{"id":"https://openalex.org/W1979946641","doi":"https://doi.org/10.1177/0091270010372105","title":"Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients","display_name":"Evaluation of Single-Point Sampling Strategies for the Estimation of Moclobemide Exposure in Depressive Patients","publication_year":2010,"publication_date":"2010-05-22","ids":{"openalex":"https://openalex.org/W1979946641","doi":"https://doi.org/10.1177/0091270010372105","mag":"1979946641","pmid":"https://pubmed.ncbi.nlm.nih.gov/20495135"},"language":"en","primary_location":{"id":"doi:10.1177/0091270010372105","doi":"https://doi.org/10.1177/0091270010372105","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0091270010372105","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008734723","display_name":"Anita Rakic Ignjatovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anita Rakic Ignjatovic","raw_affiliation_strings":["Medicines and Medical Devices Agency of Serbia, Vojvode Stepe No. 458, Belgrade 11152, Serbia. anitarakic@beotel.net","Medicines and Medical Devices Agency of Serbia, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicines and Medical Devices Agency of Serbia, Vojvode Stepe No. 458, Belgrade 11152, Serbia. anitarakic@beotel.net","institution_ids":[]},{"raw_affiliation_string":"Medicines and Medical Devices Agency of Serbia, Belgrade, Serbia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078793787","display_name":"Branislava Miljkovi\u0107","orcid":"https://orcid.org/0000-0001-5088-5976","observed_orcids":["https://orcid.org/0000-0001-5088-5976"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Branislava Miljkovic","raw_affiliation_strings":["Department of Pharmacokinetics, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101556890","display_name":"Dejan Todorovi\u0107","orcid":"https://orcid.org/0000-0002-0117-7102","observed_orcids":["https://orcid.org/0000-0002-0117-7102"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]},{"id":"https://openalex.org/I4210158996","display_name":"Institute of Mental Health","ror":"https://ror.org/04zp4vp65","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210158996"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Dejan Todorovic","raw_affiliation_strings":["Institute of Mental Health, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Mental Health, Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193","https://openalex.org/I4210158996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020037072","display_name":"I. Timotijevi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]},{"id":"https://openalex.org/I4210158996","display_name":"Institute of Mental Health","ror":"https://ror.org/04zp4vp65","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I4210158996"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Ivana Timotijevic","raw_affiliation_strings":["Institute of Mental Health, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Mental Health, Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193","https://openalex.org/I4210158996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111832714","display_name":"Milena Pokrajac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Milena Pokrajac","raw_affiliation_strings":["Department of Pharmacokinetics, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008734723"],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.3226,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.65831084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"51","issue":"5","first_page":"661","last_page":"671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.4867999851703644,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.4867999851703644,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.1859000027179718,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.12349999696016312,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moclobemide","display_name":"moclobemide","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetic-monitoring","display_name":"pharmacokinetic monitoring","score":0.5730000138282776},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.4819999933242798},{"id":"https://openalex.org/keywords/area-under-the-concentration-time-curve","display_name":"area under the concentration-time curve","score":0.8389999866485596},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.45399999618530273},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.5109999775886536},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.4819999933242798},{"id":"https://openalex.org/keywords/interpatient-variability","display_name":"interpatient variability","score":0.8289999961853027},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2780237459","wikidata":"https://www.wikidata.org/wiki/Q421934","display_name":"Moclobemide","level":4,"score":0.9762280583381653},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6959861516952515},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6309503316879272},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5461727976799011},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4513574540615082},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38642197847366333},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3334110379219055},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23772436380386353},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21591240167617798},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007297","descriptor_name":"Inpatients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008996","descriptor_name":"Monoamine