{"id":"https://openalex.org/W1978950093","doi":"https://doi.org/10.1262/jrd.09-214h","title":"Synergistic Effects of Glutathione and .BETA.-Mercaptoethanol Treatment During In Vitro Maturation of Porcine Oocytes on Early Embryonic Development in a Culture System Supplemented with L-cysteine","display_name":"Synergistic Effects of Glutathione and .BETA.-Mercaptoethanol Treatment During In Vitro Maturation of Porcine Oocytes on Early Embryonic Development in a Culture System Supplemented with L-cysteine","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1978950093","doi":"https://doi.org/10.1262/jrd.09-214h","mag":"1978950093","pmid":"https://pubmed.ncbi.nlm.nih.gov/20657156"},"language":"en","primary_location":{"id":"doi:10.1262/jrd.09-214h","doi":"https://doi.org/10.1262/jrd.09-214h","is_oa":true,"landing_page_url":"https://doi.org/10.1262/jrd.09-214h","pdf_url":"https://www.jstage.jst.go.jp/article/jrd/56/6/56_09-214H/_pdf","source":{"id":"https://openalex.org/S192692459","display_name":"Journal of Reproduction and Development","issn_l":"0916-8818","issn":["0916-8818","1348-4400"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313575","host_organization_name":"Japanese Society of Animal Reproduction","host_organization_lineage":["https://openalex.org/P4310313575"],"host_organization_lineage_names":["Japanese Society of Animal Reproduction"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jstage.jst.go.jp/article/jrd/56/6/56_09-214H/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068096033","display_name":"Changyong Choe","orcid":"https://orcid.org/0000-0003-4222-3360","observed_orcids":["https://orcid.org/0000-0003-4222-3360"]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]},{"id":"https://openalex.org/I4210128007","display_name":"National Institute of Animal Science","ror":"https://ror.org/02ty3a980","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128007"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Changyong CHOE","raw_affiliation_strings":["Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA","institution_ids":["https://openalex.org/I2800443534","https://openalex.org/I4210128007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108396129","display_name":"Yong-Won SHIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-Won SHIN","raw_affiliation_strings":["Department of Physiology, Institute of Health Sciences, Gyeongsang National University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Institute of Health Sciences, Gyeongsang National University School of Medicine","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462748","display_name":"Eun\u2010Jin Kim","orcid":"https://orcid.org/0000-0003-1068-9334","observed_orcids":["https://orcid.org/0000-0003-1068-9334"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Jin KIM","raw_affiliation_strings":["Department of Physiology, Institute of Health Sciences, Gyeongsang National University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Institute of Health Sciences, Gyeongsang National University School of Medicine","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001583598","display_name":"Sang\u2010Rae Cho","orcid":"https://orcid.org/0000-0003-0209-6248","observed_orcids":["https://orcid.org/0000-0003-0209-6248"]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]},{"id":"https://openalex.org/I4210128007","display_name":"National Institute of Animal Science","ror":"https://ror.org/02ty3a980","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128007"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang-Rae CHO","raw_affiliation_strings":["Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA","institution_ids":["https://openalex.org/I2800443534","https://openalex.org/I4210128007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112653958","display_name":"Hyunjong Kim","orcid":"https://orcid.org/0000-0002-5574-7369","observed_orcids":["https://orcid.org/0000-0002-5574-7369"]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]},{"id":"https://openalex.org/I4210128007","display_name":"National Institute of Animal Science","ror":"https://ror.org/02ty3a980","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128007"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Jong KIM","raw_affiliation_strings":["Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA","institution_ids":["https://openalex.org/I2800443534","https://openalex.org/I4210128007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101743232","display_name":"Sun-Ho