{"id":"https://openalex.org/W1978963083","doi":"https://doi.org/10.1182/blood-2010-07-297861","title":"Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma","display_name":"Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W1978963083","doi":"https://doi.org/10.1182/blood-2010-07-297861","mag":"1978963083","pmid":"https://pubmed.ncbi.nlm.nih.gov/21088137"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2010-07-297861","doi":"https://doi.org/10.1182/blood-2010-07-297861","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2010-07-297861","pdf_url":"https://ashpublications.org/blood/article-pdf/117/4/1291/1341886/zh800411001291.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/117/4/1291/1341886/zh800411001291.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016540646","display_name":"Chang Ohk Sung","orcid":"https://orcid.org/0000-0002-8567-456X","observed_orcids":["https://orcid.org/0000-0002-8567-456X"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang Ohk Sung","raw_affiliation_strings":["Department of Pathology, Samsung medical center, Sungkyunkwan University School of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Samsung medical center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103102360","display_name":"Sang Cheol Kim","orcid":"https://orcid.org/0000-0003-4389-9178","observed_orcids":["https://orcid.org/0000-0003-4389-9178"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Cheol Kim","raw_affiliation_strings":["Department of Applied Statistics, Yonsei University, Seoul, South Korea;","Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea","Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Statistics, Yonsei University, Seoul, South Korea;","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001148883","display_name":"Sivasundaram Karnan","orcid":"https://orcid.org/0000-0003-2165-7565","observed_orcids":["https://orcid.org/0000-0003-2165-7565"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]},{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sivasundaram Karnan","raw_affiliation_strings":["Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan;","institution_ids":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080232316","display_name":"Kennosuke Karube","orcid":"https://orcid.org/0000-0002-1205-858X","observed_orcids":["https://orcid.org/0000-0002-1205-858X"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]},{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kennosuke Karube","raw_affiliation_strings":["Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan;","institution_ids":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014796445","display_name":"Hyung Jin Shin","orcid":"https://orcid.org/0000-0003-0856-7098","observed_orcids":["https://orcid.org/0000-0003-0856-7098"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung Jin Shin","raw_affiliation_strings":["Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090117550","display_name":"Do\u2010Hyun Nam","orcid":"https://orcid.org/0000-0002-8477-6791","observed_orcids":["https://orcid.org/0000-0002-8477-6791"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Do-Hyun Nam","raw_affiliation_strings":["Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086471391","display_name":"Yeon\u2010Lim Suh","orcid":"https://orcid.org/0000-0001-5809-2401","observed_orcids":["https://orcid.org/0000-0001-5809-2401"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeon-Lim Suh","raw_affiliation_strings":["Department of Pathology, Samsung medical center, Sungkyunkwan University School of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Samsung medical center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114626485","display_name":"Seok\u2010Hyung Kim","orcid":"https://orcid.org/0000-0001-9028-6919","observed_orcids":["https://orcid.org/0000-0001-9028-6919"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seok-Hyung Kim","raw_affiliation_strings":["Department of Applied Statistics, Yonsei University, Seoul, South Korea;","Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea","Department of Pathology, Samsung medical center, Sungkyunkwan University School of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Statistics, Yonsei University, Seoul, South Korea;","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Pathology, Samsung medical center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396597","display_name":"Ji\u2010Yeon Kim","orcid":"https://orcid.org/0000-0002-8713-1497","observed_orcids":["https://orcid.org/0000-0002-8713-1497"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Yeon Kim","raw_affiliation_strings":["Department of Pathology, Samsung medical center, Sungkyunkwan University School of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Samsung medical center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004166441","display_name":"Seok