{"id":"https://openalex.org/W1978978999","doi":"https://doi.org/10.3892/etm.2012.454","title":"Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals","display_name":"Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals","publication_year":2012,"publication_date":"2012-01-13","ids":{"openalex":"https://openalex.org/W1978978999","doi":"https://doi.org/10.3892/etm.2012.454","mag":"1978978999","pmid":"https://pubmed.ncbi.nlm.nih.gov/22969947","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3438703"},"language":"en","primary_location":{"id":"doi:10.3892/etm.2012.454","doi":"https://doi.org/10.3892/etm.2012.454","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2012.454","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2012.454/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.spandidos-publications.com/10.3892/etm.2012.454/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054707277","display_name":"Rengyun Liu","orcid":"https://orcid.org/0000-0002-1408-2372","observed_orcids":["https://orcid.org/0000-0002-1408-2372"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"RENG-YUN LIU","raw_affiliation_strings":["Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123,  P.R. China ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123,  P.R. China ;","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110191620","display_name":"Xiaoxue Song","orcid":"https://orcid.org/0009-0005-8044-7818","observed_orcids":["https://orcid.org/0009-0005-8044-7818"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIAOXUE SONG","raw_affiliation_strings":["Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123, P.R. China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071621068","display_name":"Ping Chen","orcid":"https://orcid.org/0000-0002-8068-1891","observed_orcids":["https://orcid.org/0000-0002-8068-1891"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"PING CHEN","raw_affiliation_strings":["Computational Systems Biology Laboratory, Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, FIN-00014, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Systems Biology Laboratory, Institute of Biomedicine and Genome-Scale Biology Research Program, University of Helsinki, Helsinki, FIN-00014, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108632397","display_name":"Zhe Lei","orcid":"https://orcid.org/0000-0002-5220-7391","observed_orcids":["https://orcid.org/0000-0002-5220-7391"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZHE LEI","raw_affiliation_strings":["Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123, P.R. China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100558595","display_name":"Jingcheng Miao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JINGCHENG MIAO","raw_affiliation_strings":["Department of Cellular and Molecular Biology, Medical College of Soochow University, Suzhou 215123, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Biology, Medical College of Soochow University, Suzhou 215123, P.R. China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086059667","display_name":"Nengjun Yi","orcid":"https://orcid.org/0000-0001-5857-5868","observed_orcids":["https://orcid.org/0000-0001-5857-5868"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"NENGJUN YI","raw_affiliation_strings":["Section on Statistical Genetics, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Statistical Genetics, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435168","display_name":"Kui Zhang","orcid":"https://orcid.org/0000-0003-0647-6272","observed_orcids":["https://orcid.org/0000-0003-0647-6272"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KUI ZHANG","raw_affiliation_strings":["Section on Statistical Genetics, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Statistical Genetics, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042254050","display_name":"Boris Pasche","orcid":"https://orcid.org/0000-0002-3750-7898","observed_orcids":["https://orcid.org/0000-0002-3750-7898"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BORIS PASCHE","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, NP 2566 Birmingham, AL 35294-3300, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, NP 2566 Birmingham, AL 35294-3300, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106687009","display_name":"Hongtao Zhang","orcid":"https://orcid.org/0000-0003-4182-421X","observed_orcids":["https://orcid.org/0000-0003-4182-421X"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"HONG-TAO ZHANG","raw_affiliation_strings":["Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123, P.R. China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4431,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.38316832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"4","first_page":"655","last_page":"664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.156700000166893,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.9559999704360962},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8270000219345093},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.6980000138282776},{"id":"https://openalex.org/keywords/african-populations","display_name":"African populations","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6349999904632568},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.8153193593025208},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7887929677963257},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6324136257171631},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5753960609436035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5707030892372131},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5386111736297607},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.5010583400726318},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.497955322265625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49309059977531433},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.45897358655929565},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3677743971347809},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30603060126304626},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2561105787754059},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.22425565123558044},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19511783123016357},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.11425653100013733}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3892/etm.2012.454","doi":"https://doi.org/10.3892/etm.2012.454","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2012.454","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2012.454/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2442419","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3438703","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3438703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3438703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Ther