{"id":"https://openalex.org/W1978850243","doi":"https://doi.org/10.1093/neuonc/nou166","title":"Beating the odds: extreme long-term survival with glioblastoma","display_name":"Beating the odds: extreme long-term survival with glioblastoma","publication_year":2014,"publication_date":"2014-08-05","ids":{"openalex":"https://openalex.org/W1978850243","doi":"https://doi.org/10.1093/neuonc/nou166","mag":"1978850243","pmid":"https://pubmed.ncbi.nlm.nih.gov/25096192","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136904"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/nou166","doi":"https://doi.org/10.1093/neuonc/nou166","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/nou166","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/16/9/1159/7640685/nou166.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/16/9/1159/7640685/nou166.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047848562","display_name":"Wenya Linda Bi","orcid":"https://orcid.org/0000-0002-4635-0247","observed_orcids":["https://orcid.org/0000-0002-4635-0247"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. L. Bi","raw_affiliation_strings":["Departments of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (W.L.B.)Departments of Medicine and Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (R.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (W.L.B.)Departments of Medicine and Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (R.B.)","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041980697","display_name":"Rameen Beroukhim","orcid":"https://orcid.org/0000-0001-6303-3609","observed_orcids":["https://orcid.org/0000-0001-6303-3609","https://orcid.org/0000-0002-5506-0575"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Beroukhim","raw_affiliation_strings":["Departments of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (W.L.B.)Departments of Medicine and Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (R.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cancer Biology and Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (W.L.B.)Departments of Medicine and Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (R.B.)","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5047848562"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"9","first_page":"1159","last_page":"1160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/molecular-heterogeneity","display_name":"molecular heterogeneity","score":0.5979999899864197},{"id":"https://openalex.org/keywords/idh1-2-mutation","display_name":"IDH1/2 mutation","score":0.75},{"id":"https://openalex.org/keywords/mgmt-promoter-methylation","display_name":"MGMT promoter methylation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/1p-19q-codeletion","display_name":"1p/19q codeletion","score":0.9300000071525574},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.6570000052452087},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.4399999976158142},{"id":"https://openalex.org/keywords/extent-of-resection","display_name":"extent of resection","score":0.7250000238418579},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.43700000643730164},{"id":"https://openalex.org/keywords/survival-prediction-model","display_name":"survival prediction model","score":0.46299999952316284},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.375},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.6050000190734863},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.8223570585250854},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7093338370323181},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6889439821243286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3764328360557556},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27012282609939575},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.09662675857543945},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07593563199043274},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.05983889102935791},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017741","descriptor_name":"Survivors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/neuonc/nou166","doi":"https://doi.org/10.1093/neuonc/nou166","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/nou166","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/16/9/1159/7640685/nou166.