{"id":"https://openalex.org/W1978971276","doi":"https://doi.org/10.1016/j.bbr.2006.06.012","title":"Importance of early environment in the development of post-traumatic stress disorder-like behaviors","display_name":"Importance of early environment in the development of post-traumatic stress disorder-like behaviors","publication_year":2006,"publication_date":"2006-07-25","ids":{"openalex":"https://openalex.org/W1978971276","doi":"https://doi.org/10.1016/j.bbr.2006.06.012","mag":"1978971276","pmid":"https://pubmed.ncbi.nlm.nih.gov/16860405"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbr.2006.06.012","doi":"https://doi.org/10.1016/j.bbr.2006.06.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2006.06.012","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079788117","display_name":"Akihiro Imanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Imanaka","raw_affiliation_strings":["Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, 734-8551 Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, 734-8551 Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066885799","display_name":"Shigeru Morinobu","orcid":"https://orcid.org/0000-0002-7496-7519","observed_orcids":["https://orcid.org/0000-0002-7496-7519"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Morinobu","raw_affiliation_strings":["Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084856194","display_name":"Shigeru Toki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Toki","raw_affiliation_strings":["Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052376344","display_name":"Shigeto Yamawaki","orcid":"https://orcid.org/0000-0003-4263-6771","observed_orcids":["https://orcid.org/0000-0003-4263-6771"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shigeto Yamawaki","raw_affiliation_strings":["Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neurosciences, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052376344"],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":7.7401,"has_fulltext":false,"cited_by_count":154,"citation_normalized_percentile":{"value":0.97011017,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"173","issue":"1","first_page":"129","last_page":"137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9890000224113464},{"id":"https://openalex.org/keywords/childhood-adversity","display_name":"childhood adversity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neonatal-isolation","display_name":"neonatal isolation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/single-prolonged-stress","display_name":"single prolonged stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/environmental-enrichment","display_name":"environmental enrichment","score":0.7829999923706055},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.8600000143051147},{"id":"https://openalex.org/keywords/contextual-fear","display_name":"contextual fear","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.968999981880188},{"id":"https://openalex.org/keywords/hippocampal-dysfunction","display_name":"hippocampal dysfunction","score":0.7549999952316284},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.8920000195503235},{"id":"https://openalex.org/keywords/animal-model-of-ptsd","display_name":"animal model of PTSD","score":0.7110000252723694},{"id":"https://openalex.org/keywords/early-intervention","display_name":"early intervention","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.6885213851928711},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6428906321525574},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.629734992980957},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.6025276184082031},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.5313499569892883},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5120545029640198},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.44758903980255127},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.36317718029022217},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2685868442058563},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1946406066417694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D003214","descriptor_name":"Conditioning, Classical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005106","descriptor_name":"Exploratory Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005239","descriptor_name":"Fear","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012934","descriptor_name":"Social Isolation","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D013313","descriptor_name":"Stress Disorders, Post-Traumatic","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046352","descriptor_name":"Freezing Reaction, Cataleptic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbr.2006.06.012","doi":"https://doi.org/10.1016/j.bbr.2006.06.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2006.06.012","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},{"id":"pmid:16860405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16860405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural brain research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W270994188","https://openalex.org/W1505185418","https://openalex.org/W1536317835","https://openalex.org/W1918978841","https://openalex.org/W1920051840","https://openalex.org/W1974562646","https://openalex.org/W1984427714","https://openalex.org/W1988692227","https://openalex.org/W1998956745","https://openalex.org/W1999782689","https://openalex.org/W2002681563","https://openalex.org/W2017690535","https://openalex.org/W2018083571","https://openalex.org/W2018894807","https://openalex.org/W2022682022","https://openalex.org/W2027907042","https://openalex.org/W2031092093","https://openalex.org/W2034764820","https://openalex.org/W2039047753","https://openalex.org/W2047908047","https://openalex.org/W2054228615","https://openalex.org/W2054692302","https://openalex.org/W2055161357","https://openalex.org/W2059134061","https://openalex.org/W2061827178","https://openalex.org/W2067570041","https://openalex.org/W2070752314","https://openalex.org/W2075556243","https://openalex.org/W2091987951","https://openalex.org/W2107707803","https://openalex.org/W2111977586","https://openalex.org/W2118109922","https://openalex.org/W2119531941","https://openalex.org/W2120743339","https://openalex.org/W2123576168","https://openalex.org/W2135422013","https://openalex.org/W2144859742","https://openalex.org/W2151580142","https://openalex.org/W2170683957","https://openalex.org/W2170760271","https://openalex.org/W2170916852","https://openalex.org/W4299905289"],"related_works":["https://openalex.org/W4400721934","https://openalex.org/W2048986452","https://openalex.org/W1983196716","https://openalex.org/W1994520098","https://openalex.org/W1980129194","https://openalex.org/W3037896010","https://openalex.org/W7120637243","https://openalex.org/W2948165447","https://openalex.org/W4306667866","https://openalex.org/W1988637086"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}