{"id":"https://openalex.org/W1979956933","doi":"https://doi.org/10.1097/01.jom.0000052953.59271.e1","title":"Association Between Human Paraoxonase Gene Polymorphism and Chronic Symptoms in Pesticide-Exposed Workers","display_name":"Association Between Human Paraoxonase Gene Polymorphism and Chronic Symptoms in Pesticide-Exposed Workers","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W1979956933","doi":"https://doi.org/10.1097/01.jom.0000052953.59271.e1","mag":"1979956933","pmid":"https://pubmed.ncbi.nlm.nih.gov/12625227"},"language":"en","primary_location":{"id":"doi:10.1097/01.jom.0000052953.59271.e1","doi":"https://doi.org/10.1097/01.jom.0000052953.59271.e1","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.jom.0000052953.59271.e1","pdf_url":null,"source":{"id":"https://openalex.org/S156862075","display_name":"Journal of Occupational and Environmental Medicine","issn_l":"1076-2752","issn":["1076-2752","1536-5948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Occupational and Environmental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064128021","display_name":"Burton W. Lee","orcid":"https://orcid.org/0009-0002-3888-1766","observed_orcids":["https://orcid.org/0009-0002-3888-1766"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210119840","display_name":"Christiani","ror":"https://ror.org/02k4gk709","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210119840"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Burton W. Lee","raw_affiliation_strings":["Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA","Christiani)","Myers)","Paulauskis)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Christiani)","institution_ids":["https://openalex.org/I4210119840"]},{"raw_affiliation_string":"Myers)","institution_ids":[]},{"raw_affiliation_string":"Paulauskis)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047948007","display_name":"Leslie London","orcid":"https://orcid.org/0000-0003-1297-2758","observed_orcids":["https://orcid.org/0000-0003-1297-2758","https://orcid.org/0000-0003-2551-7287"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210119840","display_name":"Christiani","ror":"https://ror.org/02k4gk709","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210119840"]}],"countries":["DE","US","ZA"],"is_corresponding":false,"raw_author_name":"Leslie London","raw_affiliation_strings":["Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, Massachusetts (Dr Lee, Dr Christiani)","From the Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts (Dr Lee, Dr Paulauskis)","George Washington University School of Medicine, Washington, DC (Dr Lee)","and University of Cape Town, Department of Social Medicine, Republic of South Africa (Dr London, Dr Myers)","Christiani)","Myers)","Paulauskis)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, Massachusetts (Dr Lee, Dr Christiani)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"From the Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts (Dr Lee, Dr Paulauskis)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"George Washington University School of Medicine, Washington, DC (Dr Lee)","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"and University of Cape Town, Department of Social Medicine, Republic of South Africa (Dr London, Dr Myers)","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"Christiani)","institution_ids":["https://openalex.org/I4210119840"]},{"raw_affiliation_string":"Myers)","institution_ids":[]},{"raw_affiliation_string":"Paulauskis)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059895813","display_name":"Joseph D. Paulauskis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210119840","display_name":"Christiani","ror":"https://ror.org/02k4gk709","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210119840"]}],"countries":["DE","US","ZA"],"is_corresponding":false,"raw_author_name":"Joseph Paulauskis","raw_affiliation_strings":["Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, Massachusetts (Dr Lee, Dr Christiani)","From the Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts (Dr Lee, Dr Paulauskis)","George Washington University School of Medicine, Washington, DC (Dr Lee)","and University of Cape Town, Department of Social Medicine, Republic of South Africa (Dr London, Dr Myers)","Christiani)","Myers)","Paulauskis)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, Massachusetts (Dr Lee, Dr