{"id":"https://openalex.org/W1978994512","doi":"https://doi.org/10.1016/0014-2964(80)90348-5","title":"Estrogen receptor status: an important variable in predicting response to endocrine therapy in metastatic breast cancer","display_name":"Estrogen receptor status: an important variable in predicting response to endocrine therapy in metastatic breast cancer","publication_year":1980,"publication_date":"1980-03-01","ids":{"openalex":"https://openalex.org/W1978994512","doi":"https://doi.org/10.1016/0014-2964(80)90348-5","mag":"1978994512","pmid":"https://pubmed.ncbi.nlm.nih.gov/7371687"},"language":"en","primary_location":{"id":"doi:10.1016/0014-2964(80)90348-5","doi":"https://doi.org/10.1016/0014-2964(80)90348-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-2964(80)90348-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210204293","display_name":"European Journal of Cancer (1965)","issn_l":"0014-2964","issn":["0014-2964","1879-2995"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer (1965)","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019875677","display_name":"Joseph C. Allegra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C. Allegra","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028539104","display_name":"Marc E. Lippman","orcid":"https://orcid.org/0000-0001-5280-4084","observed_orcids":["https://orcid.org/0000-0001-5280-4084"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc E. Lippman","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006537594","display_name":"E. Brad Thompson","orcid":"https://orcid.org/0000-0003-1578-0241","observed_orcids":["https://orcid.org/0000-0003-1578-0241"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.Brad Thompson","raw_affiliation_strings":["Biometrics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biometrics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Simon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Simon","raw_affiliation_strings":["Biometrics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biometrics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084063436","display_name":"Audrey Barlock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey Barlock","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108584947","display_name":"Linda Green","orcid":"https://orcid.org/0000-0003-2499-8816","observed_orcids":["https://orcid.org/0000-0003-2499-8816"]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Green","raw_affiliation_strings":["Department of Oncology, Howard University, Washington, D.C., U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Howard University, Washington, D.C., U.S.A","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113177883","display_name":"Karen K. Huff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen K. Huff","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062485375","display_name":"Hoan M.Y.T.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hoan M.Y.T. Do","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088166479","display_name":"Susan C. Aitken","orcid":"https://orcid.org/0000-0003-3911-7241","observed_orcids":["https://orcid.org/0000-0003-3911-7241"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan C. Aitken","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111725869","display_name":"Robert D. Warren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Warren","raw_affiliation_strings":["Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, U.S.A","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028539104"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":7.2141,"has_fulltext":false,"cited_by_count":145,"citation_normalized_percentile":{"value":0.98439435,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"3","first_page":"323","last_page":"331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.07980000227689743,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.871999979019165},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.8379999995231628},{"id":"https://openalex.org/keywords/receptor-quantification","display_name":"receptor quantification","score":0.6579999923706055},{"id":"https://openalex.org/keywords/receptor-dissociation-constant","display_name":"receptor dissociation constant","score":0.8309999704360962},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9020000100135803},{"id":"https://openalex.org/keywords/chemotherapy-pretreatment","display_name":"chemotherapy pretreatment","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7517764568328857},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.7468341588973999},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.7213135957717896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6414026021957397},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6150397658348083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6100612878799438},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.6067669987678528},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5643416047096252},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4491356611251831},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4431040585041046},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3930635154247284},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.21529626846313477}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-2964(80)90348-5","doi":"https://doi.org/10.1016/0014-2964(80)90348-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-2964(80)90348-5","pdf_url":null,"source":{"id":"https://openalex.org/S4210204293","display_name":"European Journal of Cancer (1965)","issn_l":"0014-2964","issn":["0014-2964","1879-2995"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer (1965)","raw_type":"journal-article"},{"id":"pmid:7371687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7371687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1503693344","https://openalex.org/W1634658554","https://openalex.org/W1996753936","https://openalex.org/W2015192764","https://openalex.org/W2022590522","https://openalex.org/W2026637085","https://openalex.org/W2033821687","https://openalex.org/W2058681718","https://openalex.org/W2064367468","https://openalex.org/W2072678065","https://openalex.org/W2072767428","https://openalex.org/W2096598341","https://openalex.org/W2323269146","https://openalex.org/W2418916358","https://openalex.org/W2609689978","https://openalex.org/W3015973740","https://openalex.org/W6736923010","https://openalex.org/W7011828667"],"related_works":["https://openalex.org/W2059905840","https://openalex.org/W2340925150","https://openalex.org/W2015192764","https://openalex.org/W2025348614","https://openalex.org/W2406372835","https://openalex.org/W2079808933","https://openalex.org/W84421162","https://openalex.org/W6981641753","https://openalex.org/W1971825458","https://openalex.org/W2409188378"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}