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4136904","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4136904","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},{"id":"pmid:25096192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25096192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-oncology","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1093/neuonc/nou166","doi":"https://doi.org/10.1093/neuonc/nou166","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/nou166","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/16/9/1159/7640685/nou166.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978850243.pdf","grobid_xml":"https://content.openalex.org/works/W1978850243.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1482109403","https://openalex.org/W1485518666","https://openalex.org/W1551978591","https://openalex.org/W1569162089","https://openalex.org/W1887747927","https://openalex.org/W1989891384","https://openalex.org/W1994497191","https://openalex.org/W2040458067","https://openalex.org/W2060551076","https://openalex.org/W2105100844","https://openalex.org/W2105528101","https://openalex.org/W2109816625","https://openalex.org/W2113942802","https://openalex.org/W2122820790","https://openalex.org/W2124736921","https://openalex.org/W2126817554","https://openalex.org/W2142127259","https://openalex.org/W2156330848","https://openalex.org/W2158681922","https://openalex.org/W2161289668"],"related_works":["https://openalex.org/W2790522557","https://openalex.org/W4392813001","https://openalex.org/W2887170366","https://openalex.org/W2622584877","https://openalex.org/W2995641252","https://openalex.org/W2600671803","https://openalex.org/W4320494666","https://openalex.org/W3087485189","https://openalex.org/W2317869122","https://openalex.org/W4386287723"],"abstract_inverted_index":{"See":[0],"the":[1,13,22,99,143,198,272,318,344,351,368,377,446,501,512,580,614,622,661],"article":[2,403],"by":[3,509,544],"Gerber":[4,410],"et":[5],"al,":[6],"on":[7,207,300,564],"pages":[8],"1186\u20131195.":[9],"Amongst":[10],"all":[11,343,625],"cancers,":[12],"diagnosis":[14,205],"of":[15,21,41,53,73,83,103,123,145,162,200,218,260,268,274,282,321,327,365,367,384,406,460,482,498,500,505,525,586,616,650,660,667],"glioblastoma":[16,227,408,425],"multiforme":[17],"(GBM)":[18],"portends":[19],"one":[20,499],"most":[23,684],"malevolent":[24],"clinical":[25,60],"prognoses.":[26],"Median":[27],"survival":[28,179,359,428,495,522,643],"is":[29,125,314,467],"only":[30,380,547],"nine":[31],"months,":[32],"rising":[33],"to":[34,89,158,238,243,361,373,381,389,393,414,445,465,471,561,567,571,639,677],"15\u201316":[35],"months":[36],"for":[37,127],"those":[38],"receiving":[39],"standard":[40,166],"care":[42],"surgery":[43],"and":[44,59,76,121,130,142,188,264,277,411,441,449,496,579,609],"adjuvant":[45],"chemoradiation.1\u20133":[46],"Nevertheless,":[47],"GBMs":[48,78,106,136,153,181],"exhibit":[49,137,155,309,342,458],"a":[50,226,310,362,437,468,480,548,648,657,664],"substantial":[51,138],"degree":[52,144],"heterogeneity":[54,147,261],"in":[55,180,195,250,292,350,523,554,596,642,653],"both":[56,607],"their":[57,118,357,402,443],"molecular":[58,233,421],"profiles.":[61],"Several":[62],"dozen":[63],"somatic":[64],"genetic":[65,129,140,608],"events":[66,256],"have":[67,222,235,285,298,330],"been":[68,211,223,236,287,656],"identified":[69,182,237],"as":[70,214,245,247,258,507,632],"likely":[71],"\u201cdrivers\u201d":[72],"GBM":[74,85,293,322,353,506,582],"tumorigenesis,":[75],"individual":[77,135],"can":[79,107,154],"contain":[80],"countless":[81],"combinations":[82],"these.4":[84],"methylation":[86,459],"profiles":[87],"tend":[88],"divide":[90],"into":[91,111,175,225,397],"two":[92],"major":[93,469],"classes":[94,115],"which":[95,611],"themselves":[96],"associate":[97],"with":[98,160,192,289,347,424,427,520,644],"presence":[100,273],"or":[101,206,355],"absence":[102],"IDH1/2":[104,275],"mutations.5":[105],"also":[108,286,388,489],"be":[109,552,559,594],"sorted":[110],"at":[112,202,262,436],"least":[113],"four":[114,169,332,336,430,502],"based":[116],"upon":[117],"expression":[119,279],"profiles,":[120],"each":[122],"these":[124,339,515,526,587,603],"enriched":[126],"specific":[128],"epigenetic":[131,266],"features.6":[132],"Beyond":[133],"this,":[134],"intratumoral":[139,605],"heterogeneity,":[141,606],"this":[146,374,416,532,555],"itself":[148],"varies":[149],"between":[150,493,575],"tumors.7":[151],"Clinically,":[152],"varying":[156],"responses":[157],"treatment,":[159],"12%":[161],"patients":[163,308,328,340