{"id":"https://openalex.org/W1978772005","doi":"https://doi.org/10.1007/bf01541318","title":"CpG DNA: A pathogenic factor in systemic lupus erythematosus?","display_name":"CpG DNA: A pathogenic factor in systemic lupus erythematosus?","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W1978772005","doi":"https://doi.org/10.1007/bf01541318","mag":"1978772005","pmid":"https://pubmed.ncbi.nlm.nih.gov/8576314"},"language":"en","primary_location":{"id":"doi:10.1007/bf01541318","doi":"https://doi.org/10.1007/bf01541318","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01541318","pdf_url":null,"source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109277513","display_name":"Arthur \u039c. Krieg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arthur M. Krieg","raw_affiliation_strings":["Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA","Department of Internal Medicine, University of Iowa College of Medicine, 52242, Iowa City, Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Iowa College of Medicine, 52242, Iowa City, Iowa","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109277513"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":1.7667,"has_fulltext":false,"cited_by_count":157,"citation_normalized_percentile":{"value":0.86792453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"6","first_page":"284","last_page":"292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cpg-dinucleotides","display_name":"CpG","score":0.8920000195503235},{"id":"https://openalex.org/keywords/bacterial-dna","display_name":"bacterial DNA","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.5789999961853027},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7260000109672546},{"id":"https://openalex.org/keywords/polyclonal-b-cell-activation","display_name":"polyclonal B cell activation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/anti-dna-antibodies","display_name":"anti-DNA antibodies","score":0.8399999737739563},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/autoreactive-b-cells","display_name":"autoreactive B cells","score":0.7670000195503235},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.6489999890327454},{"id":"https://openalex.org/keywords/self-tolerance","display_name":"self-tolerance","score":0.5329999923706055},{"id":"https://openalex.org/keywords/lupus-pathogenesis","display_name":"lupus pathogenesis","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7014309167861938},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.6736084222793579},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6076583862304688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5946455001831055},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.539384126663208},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5293940901756287},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44863033294677734},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.43592169880867004},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.42930692434310913},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.42245227098464966},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4220602512359619},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3270062208175659},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.24512436985969543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22107499837875366},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19827812910079956},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10057884454727173},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015226","descriptor_name":"Dinucleoside Phosphates","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01541318","doi":"https://doi.org/10.1007/bf01541318","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01541318","pdf_url":null,"source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:8576314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8576314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1920725797","display_name":"ENDOGENOUS RETROVIRUSES AS A CAUSAL MECHANISM IN LUPUS","funder_award_id":"5r29ar042556-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3890309051","display_name":null,"funder_award_id":"R29 AR42556-01","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306274","display_name":"Roy J. Carver Charitable Trust","ror":"https://ror.org/01ah2ch91"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W23791171","https://openalex.org/W172646224","https://openalex.org/W176696130","https://openalex.org/W213645308","https://openalex.org/W1468684175","https://openalex.org/W1478898356","https://openalex.org/W1497776246","https://openalex.org/W1509217120","https://openalex.org/W1515776315","https://openalex.org/W1528772515","https://openalex.org/W1529149290","https://openalex.org/W1534735130","https://openalex.org/W1551211023","https://openalex.org/W1561970933","https://openalex.org/W1585414631","https://openalex.org/W1589939578","https://openalex.org/W1599749655","https://openalex.org/W1602504789","https://openalex.org/W1656835564","https://openalex.org/W1694021947","https://openalex.org/W1817131636","https://openalex.org/W1823692109","https://openalex.org/W1841124133","https://openalex.org/W1845785449","https://openalex.org/W1856052310","https://openalex.org/W1921475843","https://openalex.org/W1971254079","https://openalex.org/W1972120590","https://openalex.org/W1982662207","https://openalex.org/W1986616196","https://openalex.org/W1986877571","https://openalex.org/W1989539061","https://openalex.org/W1990834356","https://openalex.org/W1992379806","https://openalex.org/W1994009027","https://openalex.org/W1995108806","https://openalex.org/W1997635297","https://openalex.org/W1998831656","https://openalex.org/W2003811218","https://openalex.org/W2006083896","https://openalex.org/W2007300664","https://openalex.org/W2011410977","https://openalex.org/W2016057259","https://openalex.org/W2016563674","https://openalex.org/W2026593688","https://openalex.org/W2034271713","https://openalex.org/W2034611721","https://openalex.org/W2036532351","https://openalex.org/W2041445102","https://openalex.org/W2047366876","https://openalex.org/W2051729351","https://openalex.org/W2053816450","https://openalex.org/W2061643328","https://openalex.org/W2067401769","https://openalex.org/W2068230814","https://openalex.org/W2069218664","https://openalex.org/W2074791128","https://openalex.org/W2075939079","https://openalex.org/W2076959452","https://openalex.org/W2084118479","https://openalex.org/W2088339535","https://openalex.org/W2090819044","https://openalex.org/W2093514167","https://openalex.org/W2097885269","https://openalex.org/W2098976753","https://openalex.org/W2109284405","https://openalex.org/W2112052452","https://openalex.org/W2128804951","https://openalex.org/W2143755192","https://openalex.org/W2151590142","https://openalex.org/W2153782423","https://openalex.org/W2169395419","https://openalex.org/W2169678144","https://openalex.org/W2180476098","https://openalex.org/W2295772835","https://openalex.org/W2400597124","https://openalex.org/W2414074747"],"related_works":["https://openalex.org/W264343530","https://openalex.org/W2155872969","https://openalex.org/W204232721","https://openalex.org/W4313532343","https://openalex.org/W2263951289","https://openalex.org/W2148172386","https://openalex.org/W2116339069","https://openalex.org/W4385686630","https://openalex.org/W4416446049","https://openalex.org/W2168811473"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
