{"id":"https://openalex.org/W1979915327","doi":"https://doi.org/10.1371/journal.pone.0081547","title":"In Vivo Regulation of Brain-Derived Neurotrophic Factor in Dorsal Root Ganglia Is Mediated by Nerve Growth Factor-Triggered Akt Activation during Cystitis","display_name":"In Vivo Regulation of Brain-Derived Neurotrophic Factor in Dorsal Root Ganglia Is Mediated by Nerve Growth Factor-Triggered Akt Activation during Cystitis","publication_year":2013,"publication_date":"2013-11-26","ids":{"openalex":"https://openalex.org/W1979915327","doi":"https://doi.org/10.1371/journal.pone.0081547","mag":"1979915327","pmid":"https://pubmed.ncbi.nlm.nih.gov/24303055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3841217"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0081547","doi":"https://doi.org/10.1371/journal.pone.0081547","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0081547","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0081547&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0081547&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062970963","display_name":"Liya Y. Qiao","orcid":"https://orcid.org/0000-0002-2336-0397","observed_orcids":["https://orcid.org/0000-0002-2336-0397"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li-Ya Qiao","raw_affiliation_strings":["Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035880492","display_name":"Sharon J. Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon J. Yu","raw_affiliation_strings":["Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032964249","display_name":"Jarren Kay","orcid":"https://orcid.org/0000-0001-7555-7901","observed_orcids":["https://orcid.org/0000-0001-7555-7901"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarren C. Kay","raw_affiliation_strings":["Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000168049","display_name":"Chunmei Xia","orcid":"https://orcid.org/0000-0001-9845-9685","observed_orcids":["https://orcid.org/0000-0001-9845-9685"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun-Mei Xia","raw_affiliation_strings":["Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062970963"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.5135,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.7962178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"11","first_page":"e81547","last_page":"e81547"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":1.0},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9779999852180481},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cystitis","display_name":"cystitis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/visceral-inflammation","display_name":"visceral inflammation","score":0.6370000243186951},{"id":"https://openalex.org/keywords/sensory-over-responsivity","display_name":"sensory hypersensitivity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/primary-afferent-neurons","display_name":"primary afferent neurons","score":0.9100000262260437},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9179999828338623},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":0.8320000171661377},{"id":"https://openalex.org/keywords/neurotrophin-signaling","display_name":"neurotrophin signaling","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.7908218502998352},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.6724631786346436},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.6087324023246765},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5980364084243774},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.5950210690498352},{"id":"https://openalex.org/C2776281502","wikidata":"https://www.wikidata.org/wiki/Q1395415","display_name":"Dorsal root ganglion","level":3,"score":0.5711215138435364},{"id":"https://openalex.org/C171034665","wikidata":"https://www.wikidata.org/wiki/Q14897694","display_name":"Tropomyosin receptor kinase A","level":4,"score":0.5651461482048035},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5121150016784668},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4863458275794983},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.48619359731674194},{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.46723371744155884},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.45726191997528076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43264269828796387},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2995540499687195},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24255675077438354},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2320692539215088},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22360742092132568},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.16733571887016296},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12129142880439758}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003556","descriptor_name":"Cystitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003556","descriptor_name":"Cystitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0081547","doi":"https://doi.org/10.1371/journal.pone.0081547","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0081547","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0081547&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2833609","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3841217","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3841217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3841217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24303055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24303055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.782.3800","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.782.3800","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/de/52/pone.0081547.PMC3841217.pdf","raw_type":"text"},{"id":"pmh:oai:scholarscompass.vcu.edu:phis_pubs-1007","doi":null,"is_oa":true,"landing_page_url":"https://scholarscompass.vcu.edu/phis_pubs/19","pdf_url":null,"source":{"id":"https://openalex.org/S4377196340","display_name":"VCU Scholars Compass (Virginia Commonwealth University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Physiology and Biophysics Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:846afa091f0745e1a2c486f92ee9725e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/846afa091f0745e1a2c486f92ee9725e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 11, p e81547 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0081547","doi":"https://doi.org/10.1371/journal.pone.0081547","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0081547","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0081547&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6024073300","display_name":"Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity","funder_award_id":"R01DK077917","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1979915327.pdf","grobid_xml":"https://content.openalex.org/works/W1979915327.