{"id":"https://openalex.org/W1978865005","doi":"https://doi.org/10.1038/sj.bjp.0703816","title":"Activity of adenosine diphosphates and triphosphates on a P2YT\u2010type receptor in brain capillary endothelial cells","display_name":"Activity of adenosine diphosphates and triphosphates on a P2YT\u2010type receptor in brain capillary endothelial cells","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1978865005","doi":"https://doi.org/10.1038/sj.bjp.0703816","mag":"1978865005","pmid":"https://pubmed.ncbi.nlm.nih.gov/11156575","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1572558"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjp.0703816","doi":"https://doi.org/10.1038/sj.bjp.0703816","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0703816","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0703816","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0703816","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084246377","display_name":"Joseph Simon","orcid":"https://orcid.org/0000-0001-6349-5475","observed_orcids":["https://orcid.org/0000-0001-6349-5475"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Simon","raw_affiliation_strings":["Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062264648","display_name":"Paul Vigne","orcid":"https://orcid.org/0000-0002-7927-7920","observed_orcids":["https://orcid.org/0000-0002-7927-7920"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Vigne","raw_affiliation_strings":["Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR411, 660 Route des Lucioles, Sophia Antipolis, 06560 Valbonne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR411, 660 Route des Lucioles, Sophia Antipolis, 06560 Valbonne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057532835","display_name":"Kk. Eklund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K M Eklund","raw_affiliation_strings":["Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112133201","display_name":"A.D. Michel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A D Michel","raw_affiliation_strings":["Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111648867","display_name":"Alan M. Carruthers","orcid":"https://orcid.org/0009-0008-2701-672X","observed_orcids":["https://orcid.org/0009-0008-2701-672X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A M Carruthers","raw_affiliation_strings":["Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110434114","display_name":"Patrick P.A. Humphrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P P A Humphrey","raw_affiliation_strings":["Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084982109","display_name":"Christian Frelin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Frelin","raw_affiliation_strings":["Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR411, 660 Route des Lucioles, Sophia Antipolis, 06560 Valbonne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR411, 660 Route des Lucioles, Sophia Antipolis, 06560 Valbonne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113664881","display_name":"Eric A. Barnard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"E A Barnard","raw_affiliation_strings":["Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113664881"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.4735,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.88235294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"132","issue":"1","first_page":"173","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p2y-receptors","display_name":"P2Y receptors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/p2y1-receptor","display_name":"P2Y1 receptor","score":0.906000018119812},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/adenylyl-cyclase-inhibition","display_name":"adenylate cyclase inhibition","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cyclic-nucleotides","display_name":"cyclic nucleotides","score":0.6159999966621399},{"id":"https://openalex.org/keywords/receptor-antagonists","display_name":"receptor antagonists","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.8445463180541992},{"id":"https://openalex.org/C160225129","wikidata":"https://www.wikidata.org/wiki/Q6591687","display_name":"P2Y receptor","level":4,"score":0.702783465385437},{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.6407142281532288},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.6089420318603516},{"id":"https://openalex.org/C69101867","wikidata":"https://www.wikidata.org/wiki/Q17709777","display_name":"ADCY9","level":4,"score":0.6048272848129272},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5795858502388},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5735988616943359},{"id":"https://openalex.org/C86811712","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Competitive antagonist","level":4,"score":0.5617297291755676},{"id":"https://openalex.org/C16587737","wikidata":"https://www.wikidata.org/wiki/Q4682273","display_name":"Adenosine A2B receptor","level":5,"score":0.5430336594581604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46697044372558594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4568106234073639},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.45544055104255676},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4066705107688904},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.383015513420105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3207783102989197},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.3030974864959717},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.23465663194656372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10860195755958557}],"mesh":[{"descriptor_ui":"D000067956","descriptor_name":"Adenylyl Cyclase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000227","descriptor_name":"Adenine Nucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010566","descriptor_name":"Virulence Factors, Bordetella","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018048","descriptor_name":"Receptors, Purinergic P2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018048","descriptor_name":"Receptors, Purinergic P2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D037342","descriptor_name":"Pertussis Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037361","descriptor_name":"Adenylate