{"id":"https://openalex.org/W1979929910","doi":"https://doi.org/10.1158/1538-7445.am2013-174","title":"Abstract 174: Calorie restriction decreases spontaneous mammary tumorigenesis and upregulates ER-\u03b2 in MMTV-neu transgenic mice.","display_name":"Abstract 174: Calorie restriction decreases spontaneous mammary tumorigenesis and upregulates ER-\u03b2 in MMTV-neu transgenic mice.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W1979929910","doi":"https://doi.org/10.1158/1538-7445.am2013-174","mag":"1979929910"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-174","doi":"https://doi.org/10.1158/1538-7445.am2013-174","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-174","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080856244","display_name":"Sarah M. Dunlap","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah M. Dunlap","raw_affiliation_strings":["1University of Texas Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074878178","display_name":"Nikki Ann Ford","orcid":"https://orcid.org/0000-0002-4565-4054","observed_orcids":["https://orcid.org/0000-0002-4565-4054"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikki A. Ford","raw_affiliation_strings":["1University of Texas Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064198971","display_name":"Laura W. Bowers","orcid":"https://orcid.org/0000-0002-2124-3007","observed_orcids":["https://orcid.org/0000-0002-2124-3007","https://orcid.org/0000-0002-7922-4167"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura W. Bowers","raw_affiliation_strings":["1University of Texas Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054875096","display_name":"Emily L. Rossi","orcid":"https://orcid.org/0000-0002-2312-4239","observed_orcids":["https://orcid.org/0000-0002-2312-4239"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily L. Rossi","raw_affiliation_strings":["1University of Texas Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102736987","display_name":"Samantha Miller","orcid":"https://orcid.org/0000-0002-5060-8319","observed_orcids":["https://orcid.org/0000-0002-5060-8319"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Miller","raw_affiliation_strings":["1University of Texas Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050653724","display_name":"Lucia J. Chiao","orcid":"https://orcid.org/0000-0001-8961-0048","observed_orcids":["https://orcid.org/0000-0001-8961-0048"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucia J. Chiao","raw_affiliation_strings":["1University of Texas Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069756775","display_name":"Powel H. Brown","orcid":"https://orcid.org/0000-0002-3398-163X","observed_orcids":["https://orcid.org/0000-0002-3398-163X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Powel H. Brown","raw_affiliation_strings":["2MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036400845","display_name":"Stephen David Hursting","orcid":"https://orcid.org/0000-0003-3605-2833","observed_orcids":["https://orcid.org/0000-0003-3605-2833"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D. Hursting","raw_affiliation_strings":["1University of Texas Austin, Austin, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Texas Austin, Austin, TX;","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"174","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.1931000053882599,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.13089999556541443,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mmtv-neu-mice","display_name":"MMTV-Neu mice","score":0.7749999761581421},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.9509999752044678},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9150000214576721},{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.7269999980926514},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.4779999852180481},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.6399999856948853},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.8460000157356262},{"id":"https://openalex.org/keywords/mammary-hyperplasia","display_name":"mammary gland hyperplasia","score":0.7459999918937683},{"id":"https://openalex.org/keywords/breast-cancer-progression","display_name":"breast cancer progression","score":0.4659999907016754},{"id":"https://openalex.org/keywords/serum-hormone-levels","display_name":"serum hormone levels","score":0.4819999933242798},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.6039999723434448},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6269999742507935},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8370000123977661},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9459999799728394},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.37599998712539673},{"id":"https://openalex.org/keywords/luminal-breast-cancer","display_name":"luminal breast cancer","score":0.5809999704360962},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2778707264","wikidata":"https://www.wikidata.org/wiki/Q1332886","display_name":"Calorie