Choi","orcid":"https://orcid.org/0000-0003-4027-8923","observed_orcids":["https://orcid.org/0000-0003-4027-8923"]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]},{"id":"https://openalex.org/I4210128007","display_name":"National Institute of Animal Science","ror":"https://ror.org/02ty3a980","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128007"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sun-Ho CHOI","raw_affiliation_strings":["Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA","institution_ids":["https://openalex.org/I2800443534","https://openalex.org/I4210128007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023233838","display_name":"Manhye Han","orcid":"https://orcid.org/0000-0002-8104-4587","observed_orcids":["https://orcid.org/0000-0002-8104-4587","https://orcid.org/0000-0002-5152-1979"]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]},{"id":"https://openalex.org/I4210128007","display_name":"National Institute of Animal Science","ror":"https://ror.org/02ty3a980","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128007"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Man-Hye HAN","raw_affiliation_strings":["Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA","institution_ids":["https://openalex.org/I2800443534","https://openalex.org/I4210128007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103057451","display_name":"Jaehee Han","orcid":"https://orcid.org/0000-0002-3523-008X","observed_orcids":["https://orcid.org/0000-0002-3523-008X"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaehee HAN","raw_affiliation_strings":["Department of Physiology, Institute of Health Sciences, Gyeongsang National University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Institute of Health Sciences, Gyeongsang National University School of Medicine","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111718155","display_name":"Dongsoo Son","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800443534","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50","country_code":"KR","type":"government","lineage":["https://openalex.org/I2800443534","https://openalex.org/I2801339556","https://openalex.org/I4210090853"]},{"id":"https://openalex.org/I4210128007","display_name":"National Institute of Animal Science","ror":"https://ror.org/02ty3a980","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210128007"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Soo SON","raw_affiliation_strings":["Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA","institution_ids":["https://openalex.org/I2800443534","https://openalex.org/I4210128007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002369637","display_name":"Dawon Kang","orcid":"https://orcid.org/0000-0001-7402-7298","observed_orcids":["https://orcid.org/0000-0001-7402-7298"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dawon KANG","raw_affiliation_strings":["Department of Physiology, Institute of Health Sciences, Gyeongsang National University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Institute of Health Sciences, Gyeongsang National University School of Medicine","institution_ids":["https://openalex.org/I189442560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":110000,"currency":"JPY","value_usd":828},"apc_paid":{"value":110000,"currency":"JPY","value_usd":828},"fwci":3.2209,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.90246119,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"56","issue":"6","first_page":"575","last_page":"582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9100000262260437},{"id":"https://openalex.org/keywords/2-mercaptoethanol","display_name":"2-mercaptoethanol","score":0.9629999995231628},{"id":"https://openalex.org/keywords/in-vitro-maturation","display_name":"in vitro maturation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/porcine-oocytes","display_name":"porcine oocytes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/early-embryonic-development","display_name":"early embryonic development","score":0.7699999809265137},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cysteine","display_name":"cysteine","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.7630000114440918},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9929999709129333},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7559999823570251},{"id":"https://openalex.org/keywords/oxygen-partial-pressure","display_name":"oxygen partial pressure","score":0.777999997138977},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.8330000042915344},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dithiothreitol","display_name":"dithiothreitol","score":0.9769999980926514},{"id":"https://openalex.org/keywords/embryo-quality","display_name":"embryo