{"id":"https://openalex.org/W1978820746","doi":"https://doi.org/10.1016/0009-2797(92)90109-x","title":"Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzo[a]pyrene in hamster embryo cell cultures","display_name":"Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzo[a]pyrene in hamster embryo cell cultures","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W1978820746","doi":"https://doi.org/10.1016/0009-2797(92)90109-x","mag":"1978820746","pmid":"https://pubmed.ncbi.nlm.nih.gov/1568269"},"language":"en","primary_location":{"id":"doi:10.1016/0009-2797(92)90109-x","doi":"https://doi.org/10.1016/0009-2797(92)90109-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0009-2797(92)90109-x","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002435108","display_name":"Young-Heum Chae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Young-Heum Chae","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Purdue University, West Lafayette, IN 47907","Departments of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN47907 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Purdue University, West Lafayette, IN 47907","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Departments of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN47907 USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111548651","display_name":"David K. Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David K. Ho","raw_affiliation_strings":["College of Pharmacy, The Ohio State University, Columbus, OH43210 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The Ohio State University, Columbus, OH43210 USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031088440","display_name":"John M. Cassady","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Cassady","raw_affiliation_strings":["College of Pharmacy, The Ohio State University, Columbus, OH43210 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The Ohio State University, Columbus, OH43210 USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071272579","display_name":"Vanessa M. Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa M. Cook","raw_affiliation_strings":["Departments of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN47907 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN47907 USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002562057","display_name":"Craig B. Marcus","orcid":"https://orcid.org/0000-0001-7759-2532","observed_orcids":["https://orcid.org/0000-0001-7759-2532"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig B. Marcus","raw_affiliation_strings":["Pharmacology and Toxicology, School of Pharmacy, Purdue University, West Lafayette, IN47907 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and Toxicology, School of Pharmacy, Purdue University, West Lafayette, IN47907 USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026277311","display_name":"William M. Baird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William M. Baird","raw_affiliation_strings":["Departments of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN47907 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicinal Chemistry and Pharmacognosy, Purdue University, West Lafayette, IN47907 USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026277311"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":0.2097,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.43998124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"82","issue":"2","first_page":"181","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.384799987077713,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.384799987077713,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.21119999885559082,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.19859999418258667,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9789999723434448},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8989999890327454},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.7910000085830688},{"id":"https://openalex.org/keywords/biochanin-a","display_name":"biochanin A","score":0.9129999876022339},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hamster-embryo-cells","display_name":"hamster embryo cells","score":0.7829999923706055},{"id":"https://openalex.org/keywords/acacetin","display_name":"acacetin","score":0.7289999723434448},{"id":"https://openalex.org/keywords/kaempferide","display_name":"kaempferide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/apigenin","display_name":"apigenin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/flavones","display_name":"flavones","score":0.7820000052452087},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6359999775886536},{"id":"https://openalex.org/keywords/carcinogen-metabolism","display_name":"carcinogen metabolism","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2778958039","wikidata":"https://www.wikidata.org/wiki/Q2822213","display_name":"Acacetin","level":5,"score":0.7833048105239868},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.747541069984436},{"id":"https://openalex.org/C2778609962","wikidata":"https://www.wikidata.org/wiki/Q424567","display_name":"Apigenin","level":4,"score":0.6264612078666687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6245042085647583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.582839846611023},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.5494935512542725},{"id":"https://openalex.org/C2776292868","wikidata":"https://www.wikidata.org/wiki/Q424525","display_name":"Flavones","level":2,"score":0.5343334674835205},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5191901922225952},{"id":"https://openalex.org/C2777755551","wikidata":"https://www.wikidata.org/wiki/Q2539773","display_name":"Chinese hamster","level":3,"score":0.4706387221813202},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4233609437942505},{"id":"https://openalex.org/C2779229383","wikidata":"https://www.wikidata.org/wiki/Q1501961","display_name":"Benzopyrene","level":4,"score":0.4149414598941803},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3662078380584717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2892870306968689},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.261984258890152},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23785969614982605},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.2300652265548706},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.10385656356811523},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D001564","descriptor_name":"Benzo(a)pyrene","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0009-2797(92)90109-x","doi":"https://doi.org/10.1016/0009-2797(92)90109-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0009-2797(92)90109-x","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},{"id":"pmid:1568269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1568269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-biological interactions","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4569060135","display_name":"CHEMISTRY OF NOVEL NATURAL INHIBITORS OF CARCINOGENESIS","funder_award_id":"R01CA038151","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8411277351","display_name":"REGULATION OF CYTOCHROME P-450 BY METHYLENEDIOXYBENZENES","funder_award_id":"R29ES005311","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W149279913","https://openalex.org/W1542868541","https://openalex.org/W1562939193","https://openalex.org/W1569831652","https://openalex.org/W1644190197","https://openalex.org/W1830431811","https://openalex.org/W1881840670","https://openalex.org/W1923263537","https://openalex.org/W1972617789","https://openalex.org/W1973879040","https://openalex.org/W1982244915","https://openalex.org/W1986735216","https://openalex.org/W1994752387","https://openalex.org/W2001538225","https://openalex.org/W2007924591","https://openalex.org/W2011410554","https://openalex.org/W2018667794","https://openalex.org/W2040564475","https://openalex.org/W2041927017","https://openalex.org/W2045462456","https://openalex.org/W2062914669","https://openalex.org/W2074509460","https://openalex.org/W2075899998","https://openalex.org/W2081571311","https://openalex.org/W2084387222","https://openalex.org/W2087321974","https://openalex.org/W2091983236","https://openalex.org/W2097370913","https://openalex.org/W2103113315","https://openalex.org/W2103546065","https://openalex.org/W2104731141","https://openalex.org/W2136170309","https://openalex.org/W2137612234","https://openalex.org/W2140126147","https://openalex.org/W2140546213","https://openalex.org/W2156608990","https://openalex.org/W2156921562","https://openalex.org/W2167092337","https://openalex.org/W2271065304","https://openalex.org/W2309952453","https://openalex.org/W2325209952","https://openalex.org/W2409300856","https://openalex.org/W2414413802","https://openalex.org/W2418544355","https://openalex.org/W2429136315","https://openalex.org/W2464627891","https://openalex.org/W2935731064","https://openalex.org/W4251327654","https://openalex.org/W6638647293","https://openalex.org/W6639981956","https://openalex.org/W6650236716","https://openalex.org/W6675775632","https://openalex.org/W6719389135"],"related_works":["https://openalex.org/W1995652705","https://openalex.org/W3033668679","https://openalex.org/W2140546213","https://openalex.org/W2131944769","https://openalex.org/W2140126147","https://openalex.org/W22214763","https://openalex.org/W1972927959","https://openalex.org/W2055868863","https://openalex.org/W2011193114","https://openalex.org/W2313102230"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}