{"id":"https://openalex.org/W1979166300","doi":"https://doi.org/10.1016/j.str.2008.05.001","title":"A Specific Cholesterol Binding Site Is Established by the 2.8 \u00c5 Structure of the Human \u03b22-Adrenergic Receptor","display_name":"A Specific Cholesterol Binding Site Is Established by the 2.8 \u00c5 Structure of the Human \u03b22-Adrenergic Receptor","publication_year":2008,"publication_date":"2008-06-01","ids":{"openalex":"https://openalex.org/W1979166300","doi":"https://doi.org/10.1016/j.str.2008.05.001","mag":"1979166300","pmid":"https://pubmed.ncbi.nlm.nih.gov/18547522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2601552"},"language":"en","primary_location":{"id":"doi:10.1016/j.str.2008.05.001","doi":"https://doi.org/10.1016/j.str.2008.05.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2008.05.001","pdf_url":"http://www.cell.com/article/S0969212608001743/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0969212608001743/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007505792","display_name":"Michael A. Hanson","orcid":"https://orcid.org/0000-0002-3127-7964","observed_orcids":["https://orcid.org/0000-0002-3127-7964"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Hanson","raw_affiliation_strings":["Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063729267","display_name":"Vadim Cherezov","orcid":"https://orcid.org/0000-0002-5265-3914","observed_orcids":["https://orcid.org/0000-0002-5265-3914"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vadim Cherezov","raw_affiliation_strings":["Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029218529","display_name":"Mark T. Griffith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark T. Griffith","raw_affiliation_strings":["Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113220706","display_name":"C. Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher B. Roth","raw_affiliation_strings":["Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065316967","display_name":"Veli\u2010Pekka Jaakola","orcid":"https://orcid.org/0000-0003-2943-6417","observed_orcids":["https://orcid.org/0000-0003-2943-6417"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veli-Pekka Jaakola","raw_affiliation_strings":["Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044437187","display_name":"Ellen Y. T. Chien","orcid":"https://orcid.org/0009-0002-1731-5431","observed_orcids":["https://orcid.org/0009-0002-1731-5431"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Y.T. Chien","raw_affiliation_strings":["Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050359189","display_name":"Jeffrey Velasquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Velasquez","raw_affiliation_strings":["Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000472988","display_name":"Peter K\u00fchn","orcid":"https://orcid.org/0000-0003-2629-4505","observed_orcids":["https://orcid.org/0000-0003-2629-4505"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kuhn","raw_affiliation_strings":["Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017648766","display_name":"Raymond C. Stevens","orcid":"https://orcid.org/0000-0002-4522-8725","observed_orcids":["https://orcid.org/0000-0002-4522-8725"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raymond C. Stevens","raw_affiliation_strings":["Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017648766"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":9350,"currency":"USD","value_usd":9350},"apc_paid":null,"fwci":31.0998,"has_fulltext":true,"cited_by_count":935,"citation_normalized_percentile":{"value":0.99852457,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"16","issue":"6","first_page":"897","last_page":"905"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol-binding-sites","display_name":"cholesterol binding sites","score":0.7160000205039978},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.9520000219345093},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/timolol","display_name":"timolol","score":0.859000027179718},{"id":"https://openalex.org/keywords/inverse-agonists","display_name":"inverse agonists","score":0.8539999723434448},{"id":"https://openalex.org/keywords/receptor-dimerization","display_name":"receptor dimerization","score":0.515999972820282},{"id":"https://openalex.org/keywords/helix-packing","display_name":"helix packing","score":0.4779999852180481},{"id":"https://openalex.org/keywords/sterol-binding","display_name":"sterol binding","score":0.593999981880188},{"id":"https://openalex.org/keywords/cholesterol-analogs","display_name":"cholesterol analogs","score":0.35600000619888306},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.658717691898346},{"id":"https://openalex.org/C142089489","wikidata":"https://www.wikidata.org/wiki/Q1053976","display_name":"Antiparallel (mathematics)","level":3,"score":0.5595688223838806},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.49890613555908203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4739163815975189},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47373878955841064},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.46305274963378906},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.46004393696784973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2856670916080475},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013999","descriptor_name":"Timolol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.str.2008.05.001","doi":"https://doi.org/10.1016/j.str.2008.05.