Oxidase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008996","descriptor_name":"Monoamine Oxidase Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008996","descriptor_name":"Monoamine Oxidase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020912","descriptor_name":"Moclobemide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020912","descriptor_name":"Moclobemide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020912","descriptor_name":"Moclobemide","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D055771","descriptor_name":"Serbia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/0091270010372105","doi":"https://doi.org/10.1177/0091270010372105","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0091270010372105","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:20495135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20495135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:farfar.pharmacy.bg.ac.rs:123456789/1518","doi":null,"is_oa":false,"landing_page_url":"http://farfar.pharmacy.bg.ac.rs/handle/123456789/1518","pdf_url":null,"source":{"id":"https://openalex.org/S7407055311","display_name":"FarFar - Pharmacy Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Pharmacology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W73915906","https://openalex.org/W1513999390","https://openalex.org/W1971238903","https://openalex.org/W1982786103","https://openalex.org/W1984567164","https://openalex.org/W1995483502","https://openalex.org/W2003143162","https://openalex.org/W2004465552","https://openalex.org/W2007478137","https://openalex.org/W2009236753","https://openalex.org/W2015795623","https://openalex.org/W2018529171","https://openalex.org/W2021191619","https://openalex.org/W2021847316","https://openalex.org/W2022871996","https://openalex.org/W2026027425","https://openalex.org/W2026864077","https://openalex.org/W2033614870","https://openalex.org/W2042837804","https://openalex.org/W2044426904","https://openalex.org/W2045458382","https://openalex.org/W2046117113","https://openalex.org/W2055663014","https://openalex.org/W2060903596","https://openalex.org/W2063261636","https://openalex.org/W2068894011","https://openalex.org/W2070229664","https://openalex.org/W2079700813","https://openalex.org/W2083649927","https://openalex.org/W2086739139","https://openalex.org/W2096739998","https://openalex.org/W2096799462","https://openalex.org/W2106396324","https://openalex.org/W2112164388","https://openalex.org/W2143429012","https://openalex.org/W2145946250","https://openalex.org/W2148166921","https://openalex.org/W2150274550","https://openalex.org/W2150639957","https://openalex.org/W2153284906","https://openalex.org/W2315155350","https://openalex.org/W2318741379","https://openalex.org/W2396201631","https://openalex.org/W2465692541","https://openalex.org/W6671482594"],"related_works":["https://openalex.org/W2093687283","https://openalex.org/W2042837804","https://openalex.org/W1971238903","https://openalex.org/W2318741379","https://openalex.org/W2361899004","https://openalex.org/W2371836013","https://openalex.org/W1974555694","https://openalex.org/W4395668204","https://openalex.org/W2027404966","https://openalex.org/W2145989913"],"abstract_inverted_index":{"Because":[0],"moclobemide":[1,40,55,137,161],"pharmacokinetics":[2],"vary":[3],"considerably":[4],"among":[5],"individuals,":[6],"monitoring":[7],"of":[8,27,105,136,142,174,181],"plasma":[9],"concentrations":[10,128,147,164,177],"lends":[11],"insight":[12],"into":[13,64],"its":[14,19],"pharmacokinetic":[15,47],"behavior":[16],"and":[17,69,81,122,150,167,184],"enhances":[18],"rational":[20],"use":[21],"in":[22,111,129,190],"clinical":[23,192],"practice.":[24],"The":[25,102,139],"aim":[26],"this":[28],"study":[29],"was":[30,109,144],"to":[31],"evaluate":[32],"whether":[33],"single":[34,78],"concentration-time":[35,79,86],"points":[36,80],"could":[37],"adequately":[38],"predict":[39],"systemic":[41,162],"exposure.":[42],"Pharmacokinetic":[43],"data":[44],"(full":[45],"7-point":[46],"profiles),":[48],"obtained":[49],"from":[50,146],"21":[51],"depressive":[52],"inpatients":[53],"receiving":[54],"(150":[56],"mg":[57],"3":[58],"times":[59],"daily),":[60],"were":[61,96],"randomly":[62],"split":[63],"development":[65],"(n":[66,71],"=":[67,72],"18)":[68],"validation":[70,113],"16)":[73],"sets.":[74],"Correlations":[75],"between":[76],"the":[77,82,85,112,130,156],"area":[83],"under":[84],"curve":[87],"within":[88],"a":[89,185],"6-hour":[90],"dosing":[91],"interval":[92],"at":[93,148,165],"steady-state":[94],"(AUC(0-6))":[95],"assessed":[97],"by":[98,115],"linear":[99],"regression":[100],"analyses.":[101],"predictive":[103],"performance":[104],"single-point":[106],"sampling":[107],"strategies":[108],"evaluated":[110],"set":[114],"mean":[116,119,124],"prediction":[117],"error,":[118,121],"absolute":[120],"root":[123],"square":[125],"error.":[126],"Plasma":[127],"absorption":[131],"phase":[132],"yielded":[133],"unsatisfactory":[134],"predictions":[135],"AUC(0-6).":[138],"best":[140],"estimation":[141],"AUC(0-6)":[143],"achieved":[145],"4":[149,166],"6":[151,168],"hours":[152,169],"following":[153],"dosing.":[154],"As":[155],"most":[157],"reliable":[158],"surrogate":[159],"for":[160,187],"exposure,":[163],"should":[170],"be":[171],"used":[172],"instead":[173],"predose":[175],"trough":[176],"as":[178],"an":[179],"indicator":[180],"between-patient":[182],"variability":[183],"guide":[186],"dose":[188],"adjustments":[189],"specific":[191],"situations.":[193]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
