{"id":"https://openalex.org/W1978990274","doi":"https://doi.org/10.1073/pnas.0913862107","title":"Structural requirements of bitter taste receptor activation","display_name":"Structural requirements of bitter taste receptor activation","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W1978990274","doi":"https://doi.org/10.1073/pnas.0913862107","mag":"1978990274","pmid":"https://pubmed.ncbi.nlm.nih.gov/20534469","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890741"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0913862107","doi":"https://doi.org/10.1073/pnas.0913862107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0913862107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890741","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076819232","display_name":"Anne Brockhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Brockhoff","raw_affiliation_strings":["Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany; and","institution_ids":["https://openalex.org/I4210162705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024990714","display_name":"Maik Behrens","orcid":"https://orcid.org/0000-0003-2082-8860","observed_orcids":["https://orcid.org/0000-0003-2082-8860"]},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maik Behrens","raw_affiliation_strings":["Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany; and","institution_ids":["https://openalex.org/I4210162705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034161188","display_name":"Masha Y. Niv","orcid":"https://orcid.org/0000-0001-8275-8795","observed_orcids":["https://orcid.org/0000-0001-8275-8795"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Masha Y. Niv","raw_affiliation_strings":["Faculty of Agriculture, Food, and Environment, Institute of Biochemistry, Food Science, and Nutrition, Hebrew University of Jerusalem, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Agriculture, Food, and Environment, Institute of Biochemistry, Food Science, and Nutrition, Hebrew University of Jerusalem, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009872018","display_name":"Wolfgang Meyerhof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162705","display_name":"German Institute of Human Nutrition","ror":"https://ror.org/05xdczy51","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162705"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wolfgang Meyerhof","raw_affiliation_strings":["Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany; and","institution_ids":["https://openalex.org/I4210162705"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009872018"],"corresponding_institution_ids":["https://openalex.org/I4210162705"],"apc_list":null,"apc_paid":null,"fwci":9.9329,"has_fulltext":false,"cited_by_count":194,"citation_normalized_percentile":{"value":0.98560813,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"107","issue":"24","first_page":"11110","last_page":"11115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bitter-taste-receptors","display_name":"bitter taste receptors","score":0.8790000081062317},{"id":"https://openalex.org/keywords/agonist-selectivity","display_name":"agonist selectivity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/c-terminal-region","display_name":"C-terminal region","score":0.7490000128746033},{"id":"https://openalex.org/keywords/chimeric-receptors","display_name":"chimeric receptors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"mutagenesis","score":0.6399999856948853},{"id":"https://openalex.org/keywords/strychnine","display_name":"strychnine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/aristolochic-acid","display_name":"aristolochic acid","score":1.0},{"id":"https://openalex.org/keywords/structure-function-analysis","display_name":"structure-function analysis","score":0.796999990940094},{"id":"https://openalex.org/keywords/bitter-taste-perception","display_name":"bitter taste perception","score":0.6179999709129333},{"id":"https://openalex.org/keywords/antagonists","display_name":"antagonists","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6684386730194092},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.5955936312675476},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5893540382385254},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4864199161529541},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4786342680454254},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46441811323165894},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4530940651893616},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4403942823410034},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.43798384070396423},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.43217504024505615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3959915339946747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3709810972213745},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21087944507598877}],"mesh":[{"descriptor_ui":"D000098706","descriptor_name":"Taste