{"id":"https://openalex.org/W1978925250","doi":"https://doi.org/10.2967/jnumed.107.041079","title":"Image-Derived Input Function for Assessment of 18F-FDG Uptake by the Inflamed Lung","display_name":"Image-Derived Input Function for Assessment of 18F-FDG Uptake by the Inflamed Lung","publication_year":2007,"publication_date":"2007-10-18","ids":{"openalex":"https://openalex.org/W1978925250","doi":"https://doi.org/10.2967/jnumed.107.041079","mag":"1978925250","pmid":"https://pubmed.ncbi.nlm.nih.gov/17942803","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3172049"},"language":"en","primary_location":{"id":"doi:10.2967/jnumed.107.041079","doi":"https://doi.org/10.2967/jnumed.107.041079","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.107.041079","pdf_url":"https://jnm.snmjournals.org/content/jnumed/48/11/1889.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnm.snmjournals.org/content/jnumed/48/11/1889.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079950082","display_name":"Tobias Schroeder","orcid":"https://orcid.org/0000-0002-4439-8060","observed_orcids":["https://orcid.org/0000-0002-4439-8060"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Schroeder","raw_affiliation_strings":["Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. tschroder@partners.org","Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. tschroder@partners.org","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110565103","display_name":"Marcos F. Vidal Melo","orcid":"https://orcid.org/0000-0002-4901-4185","observed_orcids":["https://orcid.org/0000-0002-4901-4185"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. F. Vidal Melo","raw_affiliation_strings":["Department of Anesthesia and Critical Care , Massachusetts General Hospital , 55 Fruit St. , Boston , MA 02114 ","Department of Anesthesia and Critical Care , Massachusetts General Hospital and Harvard Medical School , Boston , Massachusetts ; and","Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Critical Care , Massachusetts General Hospital , 55 Fruit St. , Boston , MA 02114 ","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia and Critical Care , Massachusetts General Hospital and Harvard Medical School , Boston , Massachusetts ; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043655290","display_name":"Guido Musch","orcid":"https://orcid.org/0000-0003-1170-8699","observed_orcids":["https://orcid.org/0000-0003-1170-8699"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Musch","raw_affiliation_strings":["Department of Anesthesia and Critical Care , Massachusetts General Hospital and Harvard Medical School , Boston , Massachusetts ; and","Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Critical Care , Massachusetts General Hospital and Harvard Medical School , Boston , Massachusetts ; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109365667","display_name":"Robert Scott Harris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. S. Harris","raw_affiliation_strings":["Department of Medicine (Pulmonary and Critical Care Unit), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Pulmonary and Critical Care Unit), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109256589","display_name":"Jose Gabriel Venegas","orcid":"https://orcid.org/0009-0005-9531-9405","observed_orcids":["https://orcid.org/0009-0005-9531-9405"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. G. Venegas","raw_affiliation_strings":["Department of Anesthesia and Critical Care , Massachusetts General Hospital and Harvard Medical School , Boston , Massachusetts ; and","Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Critical Care , Massachusetts General Hospital and Harvard Medical School , Boston , Massachusetts ; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085792559","display_name":"Tilo Winkler","orcid":"https://orcid.org/0000-0002-7276-5550","observed_orcids":["https://orcid.org/0000-0002-7276-5550"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Winkler","raw_affiliation_strings":["Department of Anesthesia and Critical Care , Massachusetts General Hospital and Harvard Medical School , Boston , Massachusetts ; and","Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Critical Care , Massachusetts General Hospital and Harvard Medical School , Boston , Massachusetts ; and","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9944,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.89659974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"48","issue":"11","first_page":"1889","last_page":"1896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/18f-fdg","display_name":"18F-FDG","score":0.9860000014305115},{"id":"https://openalex.org/keywords/time-activity-curves","display_name":"time-activity curves","score":0.7149999737739563},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/two-parameter-model","display_name":"two-parameter model","score":0.5839999914169312},{"id":"https://openalex.org/keywords/dynamic-pet","display_name":"dynamic PET","score":0.5540000200271606},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C2988731192","wikidata":"https://www.wikidata.org/wiki/Q7410159","display_name":"Blood sampling","level":2,"score":0.621110737323761},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.5560019612312317},{"id":"https://openalex.org/C19609008","wikidata":"https://www.wikidata.org/wiki/Q2138203","display_name":"Region of interest","level":2,"score":0.5187326073646545},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4621478021144867},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.41268664598464966},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.39393043518066406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3192073702812195},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30523359775543213},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.21477729082107544},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.1958118975162506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14698773622512817},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.07926696538925171},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2967/jnumed.107.041079","doi":"https://doi.org/10.2967/jnumed.107.041079","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.107.041079","pdf_url":"https://jnm.snmjournals.org/content/jnumed/48/11/1889.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},{"id":"pmid:17942803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17942803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2177587","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3172049","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3172049","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3172049","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Nucl Med","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.543.9545","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.543.9545","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/48/11/1889.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.545.1360","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.545.1360","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/early/2007/10/17/jnumed.107.041079.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2967/jnumed.107.041079","doi":"https://doi.org/10.2967/jnumed.107.041079","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.107.041079","pdf_url":"https://jnm.snmjournals.org/content/jnumed/48/11/1889.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1622352503","display_name":null,"funder_award_id":"HL068011","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1954050789","display_name":null,"funder_award_id":"068011","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3248224382","display_name":null,"funder_award_id":"HL076464","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3696950997","display_name":null,"funder_award_id":"HL-056879","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3935947977","display_name":"Regional Lung Function in Acute Lung Injury","funder_award_id":"K08HL076464","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5703666592","display_name":"PET Imaging of Local Inflammation and Function in Ventilator Induced Lung Injury","funder_award_id":"R01HL086827","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7162952635","display_name":"REGIONAL CONTROLLERS OF PULMONARY GAS EXCHANGE","funder_award_id":"5r01hl056879-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8732341684","display_name":"Regional Gas Trapping in Bronchoconstricted Asthmatics","funder_award_id":"R01HL068011","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"},{"id":"https://openalex.org/F4320330250","display_name":"Roland Ernst Stiftung","ror":"https://ror.org/03m629g08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978925250.pdf","grobid_xml":"https://content.openalex.org/works/W1978925250.