{"id":"https://openalex.org/W1979931374","doi":"https://doi.org/10.1097/mog.0b013e328317c897","title":"Rotavirus vaccines and pathogenesis: 2008","display_name":"Rotavirus vaccines and pathogenesis: 2008","publication_year":2008,"publication_date":"2008-12-26","ids":{"openalex":"https://openalex.org/W1979931374","doi":"https://doi.org/10.1097/mog.0b013e328317c897","mag":"1979931374","pmid":"https://pubmed.ncbi.nlm.nih.gov/19114772","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2673536"},"language":"en","primary_location":{"id":"doi:10.1097/mog.0b013e328317c897","doi":"https://doi.org/10.1097/mog.0b013e328317c897","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mog.0b013e328317c897","pdf_url":null,"source":{"id":"https://openalex.org/S41211651","display_name":"Current Opinion in Gastroenterology","issn_l":"0267-1379","issn":["0267-1379","1531-7056"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2673536","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034229449","display_name":"Joseph M. Hyser","orcid":"https://orcid.org/0000-0001-5249-3482","observed_orcids":["https://orcid.org/0000-0001-5249-3482"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M Hyser","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA","Department of Molecular Virology and Microbiology, and Medicine \u2013 Gastroenterology, Baylor College of Medicine, Houston, Texas, USA","e-mail: [email\u00a0protected]","fax: +1 713 798 3586"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, and Medicine \u2013 Gastroenterology, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 713 798 3586","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087604589","display_name":"Mary Kolb Estes","orcid":"https://orcid.org/0000-0002-4813-4249","observed_orcids":["https://orcid.org/0000-0002-4813-4249"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary K Estes","raw_affiliation_strings":["Department of Molecular Virology and Microbiology, and Medicine \u2013 Gastroenterology, Baylor College of Medicine, Houston, Texas, USA","to Mary K. Estes, Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Tel: +1 713 798 3585; fax: +1 713 798 3586; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","fax: +1 713 798 3586"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology and Microbiology, and Medicine \u2013 Gastroenterology, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"to Mary K. Estes, Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Tel: +1 713 798 3585; fax: +1 713 798 3586; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 713 798 3586","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087604589"],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":null,"apc_paid":null,"fwci":0.5682,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.47385103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"1","first_page":"36","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rotavirus","display_name":"rotavirus","score":0.8460000157356262},{"id":"https://openalex.org/keywords/live-attenuated-vaccine","display_name":"live attenuated vaccine","score":0.8610000014305115},{"id":"https://openalex.org/keywords/rotateq","display_name":"RotaTeq","score":0.9829999804496765},{"id":"https://openalex.org/keywords/rotarix","display_name":"Rotarix","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/calcium-channel-agonists","display_name":"calcium channel agonists","score":0.8479999899864197},{"id":"https://openalex.org/keywords/antiviral-drug-targets","display_name":"antiviral drug targets","score":0.6930000185966492},{"id":"https://openalex.org/keywords/immunocompromised-children","display_name":"immunocompromised children","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pediatric-gastroenteritis","display_name":"pediatric gastroenteritis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/vaccine-implementation","display_name":"vaccine implementation","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2781367151","wikidata":"https://www.wikidata.org/wiki/Q164778","display_name":"Rotavirus","level":3,"score":0.869558572769165},{"id":"https://openalex.org/C2777227250","wikidata":"https://www.wikidata.org/wiki/Q4411598","display_name":"Rotavirus vaccine","level":4,"score":0.737324059009552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6629637479782104},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5327902436256409},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4886248707771301},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4804525077342987},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.45583438873291016},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4261952042579651},{"id":"https://openalex.org/C2780664029","wikidata":"https://www.wikidata.org/wiki/Q5282120","display_name":"Disease burden","level":3,"score":0.41943103075027466},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39178287982940674},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33465316891670227},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2563093900680542},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1425723135471344},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004196","descriptor_name":"Disease Outbreaks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005759","descriptor_name":"Gastroenteritis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005759","descriptor_name":"Gastroenteritis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005759","descriptor_name":"Gastroenteritis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012400","descriptor_name":"Rotavirus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012400","descriptor_name":"Rotavirus Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012400","descriptor_name":"Rotavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D012401","descriptor_name":"Rotavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014943","descriptor_name":"Global Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022243","descriptor_name":"Rotavirus Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/mog.0b013e328317c897","doi":"https://doi.org/10.1097/mog.0b013e328317c897","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mog.0b013e328317c897","pdf_url":null,"source":{"id":"https://openalex.org/S41211651","display_name":"Current