Med","raw_type":"Text"},{"id":"pmid:22969947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22969947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and therapeutic medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/etm.2012.454","doi":"https://doi.org/10.3892/etm.2012.454","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2012.454","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2012.454/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G1193298573","display_name":null,"funder_award_id":"NCET-09","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1482442646","display_name":"Bayesian Methods for Genome-Wide Interacting QTL Mapping","funder_award_id":"R01GM069430","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1541300415","display_name":"TGF-beta pathway polymorphisms and colon cancer risk","funder_award_id":"R01CA108741","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G40795103","display_name":"TGF-beta polymorphisms and breast cancer in families","funder_award_id":"5r01ca112520-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G736243090","display_name":null,"funder_award_id":"R01-CA112520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7531477493","display_name":"TGFBR1 Signaling in Colorectal Cancer","funder_award_id":"R01CA137000","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8657463438","display_name":null,"funder_award_id":"81171894","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000195702","display_name":null,"funder_award_id":"CA 112520","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320324720","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334924","display_name":"Program for New Century Excellent Talents in University","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978978999.pdf","grobid_xml":"https://content.openalex.org/works/W1978978999.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W2036740","https://openalex.org/W238827458","https://openalex.org/W1492343766","https://openalex.org/W1511524925","https://openalex.org/W1555772498","https://openalex.org/W1639450499","https://openalex.org/W1812598206","https://openalex.org/W1965037168","https://openalex.org/W1973452897","https://openalex.org/W1973798273","https://openalex.org/W1979423827","https://openalex.org/W1981467511","https://openalex.org/W1985955219","https://openalex.org/W1986834354","https://openalex.org/W2003165120","https://openalex.org/W2007872832","https://openalex.org/W2018152980","https://openalex.org/W2018958047","https://openalex.org/W2022200777","https://openalex.org/W2031987653","https://openalex.org/W2039418122","https://openalex.org/W2046247026","https://openalex.org/W2049862576","https://openalex.org/W2063407488","https://openalex.org/W2074356752","https://openalex.org/W2080998956","https://openalex.org/W2082626794","https://openalex.org/W2089022749","https://openalex.org/W2107328434","https://openalex.org/W2112331344","https://openalex.org/W2112792894","https://openalex.org/W2112970335","https://openalex.org/W2114481915","https://openalex.org/W2116554142","https://openalex.org/W2118278569","https://openalex.org/W2123105952","https://openalex.org/W2125435699","https://openalex.org/W2133353372","https://openalex.org/W2133962994","https://openalex.org/W2143249342","https://openalex.org/W2143693972","https://openalex.org/W2150000105","https://openalex.org/W2152310279","https://openalex.org/W2156098321","https://openalex.org/W2157823046","https://openalex.org/W2159624552","https://openalex.org/W2160035484","https://openalex.org/W2167715370","https://openalex.org/W2198233526","https://openalex.org/W2315123323","https://openalex.org/W6636781240","https://openalex.org/W6676759514"],"related_works":["https://openalex.org/W3013605495","https://openalex.org/W2198233526","https://openalex.org/W2418580809","https://openalex.org/W2613184452","https://openalex.org/W2619967189","https://openalex.org/W2888266411","https://openalex.org/W3005430403","https://openalex.org/W2161279890","https://openalex.org/W2312541413","https://openalex.org/W2337683488"],"abstract_inverted_index":{"Interleukin-6":[0],"(IL6)":[1],"is":[2,8],"a":[3,208],"pleiotropic":[4],"inflammatory":[5],"cytokine,":[6],"which":[7],"implicated":[9],"in":[10,168,178,226],"the":[11,24,40,43,47,64,113,116,119,139,158,165,190,194,198,219],"development":[12],"and":[13,32,52,79,95,104,124,135,213,224],"progression":[14],"of":[15,18,23,30,66,77,115,129,193,197,211],"several":[16],"types":[17],"cancer.":[19],"The":[20,186],"-174G/C":[21,68,141,200],"polymorphism":[22,51,123,142,201,223],"IL6":[25,31,67,120,140,199],"gene":[26],"controls":[27,97,214],"serum":[28],"levels":[29],"may":[33],"be":[34],"associated":[35,146],"with":[36,69,84,147,157,202,207],"cancer":[37,53,70,93,125,148,151,203,225],"risk,":[38],"but":[39,176],"results":[41],"from":[42],"published":[44],"studies":[45],"on":[46],"association":[48,65,117,196],"between":[49,118,221],"this":[50,222],"risk":[54,152],"are":[55,215],"conflicting.":[56],"A":[57],"comprehensive":[58],"meta-analysis":[59,188],"was":[60,143,153],"conducted":[61],"to":[62,111,162,217],"assess":[63,112],"risk.":[71,126,149,204],"Studies":[72],"were":[73,98,109,131],"identified":[74],"by":[75,133],"searches":[76],"MEDLINE":[78],"HuGE":[80],"Published":[81],"Literature":[82],"databases,":[83],"no":[85],"restrictions.":[86],"An":[87],"eligible":[88],"83":[89],"articles":[90],"involving":[91],"44,735":[92],"patients":[94],"60,747":[96],"included.":[99],"Combined":[100],"odds":[101],"ratios":[102],"(ORs)":[103],"95%":[105,172,182],"confidence":[106],"intervals":[107],"(CIs)":[108],"used":[110],"strength":[114],"-174":[121],"G/C":[122],"Potential":[127],"sources":[128],"heterogeneity":[130],"explored":[132],"meta-regression":[134],"sensitivity":[136],"analysis.":[137],"Overall,":[138],"not":[144,177],"significantly":[145],"However,":[150],"increased":[154],"for":[155],"individuals":[156],"CC":[159],"genotype":[160,167],"compared":[161],"those":[163],"carrying":[164],"GG":[166],"African":[169],"populations":[170,180],"(OR=1.83,":[171],"CI":[173,183],"1.26-2.67,":[174],"P=0.002),":[175],"Caucasian":[179],"(OR=1.00,":[181],"0.92-1.08,":[184],"P=0.938).":[185],"present":[187],"provides":[189],"first":[191],"evidence":[192],"ethnic-specific":[195],"Further":[205],"investigations":[206],"large":[209],"number":[210],"cases":[212],"required":[216],"confirm":[218],"associations":[220],"Africans.":[227]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}