{"id":"https://openalex.org/W1978764638","doi":"https://doi.org/10.1515/bchm2.1976.357.2.1477","title":"Cholic Acid Uptake into Isolated Rat Hepatocytes","display_name":"Cholic Acid Uptake into Isolated Rat Hepatocytes","publication_year":1976,"publication_date":"1976-01-01","ids":{"openalex":"https://openalex.org/W1978764638","doi":"https://doi.org/10.1515/bchm2.1976.357.2.1477","mag":"1978764638","pmid":"https://pubmed.ncbi.nlm.nih.gov/1002127"},"language":"de","primary_location":{"id":"doi:10.1515/bchm2.1976.357.2.1477","doi":"https://doi.org/10.1515/bchm2.1976.357.2.1477","is_oa":false,"landing_page_url":"https://doi.org/10.1515/bchm2.1976.357.2.1477","pdf_url":null,"source":{"id":"https://openalex.org/S4210203370","display_name":"Hoppe-Seyler\u00b4s Zeitschrift f\u00fcr physiologische Chemie","issn_l":"0018-4888","issn":["0018-4888"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hoppe-Seyler\u00b4s Zeitschrift f\u00fcr physiologische Chemie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112076454","display_name":"M. S. Anwer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Sawkat ANWER","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011281715","display_name":"Reinhard Kroker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reinhard KROKER","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110101719","display_name":"Dietmar HEGNER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dietmar HEGNER","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.2299,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.96117741,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"357","issue":"2","first_page":"1477","last_page":"1486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholic-acid","display_name":"cholic acid","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hepatocyte-uptake","display_name":"hepatocyte uptake","score":0.7300000190734863},{"id":"https://openalex.org/keywords/bile-acid-transport","display_name":"bile acid transport","score":0.9160000085830688},{"id":"https://openalex.org/keywords/carrier-mediated-transport","display_name":"carrier-mediated transport","score":0.7860000133514404},{"id":"https://openalex.org/keywords/passive-diffusion","display_name":"passive diffusion","score":0.9390000104904175},{"id":"https://openalex.org/keywords/adsorption","display_name":"adsorption","score":0.5370000004768372},{"id":"https://openalex.org/keywords/countertransport","display_name":"countertransport","score":0.6899999976158142},{"id":"https://openalex.org/keywords/taurocholic-acid","display_name":"taurocholate","score":0.8939999938011169},{"id":"https://openalex.org/keywords/chenodeoxycholic-acid","display_name":"chenodeoxycholic acid","score":1.0},{"id":"https://openalex.org/keywords/oligomycin-inhibition","display_name":"oligomycin inhibition","score":0.8889999985694885},{"id":"https://openalex.org/keywords/activation-energy","display_name":"activation energy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.5600000023841858},{"id":"https://openalex.org/keywords/rat-hepatocytes","display_name":"rat hepatocytes","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2775900799","wikidata":"https://www.wikidata.org/wiki/Q287415","display_name":"Cholic acid","level":3,"score":0.9781943559646606},{"id":"https://openalex.org/C2780480987","wikidata":"https://www.wikidata.org/wiki/Q2659931","display_name":"Taurocholic acid","level":3,"score":0.7324036359786987},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6015563011169434},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5647413730621338},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.5443688035011292},{"id":"https://openalex.org/C2781089062","wikidata":"https://www.wikidata.org/wiki/Q419028","display_name":"Chenodeoxycholic