ncbi.nlm.nih.gov/15944189"},"language":"en","primary_location":{"id":"doi:10.1242/dev.01885","doi":"https://doi.org/10.1242/dev.01885","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.01885","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/117729","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007729024","display_name":"John A. Cobb","orcid":"https://orcid.org/0000-0002-1053-2604","observed_orcids":["https://orcid.org/0000-0002-1053-2604"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"John Cobb","raw_affiliation_strings":["National Research Center (NCCR) `Frontiers in Genetics', Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Center (NCCR) `Frontiers in Genetics', Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036343790","display_name":"Denis Duboule","orcid":"https://orcid.org/0000-0001-9961-2960","observed_orcids":["https://orcid.org/0000-0001-9961-2960"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Denis Duboule","raw_affiliation_strings":["National Research Center (NCCR) `Frontiers in Genetics', Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Center (NCCR) `Frontiers in Genetics', Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114457229"],"apc_list":null,"apc_paid":null,"fwci":2.9941,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.9195591,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"132","issue":"13","first_page":"3055","last_page":"3067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13107","display_name":"Congenital limb and hand anomalies","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1309","display_name":"Developmental Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hoxd-genes","display_name":"Hoxd genes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/digit-development","display_name":"digit development","score":0.7509999871253967},{"id":"https://openalex.org/keywords/external-genitalia-development","display_name":"external genitalia development","score":0.9039999842643738},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.625},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9471126794815063},{"id":"https://openalex.org/C111039654","wikidata":"https://www.wikidata.org/wiki/Q253149","display_name":"Hox gene","level":4,"score":0.9293762445449829},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7032470107078552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5999026894569397},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.488224059343338},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.44705620408058167},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4175407290458679},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3318437933921814},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3200170397758484}],"mesh":[{"descriptor_ui":"D000099184","descriptor_name":"Serum-Glucocorticoid Regulated Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005836","descriptor_name":"Genitalia, Female","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D005837","descriptor_name":"Genitalia, Male","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036121","descriptor_name":"Receptor, EphA3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036121","descriptor_name":"Receptor, EphA3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051096","descriptor_name":"Proto-Oncogene Proteins c-ret","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1242/dev.01885","doi":"https://doi.org/10.1242/dev.01885","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.01885","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:15944189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15944189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Comparative Study"},{"id":"pmh:oai:infoscience.epfl.ch:117729","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/117729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:117729","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/117729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:open-archive.highwire.org:develop:132/13/3055","doi":null,"is_oa":false,"landing_page_url":"http://dev.biologists.org/cgi/content/short/132/13/3055","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:117729","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/117729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1510857662","https://openalex.org/W1541819796","https://openalex.org/W1568188730","https://openalex.org/W1577577364","https://openalex.org/W1578346366","https://openalex.org/W1600348798","https://openalex.org/W1666476357","https://openalex.org/W1708068686","https://openalex.org/W1963955574","https://openalex.org/W1964288202","https://openalex.org/W1971801600","https://openalex.org/W1973614663","https://openalex.org/W1978151984","https://openalex.org/W1981464105","https://openalex.org/W1985660822","https://openalex.org/W1987713796","https://openalex.org/W1991149378","https://openalex.org/W2004305614","https://openalex.org/W2007530728","https://openalex.org/W2008390304","https://openalex.org/W2012201162","https://openalex.org/W2013951425","https://openalex.org/W2014781971","https://openalex.org/W2016701198","https://openalex.org/W2018922104","https://openalex.org/W2021481221","https://openalex.org/W2022689175","https://openalex.org/W2027780440","https://openalex.org/W2038188046","https://openalex.org/W2038304451","https://openalex.org/W2042978646","https://openalex.org/W2043966795","https://openalex.org/W2054511824","https://openalex.org/W2057433337","https://openalex.org/W2059140331","https://openalex.org/W2071880700","https://openalex.org/W2074354156","https://openalex.org/W2077255366","https://openalex.org/W2077802746","https://openalex.org/W2087787913","https://openalex.org/W2096747557","https://openalex.org/W2100471807","https://openalex.org/W2101325866","https://openalex.org/W2110873651","https://openalex.org/W2112742649","https://openalex.org/W2123247959","https://openalex.org/W2124933226","https://openalex.org/W2130949246","https://openalex.org/W2137563421","https://openalex.org/W2141275674","https://openalex.org/W2143818366","https://openalex.org/W2145424250","https://openalex.org/W2145681395","https://openalex.org/W2146007051","https://openalex.org/W2146713203","https://openalex.org/W2147751805","https://openalex.org/W2150080189","https://openalex.org/W2150705960","https://openalex.org/W2151659916","https://openalex.org/W2154184353","https://openalex.org/W2157461735","https://openalex.org/W2159969199","https://openalex.org/W2162871532","https://openalex.org/W2167816721","https://openalex.org/W2185961847","https://openalex.org/W2279686844","https://openalex.org/W2292326240","https://openalex.org/W4249696587","https://openalex.org/W4253759977","https://openalex.org/W4318963851"],"related_works":["https://openalex.org/W186959296","https://openalex.org/W2169264846","https://openalex.org/W1860551774","https://openalex.org/W2031498265","https://openalex.org/W1600348798","https://openalex.org/W3120332441","https://openalex.org/W2122851562","https://openalex.org/W2090533250","https://openalex.org/W1868418021","https://openalex.org/W7099407382"],"abstract_inverted_index":{"Mammalian":[0],"Hox":[1,84,170],"genes":[2,29,44,141],"encode":[3],"transcription":[4],"factors":[5],"that":[6,135,157],"are":[7,142],"crucial":[8],"for":[9,43],"proper":[10],"morphogenesis":[11],"along":[12],"the":[13,24,58,61,78,92,95,122,136,155,169,176,195,201,204,207],"various":[14],"body":[15,184],"axes.":[16],"Despite":[17],"their":[18,27],"extensive":[19],"structural":[20],"and":[21,51,166,186,206],"functional":[22],"characterization,":[23],"nature":[25],"of":[26,60,80,94,106,111,125,138,168,200],"target":[28,108],"remains":[30],"elusive.":[31],"We":[32,101],"have":[33],"addressed":[34],"this":[35],"question":[36],"by":[37],"using":[38],"DNA":[39],"microarrays":[40],"to":[41,91,117,192],"screen":[42],"whose":[45],"expression":[46,85],"in":[47,57,87,121,145],"developing":[48],"distal":[49,197],"forelimbs":[50],"genital":[52,129],"eminences":[53],"was":[54],"significantly":[55],"modified":[56],"absence":[59],"full":[62],"Hoxd":[63],"gene":[64,171],"complement.":[65],"This":[66,153],"comparative":[67],"approach":[68],"not":[69,114],"only":[70],"identified":[71],"specific":[72],"candidate":[73,140],"genes,":[74,109],"but":[75],"also":[76],"allowed":[77],"examination":[79],"whether":[81],"a":[82,104,119,188],"similar":[83,161],"pattern":[86],"distinct":[88],"tissues":[89],"leads":[90],"modulation":[93],"same":[96],"or":[97,128],"different":[98,151,183],"downstream":[99,167],"genes.":[100],"report":[102],"here":[103],"set":[105],"potential":[107],"most":[110,196],"which":[112],"were":[113],"previously":[115],"known":[116],"play":[118],"role":[120],"early":[123],"stages":[124],"either":[126],"limb":[127],"bud":[130],"development.":[131],"Interestingly,":[132],"we":[133],"find":[134],"majority":[137],"these":[139,181],"differentially":[143],"expressed":[144],"both":[146,158,164],"structures,":[147],"although":[148],"often":[149],"at":[150],"times.":[152],"supports":[154],"idea":[156],"appendices":[159],"involve":[160],"genetic":[162],"controls,":[163],"upstream":[165],"family.":[172],"These":[173],"results":[174],"highlight":[175],"surprising":[177],"mechanistic":[178],"relationship":[179],"between":[180],"rather":[182],"parts":[185],"suggest":[187],"common":[189],"developmental":[190],"strategy":[191],"build":[193],"up":[194],"appendicular":[198],"structures":[199],"body,":[202],"i.e.":[203],"digits":[205],"penis/clitoris.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}