{"id":"https://openalex.org/W1978983980","doi":"https://doi.org/10.1080/02678292.2014.956350","title":"Effects of liquid crystallinity on anticancer activity of benzoate derivatives possessing a terminal hydroxyl group","display_name":"Effects of liquid crystallinity on anticancer activity of benzoate derivatives possessing a terminal hydroxyl group","publication_year":2014,"publication_date":"2014-11-07","ids":{"openalex":"https://openalex.org/W1978983980","doi":"https://doi.org/10.1080/02678292.2014.956350","mag":"1978983980"},"language":"en","primary_location":{"id":"doi:10.1080/02678292.2014.956350","doi":"https://doi.org/10.1080/02678292.2014.956350","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02678292.2014.956350","pdf_url":null,"source":{"id":"https://openalex.org/S15647332","display_name":"Liquid Crystals","issn_l":"0267-8292","issn":["0267-8292","1366-5855"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liquid Crystals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111957918","display_name":"Yukako Fukushi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukako Fukushi","raw_affiliation_strings":["Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101813829","display_name":"Hideaki Yoshino","orcid":"https://orcid.org/0000-0003-2705-9929","observed_orcids":["https://orcid.org/0000-0003-2705-9929"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironori Yoshino","raw_affiliation_strings":["Department of Radiological Life Sciences, Graduate School of Health Sciences, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Life Sciences, Graduate School of Health Sciences, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081151342","display_name":"Junya Ishikawa","orcid":"https://orcid.org/0000-0002-1425-8876","observed_orcids":["https://orcid.org/0000-0002-1425-8876"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junya Ishikawa","raw_affiliation_strings":["Department of Radiological Life Sciences, Graduate School of Health Sciences, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Life Sciences, Graduate School of Health Sciences, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005729319","display_name":"Masanobu Sagisaka","orcid":"https://orcid.org/0000-0001-9685-7524","observed_orcids":["https://orcid.org/0000-0001-9685-7524"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanobu Sagisaka","raw_affiliation_strings":["Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067945916","display_name":"Ikuo Kashiwakura","orcid":"https://orcid.org/0000-0002-7399-1445","observed_orcids":["https://orcid.org/0000-0002-7399-1445"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikuo Kashiwakura","raw_affiliation_strings":["Department of Radiological Life Sciences, Graduate School of Health Sciences, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Life Sciences, Graduate School of Health Sciences, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087318500","display_name":"Atsushi Yoshizawa","orcid":"https://orcid.org/0000-0003-4272-3410","observed_orcids":["https://orcid.org/0000-0003-4272-3410"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsushi Yoshizawa","raw_affiliation_strings":["Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki University, Hirosaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki University, Hirosaki, Japan","institution_ids":["https://openalex.org/I146516829"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087318500"],"corresponding_institution_ids":["https://openalex.org/I146516829"],"apc_list":null,"apc_paid":null,"fwci":0.3369,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.49912278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"41","issue":"12","first_page":"1873","last_page":"1878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10306","display_name":"Liquid Crystal Research Advancements","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10306","display_name":"Liquid Crystal Research Advancements","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liquid-crystallinity","display_name":"liquid crystallinity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/benzoic-acid-derivatives","display_name":"benzoic acid derivatives","score":0.824999988079071},{"id":"https://openalex.org/keywords/terminal-hydroxyl-groups","display_name":"terminal hydroxyl groups","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mesogenic-compounds","display_name":"mesogenic compounds","score":0.7940000295639038},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/molecular-aggregation","display_name":"molecular aggregation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/structure-property-relationships","display_name":"structure-property relationships","score":0.7369999885559082},{"id":"https://openalex.org/keywords/octanol-water-partition-coefficient","display_name":"octanol-water partition coefficient","score":0.9649999737739563},{"id":"https://openalex.org/keywords/topological-polar-surface-area","display_name":"topological polar surface area","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C46275449","wikidata":"https://www.wikidata.org/wiki/Q2458815","display_name":"Crystallinity","level":2,"score":0.7951004505157471},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5761507749557495},{"id":"https://openalex.org/C192552737","wikidata":"https://www.wikidata.org/wiki/Q898797","display_name":"Partition coefficient","level":2,"score":0.5724709033966064},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.46784886717796326},{"id":"https://openalex.org/C2777538812","wikidata":"https://www.wikidata.org/wiki/Q4890784","display_name":"Benzoates","level":2,"score":0.43225646018981934},{"id":"https://openalex.org/C2779744229","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Human lung","level":3,"score":0.4154955744743347},{"id":"https://openalex.org/C77017923","wikidata":"https://www.wikidata.org/wiki/Q912313","display_name":"Optical microscope","level":3,"score":0.4138423800468445},{"id":"https://openalex.org/C2781311116","wikidata":"https://www.wikidata.org/wiki/Q83306","display_name":"Group (periodic table)","level":2,"score":0.4106253981590271},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3256057798862457},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3200188875198364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21830248832702637},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.12032142281532288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10049223899841309},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.07513231039047241},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/02678292.2014.956350","doi":"https://doi.org/10.1080/02678292.2014.956350","is_oa":false,"landing_page_url":"https://doi.org/10.1080/02678292.2014.956350","pdf_url":null,"source":{"id":"https://openalex.org/S15647332","display_name":"Liquid Crystals","issn_l":"0267-8292","issn":["0267-8292","1366-5855"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liquid Crystals","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1910970233","display_name":"Enhancement of radiation therapy for cancer treatment by focusing on pattern recognition receptors","funder_award_id":"25861053","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1965600278","https://openalex.org/W1984974152","https://openalex.org/W2000731000","https://openalex.org/W2011505858","https://openalex.org/W2032786397","https://openalex.org/W2095142763","https://openalex.org/W2101319480","https://openalex.org/W2105547623","https://openalex.org/W2130096626","https://openalex.org/W2949136259","https://openalex.org/W2953012612"],"related_works":["https://openalex.org/W2130096626","https://openalex.org/W4316460251","https://openalex.org/W2886843627","https://openalex.org/W1964263584","https://openalex.org/W2015093313","https://openalex.org/W2604224597","https://openalex.org/W7109093189","https://openalex.org/W4249628897","https://openalex.org/W2974538447","https://openalex.org/W1970629558"],"abstract_inverted_index":{"To":[0],"elucidate":[1],"the":[2,8,57,61,71],"effects":[3],"of":[4,11,60,70],"liquid":[5],"crystallinity":[6],"on":[7],"anticancer":[9],"activity":[10,30],"a":[12,22],"small":[13],"mesogenic":[14],"molecule,":[15],"we":[16],"prepared":[17],"some":[18],"benzoate":[19,62],"derivatives":[20],"possessing":[21],"terminal":[23],"hydroxyl":[24],"group":[25],"and":[26,51,80],"investigated":[27],"their":[28,40],"anti-proliferative":[29],"against":[31],"A549":[32],"human":[33],"lung":[34],"cancer":[35],"cells.":[36],"We":[37,55],"also":[38],"observed":[39],"molecular":[41,81],"aggregation":[42,82],"properties":[43],"using":[44],"polarised":[45],"optical":[46],"microscopy,":[47],"differential":[48],"scanning":[49],"microscopy":[50],"dynamic":[52],"light":[53],"scattering.":[54],"discuss":[56],"structure\u2013property":[58],"relation":[59],"derivatives.":[63],"The":[64],"results":[65],"are":[66],"explained":[67],"in":[68],"terms":[69],"octanol\u2013water":[72],"partition":[73],"coefficient,":[74],"topological":[75],"polar":[76],"surface":[77],"area":[78],"(tPSA)":[79],"ability.":[83]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}