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1833829642","https://openalex.org/W1926948348","https://openalex.org/W1970174650","https://openalex.org/W1983817514","https://openalex.org/W1994168320","https://openalex.org/W2037232743","https://openalex.org/W2046339785","https://openalex.org/W2051228374","https://openalex.org/W2090203522","https://openalex.org/W2090306035","https://openalex.org/W2092078486","https://openalex.org/W2092084371","https://openalex.org/W2097389043","https://openalex.org/W2103796724","https://openalex.org/W2106932505","https://openalex.org/W2111251126","https://openalex.org/W2128138087","https://openalex.org/W2132038995","https://openalex.org/W2155105246","https://openalex.org/W2157066862","https://openalex.org/W2163794208","https://openalex.org/W2181620286","https://openalex.org/W2187201976","https://openalex.org/W2253706887","https://openalex.org/W2286991079","https://openalex.org/W2316519205","https://openalex.org/W7073913360"],"related_works":["https://openalex.org/W2165556954","https://openalex.org/W2541470860","https://openalex.org/W2130933585","https://openalex.org/W2111251126","https://openalex.org/W7100800378","https://openalex.org/W3128500496","https://openalex.org/W2132607678","https://openalex.org/W2273771294","https://openalex.org/W2112547854","https://openalex.org/W1992262937"],"abstract_inverted_index":{"UNLABELLED:":[0],"Pulmonary":[1],"uptake":[2,214],"of":[3,16,26,31,66,86,141,208,249,257,276,289,307],"(18)F-FDG":[4,213,279,309],"assessed":[5],"with":[6,108,170,226,312],"PET":[7,72],"has":[8],"been":[9],"used":[10,112],"to":[11,56,113,129,192,200,246],"quantify":[12],"the":[13,20,84,93,97,115,123,127,139,142,149,156,165,178,205,209,240,247,254,258,268,272,277,286],"metabolic":[14],"activity":[15,85,118],"inflammatory":[17],"cells":[18],"in":[19,35,70,168,216,310],"lung.":[21],"This":[22,49,299],"assessment":[23],"involves":[24],"modeling":[25,306],"tracer":[27],"kinetics":[28,207],"and":[29,52,88,126,144,147,282,319],"knowledge":[30],"a":[32,54,63,80,131,290,295],"time-activity":[33,94,157,179],"curve":[34,95,158,180],"pulmonary":[36,166,278,308,317,322],"artery":[37,167],"plasma":[38],"as":[39],"an":[40,59,105,189],"input":[41,60,133,194,280,297],"function,":[42],"usually":[43],"acquired":[44],"by":[45,152,160],"manual":[46,161,231],"blood":[47,87,110,162,232,251,266],"sampling.":[48],"paper":[50],"presents":[51],"validates":[53],"method":[55,76,128,187,223,269,300],"accurately":[57,176,270],"derive":[58,130,193],"function":[61,134,281],"from":[62,90,135,164,181],"blood-pool":[64,259,292],"region":[65],"interest":[67],"(ROI)":[68],"defined":[69,137],"dynamic":[71],"images.":[73],"METHODS:":[74],"The":[75,99,174,184,212],"is":[77],"based":[78],"on":[79],"2-parameter":[81,124],"model":[82,100,125,175,241],"describing":[83],"that":[89,196],"spillover":[91],"into":[92],"for":[96,138,148],"ROI.":[98],"parameters":[101],"are":[102],"determined":[103],"using":[104,221,230],"iterative":[106],"algorithm,":[107],"2":[109,263],"samples":[111,252],"calibrate":[114],"raw":[116],"PET-derived":[117],"data.":[119],"We":[120],"validated":[121],"both":[122],"quantitative":[132],"ROIs":[136],"cavities":[140],"right":[143],"left":[145],"heart":[146],"descending":[150],"aorta":[151],"comparing":[153],"them":[154],"against":[155],"obtained":[159,220,228],"sampling":[163,233],"lungs":[169,219],"acute":[171],"inflammation.":[172],"RESULTS:":[173],"described":[177],"sampled":[182,202],"blood.":[183],"2-sample":[185],"calibration":[186,250],"provided":[188],"efficient":[190],"algorithm":[191],"functions":[195],"were":[197],"virtually":[198],"identical":[199],"those":[201,227],"manually,":[203],"including":[204],"fast":[206],"early":[210],"phase.":[211],"rates":[215],"acutely":[217],"injured":[218],"this":[222],"correlated":[224],"well":[225],"exclusively":[229],"(R(2)":[234],">":[235],"0.993).":[236],"Within":[237],"some":[238],"bounds,":[239],"was":[242],"found":[243],"quite":[244],"insensitive":[245],"timing":[248],"or":[253,294,314],"exact":[255],"definition":[256],"ROIs.":[260],"CONCLUSION:":[261],"Using":[262],"mixed":[264],"venous":[265],"samples,":[267],"assesses":[271],"entire":[273],"time":[274],"course":[275],"does":[283],"not":[284],"require":[285],"precise":[287],"geometry":[288],"specific":[291],"ROI":[293],"population-based":[296],"function.":[298],"may":[301],"substantially":[302],"facilitate":[303],"studies":[304],"involving":[305],"patients":[311],"viral":[313],"bacterial":[315],"infections,":[316],"fibrosis,":[318],"chronic":[320],"obstructive":[321],"disease.":[323]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}