Receptors, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013649","descriptor_name":"Taste","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0913862107","doi":"https://doi.org/10.1073/pnas.0913862107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0913862107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1800490","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890741","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2890741","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890741","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:20534469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20534469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1800490","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890741","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310065","display_name":"Danone","ror":"https://ror.org/00aj77a24"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1496676716","https://openalex.org/W1507665550","https://openalex.org/W1516237456","https://openalex.org/W1542161320","https://openalex.org/W1729873003","https://openalex.org/W1833104430","https://openalex.org/W1969104991","https://openalex.org/W1980292173","https://openalex.org/W1980409809","https://openalex.org/W1988097700","https://openalex.org/W2005997645","https://openalex.org/W2008862835","https://openalex.org/W2021914752","https://openalex.org/W2028645925","https://openalex.org/W2044855908","https://openalex.org/W2045358393","https://openalex.org/W2053174683","https://openalex.org/W2064034213","https://openalex.org/W2069494674","https://openalex.org/W2071196106","https://openalex.org/W2079052124","https://openalex.org/W2089836418","https://openalex.org/W2089885047","https://openalex.org/W2096550848","https://openalex.org/W2109159205","https://openalex.org/W2114531054","https://openalex.org/W2115018134","https://openalex.org/W2137311570","https://openalex.org/W2155201844","https://openalex.org/W2156563976","https://openalex.org/W2159413546","https://openalex.org/W2162137515","https://openalex.org/W2169702025","https://openalex.org/W2184730195","https://openalex.org/W2235051110","https://openalex.org/W2441016847","https://openalex.org/W4214642236"],"related_works":["https://openalex.org/W2884231318","https://openalex.org/W7019222421","https://openalex.org/W4327567156","https://openalex.org/W2299580779","https://openalex.org/W7015535046","https://openalex.org/W1990205700","https://openalex.org/W2760424721","https://openalex.org/W2163644873","https://openalex.org/W2051797068","https://openalex.org/W2971782274"],"abstract_inverted_index":{"An":[0,21],"important":[1],"question":[2,25],"in":[3,33,137,164,175,186],"taste":[4,237],"research":[5],"is":[6],"how":[7],"25":[8],"receptors":[9,96,126],"of":[10,17,51,66,75,92,112,123,169,181,197,206,215,225,234],"the":[11,29,64,120,124,178,191,203,220,223],"human":[12,235],"TAS2R":[13],"family":[14],"detect":[15],"thousands":[16],"structurally":[18],"diverse":[19,47],"compounds.":[20],"answer":[22],"to":[23,38,55,154,177,201],"this":[24],"may":[26,217],"arise":[27],"from":[28,190],"observation":[30],"that":[31,119],"TAS2Rs":[32],"general":[34],"are":[35,127],"broadly":[36],"tuned":[37],"interact":[39],"with":[40,45,58],"numerous":[41],"substances.":[42],"Ultimately,":[43],"interaction":[44,207],"chemically":[46],"agonists":[48,209],"requires":[49],"architectures":[50],"binding":[52,68],"pockets":[53],"tailored":[54],"combine":[56],"flexibility":[57],"selectivity.":[59,131,157],"The":[60,90,167],"present":[61],"study":[62],"determines":[63],"structure":[65],"hTAS2R":[67],"pockets.":[69],"We":[70,117],"focused":[71],"on":[72],"a":[73],"subfamily":[74],"closely":[76],"related":[77],"hTAS2Rs":[78,216],"exhibiting":[79],"pronounced":[80],"amino":[81,106,172],"acid":[82,107],"sequence":[83],"identities":[84],"but":[85],"unique":[86],"agonist":[87,130,156,165],"activation":[88,111],"spectra.":[89],"generation":[91],"chimeric":[93],"and":[94,105,115,146,183,210],"mutant":[95],"followed":[97],"by":[98,144,149],"calcium":[99],"imaging":[100],"analyses":[101,214,233],"identified":[102,174],"receptor":[103],"regions":[104,122],"residues":[108,135],"critical":[109],"for":[110,129,222,230],"hTAS2R46,":[113,142],"-R43,":[114],"-R31.":[116],"found":[118],"carboxyl-terminal":[121],"investigated":[125],"crucial":[128],"Intriguingly,":[132],"exchanging":[133],"two":[134],"located":[136],"transmembrane":[138],"domain":[139],"seven":[140],"between":[141,208],"activated":[143,148],"strychnine,":[145],"hTAS2R31,":[147],"aristolochic":[150],"acid,":[151],"was":[152],"sufficient":[153],"invert":[155],"Further":[158],"mutagenesis":[159],"revealed":[160],"additional":[161],"positions":[162,180],"involved":[163],"interaction.":[166],"transfer":[168],"functionally":[170],"relevant":[171],"acids":[173],"hTAS2R46":[176,198],"corresponding":[179],"hTAS2R43":[182],"-R31":[184],"resulted":[185],"pharmacological":[187],"properties":[188],"indistinguishable":[189],"parental":[192],"hTAS2R46.":[193],"In":[194],"silico":[195],"modeling":[196],"allowed":[199],"us":[200],"visualize":[202],"putative":[204],"mode":[205],"hTAS2Rs.":[211],"Detailed":[212],"structure-function":[213],"ultimately":[218],"pave":[219],"way":[221],"development":[224],"specific":[226],"antagonists":[227],"urgently":[228],"needed":[229],"more":[231],"sophisticated":[232],"bitter":[236],"perception.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}