{"id":"https://openalex.org/W1978872258","doi":"https://doi.org/10.2174/1874827900801010033","title":"New Perspectives for the Treatment of Alzheimer\u2019s Disease~!2008-10-07~!2008-10-30~!2008-11-26~!","display_name":"New Perspectives for the Treatment of Alzheimer\u2019s Disease~!2008-10-07~!2008-10-30~!2008-11-26~!","publication_year":2008,"publication_date":"2008-12-01","ids":{"openalex":"https://openalex.org/W1978872258","doi":"https://doi.org/10.2174/1874827900801010033","mag":"1978872258"},"language":"en","primary_location":{"id":"doi:10.2174/1874827900801010033","doi":"https://doi.org/10.2174/1874827900801010033","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874827900801010033","pdf_url":"http://benthamopen.com/contents/pdf/TOGERIMJ/TOGERIMJ-1-33.pdf","source":{"id":"https://openalex.org/S6869138","display_name":"The Open Geriatric Medicine Journal","issn_l":"1874-8279","issn":["1874-8279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Geriatric Medicine Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://benthamopen.com/contents/pdf/TOGERIMJ/TOGERIMJ-1-33.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081436063","display_name":"Daniela Galimberti","orcid":"https://orcid.org/0000-0002-9284-5953","observed_orcids":["https://orcid.org/0000-0002-9284-5953","https://orcid.org/0000-0002-5010-6167"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Daniela Galimberti","raw_affiliation_strings":["Department of Neurological Sciences, \"Dino Ferrari\" Center, University of Milan, IRCCS Fondazione Ospedale Mag-giore Policlinico, Via F. Sforza 35, 20122, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, \"Dino Ferrari\" Center, University of Milan, IRCCS Fondazione Ospedale Mag-giore Policlinico, Via F. Sforza 35, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023350680","display_name":"Elio Angelo Scarpini","orcid":"https://orcid.org/0000-0002-6395-2119","observed_orcids":["https://orcid.org/0000-0002-6395-2119"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elio Scarpini","raw_affiliation_strings":["Department of Neurological Sciences, \"Dino Ferrari\" Center, University of Milan, IRCCS Fondazione Ospedale Mag-giore Policlinico, Via F. Sforza 35, 20122, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Sciences, \"Dino Ferrari\" Center, University of Milan, IRCCS Fondazione Ospedale Mag-giore Policlinico, Via F. Sforza 35, 20122, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081436063"],"corresponding_institution_ids":["https://openalex.org/I189158943","https://openalex.org/I2803066834"],"apc_list":null,"apc_paid":null,"fwci":0.1248,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.41978267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"1","first_page":"33","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/amyloid-hypothesis","display_name":"amyloid hypothesis","score":0.949999988079071},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7149999737739563},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8130000233650208},{"id":"https://openalex.org/keywords/secretases","display_name":"secretases","score":0.6370000243186951},{"id":"https://openalex.org/keywords/bace","display_name":"BACE","score":0.722000002861023},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9240000247955322},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8360000252723694},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/rofecoxib","display_name":"rofecoxib","score":0.781000018119812},{"id":"https://openalex.org/keywords/naproxen","display_name":"naproxen","score":0.800000011920929},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.9909999966621399},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.9629999995231628},{"id":"https://openalex.org/keywords/disease-modifying-drugs","display_name":"disease-modifying