Christiani)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"From the Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts (Dr Lee, Dr Paulauskis)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"George Washington University School of Medicine, Washington, DC (Dr Lee)","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"and University of Cape Town, Department of Social Medicine, Republic of South Africa (Dr London, Dr Myers)","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"Christiani)","institution_ids":["https://openalex.org/I4210119840"]},{"raw_affiliation_string":"Myers)","institution_ids":[]},{"raw_affiliation_string":"Paulauskis)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109808396","display_name":"Jonny E. Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210119840","display_name":"Christiani","ror":"https://ror.org/02k4gk709","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210119840"]}],"countries":["DE","US","ZA"],"is_corresponding":false,"raw_author_name":"Jonny Myers","raw_affiliation_strings":["Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, Massachusetts (Dr Lee, Dr Christiani)","From the Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts (Dr Lee, Dr Paulauskis)","George Washington University School of Medicine, Washington, DC (Dr Lee)","and University of Cape Town, Department of Social Medicine, Republic of South Africa (Dr London, Dr Myers)","Christiani)","Myers)","Paulauskis)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, Massachusetts (Dr Lee, Dr Christiani)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"From the Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts (Dr Lee, Dr Paulauskis)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"George Washington University School of Medicine, Washington, DC (Dr Lee)","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"and University of Cape Town, Department of Social Medicine, Republic of South Africa (Dr London, Dr Myers)","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"Christiani)","institution_ids":["https://openalex.org/I4210119840"]},{"raw_affiliation_string":"Myers)","institution_ids":[]},{"raw_affiliation_string":"Paulauskis)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091331939","display_name":"David C. Christiani","orcid":"https://orcid.org/0000-0002-0301-0242","observed_orcids":["https://orcid.org/0000-0002-0301-0242"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210119840","display_name":"Christiani","ror":"https://ror.org/02k4gk709","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210119840"]}],"countries":["DE","US","ZA"],"is_corresponding":true,"raw_author_name":"David C. Christiani","raw_affiliation_strings":["Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, Massachusetts (Dr Lee, Dr Christiani)","From the Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts (Dr Lee, Dr Paulauskis)","George Washington University School of Medicine, Washington, DC (Dr Lee)","and University of Cape Town, Department of Social Medicine, Republic of South Africa (Dr London, Dr Myers)","Christiani)","Myers)","Paulauskis)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, Massachusetts (Dr Lee, Dr Christiani)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"From the Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts (Dr Lee, Dr Paulauskis)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"George Washington University School of Medicine, Washington, DC (Dr Lee)","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"and University of Cape Town, Department of Social Medicine, Republic of South Africa (Dr London, Dr Myers)","institution_ids":["https://openalex.org/I157614274"]},{"raw_affiliation_string":"Christiani)","institution_ids":["https://openalex.org/I4210119840"]},{"raw_affiliation_string":"Myers)","institution_ids":[]},{"raw_affiliation_string":"Paulauskis)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5091331939"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I157614274","https://openalex.org/I193531525","https://openalex.org/I4210087915","https://openalex.org/I4210119840"],"apc_list":null,"apc_paid":null,"fwci":2.4563,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.87813915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"45","issue":"2","first_page":"118","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.14710000157356262,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paraoxonase","display_name":"paraoxonase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pon1-polymorphisms","display_name":"PON1 