{"id":"https://openalex.org/W1978999795","doi":"https://doi.org/10.1002/hep.22467","title":"The hepatic apelin system","display_name":"The hepatic apelin system","publication_year":2008,"publication_date":"2008-09-24","ids":{"openalex":"https://openalex.org/W1978999795","doi":"https://doi.org/10.1002/hep.22467","mag":"1978999795","pmid":"https://pubmed.ncbi.nlm.nih.gov/18816630"},"language":"en","primary_location":{"id":"doi:10.1002/hep.22467","doi":"https://doi.org/10.1002/hep.22467","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.22467","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.22467","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.22467","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Alessandro Principe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alessandro Principe","raw_affiliation_strings":["Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, University of Barcelona, Barcelona, Spain","Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210132431","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111698517","display_name":"Pedro Melgar\u2010Lesmes","orcid":"https://orcid.org/0000-0002-2009-5911","observed_orcids":["https://orcid.org/0000-0002-2009-5911"]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pedro Melgar\u2010Lesmes","raw_affiliation_strings":["Biochemistry and Molecular Genetics Service, Centro de Investigacio\u0301n Biome\u0301dica en Red de Enfermedades Hepa\u0301ticas y Digestivas (CIBEREHD), Hospital Cli\u0301nic, Institut d'Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigacio\u0301n Biome\u0301dica en Red de Enfermedades Hepa\u0301ticas y Digestivas (CIBEREHD), Hospital Cli\u0301nic, Institut d'Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073042095","display_name":"Guillermo Fern\u00e1ndez\u2010Varo","orcid":"https://orcid.org/0000-0002-7776-3300","observed_orcids":["https://orcid.org/0000-0002-7776-3300"]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Guillermo Fern\u00e1ndez\u2010Varo","raw_affiliation_strings":["Biochemistry and Molecular Genetics Service, Centro de Investigacio\u0301n Biome\u0301dica en Red de Enfermedades Hepa\u0301ticas y Digestivas (CIBEREHD), Hospital Cli\u0301nic, Institut d'Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigacio\u0301n Biome\u0301dica en Red de Enfermedades Hepa\u0301ticas y Digestivas (CIBEREHD), Hospital Cli\u0301nic, Institut d'Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047440401","display_name":"Luis Ruiz Del Arbol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Ruiz del Arbol","raw_affiliation_strings":["Department of Gastroenterology, Hospital Ramo\u0301n y Cajal, University of Alcala, Madrid, Spain","Department of Gastroenterology, Hospital Ram\u00f3n y Cajal, University of Alcala, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hospital Ramo\u0301n y Cajal, University of Alcala, Madrid, Spain","institution_ids":["https://openalex.org/I189268942","https://openalex.org/I4210161852"]},{"raw_affiliation_string":"Department of Gastroenterology, Hospital Ram\u00f3n y Cajal, University of Alcala, Madrid, Spain","institution_ids":["https://openalex.org/I189268942","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Josefa Ros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josefa Ros","raw_affiliation_strings":["Biochemistry and Molecular Genetics Service, Centro de Investigacio\u0301n Biome\u0301dica en Red de Enfermedades Hepa\u0301ticas y Digestivas (CIBEREHD), Hospital Cli\u0301nic, Institut d'Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigacio\u0301n Biome\u0301dica en Red de Enfermedades Hepa\u0301ticas y Digestivas (CIBEREHD), Hospital Cli\u0301nic, Institut d'Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053634127","display_name":"Manuel Morales\u2010Ruiz","orcid":"https://orcid.org/0000-0002-9074-2272","observed_orcids":["https://orcid.org/0000-0002-9074-2272"]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Morales\u2010Ruiz","raw_affiliation_strings":["Biochemistry and Molecular Genetics Service, Centro de Investigacio\u0301n Biome\u0301dica en Red de Enfermedades Hepa\u0301ticas y Digestivas (CIBEREHD), Hospital Cli\u0301nic, Institut d'Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigacio\u0301n Biome\u0301dica en Red de Enfermedades Hepa\u0301ticas y Digestivas (CIBEREHD), Hospital Cli\u0301nic, Institut d'Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089713793","display_name":"Mauro