drugs","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5388246774673462},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5218409895896912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.492652952671051},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34944623708724976},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32054686546325684},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2163248360157013}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2174/1874827900801010033","doi":"https://doi.org/10.2174/1874827900801010033","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874827900801010033","pdf_url":"http://benthamopen.com/contents/pdf/TOGERIMJ/TOGERIMJ-1-33.pdf","source":{"id":"https://openalex.org/S6869138","display_name":"The Open Geriatric Medicine Journal","issn_l":"1874-8279","issn":["1874-8279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Geriatric Medicine Journal","raw_type":"journal-article"},{"id":"pmh:oai:zenodo.org:160400","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/160400","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2152424351","doi":null,"is_oa":false,"landing_page_url":"https://benthamopen.com/ABSTRACT/TOGERIMJ-1-33","pdf_url":null,"source":{"id":"https://openalex.org/S6869138","display_name":"The Open Geriatric Medicine Journal","issn_l":"1874-8279","issn":["1874-8279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Open Geriatric Medicine Journal","raw_type":null}],"best_oa_location":{"id":"doi:10.2174/1874827900801010033","doi":"https://doi.org/10.2174/1874827900801010033","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1874827900801010033","pdf_url":"http://benthamopen.com/contents/pdf/TOGERIMJ/TOGERIMJ-1-33.pdf","source":{"id":"https://openalex.org/S6869138","display_name":"The Open Geriatric Medicine Journal","issn_l":"1874-8279","issn":["1874-8279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Geriatric Medicine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978872258.pdf","grobid_xml":"https://content.openalex.org/works/W1978872258.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W91600525","https://openalex.org/W138899936","https://openalex.org/W166560457","https://openalex.org/W188866928","https://openalex.org/W226961074","https://openalex.org/W231832547","https://openalex.org/W504742713","https://openalex.org/W1483703465","https://openalex.org/W1508140332","https://openalex.org/W1585471181","https://openalex.org/W1693283493","https://openalex.org/W1963873817","https://openalex.org/W1969927055","https://openalex.org/W1971856927","https://openalex.org/W1973716796","https://openalex.org/W1976829076","https://openalex.org/W1981513372","https://openalex.org/W1985988204","https://openalex.org/W1991763618","https://openalex.org/W1993809313","https://openalex.org/W1994925004","https://openalex.org/W2002670780","https://openalex.org/W2011347889","https://openalex.org/W2011418880","https://openalex.org/W2026453296","https://openalex.org/W2029205666","https://openalex.org/W2039428198","https://openalex.org/W2041622179","https://openalex.org/W2041726376","https://openalex.org/W2042706422","https://openalex.org/W2046454316","https://openalex.org/W2047511834","https://openalex.org/W2051792350","https://openalex.org/W2057712792","https://openalex.org/W2057716397","https://openalex.org/W2057838273","https://openalex.org/W2064759294","https://openalex.org/W2065089671","https://openalex.org/W2068477037","https://openalex.org/W2068660068","https://openalex.org/W2068872768","https://openalex.org/W2074889706","https://openalex.org/W2075110274","https://openalex.org/W2075264721","https://openalex.org/W2075713420","https://openalex.org/W2078874988","https://openalex.org/W2079863749","https://openalex.org/W2082313952","https://openalex.org/W2083556882","https://openalex.org/W2091475538","https://openalex.org/W2092388108","https://openalex.org/W2096277075","https://openalex.org/W2097362385","https://openalex.org/W2097705657","https://openalex.org/W2099271519","https://openalex.org/W2103615913","https://openalex.org/W2106931873","https://openalex.org/W2108285073","https://openalex.org/W2109891655","https://openalex.org/W2113632571","https://openalex.org/W2116784956","https://openalex.org/W2117618489","https://openalex.org/W2119120508","https://openalex.org/W2122237062","https://openalex.org/W2128124856","https://openalex.org/W2133324295","