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W183249409","https://openalex.org/W1485628639","https://openalex.org/W1551383644","https://openalex.org/W1554343522","https://openalex.org/W1568010017","https://openalex.org/W1764067125","https://openalex.org/W1914763441","https://openalex.org/W1966560356","https://openalex.org/W1968659886","https://openalex.org/W1975722785","https://openalex.org/W1978029885","https://openalex.org/W1980935526","https://openalex.org/W1981413172","https://openalex.org/W1982645845","https://openalex.org/W1983451893","https://openalex.org/W1984621921","https://openalex.org/W1989713749","https://openalex.org/W1991136936","https://openalex.org/W1992529363","https://openalex.org/W2007730810","https://openalex.org/W2008225455","https://openalex.org/W2008626844","https://openalex.org/W2008800555","https://openalex.org/W2009436798","https://openalex.org/W2011381918","https://openalex.org/W2019843044","https://openalex.org/W2021791661","https://openalex.org/W2027439578","https://openalex.org/W2027973075","https://openalex.org/W2028489659","https://openalex.org/W2029942070","https://openalex.org/W2031432874","https://openalex.org/W2032758411","https://openalex.org/W2032823103","https://openalex.org/W2033226095","https://openalex.org/W2037919084","https://openalex.org/W2037921192","https://openalex.org/W2038400469","https://openalex.org/W2042125279","https://openalex.org/W2044473723","https://openalex.org/W2050118351","https://openalex.org/W2052359962","https://openalex.org/W2054860352","https://openalex.org/W2055830074","https://openalex.org/W2059034808","https://openalex.org/W2067385623","https://openalex.org/W2068146214","https://openalex.org/W2074663801","https://openalex.org/W2077106295","https://openalex.org/W2077772823","https://openalex.org/W2079456509","https://openalex.org/W2084420320","https://openalex.org/W2086046914","https://openalex.org/W2086866828","https://openalex.org/W2108087762","https://openalex.org/W2125266565","https://openalex.org/W2126142493","https://openalex.org/W2134730303","https://openalex.org/W2134942830","https://openalex.org/W2137055184","https://openalex.org/W2142502825","https://openalex.org/W2145096738","https://openalex.org/W2151410975","https://openalex.org/W2156166679","https://openalex.org/W2162191158","https://openalex.org/W2164320803","https://openalex.org/W2168891784","https://openalex.org/W2169477624","https://openalex.org/W2170576851","https://openalex.org/W2171827987","https://openalex.org/W2734444124","https://openalex.org/W4249869975"],"related_works":["https://openalex.org/W7100821352","https://openalex.org/W2031432874","https://openalex.org/W2009814772","https://openalex.org/W2273475235","https://openalex.org/W2256743764","https://openalex.org/W2368970032","https://openalex.org/W2096539044","https://openalex.org/W2171827987","https://openalex.org/W2084420320","https://openalex.org/W2094739939"],"abstract_inverted_index":{"The":[0,94],"role":[1,220],"of":[2,40,50,82,103,144,155,173,179,197,224,229],"brain-derived":[3],"neurotrophic":[4],"factor":[5,78],"(BDNF)":[6],"in":[7,24,54,61,68,109,123,125,130,139,149,187,208,211,221,231,235],"sensory":[8,233],"hypersensitivity":[9],"has":[10],"been":[11],"suggested;":[12],"however":[13],"the":[14,45,55,69,104,115,132,145,150,176,180,188,198,201,222,232],"molecular":[15],"mechanisms":[16],"and":[17,42,47,142,205,210,226],"signal":[18],"transduction":[19],"that":[20,44,129,171,215],"regulate":[21],"BDNF":[22,51,66,90,121,138,166,185,230],"expression":[23,186],"primary":[25],"afferent":[26],"neurons":[27,234],"during":[28,92],"visceral":[29,236],"inflammation":[30,237],"are":[31],"not":[32],"clear.":[33],"Here":[34],"we":[35,127],"used":[36],"a":[37,85,160],"rat":[38],"model":[39],"cystitis":[41,131],"found":[43,128],"mRNA":[46],"protein":[48],"levels":[49,91],"were":[52],"increased":[53],"L6":[56,70,110,140,151],"dorsal":[57],"root":[58],"ganglia":[59,199],"(DRG)":[60],"response":[62],"to":[63,120,175],"bladder":[64],"inflammation.":[65],"up-regulation":[67,102,122,228],"DRG":[71,124,152,189],"was":[72,135,193],"triggered":[73],"by":[74,153,195],"endogenous":[75,146],"nerve":[76,177],"growth":[77],"(NGF)":[79],"because":[80],"neutralization":[81],"NGF":[83,87,96,174,216],"with":[84,137,159,200],"specific":[86],"antibody":[88,97],"reduced":[89,100,194],"cystitis.":[93,240],"neutralizing":[95],"also":[98],"subsequently":[99],"cystitis-induced":[101,165],"serine/threonine":[105],"kinase":[106],"Akt":[107,117,147,225],"activity":[108,148],"DRG.":[111],"To":[112],"examine":[113],"whether":[114],"NGF-induced":[116],"activation":[118,223],"led":[119],"cystitis,":[126],"phospho-Akt":[133],"immunoreactivity":[134],"co-localized":[136],"DRG,":[141],"prevention":[143],"inhibition":[154],"phosphoinositide":[156],"3-kinase":[157],"(PI3K)":[158],"potent":[161],"inhibitor":[162,203],"LY294002":[163,204],"reversed":[164],"up-regulation.":[167],"Further":[168],"study":[169],"showed":[170],"application":[172],"terminals":[178],"ganglion-nerve":[181],"two-compartmented":[182],"preparation":[183],"enhanced":[184],"neuronal":[190],"soma;":[191],"which":[192],"pre-treatment":[196],"PI3K":[202],"wortmannin.":[206],"These":[207],"vivo":[209],"vitro":[212],"experiments":[213],"indicated":[214],"played":[217],"an":[218],"important":[219],"subsequent":[227],"such":[238],"as":[239]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}