{"id":"https://openalex.org/W1979957714","doi":"https://doi.org/10.1371/journal.pone.0049932","title":"Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP","display_name":"Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP","publication_year":2012,"publication_date":"2012-11-26","ids":{"openalex":"https://openalex.org/W1979957714","doi":"https://doi.org/10.1371/journal.pone.0049932","mag":"1979957714","pmid":"https://pubmed.ncbi.nlm.nih.gov/23189173","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3506601"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0049932","doi":"https://doi.org/10.1371/journal.pone.0049932","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049932","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049932&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049932&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041663727","display_name":"Mark Andrew White","orcid":"https://orcid.org/0000-0003-1057-4203","observed_orcids":["https://orcid.org/0000-0003-1057-4203"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A. White","raw_affiliation_strings":["Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America","Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas, United States of America","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359827","display_name":"Sheng Li","orcid":"https://orcid.org/0000-0002-9073-6809","observed_orcids":["https://orcid.org/0000-0002-9073-6809"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheng Li","raw_affiliation_strings":["Department of Medicine and Biomedical Sciences Graduate program, University of California San Diego, La Jolla, California United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Biomedical Sciences Graduate program, University of California San Diego, La Jolla, California United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062125545","display_name":"Tamara N. Tsalkova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara Tsalkova","raw_affiliation_strings":["Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas, United States of America","Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas, United States of America","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064997314","display_name":"Fang C. Mei","orcid":"https://orcid.org/0000-0002-2589-1036","observed_orcids":["https://orcid.org/0000-0002-2589-1036"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fang C. Mei","raw_affiliation_strings":["Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas, United States of America","Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas, United States of America","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100392625","display_name":"Tong Liu","orcid":"https://orcid.org/0000-0001-9152-5264","observed_orcids":["https://orcid.org/0000-0001-9152-5264"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Liu","raw_affiliation_strings":["Department of Medicine and Biomedical Sciences Graduate program, University of California San Diego, La Jolla, California United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Biomedical Sciences Graduate program, University of California San Diego, La Jolla, California United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108515186","display_name":"Virgil L. Woods","orcid":"https://orcid.org/0000-0002-4796-8698","observed_orcids":["https://orcid.org/0000-0002-4796-8698"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Virgil L. Woods","raw_affiliation_strings":["Universite de Sherbrooke , Canada","Department of Medicine and Biomedical Sciences Graduate program, University of California San Diego, La Jolla, California United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite de Sherbrooke , Canada","institution_ids":["https://openalex.org/I135117807"]},{"raw_affiliation_string":"Department of Medicine and Biomedical Sciences Graduate program, University of California San Diego, La Jolla, California United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080619609","display_name":"Xiaodong Cheng","orcid":"https://orcid.org/0000-0002-3479-1694","observed_orcids":["https://orcid.org/0000-0002-3479-1694"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaodong Cheng","raw_affiliation_strings":["Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas, United States of America","Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas, United States of America","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Sealy Center for Structural Biology and Molecular Biophysics, The University of Texas Medical Branch, Galveston, Texas, United States of America","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080619609"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.3211,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.50572637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"11","first_page":"e49932","last_page":"e49932"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5181000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.40209999680519104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epac2","display_name":"Epac2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/constitutively-active-mutant","display_name":"constitutively active mutant","score":0.9399999976158142},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/conformational-dynamics","display_name":"conformational dynamics","score":0.9610000252723694},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.6389999985694885},{"id":"https://openalex.org/keywords/active-conformation","display_name":"active conformation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/hydrogen-deuterium-exchange-mass-spectrometry","display_name":"hydrogen-deuterium exchange mass spectrometry","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8542312979698181},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6661210060119629},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6297541260719299},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5880951285362244},{"id":"https://openalex.org/C167569220","wikidata":"https://www.wikidata.org/wiki/Q5954985","display_name":"Hydrogen\u2013deuterium