Bernardi","orcid":"https://orcid.org/0000-0002-1308-5440","observed_orcids":["https://orcid.org/0000-0002-1308-5440"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Bernardi","raw_affiliation_strings":["Department of Internal Medicine, Policlinico Sant'Orsola-Malpighi, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Policlinico Sant'Orsola-Malpighi, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083","https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066290707","display_name":"Vicente Arroyo","orcid":"https://orcid.org/0000-0002-2728-1848","observed_orcids":["https://orcid.org/0000-0002-2728-1848"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vicente Arroyo","raw_affiliation_strings":["Liver Unit, CIBEREHD, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain","Liver Unit, CIBEREHD, Hospital Cl\u00ednic, IDIBAPS, University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Unit, CIBEREHD, Hospital Cli\u0301nic, IDIBAPS, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Liver Unit, CIBEREHD, Hospital Cl\u00ednic, IDIBAPS, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029211589","display_name":"Wladimiro Jim\u00e9nez","orcid":"https://orcid.org/0000-0002-9376-0214","observed_orcids":["https://orcid.org/0000-0002-9376-0214","https://orcid.org/0000-0001-8739-9584"]},"institutions":[{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Wladimiro Jim\u00e9nez","raw_affiliation_strings":["Biochemistry and Molecular Genetics Service, Centro de Investigacio\u0301n Biome\u0301dica en Red de Enfermedades Hepa\u0301ticas y Digestivas (CIBEREHD), Hospital Cli\u0301nic, Institut d'Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","Department of Physiology I, University of Barcelona, Barcelona, Spain","fax: (3493)2275697","Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigacio\u0301n Biome\u0301dica en Red de Enfermedades Hepa\u0301ticas y Digestivas (CIBEREHD), Hospital Cli\u0301nic, Institut d'Investigacions Biome\u0300diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Department of Physiology I, University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"fax: (3493)2275697","institution_ids":[]},{"raw_affiliation_string":"Biochemistry and Molecular Genetics Service, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Hospital Cl\u00ednic, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5029211589"],"corresponding_institution_ids":["https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":5.8054,"has_fulltext":false,"cited_by_count":125,"citation_normalized_percentile":{"value":0.96056452,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"48","issue":"4","first_page":"1193","last_page":"1201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13505","display_name":"Apelin-related biomedical research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apelin","display_name":"apelin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apelin-receptor","display_name":"apelin receptor","score":0.9769999980926514},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/neoangiogenesis","display_name":"neoangiogenesis","score":0.765999972820282},{"id":"https://openalex.org/keywords/cardiovascular-complications","display_name":"cardiovascular complications","score":0.7860000133514404},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.9359999895095825},{"id":"https://openalex.org/keywords/advanced-liver-disease","display_name":"advanced liver disease","score":0.6620000004768372},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C2779546753","wikidata":"https://www.wikidata.org/wiki/Q2386988","display_name":"Apelin","level":3,"score":0.9047939777374268},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.5783493518829346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5322803258895874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43898624181747437},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41036394238471985},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3578052520751953},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0605851411819458}],"mesh":[{"descriptor_ui":"D000073861","descriptor_name":"Apelin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/hep.22467","doi":"https://doi.org/10.1002/hep.22467","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.22467","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.22467","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:18816630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18816630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"},{"id":"pmid:19140220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