Jin Kim","orcid":"https://orcid.org/0000-0002-2776-4401","observed_orcids":["https://orcid.org/0000-0002-2776-4401"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seok Jin Kim","raw_affiliation_strings":["Department of Applied Statistics, Yonsei University, Seoul, South Korea;","Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea","Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Statistics, Yonsei University, Seoul, South Korea;","institution_ids":["https://openalex.org/I193775966"]},{"raw_affiliation_string":"Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071885891","display_name":"Won Seog Kim","orcid":"https://orcid.org/0000-0002-5400-0466","observed_orcids":["https://orcid.org/0000-0002-5400-0466"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won Seog Kim","raw_affiliation_strings":["Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027498478","display_name":"M Seto","orcid":"https://orcid.org/0000-0003-4257-1162","observed_orcids":["https://orcid.org/0000-0003-4257-1162"]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]},{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Seto","raw_affiliation_strings":["Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan;","institution_ids":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038504707","display_name":"Young Hyeh Ko","orcid":"https://orcid.org/0000-0002-4383-0579","observed_orcids":["https://orcid.org/0000-0002-4383-0579"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Hyeh Ko","raw_affiliation_strings":["Department of Pathology, Samsung medical center, Sungkyunkwan University School of Medicine, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Samsung medical center, Sungkyunkwan University School of Medicine, Seoul, South Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.8327,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.93423867,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"117","issue":"4","first_page":"1291","last_page":"1300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-central-nervous-system-lymphoma","display_name":"primary central nervous system lymphoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7239999771118164},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.7739999890327454},{"id":"https://openalex.org/keywords/9p21-3-deletion","display_name":"9p21.3 deletion","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6460000276565552},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.7599999904632568},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7390000224113464},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.7221989631652832},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.7048028111457825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6989582777023315},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.6958795785903931},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5969322919845581},{"id":"https://openalex.org/C2781173314","wikidata":"https://www.wikidata.org/wiki/Q3246818","display_name":"Primary central nervous system lymphoma","level":3,"score":0.5386545062065125},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5162417888641357},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4913746416568756},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4592004716396332},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.45055532455444336},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44661352038383484},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4186231195926666},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3270481824874878},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3238706588745117},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.16786399483680725},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1321677267551422}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016543","descriptor_name":"Central Nervous System Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D054928","descriptor_name":"Validation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2010-07-297861","doi":"https://doi.org/10.1182/blood-2010-07-297861","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2010-07-297861","pdf_url":"https://ashpublications.org/blood/article-pdf/117/4/1291/1341886/zh800411001291.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:21088137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21088137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2010-07-297861","doi":"https://doi.org/10.1182/blood-2010-07-297861","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2010-07-297861","pdf_url":"https://ashpublications.org/blood/article-pdf/117/4/1291/1341886/zh800411001291.