{"id":"https://openalex.org/W197899944","doi":null,"title":"Bromelain Production: Current Trends and Perspective","display_name":"Bromelain Production: Current Trends and Perspective","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W197899944","mag":"197899944"},"language":"en","primary_location":{"id":"mag:197899944","doi":null,"is_oa":false,"landing_page_url":"http://irep.iium.edu.my/28364/1/Bromelain_review.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100820210","display_name":"Muntari Bala","orcid":"https://orcid.org/0000-0002-5174-2181","observed_orcids":["https://orcid.org/0000-0002-5174-2181"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muntari Bala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025703820","display_name":"Nurul Azira Ismail","orcid":"https://orcid.org/0000-0001-5368-0810","observed_orcids":["https://orcid.org/0000-0001-5368-0810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nurul Azira Ismail","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5368-0810","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051333951","display_name":"Maizirwan Mel","orcid":"https://orcid.org/0000-0003-2917-2167","observed_orcids":["https://orcid.org/0000-0003-2917-2167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maizirwan Mel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2917-2167","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009042664","display_name":"Mohammed Saedi Jami","orcid":"https://orcid.org/0000-0002-4677-316X","observed_orcids":["https://orcid.org/0000-0002-4677-316X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed Saedi Jami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082934742","display_name":"Hamzah Mohd. Salleh","orcid":"https://orcid.org/0000-0003-4627-8019","observed_orcids":["https://orcid.org/0000-0003-4627-8019"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamzah Mohd. Salleh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4627-8019","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001923189","display_name":"Azura Amid","orcid":"https://orcid.org/0000-0002-1304-7559","observed_orcids":["https://orcid.org/0000-0002-1304-7559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azura Amid","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1304-7559","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3649,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.78433312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13725","display_name":"Pineapple and bromelain studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14478","display_name":"Papaya Research and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bromelain","display_name":"bromelain","score":1.0},{"id":"https://openalex.org/keywords/stem-bromelain","display_name":"stem bromelain","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pineapple","display_name":"pineapple","score":0.6230000257492065},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.9350000023841858},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.6959999799728394},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9269999861717224},{"id":"https://openalex.org/keywords/gene-cloning","display_name":"gene cloning","score":0.7720000147819519},{"id":"https://openalex.org/keywords/fermentation-optimization","display_name":"fermentation optimization","score":0.828000009059906},{"id":"https://openalex.org/keywords/enzyme-thermostability","display_name":"enzyme thermostability","score":0.7770000100135803},{"id":"https://openalex.org/keywords/enzyme-storage-stability","display_name":"enzyme storage stability","score":0.8379999995231628},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.7490000128746033},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.4830000102519989},{"id":"https://openalex.org/keywords/anti-tumor-effect","display_name":"anti-tumor effect","score":0.7300000190734863},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7770000100135803},{"id":"https://openalex.org/keywords/digestive-aids","display_name":"digestive aids","score":0.5600000023841858},{"id":"https://openalex.org/keywords/meat-tenderization","display_name":"meat tenderization","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2777334355","wikidata":"https://www.wikidata.org/wiki/Q415756","display_name":"Bromelain","level":4,"score":0.9705545902252197},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.6457586884498596},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5458018779754639},{"id":"https://openalex.org/C3019223276","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Proteolytic enzymes","level":3,"score":0.43956056237220764},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3984617590904236},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.36634665727615356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3578440546989441},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3396836519241333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3302745819091797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3293558955192566},{"id":"https://openalex.org/C2779832904","wikidata":"https://www.wikidata.org/wiki/Q410420","display_name":"Papain","level":3,"score":0.10061880946159363},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07044190168380737}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:197899944","doi":null,"is_oa":false,"landing_page_url":"http://irep.iium.edu.my/28364/1/Bromelain_review.