quality","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.9269559383392334},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.8128789067268372},{"id":"https://openalex.org/C2777824588","wikidata":"https://www.wikidata.org/wiki/Q414783","display_name":"Dithiothreitol","level":3,"score":0.7874437570571899},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6743600368499756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6028637290000916},{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.5842524170875549},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5386725664138794},{"id":"https://openalex.org/C2993207723","wikidata":"https://www.wikidata.org/wiki/Q4927803","display_name":"Oxygen tension","level":3,"score":0.5182752013206482},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5077689290046692},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.5023324489593506},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.48935431241989136},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.48823264241218567},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4133663773536682},{"id":"https://openalex.org/C2776231299","wikidata":"https://www.wikidata.org/wiki/Q245489","display_name":"Trolox","level":4,"score":0.4128301739692688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3827223479747772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20241931080818176},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1633094847202301},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.16268548369407654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12664669752120972},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06245723366737366},{"id":"https://openalex.org/C2993539680","wikidata":"https://www.wikidata.org/wiki/Q902552","display_name":"Antioxidant capacity","level":3,"score":0.04958850145339966},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000822","descriptor_name":"Animal Husbandry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001755","descriptor_name":"Blastocyst","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004477","descriptor_name":"Ectogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008623","descriptor_name":"Mercaptoethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046149","descriptor_name":"Embryo Culture Techniques","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1262/jrd.09-214h","doi":"https://doi.org/10.1262/jrd.09-214h","is_oa":true,"landing_page_url":"https://doi.org/10.1262/jrd.09-214h","pdf_url":"https://www.jstage.jst.go.jp/article/jrd/56/6/56_09-214H/_pdf","source":{"id":"https://openalex.org/S192692459","display_name":"Journal of Reproduction and Development","issn_l":"0916-8818","issn":["0916-8818","1348-4400"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313575","host_organization_name":"Japanese Society of Animal Reproduction","host_organization_lineage":["https://openalex.org/P4310313575"],"host_organization_lineage_names":["Japanese Society of Animal Reproduction"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:20657156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20657156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of reproduction and development","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1262/jrd.09-214h","doi":"https://doi.org/10.1262/jrd.09-214h","is_oa":true,"landing_page_url":"https://doi.org/10.1262/jrd.09-214h","pdf_url":"https://www.jstage.jst.go.jp/article/jrd/56/6/56_09-214H/_pdf","source":{"id":"https://openalex.org/S192692459","display_name":"Journal of Reproduction and Development","issn_l":"0916-8818","issn":["0916-8818","1348-4400"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310313575","host_organization_name":"Japanese Society of Animal Reproduction","host_organization_lineage":["https://openalex.org/P4310313575"],"host_organization_lineage_names":["Japanese Society of Animal Reproduction"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Reproduction and Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1307146023","display_name":null,"funder_award_id":"R13-2005-012-01002-0","funder_id":"https://openalex.org/F4320322348","funder_display_name":"Korea Science and Engineering Foundation"}],"funders":[{"id":"https://openalex.org/F4320322035","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50"},{"id":"https://openalex.org/F4320322348","display_name":"Korea Science and Engineering Foundation","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978950093.pdf","grobid_xml":"https://content.openalex.org/works/W1978950093.