Opinion in Gastroenterology","issn_l":"0267-1379","issn":["0267-1379","1531-7056"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Gastroenterology","raw_type":"journal-article"},{"id":"pmid:19114772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19114772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2673536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2673536","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Gastroenterol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2673536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2673536","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Gastroenterol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4740606549","display_name":"Molecular Biology of the Rotaviruses","funder_award_id":"R56DK030144","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8906397878","display_name":"Research Training Program in Molecular Virology","funder_award_id":"T32AI007471","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000890444","display_name":"Regulation of Rotavirus Replication","funder_award_id":"R01AI080656","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000893404","display_name":"Texas Medical Center Digestive Diseases Center","funder_award_id":"P30DK056338","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1481087199","https://openalex.org/W1527217794","https://openalex.org/W1554174530","https://openalex.org/W1569200484","https://openalex.org/W1582869426","https://openalex.org/W1967649207","https://openalex.org/W1968234384","https://openalex.org/W1968772660","https://openalex.org/W1972388646","https://openalex.org/W1982514497","https://openalex.org/W1985441269","https://openalex.org/W1989038840","https://openalex.org/W1990876250","https://openalex.org/W2004932060","https://openalex.org/W2006763045","https://openalex.org/W2012922525","https://openalex.org/W2027988378","https://openalex.org/W2028465837","https://openalex.org/W2045238641","https://openalex.org/W2067317934","https://openalex.org/W2068326083","https://openalex.org/W2068844395","https://openalex.org/W2070185260","https://openalex.org/W2076656999","https://openalex.org/W2079060424","https://openalex.org/W2083047717","https://openalex.org/W2092449553","https://openalex.org/W2093178818","https://openalex.org/W2100071111","https://openalex.org/W2101144093","https://openalex.org/W2104366664","https://openalex.org/W2106428587","https://openalex.org/W2107362700","https://openalex.org/W2107779864","https://openalex.org/W2110027469","https://openalex.org/W2111915100","https://openalex.org/W2118919833","https://openalex.org/W2120770039","https://openalex.org/W2120975539","https://openalex.org/W2126330689","https://openalex.org/W2126569882","https://openalex.org/W2133210038","https://openalex.org/W2136564788","https://openalex.org/W2143233237","https://openalex.org/W2148653166","https://openalex.org/W2162190408","https://openalex.org/W2162677635","https://openalex.org/W2163306701","https://openalex.org/W2163978964","https://openalex.org/W2170584552","https://openalex.org/W2170749337","https://openalex.org/W2917693701","https://openalex.org/W4206301114","https://openalex.org/W4253384171","https://openalex.org/W4298311520"],"related_works":["https://openalex.org/W2034323018","https://openalex.org/W3089169768","https://openalex.org/W3005341510","https://openalex.org/W3158404986","https://openalex.org/W2012210518","https://openalex.org/W3021373903","https://openalex.org/W4299433677","https://openalex.org/W1971171814","https://openalex.org/W2086921979","https://openalex.org/W2093322830"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Rotaviruses":[3],"cause":[4],"life-threatening":[5],"gastroenteritis":[6,71],"in":[7,18,30,88,101,110,134,188,224],"children":[8,136,187],"throughout":[9],"the":[10,19,50,94,102,143,154,159],"world.":[11],"The":[12],"burden":[13],"of":[14,21,93,106,128,145,156,158,209],"disease":[15,185,223],"has":[16],"resulted":[17],"development":[20,144],"two":[22],"live,":[23],"attenuated":[24,60],"vaccines":[25,62,214],"that":[26],"are":[27,63,84,113],"now":[28,85,180],"licensed":[29,87,95],"many":[31,89],"countries.":[32,90,201],"This":[33],"review":[34],"summarizes":[35],"new":[36,47,146],"data":[37,48,152],"on":[38,49,126,153],"these":[39,129],"vaccines,":[40],"their":[41],"effectiveness,":[42],"and":[43,104,108,141,191,215],"remaining":[44],"challenges":[45],"including":[46,148],"rotavirus":[51,61,132,160],"enterotoxin,":[52],"a":[53,74,80,139,167,173,181],"potential":[54],"antiviral":[55,149,216],"target.":[56],"RECENT":[57],"FINDINGS:":[58],"Live":[59],"used":[64],"to":[65,123,221],"protect":[66],"infants":[67],"against":[68],"severe":[69],"rotavirus-induced":[70],"and,":[72,78],"RotaTeq,":[73],"pentavalent":[75],"bovine-based":[76],"vaccine,":[77],"Rotarix,":[79],"monovalent":[81],"human":[82],"rotavirus,":[83],"currently":[86],"Initial":[91],"results":[92,105],"RotaTeq":[96],"vaccine":[97,118],"have":[98],"been":[99],"promising":[100],"USA":[103],"immunogenicity":[107],"efficacy":[109],"developing":[111,200],"countries":[112,190],"expected":[114],"soon.":[115],"However,":[116],"universal":[117],"implementation":[119],"is":[120,179],"challenging":[121],"due":[122],"age":[124],"limitations":[125],"administration":[127],"vaccines.":[130],"Chronic":[131],"infections":[133],"immunocompromised":[135,225],"may":[137],"remain":[138],"problem":[140],"require":[142],"treatments":[147],"drugs.":[150],"Increasing":[151],"mechanisms":[155],"action":[157],"enterotoxin":[161],"highlight":[162],"this":[163,193],"pleiotropic":[164],"protein":[165],"as":[166,170,172,212],"good":[168],"target":[169],"well":[171],"unique":[174],"calcium":[175],"agonist.":[176],"SUMMARY:":[177],"Rotavirus":[178],"commonly":[182],"occurring":[183],"vaccine-preventable":[184],"among":[186],"developed":[189],"hopefully":[192],"also":[194],"will":[195,204,218],"soon":[196],"be":[197,219],"true":[198],"for":[199],"Future":[202],"studies":[203],"determine":[205],"whether":[206],"other":[207],"methods":[208],"prevention,":[210],"such":[211],"nonreplicating":[213],"drugs,":[217],"needed":[220],"treat":[222],"children.":[226]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}