19140220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Letter"},{"id":"pmh:oai:cris.unibo.it:11585/62149","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/62149","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/hep.22467","doi":"https://doi.org/10.1002/hep.22467","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.22467","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.22467","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1978999795.pdf"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1487278836","https://openalex.org/W1508944460","https://openalex.org/W1540449933","https://openalex.org/W1966508121","https://openalex.org/W1972559234","https://openalex.org/W1973342839","https://openalex.org/W1982721661","https://openalex.org/W2005496548","https://openalex.org/W2009573205","https://openalex.org/W2014447414","https://openalex.org/W2025117288","https://openalex.org/W2060660919","https://openalex.org/W2061800712","https://openalex.org/W2066996500","https://openalex.org/W2071679347","https://openalex.org/W2078109396","https://openalex.org/W2081184877","https://openalex.org/W2081213367","https://openalex.org/W2087867260","https://openalex.org/W2089330954","https://openalex.org/W2098382903","https://openalex.org/W2111288662","https://openalex.org/W2115957483","https://openalex.org/W2117196163","https://openalex.org/W2119230474","https://openalex.org/W2129224037","https://openalex.org/W2132257581","https://openalex.org/W2132332398","https://openalex.org/W2147581368","https://openalex.org/W2152479803","https://openalex.org/W2152509794","https://openalex.org/W2155885188"],"related_works":["https://openalex.org/W2774208514","https://openalex.org/W2609868671","https://openalex.org/W1974845092","https://openalex.org/W2789715999","https://openalex.org/W3097935707","https://openalex.org/W1958476984","https://openalex.org/W2057345417","https://openalex.org/W2027064904","https://openalex.org/W2322911675","https://openalex.org/W2104413192"],"abstract_inverted_index":{"UNLABELLED:":[0],"Apelin":[1,111,122,158],"is":[2,25],"a":[3,125,207,250],"peptide":[4],"that":[5],"plays":[6],"an":[7,78],"important":[8],"role":[9],"in":[10,27,40,89,96,104,115,120,129,134,170,210,226,233,254],"heart":[11],"physiology":[12],"and":[13,16,34,36,53,58,66,69,84,93,95,191,197,200,228,230,235],"pathophysiology,":[14],"inflammation,":[15],"angiogenesis.":[17],"We":[18],"evaluated":[19,88],"whether":[20],"the":[21,28,31,49,61,70,74,135,171,183,219,224,231,245],"endogenous":[22],"apelin":[23,57,59,65,67,79,103,149,166,184,211,220,240,247],"system":[24,248],"involved":[26],"pathogenesis":[29],"of":[30,47,56,64,77,102,140,174,218],"hepatic":[32,130,148,172,189,216,246],"remodeling":[33],"cardiovascular":[35,195,234],"renal":[37,198],"complications":[38],"occurring":[39],"advanced":[41],"liver":[42,255],"disease.":[43,256],"The":[44,99,214],"circulating":[45],"levels":[46,101,112,152],"apelin,":[48],"messenger":[50],"RNA":[51],"(mRNA)":[52],"protein":[54],"expression":[55],"receptor,":[60,68],"immunohistological":[62],"detection":[63],"effects":[71],"induced":[72],"by":[73,162],"chronic":[75],"administration":[76],"receptor":[80,150,167,185,241],"antagonist":[81,186],"on":[82],"fibrosis":[83,190,227],"vessel":[85,192],"density":[86],"were":[87,108,113],"rats":[90,116,141],"with":[91,106,117,142,176,179,182,223],"cirrhosis":[92,107,118,180],"ascites":[94],"control":[97],"rats.":[98],"serum":[100],"patients":[105,204],"also":[109,146,205],"measured.":[110],"higher":[114,155],"than":[119,156],"controls.":[121,157],"mRNA":[123,151],"showed":[124,147,187,206],"four-fold":[126],"rise":[127],"only":[128],"tissue,":[131],"but":[132],"not":[133],"lung,":[136],"heart,":[137],"or":[138],"kidney":[139],"cirrhosis.":[143,177],"These":[144],"animals":[145,175],"300":[153],"times":[154],"was":[159,168],"highly":[160],"expressed":[161],"stellate":[163],"cells,":[164],"whereas":[165],"overexpressed":[169],"parenchyma":[173],"Rats":[178],"treated":[181],"diminished":[188],"density,":[193],"improved":[194],"performance,":[196],"function":[199,237],"lost":[201],"ascites.":[202],"Human":[203],"marked":[208],"increase":[209],"levels.":[212],"CONCLUSION:":[213],"selective":[215],"activation":[217],"system,":[221],"together":[222],"drop":[225],"neoangiogenesis":[229],"improvement":[232],"excretory":[236],"resulting":[238],"from":[239],"blockade,":[242],"points":[243],"to":[244],"as":[249],"novel":[251],"therapeutic":[252],"target":[253]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