acid","level":3,"score":0.4911193549633026},{"id":"https://openalex.org/C124815738","wikidata":"https://www.wikidata.org/wiki/Q41509","display_name":"Mole","level":2,"score":0.41967442631721497},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3595321476459503},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.35096514225006104},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000327","descriptor_name":"Adsorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002793","descriptor_name":"Cholic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003486","descriptor_name":"Cyanides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009840","descriptor_name":"Oligomycins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1515/bchm2.1976.357.2.1477","doi":"https://doi.org/10.1515/bchm2.1976.357.2.1477","is_oa":false,"landing_page_url":"https://doi.org/10.1515/bchm2.1976.357.2.1477","pdf_url":null,"source":{"id":"https://openalex.org/S4210203370","display_name":"Hoppe-Seyler\u00b4s Zeitschrift f\u00fcr physiologische Chemie","issn_l":"0018-4888","issn":["0018-4888"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hoppe-Seyler\u00b4s Zeitschrift f\u00fcr physiologische Chemie","raw_type":"journal-article"},{"id":"pmid:1002127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1002127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hoppe-Seyler's Zeitschrift fur physiologische Chemie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W59490061","https://openalex.org/W1982464665","https://openalex.org/W1983649348","https://openalex.org/W1986798034","https://openalex.org/W1995663969","https://openalex.org/W2024797186","https://openalex.org/W2032067145","https://openalex.org/W2058261108","https://openalex.org/W2074437769"],"related_works":["https://openalex.org/W2050730045","https://openalex.org/W2010254565","https://openalex.org/W2052438404","https://openalex.org/W2415127887","https://openalex.org/W2410795899","https://openalex.org/W1969460852","https://openalex.org/W2240717838","https://openalex.org/W2178066024","https://openalex.org/W1997959107","https://openalex.org/W2093609081"],"abstract_inverted_index":{"Cholic":[0,53],"acid":[1,54,91,191],"uptake":[2,55,71,104,114,151],"was":[3,32,56,74,106,153,171,178],"studied":[4],"in":[5,199],"isolated":[6],"rat":[7],"hepatocytes":[8],"using":[9],"a":[10,35,69,84,119],"centrifugal":[11],"filtration":[12],"technique":[13],"to":[14,21,26,60,76,137,201],"allow":[15],"rapid":[16],"sampling.":[17],"Hepatocytes":[18],"were":[19,135],"found":[20],"adsorb":[22],"as":[23,25],"well":[24],"transport":[27],"cholic":[28,90,190],"acid.":[29],"The":[30,125,186],"adsorption":[31],"characterized":[33],"by":[34,83,173,194,204],"capacity":[36],"of":[37,48,87,159],"24":[38],"nmol":[39,142],"X":[40,50,92,94,97,143,145,162,165,168],"mg":[41,95,146],"cell":[42],"protein-1":[43,96,147],"and":[44,80,128,140,170,175,183,206],"an":[45,156,195],"association":[46],"constant":[47],"0.59":[49],"103":[51],"M-1.":[52],"linear":[57],"with":[58,155,180],"respect":[59],"concentration":[61],"at":[62,116,131],"or":[63],"below":[64],"10":[65,100],"degree":[66],"C,":[67],"suggesting":[68],"unsaturable":[70,111],"process":[72,152,198],"which":[73],"considered":[75],"represent":[77],"simple":[78,202],"diffusion":[79,85,203],"is":[81,192],"quantitated":[82],"coefficient":[86],"1.76":[88],"pmol":[89],"min-1":[93,144],"muM-1.":[98],"Above":[99],"degrees":[101,133],"C":[102,134],"the":[103,110,208],"curve":[105,120],"biphasic.":[107],"After":[108],"subtracting":[109],"component":[112],"from":[113],"rates":[115],"higher":[117],"temperatures,":[118],"showing":[121],"saturable":[122,150],"kinetics":[123],"resulted.":[124],"apparent":[126],"Km":[127],"V":[129],"values":[130],"37":[132],"calculated":[136],"be":[138],"31muM":[139],"0.8":[141],"respectively.":[148],"This":[149],"temperature-dependent":[154],"activation":[157],"energy":[158],"13":[160],"kcal":[161],"mol-1":[163],"(5.44":[164],"104":[166],"J":[167],"mol-1)":[169],"inhibited":[172],"oligomycin":[174],"KCN.":[176],"Countertransport":[177],"demonstrated":[179],"cholic,":[181],"taurocholic":[182],"chenodeoxycholic":[184],"acids.":[185,216],"results":[187],"suggest":[188],"that":[189,207],"transported":[193],"energy-dependent":[196],"carrier-mediated":[197],"addition":[200],"hepatocytes,":[205],"postulated":[209],"carrier":[210],"has":[211],"affinity":[212],"for":[213],"other":[214],"bile":[215]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
