{"id":"https://openalex.org/W1978997395","doi":"https://doi.org/10.1007/bf01739921","title":"Continuous infusion of acyclovir is more effective than discontinuous infusion for treatment of genital herpes in an immunocompromised patient","display_name":"Continuous infusion of acyclovir is more effective than discontinuous infusion for treatment of genital herpes in an immunocompromised patient","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W1978997395","doi":"https://doi.org/10.1007/bf01739921","mag":"1978997395","pmid":"https://pubmed.ncbi.nlm.nih.gov/8002091"},"language":"en","primary_location":{"id":"doi:10.1007/bf01739921","doi":"https://doi.org/10.1007/bf01739921","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01739921","pdf_url":null,"source":{"id":"https://openalex.org/S119914596","display_name":"Infection","issn_l":"0300-8126","issn":["0300-8126","1439-0973"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L. Mock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Mock","raw_affiliation_strings":["Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, F-54511, Vandoeuvre, France","Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, Vandoeuvre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, F-54511, Vandoeuvre, France","institution_ids":[]},{"raw_affiliation_string":"Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, Vandoeuvre, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011445627","display_name":"Lucien Dossou-Gb\u00e9t\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Dossou-Gb\u00e9t\u00e9","raw_affiliation_strings":["Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, F-54511, Vandoeuvre, France","Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, Vandoeuvre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, F-54511, Vandoeuvre, France","institution_ids":[]},{"raw_affiliation_string":"Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, Vandoeuvre, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065505469","display_name":"Myriam Merle-Melet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Merle-Melet","raw_affiliation_strings":["Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, F-54511, Vandoeuvre, France","Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, Vandoeuvre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, F-54511, Vandoeuvre, France","institution_ids":[]},{"raw_affiliation_string":"Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, Vandoeuvre, France","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"A. G\u00e9rard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. G\u00e9rard","raw_affiliation_strings":["Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, F-54511, Vandoeuvre, France","Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, Vandoeuvre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, F-54511, Vandoeuvre, France","institution_ids":[]},{"raw_affiliation_string":"Dept. of Infectious Diseases, TD6, Brabois Hospital University Center, Vandoeuvre, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.3136,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.56940951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"22","issue":"4","first_page":"290","last_page":"290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyclovir","display_name":"acyclovir","score":0.9700000286102295},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.9879999756813049},{"id":"https://openalex.org/keywords/genital-herpes","display_name":"genital herpes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.8569999933242798},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2778498788","wikidata":"https://www.wikidata.org/wiki/Q7476596","display_name":"Genital herpes","level":4,"score":0.7924236059188843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6432874798774719},{"id":"https://openalex.org/C2779450786","wikidata":"https://www.wikidata.org/wiki/Q147101","display_name":"Aciclovir","level":5,"score":0.6165834665298462},{"id":"https://openalex.org/C2779352459","wikidata":"https://www.wikidata.org/wiki/Q6031679","display_name":"Infusion therapy","level":2,"score":0.5156185030937195},{"id":"https://openalex.org/C3018112808","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Continuous infusion","level":2,"score":0.45648500323295593},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3651544451713562},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.29768964648246765},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2924650311470032},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.2223091423511505},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.15577110648155212},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.15576410293579102},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.12425485253334045},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006558","descriptor_name":"Herpes Genitalis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006558","descriptor_name":"Herpes Genitalis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016867","descriptor_name":"Immunocompromised Host","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01739921","doi":"https://doi.org/10.1007/bf01739921","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01739921","pdf_url":null,"source":{"id":"https://openalex.org/S119914596","display_name":"Infection","issn_l":"0300-8126","issn":["0300-8126","1439-0973"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection","raw_type":"journal-article"},{"id":"pmid:8002091","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8002091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1590000149","https://openalex.org/W1985270166","https://openalex.org/W1999480417","https://openalex.org/W2001394429","https://openalex.org/W2007789580","https://openalex.org/W2014013945","https://openalex.org/W2026396393","https://openalex.org/W2063399192","https://openalex.org/W2095371986","https://openalex.org/W2314294431"],"related_works":["https://openalex.org/W2065400007","https://openalex.org/W192527192","https://openalex.org/W2402604767","https://openalex.org/W2095371986","https://openalex.org/W1977925647","https://openalex.org/W2063278714","https://openalex.org/W2063885412","https://openalex.org/W4232810533","https://openalex.org/W4232961126","https://openalex.org/W4251573617"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}