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8241706749","display_name":"Understanding the molecular mechanisms of breast cancer by targeting mutant BRCA1 in hereditary breast cancer cells","funder_award_id":"22700888","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"},{"id":"https://openalex.org/F4320331722","display_name":"Samsung Biomedical Research Institute","ror":"https://ror.org/037pjb504"},{"id":"https://openalex.org/F4320332195","display_name":"Samsung","ror":"https://ror.org/04w3jy968"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978963083.pdf","grobid_xml":"https://content.openalex.org/works/W1978963083.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W179057203","https://openalex.org/W195781269","https://openalex.org/W1966059563","https://openalex.org/W1968291570","https://openalex.org/W1971423772","https://openalex.org/W1973167777","https://openalex.org/W1973850616","https://openalex.org/W1975852250","https://openalex.org/W1983965079","https://openalex.org/W1985164220","https://openalex.org/W1986815308","https://openalex.org/W2002898540","https://openalex.org/W2006120760","https://openalex.org/W2018487190","https://openalex.org/W2025621343","https://openalex.org/W2049693316","https://openalex.org/W2050604308","https://openalex.org/W2054018735","https://openalex.org/W2056350045","https://openalex.org/W2063150999","https://openalex.org/W2069526089","https://openalex.org/W2089766380","https://openalex.org/W2095102985","https://openalex.org/W2100253052","https://openalex.org/W2103914213","https://openalex.org/W2110369495","https://openalex.org/W2113909237","https://openalex.org/W2122598723","https://openalex.org/W2122683221","https://openalex.org/W2123106337","https://openalex.org/W2129831897","https://openalex.org/W2130410032","https://openalex.org/W2131769380","https://openalex.org/W2151600550","https://openalex.org/W2155746323","https://openalex.org/W2158217645","https://openalex.org/W2163338032","https://openalex.org/W2170126337","https://openalex.org/W2170741005","https://openalex.org/W2171869804","https://openalex.org/W2172201974","https://openalex.org/W2332991185","https://openalex.org/W6685272577"],"related_works":["https://openalex.org/W2889758918","https://openalex.org/W2020324291","https://openalex.org/W2109673671","https://openalex.org/W1971423772","https://openalex.org/W3187303179","https://openalex.org/W2323316436","https://openalex.org/W2566690248","https://openalex.org/W2316378089","https://openalex.org/W2153847647","https://openalex.org/W2032451867"],"abstract_inverted_index":{"Of":[0],"the":[1,46,65,76],"genetic":[2],"changes":[3,106],"in":[4,23,43,54,59,103,119,124,133,183],"primary":[5],"central":[6],"nervous":[7],"system":[8],"lymphoma":[9],"(PCNSL),":[10],"little":[11],"is":[12],"known.":[13],"To":[14],"detect":[15],"copy":[16,110],"number":[17,111],"alterations":[18],"and":[19,39,82,101,122,171,176],"differentially":[20],"expressed":[21],"genes":[22,68,93,115,131,195],"PCNSL,":[24],"we":[25,89,160],"analyzed":[26],"a":[27],"total":[28],"of":[29,45,144,173,185,202],"12":[30,47],"PCNSL":[31,81],"samples":[32],"with":[33,109,149],"high-resolution":[34],"array-based":[35,125],"comparative":[36,126],"genomic":[37,127],"hybridization":[38,128],"performed":[40],"expression":[41,79,105,120,143],"profiling":[42],"7":[44],"samples.":[48],"The":[49],"most":[50],"frequent":[51],"deletion":[52,123],"found":[53],"8":[55,91,114],"patients":[56],"(66.7%)":[57],"occurred":[58],"9p21.3":[60],"containing":[61],"CDKN2A.":[62],"We":[63],"compiled":[64],"top":[66],"96":[67],"(family-wise":[69],"error":[70],"rate,":[71],"P":[72],"<":[73],".05)":[74],"showing":[75],"greatest":[77],"differential":[78],"between":[80],"normal":[83],"lymph":[84],"node":[85],"tissues.":[86],"From":[87],"these,":[88],"selected":[90],"candidate":[92],"(NPFFR2,":[94],"C4orf7,":[95],"OSMR,":[96],"EMCN,":[97],"TPO,":[98],"FNDC1,":[99],"COL12A1,":[100],"MSC)":[102],"which":[104,179],"were":[107],"associated":[108,148],"aberrations.":[112],"All":[113],"showed":[116],"both":[117],"down-regulation":[118],"microarray":[121],"analyses.":[129],"These":[130],"participate":[132],"cell":[134,137],"signaling":[135],"or":[136],"adhesion.":[138],"In":[139,187],"addition,":[140],"low":[141],"mRNA":[142],"C4orf7":[145],"was":[146],"significantly":[147],"poor":[150],"survival":[151],"(P":[152],"=":[153],".0425).":[154],"Using":[155],"gene":[156],"set":[157],"enrichment":[158],"analysis,":[159],"identified":[161,191],"several":[162],"signal":[163],"transduction":[164],"pathways,":[165,178],"such":[166],"as":[167,199],"Janus":[168],"kinase-signal":[169],"transducers":[170],"activators":[172],"transcription":[174],"pathway":[175],"adhesion-related":[177],"may":[180,197],"be":[181],"involved":[182],"pathogenesis":[184],"PCNSL.":[186,203],"conclusion,":[188],"this":[189],"study":[190],"novel":[192],"tumor":[193],"suppressor":[194],"that":[196],"serve":[198],"therapeutic":[200],"targets":[201]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}