{"id":"https://openalex.org/W1978765308","doi":"https://doi.org/10.1073/pnas.94.26.14848","title":"Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide","display_name":"Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide","publication_year":1997,"publication_date":"1997-12-23","ids":{"openalex":"https://openalex.org/W1978765308","doi":"https://doi.org/10.1073/pnas.94.26.14848","mag":"1978765308","pmid":"https://pubmed.ncbi.nlm.nih.gov/9405702","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/25126"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.94.26.14848","doi":"https://doi.org/10.1073/pnas.94.26.14848","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.94.26.14848","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/25126","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072301654","display_name":"Randa Zakhary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randa Zakhary","raw_affiliation_strings":["Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210149717","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082015658","display_name":"Kenneth D. Poss","orcid":"https://orcid.org/0000-0002-6743-5709","observed_orcids":["https://orcid.org/0000-0002-6743-5709"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth D. Poss","raw_affiliation_strings":["Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210149717","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046085522","display_name":"Samie R. Jaffrey","orcid":"https://orcid.org/0000-0003-3615-6958","observed_orcids":["https://orcid.org/0000-0003-3615-6958"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samie R. Jaffrey","raw_affiliation_strings":["Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210149717","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113810767","display_name":"Christopher D. Ferris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D. Ferris","raw_affiliation_strings":["Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210149717","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038557565","display_name":"Susumu Tonegawa","orcid":"https://orcid.org/0000-0003-2839-8228","observed_orcids":["https://orcid.org/0000-0003-2839-8228"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susumu Tonegawa","raw_affiliation_strings":["Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210149717","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020208893","display_name":"Solomon H. Snyder","orcid":"https://orcid.org/0000-0002-6818-7022","observed_orcids":["https://orcid.org/0000-0002-6818-7022"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Solomon H. Snyder","raw_affiliation_strings":["Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street Baltimore, MD 21205; Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139-4307; and Department of Medicine, Divisions of Gastroenterology, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210149717","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2672,"has_fulltext":false,"cited_by_count":234,"citation_normalized_percentile":{"value":0.95567576,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"94","issue":"26","first_page":"14848","last_page":"14853"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-oxygenase-2","display_name":"heme oxygenase-2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/carbon-monoxide","display_name":"carbon monoxide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9549999833106995},{"id":"https://openalex.org/keywords/myenteric-ganglia","display_name":"myenteric ganglia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/non-adrenergic-non-cholinergic-relaxation","display_name":"non-adrenergic non-cholinergic relaxation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.7649999856948853},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.5199999809265137},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibitors","display_name":"nitric oxide synthase inhibitors","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2779219270","wikidata":"https://www.wikidata.org/wiki/Q419972","display_name":"Heme oxygenase","level":4,"score":0.8382809162139893},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.7400774955749512},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.713530421257019},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6107470989227295},{"id":"https://openalex.org/C2780994212","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic guanosine monophosphate","level":3,"score":0.5964489579200745},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5596792697906494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5577071905136108},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4720799922943115},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.47052040696144104},{"id":"https://openalex.org/C512735826","wikidata":"https://www.wikidata.org/wiki/Q2025","display_name":"Carbon