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W264653980","https://openalex.org/W1973610909","https://openalex.org/W1974437591","https://openalex.org/W1974523692","https://openalex.org/W1980991287","https://openalex.org/W2003607285","https://openalex.org/W2008924154","https://openalex.org/W2011253403","https://openalex.org/W2013213565","https://openalex.org/W2014464569","https://openalex.org/W2022792661","https://openalex.org/W2025265372","https://openalex.org/W2025524098","https://openalex.org/W2026336054","https://openalex.org/W2027016520","https://openalex.org/W2028171269","https://openalex.org/W2029661934","https://openalex.org/W2030541670","https://openalex.org/W2033929646","https://openalex.org/W2037858454","https://openalex.org/W2038811443","https://openalex.org/W2044114183","https://openalex.org/W2047450020","https://openalex.org/W2047775471","https://openalex.org/W2049138346","https://openalex.org/W2069414533","https://openalex.org/W2085774027","https://openalex.org/W2090276809","https://openalex.org/W2095756963","https://openalex.org/W2110479195","https://openalex.org/W2111219076","https://openalex.org/W2114267349","https://openalex.org/W2120322690","https://openalex.org/W2122487724","https://openalex.org/W2140242585","https://openalex.org/W2141917247","https://openalex.org/W2152696378","https://openalex.org/W2156701434","https://openalex.org/W2159633860","https://openalex.org/W2167631182","https://openalex.org/W2167939240","https://openalex.org/W2185607594","https://openalex.org/W3092519173","https://openalex.org/W4245957869"],"related_works":["https://openalex.org/W2117900553","https://openalex.org/W2591910881","https://openalex.org/W1967355102","https://openalex.org/W2437366919","https://openalex.org/W1990044131","https://openalex.org/W2076657451","https://openalex.org/W2089222313","https://openalex.org/W2020264447","https://openalex.org/W1976109989","https://openalex.org/W2151059198"],"abstract_inverted_index":{"Various":[0],"methods":[1],"have":[2],"been":[3],"used":[4,247],"to":[5,61,90,129,188],"remove":[6],"reactive":[7],"oxygen":[8,30],"species":[9],"(ROS)":[10],"generated":[11],"from":[12],"in":[13,76,94,173,186,255],"vitro":[14],"culture":[15,96],"(IVC)":[16],"conditions":[17],"that":[18,230],"can":[19],"cause":[20],"cell":[21,164,194],"injury":[22],"or":[23,122,178,203,215,237],"death,":[24],"including":[25],"the":[26,34,63,71,83,91,104,130,135,157,162,174,189],"application":[27],"of":[28,36,41,48,68,73,86,118,176,206,213,233,250],"low":[29],"(O(2))":[31],"tension":[32,45],"and":[33,43,65,114,154,183,192],"addition":[35,117],"antioxidants.":[37],"The":[38,211],"beneficial":[39],"effects":[40,64,85],"antioxidants":[42,69,87,105],"O(2)":[44,222],"on":[46,88],"IVC":[47,78,256],"porcine":[49,74,253],"embryos,":[50],"however,":[51,196],"are":[52,208],"controversial":[53],"among":[54],"researchers.":[55],"In":[56,160],"this":[57],"study,":[58],"we":[59,81],"sought":[60],"determine":[62],"optimal":[66],"concentrations":[67],"for":[70,143,150,156,248],"development":[72,89,128,187],"embryos":[75],"an":[77],"system.":[79],"Specifically,":[80],"examined":[82],"synergistic":[84],"blastocyst":[92,131,167,190],"stage":[93,132,191],"a":[95,231],"system":[97],"supplemented":[98],"with":[99,134,217,241],"L-cysteine":[100,218,244],"during":[101],"IVM.":[102],"Of":[103],"tested":[106],"(melatonin,":[107],"glutathione":[108],"(GSH),":[109],"\u03b2-mercaptoethanol":[110],"(\u03b2-ME),":[111],"N-acetylcysteine":[112],"(NAC)":[113],"dithiothreitol":[115],"(DTT)),":[116],"GSH":[119,177,214,236],"(1":[120],"mM)":[121],"\u03b2-ME":[123,153,216,240],"(25":[124],"\u00b5M)":[125],"significantly":[126,219],"increased":[127,169],"compared":[133],"controls":[136],"without":[137],"antioxidant":[138],"treatment":[139],"(22.2":[140],"\u00b1":[141,148],"4.2%":[142],"1":[144,234,242],"mM":[145,235,243],"GSH,":[146],"25.9":[147],"2.2%":[149],"25":[151,238],"\u00b5M":[152,239],"12-13%":[155],"control,":[158],"P<0.05).":[159],"addition,":[161],"mean":[163],"number":[165],"per":[166],"was":[168],"by":[170,200],"approximately":[171],"1.7-fold":[172],"presence":[175],"\u03b2":[179],"-ME.":[180],"These":[181,227],"GSH-":[182],"\u03b2-ME-induced":[184],"increases":[185],"total":[193],"number,":[195],"were":[197],"not":[198],"mimicked":[199],"melatonin,":[201],"NAC":[202],"DTT,":[204],"all":[205],"which":[207],"ROS":[209,224],"scavengers.":[210],"combination":[212,232],"reduced":[220],"high":[221,251],"tension-induced":[223],"production":[225,249],"(P<0.05).":[226],"results":[228],"suggest":[229],"could":[245],"be":[246],"quality":[252],"blastocysts":[254],"systems.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}