,396,426,435,670],"who":[164,329],"receive":[165],"chemoradiation":[167],"surviving":[168],"years":[170,333],"after":[171],"diagnosis.8":[172],"Initial":[173],"investigations":[174],"factors":[176],"influencing":[177],"differential":[178],"advanced":[183],"age,":[184],"pre-existing":[185],"neurologic":[186],"impairment,":[187],"poor":[189],"functional":[190],"status":[191],"worse":[193,290],"outcome":[194,249],"patients.9":[196],"Furthermore,":[197],"extent":[199],"resection,":[201],"either":[203],"initial":[204],"tumor":[208],"recurrence,":[209],"has":[210,376,655],"clearly":[212],"shown":[213],"an":[215,529],"important":[216,530,560,595],"predictor":[217],"survival.10,11":[219],"These":[220,252,307],"features":[221,301,345,366,585,627],"integrated":[224],"prognostic":[228,385,626],"model.12":[229],"More":[230],"recently,":[231],"several":[232,535],"signatures":[234],"predict":[239,303],"favorable":[240,278],"patient":[241],"response":[242,618],"treatment":[244,617,634],"well":[246],"overall":[248,352],"gliomas.":[251],"include":[253],"chromosomal":[254,283],"arm-level":[255],"such":[257],"loss":[259],"1p":[263],"19q,13":[265],"silencing":[267],"MGMT":[269],"through":[270],"methylation,14":[271],"mutations,15":[276],"signatures.16":[280],"Regions":[281],"instability":[284],"credited":[288],"prognosis":[291,349],"patients.17":[294],"However,":[295],"few":[296],"studies":[297],"focused":[299],"that":[302,313,454,463,589],"extreme":[304,358,398,455,472,540],"long-term":[305,399,407,486,494,541,577,599],"survival.":[306,473,600],"disease":[311],"course":[312],"qualitatively":[315],"different":[316,363],"from":[317,434],"vast":[319],"majority":[320],"patients.":[323],"For":[324],"example,":[325],"half":[326],"survived":[331],"will":[334,558,628,674],"survive":[335,671],"more.18":[337],"Do":[338],"simply":[341],"associated":[346,423],"good":[348],"population,":[354],"does":[356],"relate":[360],"set":[364],"disease?":[369],"A":[370],"detailed":[371],"answer":[372],"question":[375],"potential":[378],"not":[379,478,591],"enable":[382,675],"refinement":[383],"classes,":[386],"but":[387],"indicate":[390],"therapeutic":[391],"strategies":[392,635],"convert":[394],"more":[395],"survivors.":[400,487],"In":[401],"\u201cTranscriptomal":[404],"diversity":[405],"survivors\u201d,":[409],"colleagues":[412],"begin":[413],"address":[415],"question.":[417],"Their":[418],"study":[419,513,533],"evaluated":[420],"patterns":[422],"past":[429],"years,":[431],"using":[432],"data":[433,563],"single":[438],"institution":[439],"(MSKCC)":[440],"extending":[442],"results":[444],"larger":[447,565],"TCGA":[448],"REMBRANDT":[450],"databases.":[451],"They":[452,488],"found":[453,490,517],"survivors":[456,542,578],"frequently":[457],"MGMT,":[461],"suggesting":[462],"responsiveness":[464],"temozolomide":[466],"contributor":[470],"Surprisingly,":[474],"however,":[475],"they":[476],"did":[477],"identify":[479],"preponderance":[481],"IDH-mutant":[483],"tumors":[484,588],"among":[485,602,619],"no":[491,518],"relationship":[492],"membership":[497],"expression-based":[503],"subclasses":[504,516],"determined":[508],"TCGA.":[510],"Similarly,":[511],"defining":[514],"association":[519],"increased":[521],"any":[524],"groups.6":[527],"Although":[528],"start,":[531],"leaves":[534],"questions":[536],"unaddressed.":[537],"First,":[538],"because":[539],"are":[543,604],"definition":[545],"rare,":[546],"small":[549],"number":[550],"could":[551],"included":[553],"study.":[556],"It":[557],"generate":[562],"cohorts":[566],"obtain":[568],"sufficient":[569],"power":[570],"detect":[572],"robust":[573],"differences":[574],"extremely":[576,598],"general":[581],"population.":[583],"Additionally,":[584],"were":[590],"assessed":[592],"may":[593,612],"determining":[597],"Chief":[601],"epigenetic,":[610],"determine":[613,678],"uniformity":[615],"cells":[620],"within":[621],"tumor.19,20":[623],"Moreover,":[624],"need":[629],"continued":[630],"reassessment":[631],"our":[633,681],"evolve.":[636],"The":[637],"inability":[638],"show":[640],"improvements":[641],"targeted":[645],"therapeutics,":[646],"despite":[647,680],"wealth":[649],"druggable":[651],"targets":[652],"GBMs,":[654],"great":[658],"failing":[659],"field.":[662],"Hopefully,":[663],"greater":[665],"understanding":[666],"why":[668],"some":[669],"so":[672],"long":[673],"us":[676],"why,":[679],"best":[682],"efforts,":[683],"do":[685],"not.":[686]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
