{"id":"https://openalex.org/W1978953702","doi":"https://doi.org/10.1210/endo.136.8.7628397","title":"Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV","display_name":"Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W1978953702","doi":"https://doi.org/10.1210/endo.136.8.7628397","mag":"1978953702","pmid":"https://pubmed.ncbi.nlm.nih.gov/7628397"},"language":"en","primary_location":{"id":"doi:10.1210/endo.136.8.7628397","doi":"https://doi.org/10.1210/endo.136.8.7628397","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.136.8.7628397","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036263560","display_name":"Timothy J. Kieffer","orcid":"https://orcid.org/0000-0003-4548-3176","observed_orcids":["https://orcid.org/0000-0003-4548-3176"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"T J Kieffer","raw_affiliation_strings":["Department of Physiology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111557732","display_name":"Christopher H.S. McIntosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C H McIntosh","raw_affiliation_strings":["Department of Physiology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113765887","display_name":"Raymond A. Pederson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R A Pederson","raw_affiliation_strings":["Department of Physiology, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":5.9658,"has_fulltext":false,"cited_by_count":1129,"citation_normalized_percentile":{"value":0.97031849,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"136","issue":"8","first_page":"3585","last_page":"3596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-dependent-insulinotropic-polypeptide","display_name":"glucose-dependent insulinotropic polypeptide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dipeptidyl-peptidase-4","display_name":"dipeptidyl peptidase IV","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hormone-degradation","display_name":"hormone degradation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/incretin-effect","display_name":"incretin effect","score":0.8199999928474426},{"id":"https://openalex.org/keywords/n-terminal-truncation","display_name":"N-terminal truncation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/diprotin-a","display_name":"diprotin A","score":0.9010000228881836},{"id":"https://openalex.org/keywords/radiolabeled-peptides","display_name":"radiolabeled peptides","score":0.7770000100135803},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.5379999876022339},{"id":"https://openalex.org/keywords/circulating-hormone-levels","display_name":"circulating hormone levels","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2781469919","wikidata":"https://www.wikidata.org/wiki/Q5279728","display_name":"Dipeptidyl peptidase","level":3,"score":0.8154554963111877},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7265681028366089},{"id":"https://openalex.org/C2778881409","wikidata":"https://www.wikidata.org/wiki/Q1420402","display_name":"Incretin","level":4,"score":0.7137900590896606},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.678748607635498},{"id":"https://openalex.org/C2776129832","wikidata":"https://www.wikidata.org/wiki/Q22677256","display_name":"Gastric inhibitory polypeptide","level":4,"score":0.6726666688919067},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6681925654411316},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6389670372009277},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.6000984311103821},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5409295558929443},{"id":"https://openalex.org/C56191518","wikidata":"https://www.wikidata.org/wiki/Q416997","display_name":"Peptide hormone","level":3,"score":0.48208552598953247},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.46987468004226685},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45453718304634094},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4490533471107483},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.43371397256851196},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.42654505372047424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40994197130203247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.363456666469574},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.10899651050567627},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.09971064329147339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09965535998344421},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001790","descriptor_name":"Blood Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004763","descriptor_name":"Glucagon-Like Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018819","descriptor_name":"Dipeptidyl Peptidase 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/endo.136.8.7628397","doi":"https://doi.org/10.1210/endo.136.8.7628397","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.136.8.7628397","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/en.136.8.3585","doi":"https://doi.org/10.1210/en.136.8.3585","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.136.8.3585","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:7628397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7628397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.782.1444","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.782.1444","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a3/78/jdi-3-096.PMC4020726.