gene polymorphisms","score":0.9350000023841858},{"id":"https://openalex.org/keywords/organophosphate-pesticides","display_name":"organophosphorus pesticides","score":0.6169999837875366},{"id":"https://openalex.org/keywords/pesticide-applicators","display_name":"pesticide applicators","score":0.6700000166893005},{"id":"https://openalex.org/keywords/farm-workers","display_name":"farm workers","score":0.9399999976158142},{"id":"https://openalex.org/keywords/paraoxon-hydrolysis","display_name":"paraoxon hydrolysis","score":0.796999990940094},{"id":"https://openalex.org/keywords/cholinesterase-inhibition","display_name":"cholinesterase inhibition","score":0.8410000205039978},{"id":"https://openalex.org/keywords/head-trauma","display_name":"head trauma","score":0.44999998807907104},{"id":"https://openalex.org/keywords/pesticide-exposure","display_name":"pesticide exposure","score":0.42500001192092896},{"id":"https://openalex.org/keywords/western-cape","display_name":"Western Cape","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2776509667","wikidata":"https://www.wikidata.org/wiki/Q7135605","display_name":"Paraoxonase","level":3,"score":0.7307188510894775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5979873538017273},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5625205636024475},{"id":"https://openalex.org/C2778242859","wikidata":"https://www.wikidata.org/wiki/Q4802705","display_name":"Aryldialkylphosphatase","level":5,"score":0.5573204159736633},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.44338247179985046},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42567214369773865},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.4114789366722107},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3892596960067749},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2881733775138855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28393474221229553},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15294328331947327},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.08413159847259521},{"id":"https://openalex.org/C37501387","wikidata":"https://www.wikidata.org/wiki/Q18030661","display_name":"PON1","level":4,"score":0.07349759340286255},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000383","descriptor_name":"Agriculture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004950","descriptor_name":"Esterases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010575","descriptor_name":"Pesticides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010575","descriptor_name":"Pesticides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016273","descriptor_name":"Occupational Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043303","descriptor_name":"Aryldialkylphosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.jom.0000052953.59271.e1","doi":"https://doi.org/10.1097/01.jom.0000052953.59271.e1","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.jom.0000052953.59271.e1","pdf_url":null,"source":{"id":"https://openalex.org/S156862075","display_name":"Journal of Occupational and Environmental Medicine","issn_l":"1076-2752","issn":["1076-2752","1536-5948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Occupational and Environmental Medicine","raw_type":"journal-article"},{"id":"pmid:12625227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of occupational and environmental medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4769690452","display_name":"Harvard Chan School NIEHS Center for Environmental Health","funder_award_id":"P30ES000002","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G723185991","display_name":null,"funder_award_id":"ES 