https://openalex.org/W2143331187","https://openalex.org/W2150191386","https://openalex.org/W2152446053","https://openalex.org/W2154880023","https://openalex.org/W2157064933","https://openalex.org/W2158143414","https://openalex.org/W2164067072","https://openalex.org/W2164990833","https://openalex.org/W2168395197","https://openalex.org/W2171776741","https://openalex.org/W2401341471","https://openalex.org/W2413105373","https://openalex.org/W4238284706","https://openalex.org/W4319290839","https://openalex.org/W7075650045"],"related_works":["https://openalex.org/W2152424351","https://openalex.org/W7097301618","https://openalex.org/W2924155929","https://openalex.org/W2111965761","https://openalex.org/W977527364","https://openalex.org/W2121566293","https://openalex.org/W2015245863","https://openalex.org/W77262109","https://openalex.org/W4211102779","https://openalex.org/W4231115836"],"abstract_inverted_index":{"The":[0],"hallmark":[1],"pathologic":[2],"lesions":[3],"of":[4,23,36,81,87,98,114,119,125,131,150,171,239],"Alzheimer's":[5],"disease":[6],"(AD)":[7],"are":[8,136],"extracellular":[9],"senile":[10],"plaques,":[11],"composed":[12],"by":[13,58,68,73],"Amiloid":[14],"(A":[15],")":[16],"peptide":[17,38],"and":[18,47,71,92,101,128],"intraneuronal":[19],"neurofibrillary":[20],"tangles,":[21],"made":[22],"tau":[24,99,218],"protein.According":[25],"to":[26,44,75,141,168,216,230],"the":[27,30,51,112,117,123,129,148,226],"amyloid":[28],"hypothesis,":[29],"increased":[31],"production":[32],"or":[33,122,156,165],"decreased":[34],"clearance":[35],"A":[37,77,82,120,126,151],"initiates":[39],"a":[40,85],"pathological":[41,62],"process":[42],"leading":[43,229],"neurodegeneration,":[45],"dementia":[46],"death.Under":[48],"normal":[49],"circumstances,":[50],"Amyloid":[52],"Precursor":[53],"Protein":[54],"(APP)":[55],"is":[56,65,147,207],"cleaved":[57,66],"secretase,":[59],"but,":[60],"in":[61,174,182,209],"conditions,":[63],"it":[64],"first":[67],"secretase":[69],"(BACE)":[70],"subsequently":[72],"-secretase,":[74],"form":[76],"42":[78,83],"toxic":[79],"peptide.Accumulation":[80],"starts":[84],"cascade":[86],"events":[88],"associated":[89],"with":[90,153,162,176,204,220,236],"neuronal":[91,102],"synaptic":[93],"dysfunction,":[94],"inflammatory":[95],"responses,":[96],"hyperphosphorylation":[97],"protein":[100],"death.This":[103],"theory":[104],"identifies":[105],"biological":[106],"targets":[107],"for":[108],"disease-modifying":[109],"treatments,":[110],"including":[111,196],"modulation":[113,149],"APP":[115],"metabolism,":[116],"reduction":[118,130],"aggregation":[121],"enhancement":[124],"clearance,":[127],"inflammation.Regarding":[132],"secretases,":[133],"different":[134],"approaches":[135],"under":[137,242],"evaluation,":[138],"primarily":[139],"aiming":[140],"decrease":[142],"-and":[143],"-secretase.A":[144],"promising":[145],"approach":[146,214],",":[152],"either":[154],"vaccination":[155],"antiaggregation":[157],"agents.Regarding":[158],"inflammation,":[159],"despite":[160],"trials":[161],"Rofecoxib,":[163],"Naproxen":[164],"Diclofenac":[166],"failed":[167],"slow":[169],"progression":[170],"cognitive":[172,184],"decline":[173],"patients":[175],"AD,":[177],"Indomethacin":[178],"showed":[179],"positive":[180],"results":[181],"delaying":[183],"decline.However,":[185],"gastrointestinal":[186],"toxicity":[187],"was":[188],"treatment-limiting,":[189],"therefore":[190],"other":[191],"compounds":[192],"have":[193],"been":[194],"developed,":[195],"Nitroflurbiprofen.In":[197],"addition,":[198],"Rosiglitazone,":[199],"an":[200,237],"oral":[201],"anti-diabetic":[202],"agent":[203],"anti-inflammatory":[205],"properties,":[206],"currently":[208],"phase":[210],"III":[211],"study.A":[212],"further":[213],"aims":[215],"inhibit":[217],"deposition":[219],"methyl":[221],"thioninium":[222],"chloride.In":[223],"this":[224],"review,":[225],"pathogenic":[227],"steps":[228],"neurodegeneration":[231],"will":[232],"be":[233],"discussed,":[234],"together":[235],"update":[238],"diseasemodifying":[240],"drugs":[241],"testing.":[243]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}