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W387887821","https://openalex.org/W1270261677","https://openalex.org/W1508760455","https://openalex.org/W1573917252","https://openalex.org/W1576285254","https://openalex.org/W1637070219","https://openalex.org/W1908301178","https://openalex.org/W1966041647","https://openalex.org/W1967383069","https://openalex.org/W1969932276","https://openalex.org/W1972481662","https://openalex.org/W1976837127","https://openalex.org/W1978279496","https://openalex.org/W1979613556","https://openalex.org/W1989303895","https://openalex.org/W2000465889","https://openalex.org/W2009615405","https://openalex.org/W2020603363","https://openalex.org/W2025375701","https://openalex.org/W2026890663","https://openalex.org/W2037484950","https://openalex.org/W2044511675","https://openalex.org/W2050046962","https://openalex.org/W2051839278","https://openalex.org/W2058328218","https://openalex.org/W2061274996","https://openalex.org/W2067643934","https://openalex.org/W2080128749","https://openalex.org/W2086238197","https://openalex.org/W2097717126","https://openalex.org/W2102977341","https://openalex.org/W2104763836","https://openalex.org/W2126888750","https://openalex.org/W2132802847","https://openalex.org/W2162061338","https://openalex.org/W2202101161"],"related_works":["https://openalex.org/W7096485094","https://openalex.org/W2337661560","https://openalex.org/W2111865924","https://openalex.org/W2044380964","https://openalex.org/W2104239190","https://openalex.org/W1971244959","https://openalex.org/W2054649558","https://openalex.org/W2057802735","https://openalex.org/W2106824929","https://openalex.org/W2080010918"],"abstract_inverted_index":{"The":[0,66,249],"combined":[1],"actions":[2],"of":[3,45,68,81,96,110,212,223,242,262,264],"glucose-dependent":[4],"insulinotropic":[5],"polypeptide":[6],"(GIP)":[7],"and":[8,33,47,64,90,129,150,215,266,270],"truncated":[9,182],"glucagon-like":[10],"peptide-1":[11],"(tGLP-1)":[12],"may":[13,206,228,255],"fully":[14],"account":[15],"for":[16,258],"the":[17,25,43,50,59,69,79,97,124,137,147,162,173,181,192,220,224,233,260],"incretin":[18],"effect.":[19],"These":[20,131,187],"hormones":[21,83],"are":[22],"released":[23],"from":[24,155,232],"small":[26],"intestine":[27],"in":[28,84,123,146,217,252,268],"response":[29],"to":[30,73,77,180],"oral":[31],"glucose":[32],"stimulate":[34],"insulin":[35],"release.":[36],"Recently,":[37],"evidence":[38],"has":[39],"been":[40],"provided":[41],"demonstrating":[42],"degradation":[44,80,95],"GIP-(1-42)":[46],"GLP-1-(7-36)NH2":[48],"by":[49,92,105,237],"serum":[51,117,154],"enzyme":[52,211],"dipeptidyl":[53],"peptidase":[54],"IV":[55,121,140,205,226],"(DPP":[56],"IV)":[57],"into":[58,167,196],"biologically":[60,234],"inactive":[61],"products":[62,127,132,188,222],"GIP-(3-42)":[63],"GLP-1-(9-36)NH2.":[65],"objective":[67],"current":[70],"investigation":[71],"was":[72,102,144,159,178],"develop":[74],"a":[75,208],"method":[76,250],"monitor":[78],"these":[82],"vivo.":[85,218],"Synthetic":[86],"peptides":[87,98,164],"were":[88,133,151,165,189,194],"radiolabeled":[89],"purified":[91,119],"HPLC.":[93],"Subsequent":[94],"under":[99],"various":[100],"conditions":[101],"then":[103],"monitored":[104],"further":[106],"HPLC":[107],"analysis.":[108],"Incubation":[109],"[125I]GIP-(1-42)":[111],"or":[112,118],"[125I]GLP-1-(7-36)NH2":[113],"with":[114],"Wistar":[115],"rat":[116],"DPP":[120,139,156,197,204,225],"resulted":[122],"major":[125],"N-terminal-truncated":[126,221],"[125I]GIP-(3-42)":[128],"[125I]GLP-1-(9-36)NH2.":[130],"significantly":[134],"reduced":[135],"when":[136,153,191],"specific":[138],"inhibitor":[141],"diprotin":[142],"A":[143],"included":[145],"incubation":[148],"mixture":[149],"absent":[152,190],"IV-deficient":[157,198],"rats":[158,168],"used.":[160],"When":[161],"labeled":[163],"infused":[166,195],"at":[169],"hormone":[170,236,244],"levels":[171,245],"within":[172,184],"physiological":[174],"range,":[175],"over":[176],"50%":[177],"metabolized":[179],"forms":[183],"2":[185],"min.":[186],"tracers":[193],"animals.":[199],"It":[200],"is":[201],"concluded":[202],"that":[203],"be":[207,230,247,256],"primary":[209],"inactivating":[210],"both":[213],"GIP":[214,265],"tGLP-1":[216,267],"As":[219],"cleavage":[227],"not":[229],"distinguished":[231],"active":[235],"currently":[238],"employed":[239],"assays,":[240],"reports":[241],"circulating":[243],"should":[246],"reconsidered.":[248],"described":[251],"this":[253],"manuscript":[254],"useful":[257],"investigating":[259],"durations":[261],"action":[263],"normal":[269],"pathophysiological":[271],"conditions.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":31},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":37},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":37},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":42},{"year":2016,"cited_by_count":40},{"year":2015,"cited_by_count":55},{"year":2014,"cited_by_count":47},{"year":2013,"cited_by_count":53},{"year":2012,"cited_by_count":61}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
