{"id":"https://openalex.org/W1978969472","doi":"https://doi.org/10.1016/j.jalz.2009.04.911","title":"P4\u2010041: Voluntary exercise ameliorates both cognitive and noncognitive symptoms in the 3xTgAD mouse","display_name":"P4\u2010041: Voluntary exercise ameliorates both cognitive and noncognitive symptoms in the 3xTgAD mouse","publication_year":2009,"publication_date":"2009-06-25","ids":{"openalex":"https://openalex.org/W1978969472","doi":"https://doi.org/10.1016/j.jalz.2009.04.911","mag":"1978969472"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2009.04.911","doi":"https://doi.org/10.1016/j.jalz.2009.04.911","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.911","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014517534","display_name":"Yoelvis Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Yoelvis Garc\u00eda","raw_affiliation_strings":["Dept. Brain Ischemia and Neurodegeneration IIBB CSIC\u2010IDIBAPS Barcelona Spain","Dept. Brain Ischemia & Neurodegeneration, IIBB, CSIC-IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Brain Ischemia and Neurodegeneration IIBB CSIC\u2010IDIBAPS Barcelona Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]},{"raw_affiliation_string":"Dept. Brain Ischemia & Neurodegeneration, IIBB, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065265459","display_name":"Susana Revilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Susana Revilla","raw_affiliation_strings":["Dept. Brain Ischemia and Neurodegeneration IIBB CSIC\u2010IDIBAPS Barcelona Spain","Dept. Brain Ischemia & Neurodegeneration, IIBB, CSIC-IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Brain Ischemia and Neurodegeneration IIBB CSIC\u2010IDIBAPS Barcelona Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]},{"raw_affiliation_string":"Dept. Brain Ischemia & Neurodegeneration, IIBB, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005517954","display_name":"Rosa M. Crist\u00f2fol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosa Crist\u00f2fol","raw_affiliation_strings":["Dept. Brain Ischemia and Neurodegeneration IIBB CSIC\u2010IDIBAPS Barcelona Spain","Dept. Brain Ischemia & Neurodegeneration, IIBB, CSIC-IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Brain Ischemia and Neurodegeneration IIBB CSIC\u2010IDIBAPS Barcelona Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]},{"raw_affiliation_string":"Dept. Brain Ischemia & Neurodegeneration, IIBB, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011290846","display_name":"Crsistina Su\u00f1ol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Crsistina Su\u00f1ol","raw_affiliation_strings":["Dept. Neurochemistry and Neuropharmacology, IIBB, CSIC-IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Neurochemistry and Neuropharmacology, IIBB, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026487650","display_name":"Frank M. LaFerla","orcid":"https://orcid.org/0000-0003-2324-6911","observed_orcids":["https://orcid.org/0000-0003-2324-6911"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank LaFerla","raw_affiliation_strings":["Dept. Neurobiology and Behavior and Institute for Brain Aging, University of California, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Neurobiology and Behavior and Institute for Brain Aging, University of California, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069412405","display_name":"Lydia Gim\u00e9nez\u2010Llort","orcid":"https://orcid.org/0000-0002-4091-489X","observed_orcids":["https://orcid.org/0000-0002-4091-489X"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lydia Gim\u00e9nez\u2010Llort","raw_affiliation_strings":["Dept. Psychiatry and Forensic Medicine, Institute of Neuroscience, UAB, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Psychiatry and Forensic Medicine, Institute of Neuroscience, UAB, Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010410200","display_name":"Coral Sanfeliu","orcid":"https://orcid.org/0000-0002-9004-1206","observed_orcids":["https://orcid.org/0000-0002-9004-1206"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210126142","display_name":"Institut d'Investigacions Biom\u00e8diques de Barcelona","ror":"https://ror.org/02ysayy16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210126142"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Coral Sanfeliu","raw_affiliation_strings":["Dept. Brain Ischemia and Neurodegeneration IIBB CSIC\u2010IDIBAPS Barcelona Spain","Dept. Brain Ischemia & Neurodegeneration, IIBB, CSIC-IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Brain Ischemia and Neurodegeneration IIBB CSIC\u2010IDIBAPS Barcelona Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]},{"raw_affiliation_string":"Dept. Brain Ischemia & Neurodegeneration, IIBB, CSIC-IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014517534"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210126142","https://openalex.org/I4210160192"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.1171,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43597156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"4S_Part_15","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.12870000302791595,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voluntary-exercise","display_name":"voluntary