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W38656806","https://openalex.org/W100024144","https://openalex.org/W195200541","https://openalex.org/W583177846","https://openalex.org/W1432566443","https://openalex.org/W1522313725","https://openalex.org/W1532431889","https://openalex.org/W1541993952","https://openalex.org/W1554577430","https://openalex.org/W1567173797","https://openalex.org/W1570675396","https://openalex.org/W1651070947","https://openalex.org/W1963849424","https://openalex.org/W1966209673","https://openalex.org/W1966294136","https://openalex.org/W1970168185","https://openalex.org/W1972471222","https://openalex.org/W1974778814","https://openalex.org/W1980735494","https://openalex.org/W1981896469","https://openalex.org/W1982230721","https://openalex.org/W1982743653","https://openalex.org/W1983460121","https://openalex.org/W1983751826","https://openalex.org/W1985136065","https://openalex.org/W1986135931","https://openalex.org/W1988434424","https://openalex.org/W1991120168","https://openalex.org/W1993882551","https://openalex.org/W1994197396","https://openalex.org/W2000512343","https://openalex.org/W2000905693","https://openalex.org/W2006010432","https://openalex.org/W2009699663","https://openalex.org/W2010491330","https://openalex.org/W2013210522","https://openalex.org/W2025279942","https://openalex.org/W2026325996","https://openalex.org/W2026734611","https://openalex.org/W2028272343","https://openalex.org/W2028661306","https://openalex.org/W2029752663","https://openalex.org/W2032064484","https://openalex.org/W2036385228","https://openalex.org/W2039256715","https://openalex.org/W2043829818","https://openalex.org/W2049898908","https://openalex.org/W2050481706","https://openalex.org/W2051502270","https://openalex.org/W2052290075","https://openalex.org/W2057900192","https://openalex.org/W2059471171","https://openalex.org/W2062638036","https://openalex.org/W2064356776","https://openalex.org/W2072853428","https://openalex.org/W2076407261","https://openalex.org/W2081607231","https://openalex.org/W2082281361","https://openalex.org/W2085386109","https://openalex.org/W2085605711","https://openalex.org/W2086218805","https://openalex.org/W2088946981","https://openalex.org/W2091129342","https://openalex.org/W2091708154","https://openalex.org/W2092597349","https://openalex.org/W2092597821","https://openalex.org/W2095534200","https://openalex.org/W2101605036","https://openalex.org/W2110685354","https://openalex.org/W2111537738","https://openalex.org/W2116908933","https://openalex.org/W2121960150","https://openalex.org/W2128964383","https://openalex.org/W2131642521","https://openalex.org/W2131792398","https://openalex.org/W2140225233","https://openalex.org/W2146473688","https://openalex.org/W2147387658","https://openalex.org/W2149695397","https://openalex.org/W2162505168","https://openalex.org/W2167587083","https://openalex.org/W2170008613","https://openalex.org/W2170785232","https://openalex.org/W2202407564","https://openalex.org/W2213378242","https://openalex.org/W2287129993","https://openalex.org/W2336721137","https://openalex.org/W2348137108","https://openalex.org/W2351025195","https://openalex.org/W2351125227","https://openalex.org/W2353469910","https://openalex.org/W2364983493","https://openalex.org/W2367969044","https://openalex.org/W2392455247","https://openalex.org/W2511001043","https://openalex.org/W2583062189","https://openalex.org/W4256404948"],"related_works":["https://openalex.org/W2557802741","https://openalex.org/W7197810018","https://openalex.org/W2077129449","https://openalex.org/W2184657758","https://openalex.org/W1855671110","https://openalex.org/W2110685354","https://openalex.org/W7216927467","https://openalex.org/W4362459585","https://openalex.org/W2950524750","https://openalex.org/W2468522545"],"abstract_inverted_index":{"Bromelain":[0],"is":[1,36,139],"a":[2,37,60],"mixture":[3],"of":[4,13,30,65,81,99,108,116,156],"proteolytic":[5],"enzymes":[6],"derived":[7],"from":[8,70],"the":[9,63,71,78,89,93,97,128,154],"stems":[10],"and":[11,27,45,77,92,112,158],"juice":[12],"pineapples.":[14],"It":[15,42,138],"has":[16,43],"been\r\nextensively":[17],"used":[18],"in":[19,28,48,96,153],"food":[20],"industry;":[21],"for":[22,119],"meat":[23],"tenderization,":[24],"baking":[25],"processes,":[26],"prevention":[29],"browning\r\nof":[31],"apple":[32],"juice.":[33],"Stem":[34],"bromelain":[35,68,82,102,110,124,157],"highly":[38],"accepted":[39],"phytotherapeutic":[40],"agent.":[41],"anti-tumor":[44],"antiinflammatory\r\neffects,":[46],"use":[47],"wound":[49],"healing,":[50],"as":[51,125,127],"digestive":[52],"aids,":[53],"etc.":[54],"This":[55,105],"review":[56,143],"aims":[57],"at":[58],"presenting":[59],"detailed\r\naccount":[61],"on":[62,67,88],"level":[64],"achievement":[66],"production":[69,98],"conventional":[72],"methods.":[73],"Specifically,\r\nthe":[74],"isolation,":[75],"purification":[76],"biochemical":[79],"properties":[80],"are":[83,151],"discussed.":[84],"The":[85],"study":[86],"also\r\nfocused":[87],"current":[90],"trends":[91],"progress":[94],"made":[95],"recombinant":[100,123],"stem":[101,109],"in\r\nEscherichia":[103],"coli.":[104],"involved":[106],"cloning":[107],"gene":[111],"its":[113],"expression,":[114],"optimization":[115],"labscale\r\nfermentation":[117],"conditions":[118],"E.":[120],"coli":[121],"harboring":[122],"well":[126],"enzyme":[129],"thermal\r\nand":[130],"storage":[131],"stability":[132],"measured":[133],"using":[134],"differential":[135],"scanning":[136],"calorimetry.":[137],"hoped":[140],"that":[141],"this":[142],"would\r\nprovide":[144],"relevant":[145],"information":[146],"to":[147],"contemporary":[148],"researchers":[149],"who":[150],"active":[152],"field":[155],"other\r\nrelated":[159],"proteases.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