restriction","level":2,"score":0.6695049405097961},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6673966646194458},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6165634393692017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5982815027236938},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.5933667421340942},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5754058361053467},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5386459827423096},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.4748012125492096},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47128763794898987},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4621790945529938},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3425624966621399}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-174","doi":"https://doi.org/10.1158/1538-7445.am2013-174","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-174","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2184192268","https://openalex.org/W1608890347","https://openalex.org/W2604678512","https://openalex.org/W2740264933","https://openalex.org/W1573573452","https://openalex.org/W2111527802","https://openalex.org/W2034187456","https://openalex.org/W2331860348","https://openalex.org/W2060536703","https://openalex.org/W3083630325"],"abstract_inverted_index":{"Abstract":[0],"Obesity":[1],"increases":[2,8],"postmenopausal":[3,13],"breast":[4,19,42,73],"cancer":[5,43,74],"risk":[6,44],"and":[7,12,45,50,96,127,167,173,206,210,216,224,237,252,280,299,309,338,355,357,362,413],"mortality":[9],"in":[10,21,102,221,272,306,336,360,416],"pre-":[11],"women.":[14],"While":[15],"the":[16,54,67,77,103,195,301,377,424,429],"majority":[17],"of":[18,57,71,100,157,260,270,303,319,326,340,380,423,428],"cancers":[20],"obese":[22],"women":[23],"are":[24,59],"estrogen":[25],"receptor":[26],"(ER\u03b1)-positive,":[27],"ER\u03b1-negative":[28,120],"tumors":[29,111],"confer":[30],"a":[31,146,152,184,334,373],"much":[32],"worse":[33],"prognosis.":[34],"The":[35],"mechanism":[36,375],"by":[37,267,278,282],"which":[38],"obesity":[39,58,85],"affects":[40],"ER-negative":[41],"prognosis":[46],"is":[47],"not":[48],"clear,":[49],"strategies":[51],"for":[52,177,183,219,432],"offsetting":[53],"negative":[55],"effects":[56,379],"urgently":[60],"needed.":[61],"In":[62,343,365],"this":[63],"study,":[64],"we":[65,285,313],"utilized":[66],"MMTV-neu":[68,106,124,223,274,308,327,351,417],"mouse":[69],"model":[70],"luminal-type":[72],"to":[75,118,140,192,265,290],"test":[76],"hypothesis":[78],"that":[79,112,258,287,315],"energy":[80,346],"balance":[81,347],"modulation,":[82],"through":[83,98],"diet-induced":[84],"(DIO)":[86],"or":[87,151],"calorie":[88],"restriction":[89,408],"(CR)":[90],"regimens,":[91],"alters":[92],"mammary":[93,104,110,261,295,352,368,411],"tumor":[94,331,353,363],"development":[95,354],"progression":[97],"regulation":[99],"ER":[101],"epithelium.":[105],"mice":[107,126,132,158,328],"form":[108],"spontaneous":[109,350,410],"progress":[113],"from":[114],"an":[115],"ER\u03b1-positive":[116],"hyperplasia":[117,304],"aggressive":[119],"ductal":[121],"adenocarcinomas.":[122],"Female":[123],"transgenic":[125,418],"non-transgenic":[128],"host":[129],"strain":[130],"(FVB)":[131],"(6-8":[133],"weeks":[134,269,318],"old;":[135],"n=90/genotype)":[136],"were":[137,175,181],"randomized":[138],"(30/group)":[139],"receive:":[141],"control":[142,193,273,291],"diet":[143,171],"(modified":[144],"AIN-76A);":[145],"30%":[147],"CR":[148,228,288,321,330],"regimen":[149,197],"(isonutrient);":[150],"DIO":[153,196,279],"regimen.":[154],"A":[155],"subset":[156],"(n=4":[159],"per":[160],"group)":[161],"was":[162,276],"killed":[163],"at":[164,247],"1,":[165],"3,":[166],"5":[168],"months":[169],"following":[170],"initiation,":[172],"tissues":[174],"collected":[176],"analysis;":[178],"remaining":[179],"animals":[180],"followed":[182],"60-week":[185],"survival":[186,325],"study.":[187],"We":[188],"found":[189,286,314],"that,":[190],"relative":[191],"diet,":[194],"significantly":[198,229,293,322],"increased":[199,294,323,367],"body":[200,203,231,234],"weight,":[201,232],"percent":[202,233],"fat":[204,235],"(p<0.0001),":[205],"obesity-associated":[207],"serum":[208,239],"hormones":[209],"growth":[211,241],"factors":[212],"(IGF-I,":[213],"insulin,":[214],"leptin,":[215],"estradiol;":[217],"p<0.01":[218],"all)":[220],"both":[222,307],"FVB":[225,310],"controls.":[226],"Conversely,":[227],"decreased":[230,238],"(p<0.0001)":[236,298],"hormones/":[240],"factors,":[242],"while":[243],"increasing":[244],"adiponectin":[245],"(each":[246],"p<0.01).":[248],"Gene":[249],"expression":[250,254,297,370],"(qRT-PCR)":[251],"protein":[253],"(immunohistochemistry)":[255],"analysis":[256],"revealed":[257],"loss":[259],"ER\u03b1":[262,356],"expression,":[263],"known":[264],"occur":[266],"8":[268],"age":[271],"mice,":[275],"accelerated":[277],"delayed":[281,300],"CR.":[283,381],"Additionally,":[284],"(relative":[289],"diet)":[292],"ER\u03b2":[296,358,369],"onset":[302],"(p<0.001)":[305],"mice.":[311,419],"Importantly,":[312],"after":[316],"60":[317],"feeding,":[320],"tumor-free":[324],"(p=0.01).":[329],"samples":[332],"showed":[333],"decrease":[335],"vascularity":[337],"presence":[339],"mitotic":[341],"figures.":[342],"conclusion,":[344],"dietary":[345],"modulation":[348],"impacts":[349],"levels":[359],"normal":[361],"tissue.":[364],"addition,":[366],"may":[371],"represent":[372],"novel":[374],"underlying":[376],"anticancer":[378],"Citation":[382],"Format:":[383],"Sarah":[384],"M.":[385],"Dunlap,":[386],"Nikki":[387],"A.":[388],"Ford,":[389],"Laura":[390],"W.":[391],"Bowers,":[392],"Emily":[393],"L.":[394],"Rossi,":[395],"Samantha":[396],"Miller,":[397],"Lucia":[398],"J.":[399],"Chiao,":[400],"Powel":[401],"H.":[402],"Brown,":[403],"Stephen":[404],"D.":[405],"Hursting.":[406],"Calorie":[407],"decreases":[409],"tumorigenesis":[412],"upregulates":[414],"ER-\u03b2":[415],"[abstract].":[420],"In:":[421],"Proceedings":[422],"104th":[425],"Annual":[426],"Meeting":[427],"American":[430],"Association":[431],"Cancer":[433,443],"Research;":[434],"2013":[435],"Apr":[436],"6-10;":[437],"Washington,":[438],"DC.":[439],"Philadelphia":[440],"(PA):":[441],"AACR;":[442],"Res":[444],"2013;73(8":[445],"Suppl):Abstract":[446],"nr":[447],"174.":[448],"doi:10.1158/1538-7445.AM2013-174":[449]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