exercise","score":0.9959999918937683},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5870306491851807},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.5762770175933838},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5130240321159363},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.4744471311569214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4715801775455475},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.44189244508743286},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.4299624562263489},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.42346084117889404},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4051892161369324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3641371726989746},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3253892958164215},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2766203284263611}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2009.04.911","doi":"https://doi.org/10.1016/j.jalz.2009.04.911","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.911","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5061607932","display_name":null,"funder_award_id":"RD06/0913/1004","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G6118188030","display_name":null,"funder_award_id":"062931","funder_id":"https://openalex.org/F4320310701","funder_display_name":"Fundaci\u00f3 la Marat\u00f3 de TV3"}],"funders":[{"id":"https://openalex.org/F4320310701","display_name":"Fundaci\u00f3 la Marat\u00f3 de TV3","ror":"https://ror.org/00t5xc355"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1861299606","https://openalex.org/W2085986782","https://openalex.org/W2962398716","https://openalex.org/W1986677236","https://openalex.org/W4298139055","https://openalex.org/W2066151668","https://openalex.org/W4404642717","https://openalex.org/W7099103052","https://openalex.org/W7113497476","https://openalex.org/W2409228408"],"abstract_inverted_index":{"The":[0],"beneficial":[1],"effects":[2,66,184],"of":[3,22,53,67,85,109,118,121,132,155,167,185,191,246,269,271,298],"regular":[4,35],"physical":[5],"exercise":[6,36,69,187,226,247,260,300],"in":[7,29,33,70,163,178,318],"older":[8],"patients":[9],"with":[10],"depression":[11],"and":[12,50,81,88,94,97,139,141,152,157,194,220,233,254,277,312,335],"other":[13],"mood":[14,51],"disorders":[15,52],"are":[16],"well":[17],"known.":[18],"Similarly,":[19],"a":[20,34,235,262,302],"number":[21],"studies":[23],"suggest":[24],"that":[25,44],"fitness":[26],"enhances":[27],"cognition":[28],"humans.":[30],"Therefore,":[31],"participation":[32],"program":[37],"is":[38,282],"increasingly":[39],"proposed":[40],"as":[41,301],"an":[42,105],"intervention":[43],"could":[45],"prevent":[46,307],"or":[47,129,308],"reduce":[48],"cognitive":[49,80,222,276],"age-associated":[54],"dementias,":[55],"mainly":[56],"Alzheimer's":[57],"disease":[58],"(AD).":[59],"In":[60,224],"this":[61],"work":[62,281,290,323],"we":[63],"analyzed":[64,173,182],"the":[65,89,183,266,286,296],"voluntary":[68,186,299],"triple":[71],"transgenic":[72],"3xTgAD":[73,96,198,272],"mouse":[74],"model":[75],"for":[76],"AD,":[77],"on":[78],"both":[79,275],"behavioral":[82,215],"psychiatric":[83],"symptoms":[84,311],"dementia":[86],"(BPSD)":[87],"underlying":[90],"neuronal":[91],"changes.":[92],"Male":[93],"female":[95],"wild":[98],"type":[99],"mice":[100,120],"had":[101,112,124],"free":[102],"access":[103],"to":[104,115,127,169,237,284,294,306,315],"activity":[106],"wheel.":[107],"Mice":[108],"4":[110,212],"months":[111,123,131,245],"been":[113,125],"submitted":[114,126],"one":[116,128,252],"month":[117,196],"exercise;":[119],"7":[122,195,209],"six":[130,244],"exercise.":[133],"Then,":[134],"sensorimotor":[135],"abilities,":[136],"BPSD-like":[137,278],"behaviors":[138],"learning":[140],"memory":[142],"were":[143,160,205,217],"tested.":[144],"Brain":[145],"amyloid":[146],"beta":[147],"was":[148,172,248,324],"determined":[149],"by":[150,326],"ELISA":[151],"immunohistochemistry.":[153],"Levels":[154],"glutathione":[156],"antioxidant":[158,231],"enzymes":[159],"quantified":[161],"spectrophotometrically":[162],"cerebral":[164,179],"cortex.":[165,180],"Binding":[166],"flunitrazepam":[168],"GABAA":[170,239],"receptor":[171,240],"through":[174],"radiometric":[175],"binding":[176],"methods":[177],"We":[181],"at":[188,208,211,265],"early":[189,267],"stages":[190,268],"AD":[192,202,270,310],"(4":[193],"old":[197],"mice).":[199],"As":[200],"expected,":[201],"neuropathological":[203,228],"traits":[204],"more":[206,292],"significant":[207],"than":[210,250],"months.":[213],"Main":[214],"alterations":[216],"higher":[218],"anxiety":[219],"lesser":[221],"capacity.":[223],"general,":[225],"ameliorated":[227],"behaviors,":[229],"increased":[230],"defense,":[232],"showed":[234,261],"tendency":[236],"ameliorate":[238,309],"functionality.":[241],"Neuroprotection":[242],"after":[243,251],"stronger":[249],"month,":[253],"totally":[255],"prevented":[256],"anxiety-related":[257],"behaviors.":[258,279],"Voluntary":[259],"neuroprotective":[263],"effect":[264],"mice,":[273],"including":[274],"More":[280],"ongoing":[283],"clarify":[285],"mechanisms":[287],"involved.":[288],"This":[289],"provides":[291],"evidence":[293],"demonstrate":[295],"validity":[297],"promising":[303],"coadyuvant":[304],"therapy":[305],"its":[313],"relevance":[314],"be":[316],"included":[317],"our":[319],"life":[320],"style.":[321],"(This":[322],"supported":[325],"grants":[327],"062931":[328],"from":[329,337],"Fundaci\u00f3":[330],"La":[331],"Marat\u00f3":[332],"de":[333],"TV3":[334],"RD06/0913/1004":[336],"ISCIII,":[338],"Spain).":[339]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