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2008.05.001","pdf_url":"http://www.cell.com/article/S0969212608001743/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},{"id":"pmid:18547522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18547522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure (London, England : 1993)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2601552","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2601552","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Structure","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.str.2008.05.001","doi":"https://doi.org/10.1016/j.str.2008.05.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.str.2008.05.001","pdf_url":"http://www.cell.com/article/S0969212608001743/pdf","source":{"id":"https://openalex.org/S7112016","display_name":"Structure","issn_l":"0969-2126","issn":["0969-2126","1878-4186"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Structure","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1020878034","display_name":"Robotic Dispensing of Cubic Phase for Crystallizing Membrane Proteins","funder_award_id":"0308078","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2215811233","display_name":"Membrane Proteins, Crystallogenesis and X-ray Structure","funder_award_id":"R01GM075915","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2219523378","display_name":null,"funder_award_id":"Y1-GM-1104","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G222407312","display_name":null,"funder_award_id":"Y1-CO-1020","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2363639003","display_name":null,"funder_award_id":"Y1-CO-1020","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2807903422","display_name":null,"funder_award_id":"GM074961","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3250212683","display_name":null,"funder_award_id":"GM074961","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3925135328","display_name":null,"funder_award_id":"GM 075915","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G402281873","display_name":null,"funder_award_id":"Y1-GM-1104","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4824391660","display_name":null,"funder_award_id":"GM073197","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4866076653","display_name":null,"funder_award_id":"Y1-GM-1104","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5621587259","display_name":"Gene to Structure for $10K (GTS10K)","funder_award_id":"U54GM074961","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5774141804","display_name":"The Structural Biology of Membrane Proteins: Proteomics via Crystal Structure","funder_award_id":"02/IN.1/B266","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"},{"id":"https://openalex.org/G6281797270","display_name":"JCIMPT-Complexes","funder_award_id":"P50GM073197","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7374214904","display_name":null,"funder_award_id":"Y1-CO-1020","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000195289","display_name":null,"funder_award_id":"GM074961","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000270603","display_name":null,"funder_award_id":"GM073197","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320320862","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1979166300.pdf","grobid_xml":"https://content.openalex.org/works/W1979166300.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1564046100","https://openalex.org/W1825353903","https://openalex.org/W1833104430","https://openalex.org/W1972870617","https://openalex.org/W1976258716","https://openalex.org/W1978846511","https://openalex.org/W1985935502","https://openalex.org/W1987970138","https://openalex.org/W1990394752","https://openalex.org/W1992035790","https://openalex.org/W1996795941","https://openalex.org/W2005690045","https://openalex.org/W2010122297","https://openalex.org/W2020349198","https://openalex.org/W2023286308","https://openalex.org/W2023827988","https://openalex.org/W2033320890","https://openalex.org/W2035546546","https://openalex.org/W2035828382","https://openalex.org/W2043864366","https://openalex.org/W2048327066","https://openalex.org/W2049848440","https://openalex.org/W2057535168","https://openalex.org/W2063044149","https://openalex.org/W2071953701","https://openalex.org/W2080231167","https://openalex.org/W2081606553","https://openalex.org/W2084914807","https://openalex.org/W2091179696","https://openalex.org/W2091659381","https://openalex.org/W2104477830","https://openalex.org/W2109459193","https://openalex.org/W2118434640","https://openalex.org/W2122646377","https://openalex.org/W2124035137","https://openalex.org/W2143957256","https://openalex.org/W2144335734","https://openalex.org/W2146804777"],"related_works":["https://openalex.org/W1969209004","https://openalex.org/W2085348517","https://openalex.org/W1965984853","https://openalex.org/W4281935358","https://openalex.org/W2559345010","https://openalex.org/W3169666629","https://openalex.org/W2009614301","https://openalex.org/W3022866527","https://openalex.org/W2096478565","https://openalex.org/W1979200280"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":39},{"year":2021,"cited_by_count":51},{"year":2020,"cited_by_count":46},{"year":2019,"cited_by_count":59},{"year":2018,"cited_by_count":44},{"year":2017,"cited_by_count":41},{"year":2016,"cited_by_count":66},{"year":2015,"cited_by_count":58},{"year":2014,"cited_by_count":57},{"year":2013,"cited_by_count":68},{"year":2012,"cited_by_count":79}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}