{"id":"https://openalex.org/W1978856958","doi":"https://doi.org/10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","title":"Relationship of metastatic medullary thyroid carcinoma to calcitonin content of pheochromocytomas an immunohistochemical study","display_name":"Relationship of metastatic medullary thyroid carcinoma to calcitonin content of pheochromocytomas an immunohistochemical study","publication_year":1980,"publication_date":"1980-02-01","ids":{"openalex":"https://openalex.org/W1978856958","doi":"https://doi.org/10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","mag":"1978856958","pmid":"https://pubmed.ncbi.nlm.nih.gov/7353201"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","doi":"https://doi.org/10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819800201%2945%3A3%3C498%3A%3AAID-CNCR2820450314%3E3.0.CO%3B2-R","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819800201%2945%3A3%3C498%3A%3AAID-CNCR2820450314%3E3.0.CO%3B2-R","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015179016","display_name":"Geoffrey Mendelsohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Geoffrey Mendelsohn","raw_affiliation_strings":["Department of Pathology, and the Oncology Center, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland","Geoffrey Mendelsohn, MD, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and the Oncology Center, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Geoffrey Mendelsohn, MD, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058612163","display_name":"Stephen B. Baylin","orcid":"https://orcid.org/0000-0003-3697-3798","observed_orcids":["https://orcid.org/0000-0003-3697-3798"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Baylin","raw_affiliation_strings":["Department of Medicine, and the Oncology Center, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland","Recipient of Research Career Development Award 10K04-CA-000\u201327\u201301 from the National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, and the Oncology Center, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"Recipient of Research Career Development Award 10K04-CA-000\u201327\u201301 from the National Institutes of Health","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109977522","display_name":"Joseph C. Eggleston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C. Eggleston","raw_affiliation_strings":["Department of Pathology, and the Oncology Center, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and the Oncology Center, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015179016"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.711,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.72328274,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"3","first_page":"498","last_page":"502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.5098000168800354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.4027999937534332,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.03060000017285347,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.902999997138977},{"id":"https://openalex.org/keywords/pheochromocytoma","display_name":"pheochromocytoma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-2","display_name":"multiple endocrine neoplasia type 2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/metastatic-thyroid-carcinoma","display_name":"metastatic thyroid cancer","score":0.6679999828338623},{"id":"https://openalex.org/keywords/adrenal-medulla","display_name":"adrenal medulla","score":0.7450000047683716},{"id":"https://openalex.org/keywords/apud-cells","display_name":"APUD cells","score":0.7390000224113464},{"id":"https://openalex.org/keywords/neural-crest-origin","display_name":"neural crest origin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.9524093866348267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8441426753997803},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.7682713270187378},{"id":"https://openalex.org/C2779512018","wikidata":"https://www.wikidata.org/wiki/Q536269","display_name":"Pheochromocytoma","level":2,"score":0.7435536980628967},{"id":"https://openalex.org/C2776667971","wikidata":"https://www.wikidata.org/wiki/Q6807316","display_name":"Medullary carcinoma","level":4,"score":0.7161949872970581},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6632336974143982},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.6394630074501038},{"id":"https://openalex.org/C128102431","wikidata":"https://www.wikidata.org/wiki/Q6005550","display_name":"Immunoperoxidase","level":4,"score":0.5732380151748657},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5274786353111267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.515228807926178},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49478262662887573},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10261914134025574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.06435877084732056},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001079","descriptor_name":"Apudoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002116","descriptor_name":"Calcitonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007120","descriptor_name":"Immunochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009378","descriptor_name":"Neoplasms, Multiple Primary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","doi":"https://doi.org/10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819800201%2945%3A3%3C498%3A%3AAID-CNCR2820450314%3E3.0.CO%3B2-R","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:7353201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7353201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","doi":"https://doi.org/10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19800201)45:3<498::aid-cncr2820450314>3.0.co;2-r","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819800201%2945%3A3%3C498%3A%3AAID-CNCR2820450314%3E3.0.CO%3B2-R","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978856958.pdf","grobid_xml":"https://content.openalex.org/works/W1978856958.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W133676264","https://openalex.org/W228995320","https://openalex.org/W1562435271","https://openalex.org/W1981724684","https://openalex.org/W1987365521","https://openalex.org/W2012919920","https://openalex.org/W2025189606","https://openalex.org/W2030262151","https://openalex.org/W2060013283","https://openalex.org/W2065579144","https://openalex.org/W2066642755","https://openalex.org/W2089094479","https://openalex.org/W2121970397","https://openalex.org/W2124663059","https://openalex.org/W2181892845","https://openalex.org/W2320385819","https://openalex.org/W2339157379","https://openalex.org/W2347148142","https://openalex.org/W2402287504","https://openalex.org/W2408322911","https://openalex.org/W2409360372","https://openalex.org/W2618418440","https://openalex.org/W2887476960","https://openalex.org/W4301168585"],"related_works":["https://openalex.org/W201453402","https://openalex.org/W2065579144","https://openalex.org/W2046988541","https://openalex.org/W2420833017","https://openalex.org/W2085351013","https://openalex.org/W2887476960","https://openalex.org/W2400021107","https://openalex.org/W2404851903","https://openalex.org/W2327292189","https://openalex.org/W2051711382"],"abstract_inverted_index":{"Immunoperoxidase":[0],"studies":[1],"have":[2,26,65],"been":[3,27,67],"utilized":[4],"to":[5,29,69,124],"investigate":[6],"further":[7],"the":[8,45,55,61],"previously":[9],"reported":[10],"presence":[11,107],"of":[12,80,97,108],"immunoassayable":[13],"calcitonin":[14,31,56,72,109],"in":[15,32,36,43,60,73,78,110,117],"pheochromocytoma":[16,33],"tissue":[17,34],"from":[18],"some":[19],"patients":[20,38,82],"with":[21,39,83,122],"MEN":[22,40,86],"II":[23,41],"syndromes.":[24,87],"We":[25,64],"able":[28,68],"demonstrate":[30,70],"only":[35,59],"two":[37],"syndromes":[42],"whom":[44],"pheochromocytomas":[46,79],"contained":[47],"metastatic":[48],"medullary":[49,62,89,111],"thyroid":[50,92,112],"carcinoma.":[51,63],"In":[52],"both":[53,96,102],"cases,":[54],"was":[57],"present":[58],"not":[66,116],"immunoreactive":[71],"normal":[74],"adrenal":[75],"glands":[76],"or":[77],"other":[81],"and":[84,91,101,115,127],"without":[85],"Adrenal":[88],"cells":[90,94,114],"C":[93],"are":[95],"neural":[98],"crest":[99],"origin":[100],"possess":[103],"APUD":[104],"characteristics.":[105],"The":[106],"carcinoma":[113],"pheochromocytes":[118],"has":[119],"important":[120],"implications":[121],"regard":[123],"cellular":[125],"differentiation":[126],"peptide":[128],"hormone":[129],"production.":[130]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
