{"id":"https://openalex.org/W1978775178","doi":"https://doi.org/10.1006/scbi.2000.0342","title":"Cellular transformation by SV40 large T antigen: interaction with host proteins","display_name":"Cellular transformation by SV40 large T antigen: interaction with host proteins","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W1978775178","doi":"https://doi.org/10.1006/scbi.2000.0342","mag":"1978775178","pmid":"https://pubmed.ncbi.nlm.nih.gov/11243895"},"language":"en","primary_location":{"id":"doi:10.1006/scbi.2000.0342","doi":"https://doi.org/10.1006/scbi.2000.0342","is_oa":false,"landing_page_url":"https://doi.org/10.1006/scbi.2000.0342","pdf_url":null,"source":{"id":"https://openalex.org/S154149207","display_name":"Seminars in Cancer Biology","issn_l":"1044-579X","issn":["1044-579X","1096-3650"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Cancer Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1978775178"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101110514","display_name":"Syed Hamid Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed Hamid Ali","raw_affiliation_strings":["Department of Adult Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081560191","display_name":"James A. DeCaprio","orcid":"https://orcid.org/0000-0002-0896-167X","observed_orcids":["https://orcid.org/0000-0002-0896-167X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James A. DeCaprio","raw_affiliation_strings":["Department of Adult Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081560191"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":6060,"currency":"USD","value_usd":6060},"apc_paid":null,"fwci":3.1629,"has_fulltext":false,"cited_by_count":385,"citation_normalized_percentile":{"value":0.93814433,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"15","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sv40-large-t-antigen","display_name":"SV40 large T antigen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oncoprotein","display_name":"oncoprotein","score":0.8529999852180481},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9739999771118164},{"id":"https://openalex.org/keywords/p53-tumor-suppressor","display_name":"p53 tumor suppressor","score":0.9309999942779541},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cbp","display_name":"CBP","score":0.9430000185966492},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.9639999866485596},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.6617717742919922},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6007813811302185},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5996060371398926},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5492435097694397},{"id":"https://openalex.org/C2776577112","wikidata":"https://www.wikidata.org/wiki/Q500695","display_name":"Retinoblastoma","level":3,"score":0.5347923636436462},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5197027325630188},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.44305652379989624},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.41801536083221436},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4008183181285858},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3443599343299866},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21068400144577026},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.20106825232505798},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1967897117137909}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000952","descriptor_name":"Antigens, Polyomavirus Transforming","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/scbi.2000.0342","doi":"https://doi.org/10.1006/scbi.2000.0342","is_oa":false,"landing_page_url":"https://doi.org/10.1006/scbi.2000.0342","pdf_url":null,"source":{"id":"https://openalex.org/S154149207","display_name":"Seminars in Cancer Biology","issn_l":"1044-579X","issn":["1044-579X","1096-3650"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Cancer Biology","raw_type":"journal-article"},{"id":"pmid:11243895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11243895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in cancer biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8900337930","display_name":"RB-Related Proteins and Polyomavirus Large T antigen Transformation","funder_award_id":"R01CA063113","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G936734049","display_name":null,"funder_award_id":"R01-CA50661","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W12635241","https://openalex.org/W14762771","https://openalex.org/W34095788","https://openalex.org/W34171714","https://openalex.org/W168561149","https://openalex.org/W191946090","https://openalex.org/W1496370438","https://openalex.org/W1548972556","https://openalex.org/W1554738594","https://openalex.org/W1565881767","https://openalex.org/W1583419301","https://openalex.org/W1609607086","https://openalex.org/W1799167605","https://openalex.org/W1810419160","https://openalex.org/W1818354890","https://openalex.org/W1834050293","https://openalex.org/W1846573294","https://openalex.org/W1861504067","https://openalex.org/W1884928119","https://openalex.org/W1906412621","https://openalex.org/W1965080968","https://openalex.org/W1966063731","https://openalex.org/W1967404701","https://openalex.org/W1970107528","https://openalex.org/W1975232450","https://openalex.org/W1981004390","https://openalex.org/W1981391513","https://openalex.org/W1982622947","https://openalex.org/W1983971803","https://openalex.org/W1985118687","https://openalex.org/W1985840237","https://openalex.org/W1991494214","https://openalex.org/W1994840092","https://openalex.org/W2008301561","https://openalex.org/W2018385269","https://openalex.org/W2021326683","https://openalex.org/W2024387238","https://openalex.org/W2033529039","https://openalex.org/W2035410753","https://openalex.org/W2039543373","https://openalex.org/W2044119126","https://openalex.org/W2048566300","https://openalex.org/W2050932117","https://openalex.org/W2053432671","https://openalex.org/W2063158632","https://openalex.org/W2063877452","https://openalex.org/W2066125587","https://openalex.org/W2072319696","https://openalex.org/W2085195718","https://openalex.org/W2087390195","https://openalex.org/W2091098061","https://openalex.org/W2092675732","https://openalex.org/W2099742439","https://openalex.org/W2101760437","https://openalex.org/W2105902888","https://openalex.org/W2111600528","https://openalex.org/W2117554207","https://openalex.org/W2127237580","https://openalex.org/W2128366838","https://openalex.org/W2131757108","https://openalex.org/W2132682224","https://openalex.org/W2136306650","https://openalex.org/W2139449371","https://openalex.org/W2141711704","https://openalex.org/W2145596465","https://openalex.org/W2148142571","https://openalex.org/W2149652167","https://openalex.org/W2150710841","https://openalex.org/W2153055905","https://openalex.org/W2154147940","https://openalex.org/W2155009866","https://openalex.org/W2164436574","https://openalex.org/W2164654743","https://openalex.org/W2166091854","https://openalex.org/W2248056767","https://openalex.org/W2895139290","https://openalex.org/W4296142355","https://openalex.org/W6600510063","https://openalex.org/W6601357843","https://openalex.org/W6601368522","https://openalex.org/W6607760920","https://openalex.org/W6832934383"],"related_works":["https://openalex.org/W2415156747","https://openalex.org/W2046671223","https://openalex.org/W2141711704","https://openalex.org/W1979051583","https://openalex.org/W2072104095","https://openalex.org/W2465363299","https://openalex.org/W2036207434","https://openalex.org/W21187551","https://openalex.org/W2057744900","https://openalex.org/W2098220950"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}