exchange","level":3,"score":0.5611453056335449},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.520712673664093},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.49677783250808716},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4703935384750366},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45284074544906616},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.43476101756095886},{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.42886072397232056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3579251170158386},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32027941942214966},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.19585350155830383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18942385911941528},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1817437708377838},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0049932","doi":"https://doi.org/10.1371/journal.pone.0049932","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049932","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049932&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3506601","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3506601","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23189173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23189173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.278.5019","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.5019","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://xray.utmb.edu/pubs/Pone.0049932-Epac2f435g.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e4407aa16482427d8aea4f83e9dc9941","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e4407aa16482427d8aea4f83e9dc9941","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 11, p e49932 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/116874","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Structural_Analyses_of_a_Constitutively_Active_Mutant_of_Exchange_Protein_Directly_Activated_by_cAMP__/116874","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0049932","doi":"https://doi.org/10.1371/journal.pone.0049932","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0049932","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049932&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G131960621","display_name":"Cellular Response Mechanisms to Environmental Challenge","funder_award_id":"P30ES006676","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G1652381656","display_name":"Action of Lipolytic Enzymes","funder_award_id":"R01GM020501","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1828974082","display_name":"Regulation, signaling, and dynamics of glucan phosphatases","funder_award_id":"R01NS070899","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G1939342338","display_name":"Sensitive Deuterium Exchange MS for Membrane Proteins","funder_award_id":"R01GM093325","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1953105538","display_name":null,"funder_award_id":"GM020501","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2782264667","display_name":"DESIGN OF AMPHIPHILIC PEPTOID ASSEMBLIES","funder_award_id":"F32GM020501","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G409918591","display_name":"STRUCTURE DRIVEN ANALYSIS OF EBOLA VIRUS RECEPTOR BINDING SITE","funder_award_id":"R01AI081982","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G580406604","display_name":"Current Generation Integrated Instrumentation for H-D Exchange LC-MS","funder_award_id":"S10RR029388","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6831578510","display_name":"Epac/cAMP-GEF, A Novel Intracellular cAMP Receptor","funder_award_id":"R01GM066170","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G831696663","display_name":null,"funder_award_id":"AI2008031","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1979957714.pdf","grobid_xml":"https://content.openalex.org/works/W1979957714.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W12382117","https://openalex.org/W1885709862","https://openalex.org/W1967969238","https://openalex.org/W1973983376","https://openalex.org/W1974543768","https://openalex.org/W1974947279","https://openalex.org/W1995017064","https://openalex.org/W1996683094","https://openalex.org/W2005847898","https://openalex.org/W2009061745","https://openalex.org/W2015400791","https://openalex.org/W2017393660","https://openalex.org/W2017421343","https://openalex.org/W2039629780","https://openalex.org/W2049551487","https://openalex.org/W2050582664","https://openalex.org/W2055749522","https://openalex.org/W2068064315","https://openalex.org/W2075957044","https://openalex.org/W2078037416","https://openalex.org/W2089519239","https://openalex.org/W2107414468","https://openalex.org/W2110810762","https://openalex.org/W2118200955","https://openalex.org/W2124026197","https://openalex.org/W2130273970","https://openalex.org/W2154714625","https://openalex.org/W2156512653","https://openalex.org/W2160753998","https://openalex.org/W2168130018","https://openalex.org/W2171241069"],"related_works":["https://openalex.org/W2055749522","https://openalex.org/W2160753998","https://openalex.org/W2995252055","https://openalex.org/W2005847898","https://openalex.org/W2009061745","https://openalex.org/W7171922620","https://openalex.org/W1974947279","https://openalex.org/W1989393346","https://openalex.org/W2288595724","https://openalex.org/W2086889910"],"abstract_inverted_index":{"Exchange":[0],"proteins":[1],"directly":[2],"activated":[3],"by":[4],"cAMP":[5],"(EPACs)":[6],"are":[7],"important":[8],"allosteric":[9],"regulators":[10],"of":[11,21,46,76],"cAMP-mediated":[12],"signal":[13],"transduction":[14],"pathways.":[15],"To":[16],"understand":[17],"the":[18,41,74,80],"molecular":[19],"mechanism":[20],"EPAC":[22,65],"activation,":[23],"we":[24],"have":[25],"combined":[26],"site-directed":[27],"mutagenesis,":[28],"X-ray":[29],"crystallography,":[30],"and":[31,43],"peptide":[32],"amide":[33],"hydrogen/deuterium":[34],"exchange":[35],"mass":[36],"spectrometry":[37],"(DXMS)":[38],"to":[39],"probe":[40],"structural":[42],"conformational":[44,57,77],"dynamics":[45,58,78],"EPAC2-F435G,":[47],"a":[48,60],"constitutively":[49],"active":[50,82],"EPAC2":[51],"mutant.":[52],"Our":[53],"study":[54],"demonstrates":[55],"that":[56],"plays":[59],"critical":[61],"role":[62],"in":[63],"cAMP-induced":[64],"activation.":[66],"A":[67],"glycine":[68],"mutation":[69],"at":[70],"435":[71],"position":[72],"shifts":[73],"equilibrium":[75],"towards":[79],"extended":[81],"conformation.":[83]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}