00002","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1529163","https://openalex.org/W1782492077","https://openalex.org/W1916152847","https://openalex.org/W1967607974","https://openalex.org/W1995784991","https://openalex.org/W2015635131","https://openalex.org/W2022865333","https://openalex.org/W2024640312","https://openalex.org/W2030423815","https://openalex.org/W2064409755","https://openalex.org/W2081927835","https://openalex.org/W2098179837","https://openalex.org/W2115002909","https://openalex.org/W2115848618","https://openalex.org/W2196684869","https://openalex.org/W2412826920"],"related_works":["https://openalex.org/W2060390538","https://openalex.org/W2049237999","https://openalex.org/W2366889126","https://openalex.org/W1964410653","https://openalex.org/W2144618593","https://openalex.org/W1993786841","https://openalex.org/W2040351113","https://openalex.org/W2066070014","https://openalex.org/W2078517491","https://openalex.org/W130352976"],"abstract_inverted_index":{"Learning":[0],"Objectives":[1],"Explain":[2],"the":[3,12,17,47,54,89,169,182,196,230,269,284,343],"role":[4],"of":[5,14,32,49,64,91,109,145,157,161,181,195,204,233,239,245,268,286,340,361,370,380],"paraoxonase":[6,122,183],"(PON)":[7,87],"in":[8,16,35,168,243,290],"organophosphate":[9,363],"metabolism":[10],"and":[11,29,60,95,143,265,326],"implications":[13],"polymorphism":[15,103,180],"human":[18],"PON":[19,55,110,135,141,374],"gene":[20,184],"for":[21,179],"farm":[22,36,153,166,175],"workers":[23,37,167,176],"exposed":[24,38],"to":[25,39,44,53,78,125,201,305,317,384],"pesticides.":[26],"Identify":[27],"demographic":[28],"clinical":[30],"correlates":[31],"chronic":[33,50,146,205,234,287,371,385],"toxicity":[34,52,148,163,235,288],"pesticides":[40],"when":[41],"applying":[42],"them":[43],"crops.":[45],"Relate":[46],"occurrence":[48],"pesticide":[51,66,98,147,162,257,297,308,320,329,386],"genotypes":[56,276,334],"associated":[57,118,131],"with":[58,119,132,191,299,310,322,331],"\u201cfast\u201d":[59],"\u201cslow\u201d":[61],"enzymatic":[62],"hydrolysis":[63,90],"toxic":[65,93],"metabolites.":[67],"Pesticides,":[68],"such":[69],"as":[70,255],"parathion,":[71],"are":[72],"metabolized":[73],"by":[74],"cytochrome":[75],"p-450":[76],"system":[77],"paraoxon,":[79],"which":[80],"is":[81,117,130,376],"a":[82,158,256,291,300,381],"potent":[83],"cholinesterase":[84,356],"inhibitor.":[85],"Paraoxonase":[86],"catalyzes":[88],"these":[92],"metabolites":[94],"protects":[96],"against":[97],"toxicity.":[99,372],"A":[100],"glutamine/arginine":[101],"(Gln/Arg)":[102],"at":[104,185],"amino":[105,186],"acid":[106,187],"position":[107,188],"192":[108],"has":[111],"been":[112],"described.":[113],"The":[114,127,137,373],"Arg/Arg":[115],"genotype":[116,129,142,375],"higher":[120],"serum":[121,134],"activity":[123],"compared":[124],"Gln/Gln.":[126],"Arg/Gln":[128],"intermediate":[133],"activity.":[136],"potential":[138],"association":[139],"between":[140],"symptoms":[144,198],"was":[149],"examined":[150],"among":[151,164,296,307,319,328],"100":[152,174],"workers.":[154],"As":[155],"part":[156],"cross-sectional":[159],"study":[160],"mixed-race":[165],"Western":[170],"Cape,":[171],"South":[172],"Africa,":[173],"were":[177,199,236,365],"genotyped":[178],"192.":[189],"Subjects":[190],"two":[192,270],"or":[193,222,274,314,352,358],"more":[194],"following":[197],"considered":[200],"have":[202],"evidence":[203],"toxicity:":[206],"abdominal":[207],"pain,":[208,221],"nausea,":[209],"rhinorrhea,":[210],"dizziness,":[211],"headache,":[212],"somnolence,":[213],"fatigue,":[214],"gait":[215],"disturbance,":[216],"limb":[217,220,223],"numbness,":[218],"paresthesias,":[219],"weakness.":[224],"In":[225],"multivariable":[226],"logistic":[227],"regression":[228],"analysis,":[229],"independent":[231],"predictors":[232,369],"previous":[237,359],"history":[238,360],"head":[240],"trauma":[241],"resulting":[242],"loss":[244],"consciousness":[246],"(OR":[247,259,277],"2.8,":[248],"95%":[249,261,279],"CI":[250,262,280],"=":[251,263,281,336],"1.7\u20136.7),":[252],"having":[253,266],"worked":[254],"applicator":[258],"5.4,":[260],"3.2\u20138.9),":[264],"one":[267],"\u201cslow":[271,311,332],"metabolism\u201d":[272,302,312,324,333],"(Gln/Gln":[273,313],"Gln/Arg)":[275,315],"2.9,":[278],"1.7\u20136.9).":[282],"Furthermore,":[283],"prevalence":[285],"increased":[289],"stepwise":[292],"fashion":[293],"from":[294],"15%":[295],"nonapplicators":[298,309],"\u201cfast":[301,323],"(Arg/Arg)":[303],"genotype,":[304,325],"42.9%":[306],"genotypes,":[316],"58.8%":[318],"applicators":[321,330],"75.0%":[327],"(P":[335],"0.001).":[337],"Age,":[338],"number":[339],"years":[341],"on":[342],"job,":[344],"smoking":[345],"history,":[346,348],"alcohol":[347],"education":[349],"level,":[350,357],"plasma":[351],"red":[353],"blood":[354],"cell":[355],"acute":[362],"poisoning":[364],"not":[366],"statistically":[367],"significant":[368],"an":[377],"important":[378],"determinant":[379],"farmworker\u2019s":[382],"susceptibility":[383],"poisoning.":[387]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