monoxide","level":3,"score":0.45515626668930054},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.44828709959983826},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36620473861694336},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35437917709350586},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32038718461990356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31462323665618896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3010491132736206},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16527706384658813},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1542414426803589},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14474037289619446},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017615","descriptor_name":"Enteric Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.94.26.14848","doi":"https://doi.org/10.1073/pnas.94.26.14848","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.94.26.14848","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:25126","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/25126","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9405702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9405702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:25126","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/25126","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G154064031","display_name":null,"funder_award_id":"DA-00266","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G1609066045","display_name":"Drug Abuse Research Center","funder_award_id":"P50DA000266","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G1615557336","display_name":null,"funder_award_id":"DA 00074","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2142176442","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007309","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2391789615","display_name":null,"funder_award_id":"00266","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4763053320","display_name":"CALCIUM-DEPENDENT REGULATORY PROTEIN OF THE IP3 RECEPTOR","funder_award_id":"F31AA005418","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G58031844","display_name":null,"funder_award_id":"DA.00266","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7243145451","display_name":null,"funder_award_id":"DA-00074","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7464135931","display_name":null,"funder_award_id":"GM-07309","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7679270143","display_name":"Neurotransmitter Receptors","funder_award_id":"K05DA000074","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7816012306","display_name":"Molecular Genetic Approaches to Learning and Memory","funder_award_id":"R01NS032925","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000144308","display_name":null,"funder_award_id":"DA00266","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W304581165","https://openalex.org/W1529716765","https://openalex.org/W1529948332","https://openalex.org/W1587935192","https://openalex.org/W1594700207","https://openalex.org/W1597939951","https://openalex.org/W1903443535","https://openalex.org/W1926494419","https://openalex.org/W1966322594","https://openalex.org/W1966733094","https://openalex.org/W1975333295","https://openalex.org/W1976866228","https://openalex.org/W1980351331","https://openalex.org/W1981165639","https://openalex.org/W1986271944","https://openalex.org/W1993309579","https://openalex.org/W1993411417","https://openalex.org/W2001323948","https://openalex.org/W2012753695","https://openalex.org/W2019646554","https://openalex.org/W2021569785","https://openalex.org/W2035880314","https://openalex.org/W2038978204","https://openalex.org/W2039903290","https://openalex.org/W2040420061","https://openalex.org/W2042057704","https://openalex.org/W2051478582","https://openalex.org/W2054802842","https://openalex.org/W2055620557","https://openalex.org/W2060119066","https://openalex.org/W2070051672","https://openalex.org/W2079625010","https://openalex.org/W2081347741","https://openalex.org/W2108999152","https://openalex.org/W2124433916","https://openalex.org/W2125507492","https://openalex.org/W2131173683","https://openalex.org/W2145530136","https://openalex.org/W2154490004","https://openalex.org/W2292368642","https://openalex.org/W2405690953","https://openalex.org/W2418066417","https://openalex.org/W4206302388","https://openalex.org/W4251003048"],"related_works":["https://openalex.org/W2036725419","https://openalex.org/W2136731748","https://openalex.org/W2003677957","https://openalex.org/W1522191426","https://openalex.org/W2006295709","https://openalex.org/W1983895879","https://openalex.org/W2000074569","https://openalex.org/W2131173683","https://openalex.org/W2023126641","https://openalex.org/W2152319284"],"abstract_inverted_index":{"Neuronal":[0],"nitric":[1],"oxide":[2],"synthase":[3],"(nNOS)":[4],"generates":[5],"NO":[6,22],"in":[7,25,45,65,98],"neurons,":[8],"and":[9,23,43,51,68,76,93],"heme-oxygenase-2":[10],"(HO-2)":[11],"synthesizes":[12],"carbon":[13],"monoxide":[14],"(CO).":[15],"We":[16],"have":[17],"evaluated":[18],"the":[19],"roles":[20],"of":[21,33,41],"CO":[24],"intestinal":[26],"neurotransmission":[27],"using":[28],"mice":[29],"with":[30],"targeted":[31],"deletions":[32],"nNOS":[34,42],"or":[35],"HO-2.":[36],"Immunohistochemical":[37],"analysis":[38],"demonstrated":[39],"colocalization":[40],"HO-2":[44],"myenteric":[46],"ganglia.":[47],"Nonadrenergic":[48],"noncholinergic":[49,82],"relaxation":[50],"cyclic":[52],"guanosine":[53],"3',5'":[54],"monophosphate":[55],"elevations":[56],"evoked":[57],"by":[58],"electrical":[59],"field":[60],"stimulation":[61],"were":[62,96],"diminished":[63],"markedly":[64],"both":[66],"nNOSDelta/Delta":[67,85],"HO-2(Delta)/Delta":[69,99],"mice.":[70],"In":[71,84],"wild-type":[72],"mice,":[73],"NOS":[74,87],"inhibitors":[75,78,88,95],"HO":[77,94],"partially":[79],"inhibited":[80],"nonadrenergic":[81],"relaxation.":[83],"animals,":[86],"selectively":[89],"lost":[90],"their":[91],"efficacy,":[92],"inactive":[97],"animals.":[100]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