Cyclase Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058472","descriptor_name":"Receptors, Purinergic P2Y1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058910","descriptor_name":"Purinergic P2 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058919","descriptor_name":"Purinergic P2 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058925","descriptor_name":"Receptors, Purinergic P2Y12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjp.0703816","doi":"https://doi.org/10.1038/sj.bjp.0703816","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0703816","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0703816","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1572558","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1572558","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:11156575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11156575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/sj.bjp.0703816","doi":"https://doi.org/10.1038/sj.bjp.0703816","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjp.0703816","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/sj.bjp.0703816","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978865005.pdf","grobid_xml":"https://content.openalex.org/works/W1978865005.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1536081396","https://openalex.org/W1567363998","https://openalex.org/W1798670049","https://openalex.org/W1877982959","https://openalex.org/W1897834196","https://openalex.org/W1947888345","https://openalex.org/W1967714236","https://openalex.org/W1975160979","https://openalex.org/W1981183509","https://openalex.org/W1981288936","https://openalex.org/W1987441962","https://openalex.org/W1991433173","https://openalex.org/W1999603677","https://openalex.org/W2007913522","https://openalex.org/W2008054762","https://openalex.org/W2011325376","https://openalex.org/W2012495474","https://openalex.org/W2016217548","https://openalex.org/W2016590082","https://openalex.org/W2017031022","https://openalex.org/W2028876959","https://openalex.org/W2030204779","https://openalex.org/W2030569295","https://openalex.org/W2035054244","https://openalex.org/W2040943961","https://openalex.org/W2048443303","https://openalex.org/W2053278403","https://openalex.org/W2060259870","https://openalex.org/W2066177774","https://openalex.org/W2069222444","https://openalex.org/W2075760418","https://openalex.org/W2082969662","https://openalex.org/W2095225735","https://openalex.org/W2099757747","https://openalex.org/W2109311512","https://openalex.org/W2122408215","https://openalex.org/W2134675068","https://openalex.org/W2134723230","https://openalex.org/W2160606813","https://openalex.org/W2334412775","https://openalex.org/W2336463032","https://openalex.org/W2342357931","https://openalex.org/W2417118565","https://openalex.org/W2467435362","https://openalex.org/W2473571716","https://openalex.org/W2617061729","https://openalex.org/W4211044690","https://openalex.org/W6632471898"],"related_works":["https://openalex.org/W2052534560","https://openalex.org/W1985873827","https://openalex.org/W1967714236","https://openalex.org/W7099468944","https://openalex.org/W2059161484","https://openalex.org/W2030665376","https://openalex.org/W2094046861","https://openalex.org/W2415751623","https://openalex.org/W1973298520","https://openalex.org/W2069222444"],"abstract_inverted_index":{"1.":[0],"A":[1,138],"P2Y":[2,43],"(nucleotide)":[3],"receptor":[4,34,44,169,178,220],"activity":[5,134],"in":[6,48,170,221,231],"a":[7,49,152,218],"clonal":[8],"population":[9],"(B10)":[10],"of":[11,21,37,52,81,142,155,199],"rat":[12],"brain":[13,214],"capillary":[14],"endothelial":[15,215],"cells":[16,54,216],"is":[17,164],"coupled":[18],"to":[19,28,74,223],"inhibition":[20,80,198],"adenylyl":[22,83,193,200],"cyclase":[23,84,201],"and":[24,115,123,127,183,240,252],"has":[25],"functional":[26],"similarities":[27,230],"the":[29,41,59,133,143,167,171,175,180,192,224,250],"P2Y(T)":[30,145,254],"(previously":[31],"designated":[32],"'P2T')":[33],"for":[35,97],"ADP":[36],"blood":[38],"platelets.":[39],"However,":[40],"only":[42],"which":[45,62],"was":[46,58,89,100,106,151,204],"detectable":[47],"previous":[50],"study":[51],"B10":[53,92,157,251],"by":[55,86,202,207,238,241],"mRNA":[56],"analysis":[57],"P2Y(1)":[60,168,177,225],"receptor,":[61,146,159],"elsewhere":[63],"shows":[64],"no":[65],"transduction":[66],"via":[67],"cyclic":[68],"nucleotides.":[69],"We":[70],"have":[71,229],"sought":[72],"here":[73],"clarify":[75],"these":[76,213],"issues.":[77],"2.":[78],"The":[79,94,197,227,246],"forskolin-stimulated":[82],"induced":[85],"purified":[87],"nucleotides":[88],"measured":[90],"on":[91,135],"cells.":[93,173],"EC(50)":[95],"value":[96],"2-methylthioADP":[98],"(2-MeSADP)":[99],"2.2":[101],"nM":[102],"and,":[103],"surprisingly,":[104],"2-MeSATP":[105],"an":[107],"almost":[108],"equally":[109],"strong":[110],"agonist":[111,232],"(EC(50)=3.5":[112],"nM).":[113],"ATP":[114],"2-ClATP":[116],"were":[117],"weak":[118,189],"partial":[119],"agonists":[120,190],"(EC(50)=26":[121],"microM":[122,125],"10":[124],"respectively)":[126],"under":[128],"appropriate":[129],"conditions":[130],"could":[131],"antagonise":[132],"2-MeSADP.":[136],"3.":[137],"known":[139],"selective":[140],"antagonist":[141,154],"platelet":[144,253],"2-propylthioadenosine-5'-(beta,gamma)-difluoromethylene)":[147],"triphosphonate":[148],"(AR-C":[149],"66096),":[150],"competitive":[153,176],"this":[156],"cell":[158],"with":[160],"pK(B)=7.6.":[161],"That":[162],"ligand":[163],"inactive":[165],"at":[166,191],"same":[172],"Conversely,":[174],"antagonists,":[179],"3',":[181],"5'-":[182],"2',":[184],"5'-adenosine":[185],"bis-monophosphates,":[186],"are,":[187],"instead,":[188],"cyclase-inhibitory":[194],"receptor.":[195,226],"4.":[196],"2-MeSADP":[203],"completely":[205],"abolished":[206],"pertussis":[208],"toxin.":[209],"5.":[210],"In":[211],"summary,":[212],"possess":[217],"P2Y(T)-type":[219],"addition":[222],"two":[228],"profiles":[233],"but":[234],"are":[235,256],"clearly":[236],"distinguishable":[237],"antagonists":[239],"their":[242],"second":[243],"messenger":[244],"activations.":[245],"possible":[247],"relationships":[248],"between":[249],"receptors":[255],"discussed.":[257]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}