{"id":"https://openalex.org/W1979032809","doi":"https://doi.org/10.1007/bf01852230","title":"Accumulation of insulin and glucagon in the liver (via portal vein catheter or with liposomes) does not stimulate liver cell regeneration after partial hepatectomy in normal or portocaval shunted rats","display_name":"Accumulation of insulin and glucagon in the liver (via portal vein catheter or with liposomes) does not stimulate liver cell regeneration after partial hepatectomy in normal or portocaval shunted rats","publication_year":1982,"publication_date":"1982-02-01","ids":{"openalex":"https://openalex.org/W1979032809","doi":"https://doi.org/10.1007/bf01852230","mag":"1979032809","pmid":"https://pubmed.ncbi.nlm.nih.gov/7043683"},"language":"en","primary_location":{"id":"doi:10.1007/bf01852230","doi":"https://doi.org/10.1007/bf01852230","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01852230","pdf_url":null,"source":{"id":"https://openalex.org/S86772520","display_name":"Research in Experimental Medicine","issn_l":"0300-9130","issn":["0300-9130","1433-8580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108765378","display_name":"J\u00fcrgen Freise","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Freise","raw_affiliation_strings":["Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Hannover 61, Federal Republic of Germany","Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Hannover 61, Federal Republic of Germany","institution_ids":["https://openalex.org/I114112103","https://openalex.org/I34809795"]},{"raw_affiliation_string":"Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Federal Republic of Germany","institution_ids":["https://openalex.org/I114112103","https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W. H. Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. H. Mueller","raw_affiliation_strings":["Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Hannover 61, Federal Republic of Germany","Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Hannover 61, Federal Republic of Germany","institution_ids":["https://openalex.org/I114112103","https://openalex.org/I34809795"]},{"raw_affiliation_string":"Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Federal Republic of Germany","institution_ids":["https://openalex.org/I114112103","https://openalex.org/I34809795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113779053","display_name":"Ch.E. Broelsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114112103","display_name":"Leibniz University Hannover","ror":"https://ror.org/0304hq317","country_code":"DE","type":"education","lineage":["https://openalex.org/I114112103"]},{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ch. E. Broelsch","raw_affiliation_strings":["Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Hannover 61, Federal Republic of Germany","Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Hannover 61, Federal Republic of Germany","institution_ids":["https://openalex.org/I114112103","https://openalex.org/I34809795"]},{"raw_affiliation_string":"Dept. of Gastroenterology and Hepatology, University of Hannover Medical School, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Federal Republic of Germany","institution_ids":["https://openalex.org/I114112103","https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.18813839,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"180","issue":"1","first_page":"31","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.859000027179718},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/glucagon","display_name":"glucagon","score":1.0},{"id":"https://openalex.org/keywords/portacaval-shunt","display_name":"portacaval shunt","score":0.8939999938011169},{"id":"https://openalex.org/keywords/portal-vein-infusion","display_name":"portal vein infusion","score":0.9240000247955322},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.5320000052452087},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/pancreatic-hormones","display_name":"pancreatic hormones","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.8404173851013184},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6659330725669861},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.6371970176696777},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.6260746121406555},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6062304973602295},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.6017130613327026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5624368190765381},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5582178831100464},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5544431209564209},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.46669939160346985},{"id":"https://openalex.org/C2779033008","wikidata":"https://www.wikidata.org/wiki/Q464543","display_name":"Portal vein","level":2,"score":0.4583418369293213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4251544177532196},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4173542857170105},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.4168546199798584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40780454874038696},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2220667004585266},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13847076892852783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09881824254989624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08568981289863586},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.081147700548172},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008112","descriptor_name":"Liver Glycogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011167","descriptor_name":"Portacaval Shunt, Surgical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01852230","doi":"https://doi.org/10.1007/bf01852230","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01852230","pdf_url":null,"source":{"id":"https://openalex.org/S86772520","display_name":"Research in Experimental Medicine","issn_l":"0300-9130","issn":["0300-9130","1433-8580"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:7043683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7043683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W157199325","https://openalex.org/W1557370431","https://openalex.org/W1590377674","https://openalex.org/W1600636754","https://openalex.org/W1775749144","https://openalex.org/W1906197854","https://openalex.org/W1980095603","https://openalex.org/W1985021283","https://openalex.org/W1989036548","https://openalex.org/W2112771805","https://openalex.org/W2139257534","https://openalex.org/W2189737808","https://openalex.org/W2398724468","https://openalex.org/W2415505307","https://openalex.org/W2415658279","https://openalex.org/W2419580667","https://openalex.org/W2470266932","https://openalex.org/W4234657311"],"related_works":["https://openalex.org/W2112771805","https://openalex.org/W2414144590","https://openalex.org/W2475174153","https://openalex.org/W2034395239","https://openalex.org/W4231811109","https://openalex.org/W2805821293","https://openalex.org/W2461767015","https://openalex.org/W2399249200","https://openalex.org/W2120124611","https://openalex.org/W2463510429"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}